Hub : Genes

LRRC66

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Heart Atrial Appendage 0.059 0.039 0.0073 0.025 NA 0.007 NA 0.013 0.0270 NA 0.14000 NA 0.0790
2 GTEx Pancreas 0.572 0.140 0.0095 0.002 NA 0.071 NA 0.051 0.2600 NA 0.00061 NA 0.0034
3 TCGA Bladder Urothelial Carcinoma 0.062 0.044 0.0072 0.022 0.022 -0.001 NA 0.011 0.0051 0.0054 0.37000 NA 0.0350
4 TCGA Colon Adenocarcinoma 0.066 0.062 0.0048 0.026 0.043 0.048 NA 0.049 0.0110 0.0017 0.00095 NA 0.0008

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.4 2.2 5.1 0.4 0.0 2.3 1.9
Bipolar Disorder or Schizophrenia 1.3 3.2 6.4 -0.2 0.0 2.5 2.5
Depressed Affect (Nagel 2018) 0.0 0.0 0.0 0.0 0.0 0.2 -0.1
Depression (Nagel 2018) 0.4 0.6 1.7 0.7 0.0 1.3 0.1
Intelligence (Savage-Jansen 2018) 0.7 2.1 4.1 2.0 0.0 -1.1 -1.8
Neuroticism (Nagel 2018) 0.8 1.8 2.8 -1.4 0.0 1.7 1.5
Schizophrenia (2018) 0.6 1.3 2.7 -0.6 0.0 1.4 1.6
Schizophrenia vs Biploar Disorder 1.2 1.5 3.9 0.5 0.0 -1.4 -2.0
Worry (Nagel 2018) 2.3 5.0 8.1 -2.7 0.0 2.1 2.8
Alzheimer’s Disease (in mother) 0.3 0.4 1.4 -1.2 0.0 0.4 0.1
Alzheimer’s Disease (in father) 0.4 0.5 1.5 -1.2 0.0 0.5 -0.1
Alzheimer’s Disease (including proxy) 1.3 1.8 4.0 -2.0 0.0 1.7 0.7
Crohns Disease (2017) 0.4 1.0 2.4 0.1 0.0 -1.6 -1.2
Irritable Bowel Disease (IBD) 0.0 0.1 0.2 -0.2 0.0 -0.5 -0.2
Ulcerative Colitis (UC) 0.0 0.0 0.1 0.1 0.0 0.3 0.1
Major Depression (MDD) 1.6 1.9 5.3 2.3 0.0 -0.5 -1.5
Reaction Time 1.1 2.0 4.7 -1.3 0.0 1.3 2.2
Verbal and Numeric Reasoning (VNR) 0.8 1.9 4.8 2.2 0.0 -0.9 -1.4
Breast Cancer 1.4 3.3 7.8 -1.7 0.0 1.6 2.8
Ovarian Cancer 1.0 1.3 2.8 -0.3 0.0 1.5 1.7
Prostate Cancer 0.7 1.0 1.9 1.4 0.0 -1.2 -0.9
Age at First Birth 2.3 3.4 7.4 -0.9 0.0 2.7 2.3
Bipolar Disorder (2011) 0.5 0.4 1.6 1.3 0.0 0.4 -0.1
Body Mass Index (BMI) (2010) 1.3 1.8 4.0 1.6 0.0 -0.8 -2.0
Coronary Artery Disease (CAD) 3.1 3.7 7.3 0.5 0.0 -2.7 -2.7
Crohns Disease (2012) 0.4 0.7 2.1 -0.5 0.0 -1.5 -0.7
Mean Putamen Volume 0.6 0.7 1.4 -1.2 0.0 -0.3 1.0
Fasting Glucose 0.3 0.4 1.2 0.6 0.0 -0.2 -1.1
HbA1C 1.8 2.0 4.4 1.3 0.0 -1.5 -2.1
HDL Cholesterol 0.8 1.4 2.2 -1.4 0.0 1.1 1.5
LDL Cholesterol 0.1 0.2 0.4 0.7 0.0 0.5 -0.3
Lupus 0.2 0.3 0.7 0.8 0.0 0.5 -0.5
Neuroticism (2016) 0.3 0.4 1.3 -0.3 0.0 1.1 0.6
Primary Biliary Cirrhosis 0.5 0.7 1.8 1.3 0.0 -0.8 -0.7
Rheumatoid Arthritis 0.7 1.0 2.5 -0.9 0.0 0.9 1.6
Schizophrenia (2014) 0.4 0.9 2.3 -0.5 0.0 1.1 1.5
Triglycerides 0.1 0.2 0.5 0.7 0.0 0.2 -0.7
Type 2 Diabetes (T2D) (2012) 1.0 1.2 2.2 1.3 0.0 -1.0 -1.5
Ulcerative Colitis 0.2 0.2 0.7 -0.8 0.0 -0.5 0.1
Blood Eosinophil Count 0.5 3.9 6.7 2.6 0.0 -1.7 -2.4
Blood Platelet Count 1.4 16.6 24.9 5.0 0.0 -4.5 -4.6
Blood Red Count 0.0 0.5 1.1 1.1 0.0 0.5 0.7
Blood White Count 0.8 6.2 15.6 4.0 0.0 -1.8 -2.5
Heel T-Score 0.1 0.7 2.6 0.1 0.0 -1.6 -0.5
BMI 1.8 10.5 18.5 4.3 0.0 -2.6 -4.1
Height 2.3 44.1 70.9 8.2 0.0 -6.2 -8.4
Waist Hip Ratio (WHR) 0.1 0.4 0.8 -0.8 0.0 -0.9 -0.3
Systolic Blood Pressure 3.2 15.9 35.3 5.9 0.0 -3.1 -4.3
Smoking Status 0.1 0.3 0.8 0.5 0.0 0.9 -0.1
Allergy or Eczema 0.4 1.1 2.7 0.1 0.0 -1.2 -1.6
Cardiovascular Disease 3.0 10.1 21.2 3.3 0.0 -2.9 -4.6
Hypothyroidism (self reported) 0.1 0.2 0.3 -0.4 0.0 -0.6 -0.4
Respiratory disease 0.2 0.4 0.8 0.9 0.0 -0.9 -0.3
Type 2 Diabetes (T2D) (2018) 5.6 10.5 24.0 4.9 0.0 -2.5 -3.4
Lung FEV1/FVC ratio 0.4 2.2 6.6 -0.4 0.0 2.6 1.4
Lung FVC 0.8 4.0 8.5 -1.4 0.0 2.3 2.9
Neuroticism 0.4 0.9 2.5 -1.6 0.0 0.6 0.9
Chronotype (morning person) 1.7 3.8 7.8 -1.9 0.0 2.0 2.8
Hair Pigment 0.0 0.3 1.1 0.3 0.0 1.1 0.2
Tanning 0.0 0.4 1.2 1.1 0.0 0.5 -0.6
Hand grip strength (left) 0.6 1.5 3.1 1.8 0.0 -0.9 -1.5
Number of treatments/medications taken 3.4 6.0 12.6 3.5 0.0 -1.6 -3.0
Average weekly spirits intake 0.0 0.1 0.2 -0.3 0.0 0.0 0.4
Sensitivity / hurt feelings 0.0 0.1 0.2 0.2 0.0 0.3 -0.4
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.4 -0.3 0.0 1.2 0.3
Hearing difficulty/problems: Yes 0.2 0.3 0.5 0.7 0.0 -0.5 -0.7
Relative age of first facial hair 0.5 1.0 2.6 -1.6 0.0 0.8 0.9
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.6 -1.6 0.0 0.7 0.6
Ever used hormone-replacement therapy (HRT) 1.6 2.0 3.4 -1.3 0.0 1.8 1.7
Ever had hysterectomy (womb removed) 0.6 0.6 1.1 0.7 0.0 -1.0 -1.1
Systolic blood pressure, automated reading 4.1 12.0 20.4 4.5 0.0 -3.2 -4.1
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 1.3 1.2 0.0 0.5 -0.5
Angina 1.1 1.5 3.3 1.8 0.0 -0.4 -1.6
Medication for hormone replacement therapy 1.2 1.3 3.2 -0.5 0.0 1.3 1.8
Vitamin and mineral supplements 0.5 0.6 1.5 0.8 0.0 -1.2 -0.6
Supplements: Zinc 0.2 0.2 0.9 -0.9 0.0 -0.2 0.3
Medication: Co-codamol 0.6 0.7 1.2 0.8 0.0 -1.0 -1.1
Medication: Metformin 7.3 10.3 28.2 5.3 0.0 -2.0 -3.0
Diabetes (father) 0.4 0.4 1.1 0.9 0.0 -1.0 -0.0
Diabetes (mother) 0.3 0.4 1.3 1.1 0.0 0.4 -0.3
Severe depression (siblings) 0.4 0.4 0.8 0.6 0.0 0.9 0.8
Pack years adult smoking proportion 0.2 0.2 0.6 0.8 0.0 -0.2 -0.6
Impedance of leg (right) 0.3 1.3 2.7 -1.5 0.0 0.6 1.6
Leg fat-free mass (left) 2.9 15.4 26.6 4.7 0.0 -3.6 -5.2
Trunk fat percentage 3.0 12.2 21.3 3.5 0.0 -3.9 -4.6
Hand grip strength (right) 0.2 0.5 0.9 0.7 0.0 -0.8 -1.0
Townsend deprivation index at recruitment 0.2 0.3 1.2 1.1 0.0 0.2 -0.1
Current tobacco smoking 0.2 0.3 1.0 0.3 0.0 1.0 0.3
Average weekly fortified wine intake 0.3 0.3 0.7 -0.8 0.0 0.6 0.6
Maternal smoking around birth 0.2 0.3 0.6 0.8 0.0 0.3 -0.7
Fed-up feelings 0.2 0.3 1.0 0.4 0.0 -0.4 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 2.0 0.3 0.0 1.4 0.8
Relative age voice broke 1.0 1.5 2.8 1.4 0.0 -1.2 -1.7
Taking other prescription medications 0.5 0.7 1.3 1.1 0.0 -0.7 -1.1
Age when periods started (menarche) 0.1 0.2 0.5 0.5 0.0 0.3 -0.7
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.2 0.7 0.0 -1.1 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 1.9 -1.4 0.0 -0.3 0.2
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 2.9 0.7 0.0 -1.7 -1.6
Qualifications: CSEs or equivalent 1.9 2.6 4.5 2.1 0.0 -1.9 -1.4
Serious illness, injury or assault to yourself 0.3 0.4 1.4 0.4 0.0 -0.0 -1.2
High blood pressure 1.8 5.2 11.7 2.4 0.0 -1.8 -3.4
Hayfever, allergic rhinitis or eczema 1.2 2.5 5.0 0.7 0.0 -2.2 -2.1
Multivitamins +/- minerals 0.6 0.8 1.5 -1.0 0.0 1.2 0.8
Stomach or abdominal pain in last month 0.3 0.4 0.6 -0.8 0.0 0.7 0.7
Supplements: Glucosamine 0.5 0.7 1.5 -1.2 0.0 -1.1 -0.2
Diverticular disease/diverticulitis (self-reported) 0.0 0.1 0.1 0.2 0.0 0.4 -0.2
Medication: Atenolol 3.9 4.8 9.9 3.1 0.0 -1.5 -2.7
Medication: Levothyroxine sodium 0.2 0.4 0.8 -0.1 0.0 0.9 0.9
Sitting height 1.1 8.0 15.1 3.1 0.0 -2.7 -3.9
Chronic bronchitis/emphysema (father) 0.3 0.4 0.7 0.9 0.0 0.7 -0.4
High blood pressure (mother) 0.8 1.1 2.3 1.1 0.0 -1.0 -1.5
Body mass index (BMI) 1.9 8.2 14.2 3.3 0.0 -2.8 -3.8
Impedance of leg (left) 0.2 1.2 2.3 -1.4 0.0 0.6 1.5
Leg predicted mass (left) 2.9 15.3 26.2 4.7 0.0 -3.6 -5.1
Trunk fat mass 4.1 17.7 31.3 4.4 0.0 -4.4 -5.6
Waist circumference 2.9 10.5 19.2 3.3 0.0 -3.5 -4.4
Number of incorrect matches in round 1.8 2.9 8.6 -2.9 0.0 0.8 1.6
Past tobacco smoking 0.2 0.3 1.1 -0.5 0.0 0.1 1.0
Alcohol usually taken with meals 0.4 0.6 2.1 -1.4 0.0 -0.1 0.5
Nervous feelings 0.4 0.7 1.1 -0.7 0.0 1.0 1.1
Frequency of tenseness / restlessness in last 2 weeks 2.0 3.1 4.3 -2.1 0.0 2.0 2.0
Hearing difficulty/problems with background noise 0.0 0.0 0.0 -0.1 0.0 -0.0 0.2
Hair/balding pattern: Pattern 2 0.0 0.0 0.1 -0.2 0.0 -0.2 -0.3
Had menopause 1.5 1.9 5.9 -2.4 0.0 0.0 1.3
Had other major operations 0.1 0.2 0.4 -0.3 0.0 0.4 0.6
Forced vital capacity (FVC) 0.1 0.2 0.5 0.6 0.0 -0.7 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.9 -0.9 0.0 -0.1 0.3
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 2.5 1.6 0.0 0.2 -0.8
Qualifications: None of the above 0.3 0.7 1.6 1.2 0.0 0.8 -0.8
Financial difficulties in last 2 years 0.2 0.2 0.8 0.9 0.0 -0.1 -0.2
Mouth/teeth dental problems 0.2 0.3 0.7 -0.8 0.0 0.2 0.6
Heart attack 2.7 3.4 8.4 2.9 0.0 -0.9 -2.1
Allergy 1.5 3.5 5.5 -1.8 0.0 2.4 2.3
Pain all over the body in last month 0.4 0.4 1.1 -0.6 0.0 1.0 -0.1
Diabetes (self-reported) 4.8 7.5 12.8 3.6 0.0 -2.6 -3.2
Hayfever/allergic rhinitis (self-reported) 0.7 1.0 1.8 0.9 0.0 -1.3 -1.2
Medication: Ramipril 3.3 4.2 9.5 3.1 0.0 -0.6 -2.6
Medication: Simvastatin 4.9 7.1 19.2 4.4 0.0 -1.6 -2.6
Fluid intelligence score 0.1 0.1 0.2 0.4 0.0 -0.4 -0.5
Illnesses of siblings 2.5 3.5 7.3 -2.7 0.0 1.1 2.3
Neuroticism score 0.7 1.5 2.3 -1.3 0.0 1.5 1.5
Weight 4.2 20.7 35.9 5.1 0.0 -4.5 -6.0
Impedance of arm (right) 0.1 0.7 1.8 -0.8 0.0 0.6 1.3
Arm fat percentage (right) 2.1 8.2 13.5 3.3 0.0 -2.9 -3.7
Trunk fat-free mass 2.8 15.8 27.8 4.7 0.0 -3.6 -5.3
Hip circumference 3.5 14.9 26.5 4.3 0.0 -3.8 -5.2
Time employed in main current job 0.0 0.0 0.0 -0.1 0.0 -0.1 -0.1
Alcohol intake versus 10 years previously 2.4 3.5 9.3 3.0 0.0 -0.8 -2.0
Father’s age at death 6.2 8.3 21.2 -4.6 0.0 2.0 2.8
Worrier / anxious feelings 1.2 2.4 6.2 -2.5 0.0 0.8 1.6
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.3 -0.4 0.0 1.2 0.8
Falls in the last year 0.0 0.0 0.1 0.3 0.0 -0.2 0.0
Hair/balding pattern: Pattern 3 0.6 0.9 1.9 1.4 0.0 -1.0 -0.7
Number of live births 0.9 1.3 3.1 -0.0 0.0 1.8 1.5
Forced expiratory volume in 1-second (FEV1) 0.0 0.1 0.4 0.6 0.0 0.3 0.1
Pulse rate 1.0 1.6 2.9 -1.5 0.0 1.2 1.7
Happiness 0.5 0.6 1.3 -0.7 0.0 0.7 1.1
Noisy workplace 0.2 0.2 0.5 0.7 0.0 0.4 -0.5
Qualifications: A levels/AS levels or equivalent 0.3 0.8 2.8 -1.7 0.0 -0.4 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.1 -0.4 0.0 0.3 0.4
Mouth/teeth dental problems: Dentures 1.5 2.5 6.5 1.2 0.0 -1.5 -2.6
Asthma 0.1 0.3 1.0 0.0 0.0 -0.2 1.0
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 3.1 -0.6 0.0 1.3 1.8
Medication: Cholesterol lowering 2.3 3.6 9.5 3.1 0.0 -1.2 -1.9
Depression (self-reported) 0.7 0.8 1.4 -1.0 0.0 1.0 1.2
Medication: Lansoprazole 0.2 0.3 0.5 0.7 0.0 -0.6 -0.5
Prospective memory result 1.8 2.2 4.0 -2.0 0.0 1.2 1.8
Lung cancer (father) 2.3 2.7 6.6 0.7 0.0 -1.9 -2.6
Illnesses of mother 0.9 1.1 2.2 -1.5 0.0 0.1 1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.5 0.4 0.0 -0.4 -0.7
Pulse wave Arterial Stiffness index 0.7 0.8 2.1 -1.4 0.0 -1.0 -0.0
Impedance of arm (left) 0.2 0.8 1.9 -0.9 0.0 0.7 1.4
Arm fat mass (right) 3.6 14.7 24.3 4.6 0.0 -3.7 -4.9
Trunk predicted mass 2.7 15.3 26.9 4.7 0.0 -3.5 -5.2
Standing height 2.0 20.0 34.3 4.9 0.0 -4.7 -5.9
Length of working week for main job 1.3 1.4 3.4 0.9 0.0 -1.8 -1.2
Exposure to tobacco smoke at home 0.0 0.0 0.1 0.3 0.0 -0.1 0.3
Breastfed as a baby 1.4 1.8 5.8 -2.4 0.0 -0.9 0.7
Tense / ‘highly strung’ 4.4 7.2 11.4 -2.6 0.0 3.4 3.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 1.3 0.4 0.0 1.1 0.1
Hair/balding pattern: Pattern 4 1.1 2.8 5.3 -2.3 0.0 1.4 2.0
Birth weight of first child 0.3 0.6 1.6 -1.3 0.0 0.8 0.4
Peak expiratory flow (PEF) 1.7 3.9 9.8 3.1 0.0 -1.3 -2.0
Pulse wave reflection index 0.7 0.9 2.9 -1.7 0.0 -0.9 -0.0
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.8 -0.6 0.0 0.9 0.1
Loud music exposure frequency 0.2 0.3 0.7 -0.8 0.0 0.4 0.5
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 3.7 -0.0 0.0 -1.9 -0.8
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.1 -0.4 0.0 -1.1 0.4
Blood clot in the leg (DVT) 5.2 6.7 10.4 2.9 0.0 -3.2 -2.8
Medication: Paracetamol 2.7 4.5 7.9 2.8 0.0 -1.8 -2.6
Headache pain in last month 0.3 0.5 1.8 1.3 0.0 0.4 0.1
Medication for cholesterol, blood pressure or diabetes 3.3 5.4 10.2 -3.2 0.0 1.7 2.9
Glaucoma (self-reported) 0.8 0.9 3.1 -1.8 0.0 0.3 0.6
Gout (self-reported) 0.7 0.9 2.3 -0.5 0.0 -1.5 -1.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 1.1 -1.1 0.0 -0.4 -0.1
Medication: Amlodipine 0.1 0.1 0.2 0.4 0.0 0.3 -0.5
Medication: Ventolin 100micrograms inhaler 1.1 1.4 3.3 0.9 0.0 -1.8 -1.2
Birth weight 1.0 2.3 4.5 2.1 0.0 -1.0 -1.9
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.0 1.4 0.0 -0.3 -1.2
High blood pressure (siblings) 1.8 2.6 6.3 2.5 0.0 -1.0 -1.8
Forced vital capacity (FVC), Best measure 0.3 1.2 2.4 0.8 0.0 -1.3 -1.6
Body fat percentage 2.5 9.8 17.3 3.1 0.0 -3.5 -4.2
Leg fat percentage (right) 1.5 5.5 9.4 2.2 0.0 -2.8 -3.1
Arm fat-free mass (right) 3.2 16.7 30.0 4.7 0.0 -3.8 -5.5
Exposure to tobacco smoke outside home 0.8 1.0 2.2 -0.1 0.0 1.4 1.5
Comparative body size at age 10 0.2 0.4 1.6 -1.3 0.0 0.1 0.3
Number of full brothers 0.1 0.1 0.4 -0.0 0.0 -0.3 -0.6
Worry too long after embarrassment 0.8 1.3 2.1 -1.3 0.0 1.4 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.3 1.1 -0.3 0.0 1.1 0.3
Wheeze or whistling in the chest in last year 0.1 0.1 0.4 0.1 0.0 -0.6 -0.2
Number of children fathered 1.5 1.7 3.3 -0.4 0.0 -1.8 -1.8
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.9 -1.0 0.0 0.6 0.2
Age at first live birth 3.0 5.2 9.2 -3.0 0.0 2.0 2.8
Pulse wave peak to peak time 0.9 1.1 3.8 1.9 0.0 0.5 -0.5
Health satisfaction 0.6 0.8 2.4 -0.0 0.0 1.6 0.8
Shortness of breath walking on level ground 2.6 3.1 7.6 -0.1 0.0 2.8 2.2
Qualifications: College or University degree 0.3 0.8 2.9 -1.7 0.0 0.3 0.5
Eye problems/disorders: None of the above 1.0 1.2 3.0 1.7 0.0 -1.1 -0.7
Mouth/teeth dental problems: Loose teeth 1.0 1.1 2.0 0.9 0.0 -1.3 -1.4
Emphysema/chronic bronchitis 0.1 0.1 0.2 -0.2 0.0 0.3 0.5
Medication for pain relief, constipation, heartburn 1.6 2.8 8.7 -3.0 0.0 0.7 1.4
Neck or shoulder pain in last month 0.5 0.8 2.5 1.6 0.0 0.7 -0.3
Medication: Blood pressure 1.1 1.9 5.1 2.3 0.0 -0.2 -1.6
Angina (self-reported) 1.4 1.9 4.2 2.1 0.0 -0.3 -1.8
Migraine (self-reported) 0.2 0.2 0.7 0.8 0.0 0.2 -0.3
Medication: Ibuprofen 0.4 0.5 1.2 -0.7 0.0 0.7 1.1
Medication: Allopurinol 0.6 0.8 1.5 -0.8 0.0 -1.2 -1.1
Medication: Omeprazole 0.2 0.2 0.5 0.6 0.0 0.2 -0.7
Medication: Seretide 50 evohaler 2.2 2.5 3.6 1.7 0.0 -1.9 -1.9
Mean time to correctly identify matches 1.0 1.9 4.5 -1.6 0.0 0.8 2.1
Heart disease (mother) 0.4 0.5 1.9 1.4 0.0 -0.1 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.5 0.2 0.0 -0.7 0.5
Whole body fat mass 3.6 15.1 26.8 4.3 0.0 -3.9 -5.2
Leg fat mass (right) 2.9 11.4 19.3 3.8 0.0 -3.4 -4.4
Arm predicted mass (right) 3.4 17.2 31.2 4.8 0.0 -3.9 -5.6
Pulse rate, automated reading 1.2 4.0 6.2 -1.9 0.0 2.5 2.5
Alcohol intake frequency. 3.3 7.8 13.7 3.7 0.0 -2.2 -3.5
Comparative height size at age 10 2.1 11.7 21.3 3.4 0.0 -3.7 -4.6
Number of full sisters 0.7 0.9 3.1 0.1 0.0 1.8 0.6
Suffer from ‘nerves’ 1.0 1.5 3.7 -1.1 0.0 1.1 1.9
Overall health rating 0.4 0.8 2.0 0.9 0.0 -0.5 -1.4
Chest pain or discomfort 0.2 0.3 1.0 0.1 0.0 1.0 0.4
Had major operations 1.0 1.2 2.3 0.4 0.0 -1.5 -1.5
Age at last live birth 3.3 4.8 9.7 -2.0 0.0 2.4 3.1
Family relationship satisfaction 0.2 0.2 0.6 0.8 0.0 -0.4 -0.4
Leg pain on walking 0.2 0.3 1.1 1.1 0.0 0.1 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.7 0.8 0.0 0.3 0.4
Commuting to job workplace: Car/motor vehicle 1.1 1.2 1.9 1.1 0.0 -1.3 -1.4
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.9 -0.2 0.0 -1.7 -1.0
Medication: Aspirin 8.4 11.1 26.0 5.1 0.0 -2.3 -3.6
Supplements: Vitamin C 0.4 0.5 1.8 -1.4 0.0 -0.2 0.1
Knee pain experienced in last month 0.3 0.5 1.3 1.1 0.0 -0.5 -0.8
Hypertension (Self-reported) 2.2 6.1 14.2 2.5 0.0 -1.9 -3.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.1 0.1 0.0 -0.6 -1.0
Illnesses of father: Heart disease 0.3 0.4 1.2 1.1 0.0 -0.6 -0.4
Illnesses of siblings: Diabetes 0.3 0.4 0.9 0.6 0.0 0.3 -1.0
Smoking status: Previous 0.2 0.3 1.0 0.4 0.0 -0.5 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 4.3 2.1 0.0 0.2 -0.8
Whole body fat-free mass 2.9 16.6 29.1 4.8 0.0 -3.8 -5.4
Leg fat-free mass (right) 2.7 14.3 24.9 4.5 0.0 -3.5 -5.0
Arm fat percentage (left) 2.0 7.9 13.3 3.2 0.0 -2.8 -3.6
Average weekly red wine intake 0.8 1.2 2.6 -1.6 0.0 0.8 1.3
Handedness (chirality/laterality): Left-handed 1.4 1.7 4.1 -0.6 0.0 1.5 2.0
Mood swings 0.1 0.1 0.3 -0.5 0.0 0.4 0.3
Loneliness, isolation 0.4 0.5 1.2 -0.1 0.0 0.9 1.1
Long-standing illness, disability or infirmity 1.4 2.2 4.3 2.1 0.0 -1.0 -1.9
Ever had bowel cancer screening 0.2 0.3 0.9 -1.0 0.0 0.5 -0.1
Diabetes diagnosed by doctor 4.7 7.8 16.2 4.0 0.0 -2.3 -3.1
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.3 0.9 -0.9 0.0 0.2 0.3
Friendships satisfaction 0.3 0.4 1.5 0.0 0.0 -1.2 0.2
Qualifications: nursing, teaching 0.1 0.1 0.3 -0.5 0.0 -0.3 0.0
Commuting to job workplace: Walk 1.4 1.5 3.8 -0.3 0.0 1.5 2.0
Eye problems/disorders: Cataract 2.1 2.4 4.8 -1.4 0.0 2.2 1.7
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.5 0.7 0.0 0.8 1.2
Medication for cholesterol 2.2 3.3 6.4 -2.5 0.0 1.6 2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.4 -0.5 0.0 0.6 0.6
Back pain experienced in last month 3.7 5.4 9.7 3.0 0.0 -1.6 -3.1
Mineral and other dietary supplements 0.5 0.7 1.2 -0.8 0.0 1.0 1.1
Breast cancer (self-reported) 0.4 0.4 1.0 0.7 0.0 -1.0 -0.4
Asthma (self-reported) 0.2 0.3 1.2 0.0 0.0 -0.1 1.1
Osteoporosis (self-reported) 0.4 0.5 1.3 -0.5 0.0 0.6 1.1
Osteoarthritis (self-reported) 0.2 0.2 0.8 -0.9 0.0 -0.1 0.1
Medication: Aspirin 8.0 10.5 23.7 4.9 0.0 -2.2 -3.6
Medication: Gliclazide 1.1 1.3 4.5 2.1 0.0 -0.4 -0.7
Illnesses of father: None of the above (group 1) 0.4 0.5 0.8 -0.9 0.0 0.6 0.9
Smoking status: Current 0.3 0.5 1.7 0.3 0.0 1.3 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.2 4.1 -2.0 0.0 1.3 1.7
Whole body water mass 2.9 16.7 29.1 4.8 0.0 -3.8 -5.4
Leg predicted mass (right) 2.6 14.1 24.3 4.5 0.0 -3.5 -4.9
Arm fat mass (left) 3.4 13.9 23.4 4.3 0.0 -3.7 -4.8
Number of self-reported non-cancer illnesses 2.2 3.7 7.2 1.4 0.0 -2.4 -2.7
Average weekly champagne plus white wine intake 0.1 0.1 0.5 -0.3 0.0 -0.7 -0.0
Miserableness 0.1 0.1 0.5 -0.0 0.0 0.7 0.1
Guilty feelings 0.3 0.4 0.9 -0.8 0.0 0.4 0.9
Wears glasses or contact lenses 1.1 1.3 2.8 -1.7 0.0 1.0 1.2
Ever taken oral contraceptive pill 0.8 0.9 1.7 -1.3 0.0 0.8 1.2
Hearing aid user 0.4 0.5 1.0 0.9 0.0 -0.0 -1.0
Mother’s age at death 3.0 3.8 6.0 -2.4 0.0 2.4 1.9
Financial situation satisfaction 1.2 1.5 3.3 0.8 0.0 1.8 1.4
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.7 0.0 0.0 0.9 0.5
Commuting to job workplace: Public transport 0.4 0.5 1.2 -1.1 0.0 0.8 0.5
Eye problems/disorders: Glaucoma 1.4 1.7 5.9 -2.4 0.0 0.6 0.8
Medication: Blood pressure 3.8 7.3 12.5 3.2 0.0 -2.6 -3.5
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.5 1.2 0.0 -0.5 -0.8
Supplements: Fish oil (including cod liver oil) 0.0 0.1 0.1 0.4 0.0 0.2 -0.2
High cholesterol (Self-reported) 1.8 3.2 5.5 2.3 0.0 -1.4 -2.3
Medication: Bendroflumethiazide 2.9 4.4 9.2 2.2 0.0 -1.8 -3.0
Medication: Paracetamol 2.6 4.1 7.2 2.0 0.0 -2.2 -2.7
Medication: Lisinopril 0.2 0.2 0.7 0.3 0.0 0.2 -0.8
Medication: Atorvastatin 0.6 0.7 1.9 0.6 0.0 -1.4 -0.7
Illnesses of father: High blood pressure 0.1 0.1 0.5 0.7 0.0 -0.2 -0.1
Alcohol drinker status: Never 2.2 2.6 5.3 2.3 0.0 -1.2 -1.9
Ever smoked 0.3 0.4 1.5 -1.2 0.0 0.2 0.5
Basal metabolic rate 3.2 17.8 30.9 5.0 0.0 -3.9 -5.6
Leg fat percentage (left) 1.5 5.5 9.4 2.2 0.0 -2.7 -3.1
Arm fat-free mass (left) 3.5 17.7 31.2 4.6 0.0 -4.2 -5.6
Number of operations (self-reported) 0.0 0.1 0.2 0.5 0.0 0.0 -0.1
Average weekly beer plus cider intake 0.9 1.3 2.8 1.2 0.0 -0.9 -1.7
Irritability 1.2 2.1 4.5 -1.4 0.0 2.1 1.3
Risk taking 0.1 0.1 0.4 -0.7 0.0 -0.2 -0.1
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.6 -1.3 0.0 0.8 0.7
Fractured/broken bones in last 5 years 0.1 0.1 0.4 -0.3 0.0 -0.6 -0.2
Age started oral contraceptive pill 0.1 0.1 0.2 -0.3 0.0 -0.5 -0.4
Diastolic blood pressure, automated reading 0.7 2.0 6.1 2.5 0.0 -0.8 -1.2
Ever depressed for a whole week 1.5 1.8 5.8 2.4 0.0 1.2 -0.2
Unable to work because of sickness or disability 0.7 0.9 2.1 -0.4 0.0 1.4 1.1
Commuting to job workplace: Cycle 0.1 0.1 0.2 -0.0 0.0 -0.4 -0.4
Myopia 0.0 0.0 0.0 0.2 0.0 0.1 0.1
Vascular/heart problems diagnosed by doctor 2.8 7.6 16.5 -3.1 0.0 2.1 4.1
Cholesterol lowering medication 4.0 5.9 11.1 3.3 0.0 -1.9 -3.0
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.5 0.2 0.0 0.7 0.2
Pain experienced in last month 1.2 2.1 6.1 -2.5 0.0 -0.0 1.5
Supplements: Calcium 0.3 0.3 1.0 0.3 0.0 -0.4 -1.0
Basal cell carcinoma (self-reported) 0.1 0.1 0.2 -0.5 0.0 -0.2 0.1
Heart attack/myocardial infarction (self-reported) 2.5 3.2 7.2 2.7 0.0 -1.0 -2.2
Deep venous thrombosis (DVT) (self-reported) 5.3 6.9 11.5 2.7 0.0 -3.4 -2.9
Heart disease (siblings) 1.5 1.8 3.2 1.1 0.0 -1.6 -1.8
Alcohol drinker status: Previous 1.6 1.8 3.0 -1.6 0.0 1.3 1.7
Pack years of smoking 0.4 0.5 1.1 1.0 0.0 -0.5 -0.9
Impedance of whole body 0.2 1.2 2.7 -1.4 0.0 0.6 1.6
Leg fat mass (left) 3.0 11.6 19.5 3.9 0.0 -3.4 -4.4
Arm predicted mass (left) 3.4 17.2 31.2 4.6 0.0 -4.1 -5.6