Best TWAS P=4.21e-09 · Best GWAS P=2.05e-08 conditioned to 0.00432
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | PCYT1A | 0.11 | 0.03 | lasso | 3 | 0.00 | 3.9e-01 | 5.5 | -5.5 | 4.8e-08 | -0.08 | 0.01 | 0.88 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | SLC51A | 0.28 | 0.06 | lasso | 6 | 0.14 | 1.3e-07 | 2.8 | -5.2 | 2.3e-07 | 0.01 | 0.07 | 0.86 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | UBXN7 | 0.20 | 0.00 | enet | 16 | 0.02 | 3.5e-02 | -4.9 | -5.3 | 1.0e-07 | 0.02 | 0.03 | 0.87 | FALSE |
| 4 | GTEx | Pancreas | XXYLT1 | 0.13 | 0.07 | enet | 13 | 0.07 | 8.7e-04 | -4.3 | 5.3 | 1.1e-07 | -0.41 | 0.20 | 0.35 | FALSE |
| 5 | GTEx | Spleen | PCYT1A | 0.19 | 0.05 | lasso | 4 | 0.09 | 3.1e-03 | -4.1 | -5.2 | 1.8e-07 | -0.06 | 0.05 | 0.53 | FALSE |
| 6 | GTEx | Stomach | SLC51A | 0.13 | 0.06 | enet | 12 | 0.03 | 1.9e-02 | 4.7 | -5.8 | 5.4e-09 | -0.08 | 0.02 | 0.94 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | C3orf21 | 0.16 | 0.08 | enet | 18 | 0.16 | 1.7e-09 | -5.2 | 5.7 | 1.6e-08 | -0.67 | 0.03 | 0.97 | TRUE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | UBXN7 | 0.02 | 0.01 | blup | 45 | 0.02 | 4.2e-03 | 4.1 | -5.9 | 4.2e-09 | -0.05 | 0.02 | 0.56 | TRUE |
| 9 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PCYT1A | 0.12 | 0.05 | blup | 68 | 0.06 | 2.0e-04 | 4.8 | -5.6 | 2.5e-08 | -0.07 | 0.01 | 0.91 | FALSE |