Best TWAS P=2.02e-11 · Best GWAS P=1.83e-10 conditioned to 0.284
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SGCB | 0.02 | 0.02 | enet | 21 | 0.01 | 9.7e-03 | 5.6 | 5.3 | 1.2e-07 | 0.69 | 0.05 | 0.84 | FALSE |
2 | GTEx | Brain Cerebellum | OCIAD1 | 0.10 | 0.04 | lasso | 5 | 0.02 | 1.1e-01 | 5.2 | -5.3 | 1.3e-07 | -0.50 | 0.07 | 0.36 | FALSE |
3 | GTEx | Breast Mammary Tissue | DCUN1D4 | 0.08 | 0.02 | enet | 11 | 0.04 | 2.4e-03 | 6.2 | 5.9 | 3.1e-09 | 0.89 | 0.04 | 0.89 | FALSE |
4 | GTEx | Breast Mammary Tissue (Female) | DCUN1D4 | 0.02 | 0.03 | lasso | 1 | 0.02 | 8.2e-02 | 6.2 | 6.2 | 6.5e-10 | 0.96 | 0.02 | 0.21 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | DCUN1D4 | 0.05 | 0.04 | enet | 15 | 0.04 | 7.8e-04 | 5.6 | 5.5 | 3.2e-08 | 0.85 | 0.06 | 0.88 | FALSE |
6 | GTEx | Colon Transverse | OCIAD1 | 0.07 | 0.07 | lasso | 5 | 0.05 | 2.8e-03 | 5.3 | -5.2 | 2.6e-07 | -0.44 | 0.18 | 0.67 | FALSE |
7 | GTEx | Esophagus Mucosa | OCIAD1 | 0.07 | 0.06 | lasso | 4 | 0.06 | 9.9e-05 | 5.7 | -5.2 | 1.7e-07 | -0.44 | 0.10 | 0.90 | FALSE |
8 | GTEx | Esophagus Muscularis | OCIAD1 | 0.12 | 0.16 | lasso | 6 | 0.17 | 9.1e-11 | 5.3 | -5.2 | 2.0e-07 | -0.46 | 0.13 | 0.87 | FALSE |
9 | GTEx | Nerve Tibial | DCUN1D4 | 0.10 | 0.09 | lasso | 3 | 0.10 | 6.8e-08 | 5.6 | 6.0 | 1.5e-09 | 0.93 | 0.09 | 0.91 | FALSE |
10 | GTEx | Ovary | FRYL | 0.12 | -0.01 | enet | 21 | 0.03 | 7.2e-02 | 5.5 | 5.9 | 3.1e-09 | 0.62 | 0.07 | 0.52 | FALSE |
11 | GTEx | Skin Sun Exposed Lower leg | FRYL | 0.05 | 0.01 | enet | 19 | 0.02 | 8.6e-03 | -3.8 | 5.4 | 7.5e-08 | 0.45 | 0.17 | 0.53 | FALSE |
12 | GTEx | Testis | DCUN1D4 | 0.19 | 0.17 | enet | 14 | 0.16 | 8.7e-08 | 5.6 | 5.7 | 1.1e-08 | 0.84 | 0.10 | 0.90 | FALSE |
13 | GTEx | Thyroid | DCUN1D4 | 0.03 | 0.05 | lasso | 1 | 0.04 | 2.4e-04 | 6.2 | 6.2 | 6.5e-10 | 0.96 | 0.03 | 0.93 | FALSE |
14 | ROSMAP | Brain Pre-frontal Cortex | SGCB | 0.03 | 0.03 | enet | 9 | 0.03 | 7.0e-05 | 5.8 | 6.7 | 2.0e-11 | 0.87 | 0.04 | 0.95 | TRUE |
15 | The Cancer Genome Atlas | Colon Adenocarcinoma | LRRC66 | 0.07 | 0.03 | lasso | 3 | 0.05 | 8.0e-04 | 5.6 | -5.6 | 2.2e-08 | -0.62 | 0.03 | 0.41 | FALSE |
16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FRYL | 0.03 | 0.03 | enet | 8 | 0.03 | 3.2e-04 | 5.2 | 5.6 | 2.5e-08 | 0.40 | 0.04 | 0.84 | FALSE |
17 | The Cancer Genome Atlas | Thyroid Carcinoma | FRYL | 0.02 | 0.01 | blup | 93 | 0.01 | 3.6e-02 | 5.1 | 5.3 | 1.1e-07 | 0.49 | 0.03 | 0.74 | FALSE |