TWAS hub - LRRC66

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.059	0.039	0.0073	0.025	NA	0.007	NA	0.013	0.0270	NA	0.14000	NA	0.0790
2	GTEx	Pancreas	0.572	0.140	0.0095	0.002	NA	0.071	NA	0.051	0.2600	NA	0.00061	NA	0.0034
3	TCGA	Bladder Urothelial Carcinoma	0.062	0.044	0.0072	0.022	0.022	-0.001	NA	0.011	0.0051	0.0054	0.37000	NA	0.0350
4	TCGA	Colon Adenocarcinoma	0.066	0.062	0.0048	0.026	0.043	0.048	NA	0.049	0.0110	0.0017	0.00095	NA	0.0008

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4
Medication: Aspirin	8.4	11.1	26.0	5.1	-2.3	-3.6
Medication: Aspirin	8.0	10.5	23.7	4.9	-2.2	-3.6
Medication: Metformin	7.3	10.3	28.2	5.3	-2.0	-3.0
Father’s age at death	6.2	8.3	21.2	-4.6	2.0	2.8
Type 2 Diabetes (T2D) (2018)	5.6	10.5	24.0	4.9	-2.5	-3.4
Deep venous thrombosis (DVT) (self-reported)	5.3	6.9	11.5	2.7	-3.4	-2.9
Blood clot in the leg (DVT)	5.2	6.7	10.4	2.9	-3.2	-2.8
Medication: Simvastatin	4.9	7.1	19.2	4.4	-1.6	-2.6
Diabetes (self-reported)	4.8	7.5	12.8	3.6	-2.6	-3.2
Diabetes diagnosed by doctor	4.7	7.8	16.2	4.0	-2.3	-3.1
Tense / ‘highly strung’	4.4	7.2	11.4	-2.6	3.4	3.3
Weight	4.2	20.7	35.9	5.1	-4.5	-6.0
Systolic blood pressure, automated reading	4.1	12.0	20.4	4.5	-3.2	-4.1
Trunk fat mass	4.1	17.7	31.3	4.4	-4.4	-5.6
Cholesterol lowering medication	4.0	5.9	11.1	3.3	-1.9	-3.0
Medication: Atenolol	3.9	4.8	9.9	3.1	-1.5	-2.7
Medication: Blood pressure	3.8	7.3	12.5	3.2	-2.6	-3.5
Back pain experienced in last month	3.7	5.4	9.7	3.0	-1.6	-3.1
Arm fat mass (right)	3.6	14.7	24.3	4.6	-3.7	-4.9
Whole body fat mass	3.6	15.1	26.8	4.3	-3.9	-5.2
Hip circumference	3.5	14.9	26.5	4.3	-3.8	-5.2
Arm fat-free mass (left)	3.5	17.7	31.2	4.6	-4.2	-5.6
Number of treatments/medications taken	3.4	6.0	12.6	3.5	-1.6	-3.0
Arm predicted mass (right)	3.4	17.2	31.2	4.8	-3.9	-5.6
Arm fat mass (left)	3.4	13.9	23.4	4.3	-3.7	-4.8
Arm predicted mass (left)	3.4	17.2	31.2	4.6	-4.1	-5.6
Medication: Ramipril	3.3	4.2	9.5	3.1	-0.6	-2.6
Medication for cholesterol, blood pressure or diabetes	3.3	5.4	10.2	-3.2	1.7	2.9
Alcohol intake frequency.	3.3	7.8	13.7	3.7	-2.2	-3.5
Age at last live birth	3.3	4.8	9.7	-2.0	2.4	3.1
Systolic Blood Pressure	3.2	15.9	35.3	5.9	-3.1	-4.3
Arm fat-free mass (right)	3.2	16.7	30.0	4.7	-3.8	-5.5
Basal metabolic rate	3.2	17.8	30.9	5.0	-3.9	-5.6
Coronary Artery Disease (CAD)	3.1	3.7	7.3	0.5	-2.7	-2.7
Cardiovascular Disease	3.0	10.1	21.2	3.3	-2.9	-4.6
Trunk fat percentage	3.0	12.2	21.3	3.5	-3.9	-4.6
Age at first live birth	3.0	5.2	9.2	-3.0	2.0	2.8
Mother’s age at death	3.0	3.8	6.0	-2.4	2.4	1.9
Leg fat mass (left)	3.0	11.6	19.5	3.9	-3.4	-4.4
Leg fat-free mass (left)	2.9	15.4	26.6	4.7	-3.6	-5.2
Leg predicted mass (left)	2.9	15.3	26.2	4.7	-3.6	-5.1
Waist circumference	2.9	10.5	19.2	3.3	-3.5	-4.4
Leg fat mass (right)	2.9	11.4	19.3	3.8	-3.4	-4.4
Whole body fat-free mass	2.9	16.6	29.1	4.8	-3.8	-5.4
Whole body water mass	2.9	16.7	29.1	4.8	-3.8	-5.4
Medication: Bendroflumethiazide	2.9	4.4	9.2	2.2	-1.8	-3.0
Trunk fat-free mass	2.8	15.8	27.8	4.7	-3.6	-5.3
Vascular/heart problems diagnosed by doctor	2.8	7.6	16.5	-3.1	2.1	4.1
Heart attack	2.7	3.4	8.4	2.9	-0.9	-2.1
Trunk predicted mass	2.7	15.3	26.9	4.7	-3.5	-5.2
Medication: Paracetamol	2.7	4.5	7.9	2.8	-1.8	-2.6
Leg fat-free mass (right)	2.7	14.3	24.9	4.5	-3.5	-5.0
Shortness of breath walking on level ground	2.6	3.1	7.6	-0.1	2.8	2.2
Leg predicted mass (right)	2.6	14.1	24.3	4.5	-3.5	-4.9
Medication: Paracetamol	2.6	4.1	7.2	2.0	-2.2	-2.7
Illnesses of siblings	2.5	3.5	7.3	-2.7	1.1	2.3
Body fat percentage	2.5	9.8	17.3	3.1	-3.5	-4.2
Heart attack/myocardial infarction (self-reported)	2.5	3.2	7.2	2.7	-1.0	-2.2
Alcohol intake versus 10 years previously	2.4	3.5	9.3	3.0	-0.8	-2.0
Worry (Nagel 2018)	2.3	5.0	8.1	-2.7	2.1	2.8
Age at First Birth	2.3	3.4	7.4	-0.9	2.7	2.3
Height	2.3	44.1	70.9	8.2	-6.2	-8.4
Medication: Cholesterol lowering	2.3	3.6	9.5	3.1	-1.2	-1.9
Lung cancer (father)	2.3	2.7	6.6	0.7	-1.9	-2.6
Medication: Seretide 50 evohaler	2.2	2.5	3.6	1.7	-1.9	-1.9
Hypertension (Self-reported)	2.2	6.1	14.2	2.5	-1.9	-3.8
Medication for cholesterol	2.2	3.3	6.4	-2.5	1.6	2.1
Number of self-reported non-cancer illnesses	2.2	3.7	7.2	1.4	-2.4	-2.7
Alcohol drinker status: Never	2.2	2.6	5.3	2.3	-1.2	-1.9
Arm fat percentage (right)	2.1	8.2	13.5	3.3	-2.9	-3.7
Comparative height size at age 10	2.1	11.7	21.3	3.4	-3.7	-4.6
Eye problems/disorders: Cataract	2.1	2.4	4.8	-1.4	2.2	1.7
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	4.3	-2.1	2.0	2.0
Standing height	2.0	20.0	34.3	4.9	-4.7	-5.9
Arm fat percentage (left)	2.0	7.9	13.3	3.2	-2.8	-3.6
Qualifications: CSEs or equivalent	1.9	2.6	4.5	2.1	-1.9	-1.4
Body mass index (BMI)	1.9	8.2	14.2	3.3	-2.8	-3.8
HbA1C	1.8	2.0	4.4	1.3	-1.5	-2.1
BMI	1.8	10.5	18.5	4.3	-2.6	-4.1
High blood pressure	1.8	5.2	11.7	2.4	-1.8	-3.4
Number of incorrect matches in round	1.8	2.9	8.6	-2.9	0.8	1.6
Prospective memory result	1.8	2.2	4.0	-2.0	1.2	1.8
High blood pressure (siblings)	1.8	2.6	6.3	2.5	-1.0	-1.8
High cholesterol (Self-reported)	1.8	3.2	5.5	2.3	-1.4	-2.3
Chronotype (morning person)	1.7	3.8	7.8	-1.9	2.0	2.8
Peak expiratory flow (PEF)	1.7	3.9	9.8	3.1	-1.3	-2.0
Major Depression (MDD)	1.6	1.9	5.3	2.3	-0.5	-1.5
Ever used hormone-replacement therapy (HRT)	1.6	2.0	3.4	-1.3	1.8	1.7
Medication for pain relief, constipation, heartburn	1.6	2.8	8.7	-3.0	0.7	1.4
Alcohol drinker status: Previous	1.6	1.8	3.0	-1.6	1.3	1.7
Had menopause	1.5	1.9	5.9	-2.4	0.0	1.3
Allergy	1.5	3.5	5.5	-1.8	2.4	2.3
Mouth/teeth dental problems: Dentures	1.5	2.5	6.5	1.2	-1.5	-2.6
Leg fat percentage (right)	1.5	5.5	9.4	2.2	-2.8	-3.1
Number of children fathered	1.5	1.7	3.3	-0.4	-1.8	-1.8
Leg fat percentage (left)	1.5	5.5	9.4	2.2	-2.7	-3.1
Ever depressed for a whole week	1.5	1.8	5.8	2.4	1.2	-0.2
Heart disease (siblings)	1.5	1.8	3.2	1.1	-1.6	-1.8
Bipolar Disorder (2018)	1.4	2.2	5.1	0.4	2.3	1.9
Breast Cancer	1.4	3.3	7.8	-1.7	1.6	2.8
Blood Platelet Count	1.4	16.6	24.9	5.0	-4.5	-4.6
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	2.9	0.7	-1.7	-1.6
Breastfed as a baby	1.4	1.8	5.8	-2.4	-0.9	0.7
Angina (self-reported)	1.4	1.9	4.2	2.1	-0.3	-1.8
Handedness (chirality/laterality): Left-handed	1.4	1.7	4.1	-0.6	1.5	2.0
Long-standing illness, disability or infirmity	1.4	2.2	4.3	2.1	-1.0	-1.9
Commuting to job workplace: Walk	1.4	1.5	3.8	-0.3	1.5	2.0
Eye problems/disorders: Glaucoma	1.4	1.7	5.9	-2.4	0.6	0.8
Bipolar Disorder or Schizophrenia	1.3	3.2	6.4	-0.2	2.5	2.5
Alzheimer’s Disease (including proxy)	1.3	1.8	4.0	-2.0	1.7	0.7
Body Mass Index (BMI) (2010)	1.3	1.8	4.0	1.6	-0.8	-2.0
Length of working week for main job	1.3	1.4	3.4	0.9	-1.8	-1.2
Schizophrenia vs Biploar Disorder	1.2	1.5	3.9	0.5	-1.4	-2.0
Medication for hormone replacement therapy	1.2	1.3	3.2	-0.5	1.3	1.8
Hayfever, allergic rhinitis or eczema	1.2	2.5	5.0	0.7	-2.2	-2.1
Worrier / anxious feelings	1.2	2.4	6.2	-2.5	0.8	1.6
Pulse rate, automated reading	1.2	4.0	6.2	-1.9	2.5	2.5
Financial situation satisfaction	1.2	1.5	3.3	0.8	1.8	1.4
Irritability	1.2	2.1	4.5	-1.4	2.1	1.3
Pain experienced in last month	1.2	2.1	6.1	-2.5	-0.0	1.5
Reaction Time	1.1	2.0	4.7	-1.3	1.3	2.2
Angina	1.1	1.5	3.3	1.8	-0.4	-1.6
Sitting height	1.1	8.0	15.1	3.1	-2.7	-3.9
Hair/balding pattern: Pattern 4	1.1	2.8	5.3	-2.3	1.4	2.0
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.3	0.9	-1.8	-1.2
Medication: Blood pressure	1.1	1.9	5.1	2.3	-0.2	-1.6
Commuting to job workplace: Car/motor vehicle	1.1	1.2	1.9	1.1	-1.3	-1.4
Medication: Gliclazide	1.1	1.3	4.5	2.1	-0.4	-0.7
Wears glasses or contact lenses	1.1	1.3	2.8	-1.7	1.0	1.2
Ovarian Cancer	1.0	1.3	2.8	-0.3	1.5	1.7
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.2	1.3	-1.0	-1.5
Relative age voice broke	1.0	1.5	2.8	1.4	-1.2	-1.7
Pulse rate	1.0	1.6	2.9	-1.5	1.2	1.7
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.1	-0.6	1.3	1.8
Birth weight	1.0	2.3	4.5	2.1	-1.0	-1.9
Eye problems/disorders: None of the above	1.0	1.2	3.0	1.7	-1.1	-0.7
Mouth/teeth dental problems: Loose teeth	1.0	1.1	2.0	0.9	-1.3	-1.4
Mean time to correctly identify matches	1.0	1.9	4.5	-1.6	0.8	2.1
Suffer from ‘nerves’	1.0	1.5	3.7	-1.1	1.1	1.9
Had major operations	1.0	1.2	2.3	0.4	-1.5	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	4.1	-2.0	1.3	1.7
Number of live births	0.9	1.3	3.1	-0.0	1.8	1.5
Illnesses of mother	0.9	1.1	2.2	-1.5	0.1	1.5
Pulse wave peak to peak time	0.9	1.1	3.8	1.9	0.5	-0.5
Average weekly beer plus cider intake	0.9	1.3	2.8	1.2	-0.9	-1.7
Neuroticism (Nagel 2018)	0.8	1.8	2.8	-1.4	1.7	1.5
Verbal and Numeric Reasoning (VNR)	0.8	1.9	4.8	2.2	-0.9	-1.4
HDL Cholesterol	0.8	1.4	2.2	-1.4	1.1	1.5
Blood White Count	0.8	6.2	15.6	4.0	-1.8	-2.5
Lung FVC	0.8	4.0	8.5	-1.4	2.3	2.9
High blood pressure (mother)	0.8	1.1	2.3	1.1	-1.0	-1.5
Glaucoma (self-reported)	0.8	0.9	3.1	-1.8	0.3	0.6
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.0	1.4	-0.3	-1.2
Exposure to tobacco smoke outside home	0.8	1.0	2.2	-0.1	1.4	1.5
Worry too long after embarrassment	0.8	1.3	2.1	-1.3	1.4	1.3
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.9	-0.2	-1.7	-1.0
Average weekly red wine intake	0.8	1.2	2.6	-1.6	0.8	1.3
Ever taken oral contraceptive pill	0.8	0.9	1.7	-1.3	0.8	1.2
Intelligence (Savage-Jansen 2018)	0.7	2.1	4.1	2.0	-1.1	-1.8
Prostate Cancer	0.7	1.0	1.9	1.4	-1.2	-0.9
Rheumatoid Arthritis	0.7	1.0	2.5	-0.9	0.9	1.6
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	1.8	0.9	-1.3	-1.2
Neuroticism score	0.7	1.5	2.3	-1.3	1.5	1.5
Depression (self-reported)	0.7	0.8	1.4	-1.0	1.0	1.2
Pulse wave Arterial Stiffness index	0.7	0.8	2.1	-1.4	-1.0	-0.0
Pulse wave reflection index	0.7	0.9	2.9	-1.7	-0.9	-0.0
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.7	-0.0	-1.9	-0.8
Gout (self-reported)	0.7	0.9	2.3	-0.5	-1.5	-1.1
Number of full sisters	0.7	0.9	3.1	0.1	1.8	0.6
Diastolic blood pressure, automated reading	0.7	2.0	6.1	2.5	-0.8	-1.2
Unable to work because of sickness or disability	0.7	0.9	2.1	-0.4	1.4	1.1
Schizophrenia (2018)	0.6	1.3	2.7	-0.6	1.4	1.6
Mean Putamen Volume	0.6	0.7	1.4	-1.2	-0.3	1.0
Hand grip strength (left)	0.6	1.5	3.1	1.8	-0.9	-1.5
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.6	-1.6	0.7	0.6
Ever had hysterectomy (womb removed)	0.6	0.6	1.1	0.7	-1.0	-1.1
Medication: Co-codamol	0.6	0.7	1.2	0.8	-1.0	-1.1
Multivitamins +/- minerals	0.6	0.8	1.5	-1.0	1.2	0.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.5	1.6	0.2	-0.8
Hair/balding pattern: Pattern 3	0.6	0.9	1.9	1.4	-1.0	-0.7
Health satisfaction	0.6	0.8	2.4	-0.0	1.6	0.8
Medication: Allopurinol	0.6	0.8	1.5	-0.8	-1.2	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	4.3	2.1	0.2	-0.8
Medication: Atorvastatin	0.6	0.7	1.9	0.6	-1.4	-0.7
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.6	-1.3	0.8	0.7
Bipolar Disorder (2011)	0.5	0.4	1.6	1.3	0.4	-0.1
Primary Biliary Cirrhosis	0.5	0.7	1.8	1.3	-0.8	-0.7
Blood Eosinophil Count	0.5	3.9	6.7	2.6	-1.7	-2.4
Relative age of first facial hair	0.5	1.0	2.6	-1.6	0.8	0.9
Vitamin and mineral supplements	0.5	0.6	1.5	0.8	-1.2	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.0	0.3	1.4	0.8
Taking other prescription medications	0.5	0.7	1.3	1.1	-0.7	-1.1
Supplements: Glucosamine	0.5	0.7	1.5	-1.2	-1.1	-0.2
Happiness	0.5	0.6	1.3	-0.7	0.7	1.1
Neck or shoulder pain in last month	0.5	0.8	2.5	1.6	0.7	-0.3
Mineral and other dietary supplements	0.5	0.7	1.2	-0.8	1.0	1.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.5	1.2	-0.5	-0.8
Depression (Nagel 2018)	0.4	0.6	1.7	0.7	1.3	0.1
Alzheimer’s Disease (in father)	0.4	0.5	1.5	-1.2	0.5	-0.1
Crohns Disease (2017)	0.4	1.0	2.4	0.1	-1.6	-1.2
Crohns Disease (2012)	0.4	0.7	2.1	-0.5	-1.5	-0.7
Schizophrenia (2014)	0.4	0.9	2.3	-0.5	1.1	1.5
Allergy or Eczema	0.4	1.1	2.7	0.1	-1.2	-1.6
Lung FEV1/FVC ratio	0.4	2.2	6.6	-0.4	2.6	1.4
Neuroticism	0.4	0.9	2.5	-1.6	0.6	0.9
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.3	1.2	0.5	-0.5
Diabetes (father)	0.4	0.4	1.1	0.9	-1.0	-0.0
Severe depression (siblings)	0.4	0.4	0.8	0.6	0.9	0.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.2	0.7	-1.1	-0.7
Alcohol usually taken with meals	0.4	0.6	2.1	-1.4	-0.1	0.5
Nervous feelings	0.4	0.7	1.1	-0.7	1.0	1.1
Pain all over the body in last month	0.4	0.4	1.1	-0.6	1.0	-0.1
Medication: Ibuprofen	0.4	0.5	1.2	-0.7	0.7	1.1
Heart disease (mother)	0.4	0.5	1.9	1.4	-0.1	-0.2
Overall health rating	0.4	0.8	2.0	0.9	-0.5	-1.4
Supplements: Vitamin C	0.4	0.5	1.8	-1.4	-0.2	0.1
Loneliness, isolation	0.4	0.5	1.2	-0.1	0.9	1.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.5	0.7	0.8	1.2
Breast cancer (self-reported)	0.4	0.4	1.0	0.7	-1.0	-0.4
Osteoporosis (self-reported)	0.4	0.5	1.3	-0.5	0.6	1.1
Illnesses of father: None of the above (group 1)	0.4	0.5	0.8	-0.9	0.6	0.9
Hearing aid user	0.4	0.5	1.0	0.9	-0.0	-1.0
Commuting to job workplace: Public transport	0.4	0.5	1.2	-1.1	0.8	0.5
Pack years of smoking	0.4	0.5	1.1	1.0	-0.5	-0.9
Alzheimer’s Disease (in mother)	0.3	0.4	1.4	-1.2	0.4	0.1
Fasting Glucose	0.3	0.4	1.2	0.6	-0.2	-1.1
Neuroticism (2016)	0.3	0.4	1.3	-0.3	1.1	0.6
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.4	-0.3	1.2	0.3
Diabetes (mother)	0.3	0.4	1.3	1.1	0.4	-0.3
Impedance of leg (right)	0.3	1.3	2.7	-1.5	0.6	1.6
Average weekly fortified wine intake	0.3	0.3	0.7	-0.8	0.6	0.6
Serious illness, injury or assault to yourself	0.3	0.4	1.4	0.4	-0.0	-1.2
Stomach or abdominal pain in last month	0.3	0.4	0.6	-0.8	0.7	0.7
Chronic bronchitis/emphysema (father)	0.3	0.4	0.7	0.9	0.7	-0.4
Qualifications: None of the above	0.3	0.7	1.6	1.2	0.8	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.3	-0.4	1.2	0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.8	2.8	-1.7	-0.4	0.3
Birth weight of first child	0.3	0.6	1.6	-1.3	0.8	0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	-0.4	-1.1	0.4
Headache pain in last month	0.3	0.5	1.8	1.3	0.4	0.1
Forced vital capacity (FVC), Best measure	0.3	1.2	2.4	0.8	-1.3	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	1.1	-0.3	1.1	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.9	-1.0	0.6	0.2
Qualifications: College or University degree	0.3	0.8	2.9	-1.7	0.3	0.5
Knee pain experienced in last month	0.3	0.5	1.3	1.1	-0.5	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.1	0.1	-0.6	-1.0
Illnesses of father: Heart disease	0.3	0.4	1.2	1.1	-0.6	-0.4
Illnesses of siblings: Diabetes	0.3	0.4	0.9	0.6	0.3	-1.0
Friendships satisfaction	0.3	0.4	1.5	0.0	-1.2	0.2
Smoking status: Current	0.3	0.5	1.7	0.3	1.3	0.4
Guilty feelings	0.3	0.4	0.9	-0.8	0.4	0.9
Ever smoked	0.3	0.4	1.5	-1.2	0.2	0.5
Supplements: Calcium	0.3	0.3	1.0	0.3	-0.4	-1.0
Lupus	0.2	0.3	0.7	0.8	0.5	-0.5
Ulcerative Colitis	0.2	0.2	0.7	-0.8	-0.5	0.1
Respiratory disease	0.2	0.4	0.8	0.9	-0.9	-0.3
Hearing difficulty/problems: Yes	0.2	0.3	0.5	0.7	-0.5	-0.7
Supplements: Zinc	0.2	0.2	0.9	-0.9	-0.2	0.3
Pack years adult smoking proportion	0.2	0.2	0.6	0.8	-0.2	-0.6
Hand grip strength (right)	0.2	0.5	0.9	0.7	-0.8	-1.0
Townsend deprivation index at recruitment	0.2	0.3	1.2	1.1	0.2	-0.1
Current tobacco smoking	0.2	0.3	1.0	0.3	1.0	0.3
Maternal smoking around birth	0.2	0.3	0.6	0.8	0.3	-0.7
Fed-up feelings	0.2	0.3	1.0	0.4	-0.4	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.9	-1.4	-0.3	0.2
Medication: Levothyroxine sodium	0.2	0.4	0.8	-0.1	0.9	0.9
Impedance of leg (left)	0.2	1.2	2.3	-1.4	0.6	1.5
Past tobacco smoking	0.2	0.3	1.1	-0.5	0.1	1.0
Financial difficulties in last 2 years	0.2	0.2	0.8	0.9	-0.1	-0.2
Mouth/teeth dental problems	0.2	0.3	0.7	-0.8	0.2	0.6
Noisy workplace	0.2	0.2	0.5	0.7	0.4	-0.5
Medication: Lansoprazole	0.2	0.3	0.5	0.7	-0.6	-0.5
Impedance of arm (left)	0.2	0.8	1.9	-0.9	0.7	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.3	0.4	1.1	0.1
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.8	-0.6	0.9	0.1
Loud music exposure frequency	0.2	0.3	0.7	-0.8	0.4	0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.1	-1.1	-0.4	-0.1
Comparative body size at age 10	0.2	0.4	1.6	-1.3	0.1	0.3
Migraine (self-reported)	0.2	0.2	0.7	0.8	0.2	-0.3
Medication: Omeprazole	0.2	0.2	0.5	0.6	0.2	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	0.2	-0.7	0.5
Chest pain or discomfort	0.2	0.3	1.0	0.1	1.0	0.4
Family relationship satisfaction	0.2	0.2	0.6	0.8	-0.4	-0.4
Leg pain on walking	0.2	0.3	1.1	1.1	0.1	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.7	0.8	0.3	0.4
Smoking status: Previous	0.2	0.3	1.0	0.4	-0.5	-1.0
Ever had bowel cancer screening	0.2	0.3	0.9	-1.0	0.5	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.9	-0.9	0.2	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.4	-0.5	0.6	0.6
Asthma (self-reported)	0.2	0.3	1.2	0.0	-0.1	1.1
Osteoarthritis (self-reported)	0.2	0.2	0.8	-0.9	-0.1	0.1
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.7	0.0	0.9	0.5
Medication: Lisinopril	0.2	0.2	0.7	0.3	0.2	-0.8
Impedance of whole body	0.2	1.2	2.7	-1.4	0.6	1.6
LDL Cholesterol	0.1	0.2	0.4	0.7	0.5	-0.3
Triglycerides	0.1	0.2	0.5	0.7	0.2	-0.7
Heel T-Score	0.1	0.7	2.6	0.1	-1.6	-0.5
Waist Hip Ratio (WHR)	0.1	0.4	0.8	-0.8	-0.9	-0.3
Smoking Status	0.1	0.3	0.8	0.5	0.9	-0.1
Hypothyroidism (self reported)	0.1	0.2	0.3	-0.4	-0.6	-0.4
Age when periods started (menarche)	0.1	0.2	0.5	0.5	0.3	-0.7
Had other major operations	0.1	0.2	0.4	-0.3	0.4	0.6
Forced vital capacity (FVC)	0.1	0.2	0.5	0.6	-0.7	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.9	-0.9	-0.1	0.3
Fluid intelligence score	0.1	0.1	0.2	0.4	-0.4	-0.5
Impedance of arm (right)	0.1	0.7	1.8	-0.8	0.6	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.4	0.3	0.4
Asthma	0.1	0.3	1.0	0.0	-0.2	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.5	0.4	-0.4	-0.7
Medication: Amlodipine	0.1	0.1	0.2	0.4	0.3	-0.5
Number of full brothers	0.1	0.1	0.4	-0.0	-0.3	-0.6
Wheeze or whistling in the chest in last year	0.1	0.1	0.4	0.1	-0.6	-0.2
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.2	0.3	0.5
Mood swings	0.1	0.1	0.3	-0.5	0.4	0.3
Qualifications: nursing, teaching	0.1	0.1	0.3	-0.5	-0.3	0.0
Average weekly champagne plus white wine intake	0.1	0.1	0.5	-0.3	-0.7	-0.0
Miserableness	0.1	0.1	0.5	-0.0	0.7	0.1
Illnesses of father: High blood pressure	0.1	0.1	0.5	0.7	-0.2	-0.1
Risk taking	0.1	0.1	0.4	-0.7	-0.2	-0.1
Fractured/broken bones in last 5 years	0.1	0.1	0.4	-0.3	-0.6	-0.2
Age started oral contraceptive pill	0.1	0.1	0.2	-0.3	-0.5	-0.4
Commuting to job workplace: Cycle	0.1	0.1	0.2	-0.0	-0.4	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.5	0.2	0.7	0.2
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	-0.5	-0.2	0.1
Depressed Affect (Nagel 2018)	0.0	0.0	0.0	0.0	0.2	-0.1
Irritable Bowel Disease (IBD)	0.0	0.1	0.2	-0.2	-0.5	-0.2
Ulcerative Colitis (UC)	0.0	0.0	0.1	0.1	0.3	0.1
Blood Red Count	0.0	0.5	1.1	1.1	0.5	0.7
Hair Pigment	0.0	0.3	1.1	0.3	1.1	0.2
Tanning	0.0	0.4	1.2	1.1	0.5	-0.6
Average weekly spirits intake	0.0	0.1	0.2	-0.3	0.0	0.4
Sensitivity / hurt feelings	0.0	0.1	0.2	0.2	0.3	-0.4
Diverticular disease/diverticulitis (self-reported)	0.0	0.1	0.1	0.2	0.4	-0.2
Hearing difficulty/problems with background noise	0.0	0.0	0.0	-0.1	-0.0	0.2
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	-0.2	-0.2	-0.3
Time employed in main current job	0.0	0.0	0.0	-0.1	-0.1	-0.1
Falls in the last year	0.0	0.0	0.1	0.3	-0.2	0.0
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.4	0.6	0.3	0.1
Exposure to tobacco smoke at home	0.0	0.0	0.1	0.3	-0.1	0.3
Supplements: Fish oil (including cod liver oil)	0.0	0.1	0.1	0.4	0.2	-0.2
Number of operations (self-reported)	0.0	0.1	0.2	0.5	0.0	-0.1
Myopia	0.0	0.0	0.0	0.2	0.1	0.1

Hub : Genes

LRRC66

Models

Trait associations