TWAS hub - SGCB

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0250	0.0160	0.00340	0.017	0.011	0.013	0.011	0.007	0.0033	0.01400	0.00980	0.01400	0.04700
2	ROSMAP	Brain Pre-frontal Cortex	0.0297	0.0164	0.00046	0.029	0.025	0.031	0.026	0.028	0.0001	0.00031	0.00007	0.00026	0.00014

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Medication: Aspirin	19.7	26.0	30.7	5.5	4.6
Medication: Aspirin	19.1	24.8	28.4	5.3	4.6
Medication: Simvastatin	13.7	20.2	21.1	4.4	4.6
Medication: Metformin	13.6	19.1	19.2	4.4	4.4
Father’s age at death	10.4	14.0	16.4	-3.4	-4.0
Diabetes (self-reported)	10.0	15.4	17.6	4.2	3.6
Type 2 Diabetes (T2D) (2018)	9.3	17.4	19.0	4.4	4.0
Trunk fat mass	8.5	36.5	45.0	5.3	6.7
High blood pressure (siblings)	8.4	12.1	12.5	3.5	3.4
Diabetes diagnosed by doctor	8.3	13.7	15.5	3.9	3.4
Cholesterol lowering medication	8.2	12.0	12.5	3.5	3.4
Whole body fat mass	8.1	33.7	40.8	5.2	6.4
Body Mass Index (BMI) (2010)	7.8	10.6	11.5	3.1	3.4
Illnesses of siblings	7.8	10.9	12.2	-3.1	-3.5
Systolic blood pressure, automated reading	7.7	22.3	22.5	4.7	4.7
Alcohol intake versus 10 years previously	7.5	11.2	11.7	3.4	3.3
Arm fat mass (right)	7.5	31.0	36.3	5.1	6.0
Waist circumference	7.4	27.1	31.2	4.8	5.6
Leg fat mass (right)	7.4	28.5	32.7	4.9	5.7
Trunk fat percentage	7.3	29.1	37.2	4.6	6.1
Arm fat mass (left)	7.3	30.0	35.1	5.0	5.9
Weight	7.2	35.6	42.6	5.3	6.5
Leg fat mass (left)	7.2	28.2	32.5	4.9	5.7
Medication: Cholesterol lowering	6.8	10.6	12.5	3.5	2.9
Prospective memory result	6.6	8.1	9.5	-3.1	-2.6
Body fat percentage	6.6	26.0	32.1	4.5	5.7
Hip circumference	6.4	27.5	34.9	4.5	5.9
Number of treatments/medications taken	6.3	11.4	11.5	3.4	3.3
Breastfed as a baby	5.7	7.1	8.1	-2.5	-2.8
Arm fat percentage (left)	5.7	22.8	28.4	4.1	5.3
Medication: Bendroflumethiazide	5.7	8.7	10.4	2.7	3.2
Medication for cholesterol, blood pressure or diabetes	5.5	9.2	10.2	-2.8	-3.2
Age at first live birth	5.5	9.8	13.6	-2.5	-3.7
Arm fat percentage (right)	5.4	21.4	26.3	4.1	5.1
Ever depressed for a whole week	5.2	6.4	6.8	2.4	2.6
Systolic Blood Pressure	5.1	25.6	26.4	5.0	5.1
Heart attack	5.1	6.5	6.9	2.6	2.5
Medication: Ramipril	5.1	6.5	7.9	2.3	2.8
Medication: Blood pressure	5.1	9.6	9.7	3.1	3.1
Heart attack/myocardial infarction (self-reported)	5.1	6.6	7.5	2.7	2.4
Chronotype (morning person)	4.9	11.4	13.5	-3.7	-3.0
Alcohol intake frequency.	4.9	11.3	15.8	2.6	4.0
Hearing difficulty/problems: Yes	4.8	7.3	11.3	3.4	1.8
Medication: Atenolol	4.8	6.0	7.0	2.6	2.2
Body mass index (BMI)	4.7	20.1	21.7	4.3	4.7
Leg fat percentage (right)	4.7	17.0	19.7	3.8	4.4
Long-standing illness, disability or infirmity	4.7	7.2	7.4	2.7	2.6
Medication for cholesterol	4.7	7.1	8.7	-3.0	-2.3
High cholesterol (Self-reported)	4.7	8.3	8.9	3.0	2.8
BMI	4.5	26.2	29.6	4.8	5.4
Leg fat percentage (left)	4.5	16.4	18.6	3.8	4.3
Blood clot in the leg (DVT)	4.4	5.6	6.5	2.2	2.5
Ever unenthusiastic/disinterested for a whole week	4.2	5.2	5.4	2.3	2.2
Medication for pain relief, constipation, heartburn	4.1	7.0	7.8	-2.8	-2.5
Basal metabolic rate	4.0	22.1	24.8	4.4	5.0
Number of self-reported non-cancer illnesses	3.9	6.8	7.1	2.6	2.7
Major Depression (MDD)	3.8	4.6	5.0	2.2	2.1
Arm predicted mass (right)	3.8	19.7	19.9	4.5	4.4
Back pain experienced in last month	3.8	5.6	7.6	1.9	2.8
Deep venous thrombosis (DVT) (self-reported)	3.8	4.9	5.9	2.0	2.4
Heart disease (siblings)	3.7	4.6	5.3	2.3	2.0
Arm predicted mass (left)	3.7	19.0	19.2	4.4	4.3
Supplements: Glucosamine	3.6	4.6	5.8	-2.4	-1.9
Leg predicted mass (left)	3.6	18.9	22.7	3.9	4.8
Eye problems/disorders: Glaucoma	3.6	4.3	5.3	-1.8	-2.3
Alcohol drinker status: Never	3.6	4.3	7.2	1.2	2.7
Arm fat-free mass (left)	3.6	18.4	18.6	4.3	4.3
Leg fat-free mass (left)	3.5	18.7	22.8	3.8	4.8
Medication: Paracetamol	3.5	5.7	6.1	2.3	2.5
Arm fat-free mass (right)	3.5	17.9	18.7	4.1	4.3
Mouth/teeth dental problems: Dentures	3.4	5.7	7.1	2.7	2.1
Had menopause	3.3	4.1	4.6	-1.9	-2.1
Pulse wave reflection index	3.3	4.1	4.7	-2.2	-1.9
Angina (self-reported)	3.3	4.4	4.8	2.2	2.0
Alcohol drinker status: Previous	3.3	3.8	3.9	-1.9	-2.0
Cardiovascular Disease	3.2	10.5	10.8	3.3	3.2
Leg pain on walking	3.2	4.0	4.0	2.0	2.0
Whole body fat-free mass	3.2	18.3	20.0	4.1	4.5
Average weekly red wine intake	3.2	4.7	5.9	-2.4	-1.8
Whole body water mass	3.2	18.1	19.7	4.1	4.4
Medication: Paracetamol	3.2	5.0	5.5	2.1	2.3
Irritability	3.2	5.5	6.5	-2.5	-2.1
Vascular/heart problems diagnosed by doctor	3.2	8.7	8.7	-2.9	-2.9
Trunk fat-free mass	3.1	17.7	17.9	4.2	4.2
Trunk predicted mass	3.1	17.7	17.8	4.2	4.2
Leg fat-free mass (right)	3.1	16.6	19.9	3.6	4.5
Leg predicted mass (right)	3.1	16.5	19.6	3.6	4.4
Number of incorrect matches in round	3.0	5.0	6.0	-2.0	-2.5
Birth weight	3.0	6.5	7.4	2.4	2.7
Medication: Blood pressure	3.0	5.2	5.4	2.3	2.3
Comparative height size at age 10	3.0	16.8	23.7	3.1	4.9
Taking other prescription medications	2.9	4.5	5.0	2.2	2.0
Supplements: Vitamin C	2.9	3.4	5.2	-2.3	-1.3
Mother’s age at death	2.9	3.7	4.4	-2.1	-1.7
Fasting Glucose	2.8	3.4	4.4	2.1	1.5
Lung cancer (father)	2.8	3.3	3.5	1.9	1.8
Mean Putamen Volume	2.7	3.1	3.2	-1.8	-1.7
Depression (Nagel 2018)	2.6	4.0	6.3	2.5	1.3
Breast Cancer	2.6	6.2	10.2	-1.5	-3.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.6	5.5	7.0	-2.7	-2.0
Worry (Nagel 2018)	2.5	5.2	7.4	-1.7	-2.7
Blood White Count	2.5	18.7	20.1	4.2	4.5
Worrier / anxious feelings	2.5	4.6	5.0	-2.2	-2.1
Tense / ‘highly strung’	2.5	4.2	5.4	-1.7	-2.3
Age at last live birth	2.5	3.7	5.3	-1.4	-2.3
Pain experienced in last month	2.5	4.2	4.5	-2.1	-2.0
Height	2.4	45.9	63.0	5.4	7.9
Angina	2.4	3.2	3.5	1.9	1.7
Serious illness, injury or assault to yourself	2.3	2.8	3.2	1.8	1.5
Chronic bronchitis/emphysema (father)	2.3	2.7	3.0	1.5	1.7
Osteoporosis (self-reported)	2.3	2.8	3.3	-1.5	-1.8
Ever had hysterectomy (womb removed)	2.2	2.5	3.8	2.0	1.0
Qualifications: CSEs or equivalent	2.2	2.9	5.4	0.7	2.3
Pulse wave peak to peak time	2.2	2.6	2.8	1.7	1.6
Diabetes (mother)	2.1	2.7	3.2	1.5	1.8
Peak expiratory flow (PEF)	2.1	5.0	8.5	1.2	2.9
Medication: Amlodipine	2.1	2.9	4.2	2.1	1.3
Hypertension (Self-reported)	2.1	5.9	6.6	2.6	2.3
Schizophrenia vs Biploar Disorder	2.0	2.6	3.6	1.3	1.9
Neuroticism (2016)	2.0	3.0	4.3	2.1	1.3
Alcohol usually taken with meals	2.0	3.2	3.2	-1.8	-1.8
Coronary Artery Disease (CAD)	1.9	2.2	3.3	1.1	1.8
Financial difficulties in last 2 years	1.9	2.6	3.0	1.7	1.5
Rheumatoid Arthritis	1.8	2.4	2.8	-1.4	-1.7
Blood Platelet Count	1.8	20.5	22.4	4.7	4.3
Illnesses of mother	1.8	2.3	2.8	-1.3	-1.7
Standing height	1.8	17.7	25.2	3.2	5.0
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	4.7	2.2	1.7
Financial situation satisfaction	1.8	2.3	2.8	1.7	1.3
Medication: Lisinopril	1.8	2.3	3.6	1.0	1.9
Average weekly beer plus cider intake	1.8	2.6	3.7	1.2	1.9
Verbal and Numeric Reasoning (VNR)	1.7	4.0	5.2	1.7	2.3
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	3.4	1.8	0.6
Glaucoma (self-reported)	1.7	1.9	2.8	-1.1	-1.7
Eye problems/disorders: None of the above	1.7	1.9	3.3	0.7	1.8
Medication: Gliclazide	1.7	1.9	2.2	1.3	1.5
Reaction Time	1.6	3.1	4.5	-1.3	-2.1
Smoking Status	1.6	3.7	5.8	2.4	1.3
Medication: Co-codamol	1.6	1.8	2.4	1.1	1.6
Type 2 Diabetes (T2D) (2012)	1.5	1.8	2.4	1.6	1.1
High blood pressure	1.5	4.1	4.1	2.0	2.0
Migraine (self-reported)	1.5	1.8	2.7	1.0	1.6
Medication: Seretide 50 evohaler	1.5	1.7	2.7	0.9	1.6
Family relationship satisfaction	1.5	1.9	2.3	1.5	1.2
Relative age of first facial hair	1.4	2.9	3.1	-1.6	-1.8
Pulse wave Arterial Stiffness index	1.4	1.7	2.1	-1.4	-1.1
Overall health rating	1.4	3.1	3.3	1.7	1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	1.7	-1.3	-1.1
Eye problems/disorders: Cataract	1.4	1.7	1.8	-1.2	-1.4
Hearing aid user	1.4	1.5	1.7	1.3	1.2
Diastolic blood pressure, automated reading	1.4	4.3	6.6	1.4	2.6
Ovarian Cancer	1.3	1.8	2.0	-1.4	-1.2
Hair/balding pattern: Pattern 3	1.3	2.0	2.1	1.3	1.4
Knee pain experienced in last month	1.3	1.9	2.3	1.5	1.3
Illnesses of father: None of the above (group 1)	1.3	1.6	2.2	-1.0	-1.5
Qualifications: None of the above	1.2	2.5	3.3	1.8	1.3
Hair/balding pattern: Pattern 4	1.2	2.9	3.8	-1.4	-2.0
Mean time to correctly identify matches	1.2	2.2	3.8	-0.8	-1.9
Chest pain or discomfort	1.2	1.7	2.0	1.4	1.2
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	1.9	0.9	1.4
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.3	-1.5	-0.8
Depressed Affect (Nagel 2018)	1.1	2.3	3.7	1.9	0.9
Alzheimer’s Disease (including proxy)	1.1	1.6	1.7	-1.2	-1.3
Blood Eosinophil Count	1.1	8.1	8.5	2.8	2.9
Miserableness	1.1	2.0	3.4	1.9	0.7
Pack years of smoking	1.1	1.6	2.4	0.9	1.5
Intelligence (Savage-Jansen 2018)	1.0	3.2	3.8	1.6	1.9
Age at First Birth	1.0	1.4	1.9	-0.9	-1.4
Lung FVC	1.0	4.8	5.8	-2.4	-2.0
Qualifications: College or University degree	1.0	3.3	4.7	-2.2	-1.4
Average weekly champagne plus white wine intake	1.0	1.4	1.4	-1.2	-1.2
Bipolar Disorder or Schizophrenia	0.9	2.1	2.4	-1.3	-1.6
Current tobacco smoking	0.9	1.5	2.3	1.5	0.8
High blood pressure (mother)	0.9	1.2	1.7	1.3	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	1.8	-1.0	-1.3
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	1.4	-0.9	-1.2
Medication: Omeprazole	0.9	1.1	2.1	0.1	1.4
Osteoarthritis (self-reported)	0.9	1.2	1.4	-1.2	-1.0
Schizophrenia (2018)	0.8	1.7	2.7	-1.6	-0.9
HDL Cholesterol	0.8	1.4	2.6	-0.4	-1.6
Pack years adult smoking proportion	0.8	1.2	1.7	0.9	1.3
Sitting height	0.8	5.8	9.0	1.6	3.0
Hearing difficulty/problems with background noise	0.8	1.3	1.7	1.3	1.0
Had other major operations	0.8	1.0	1.9	-0.4	-1.4
Fluid intelligence score	0.8	1.8	2.0	1.2	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.7	-0.5	-1.3
Headache pain in last month	0.8	1.4	1.4	1.2	1.1
Number of children fathered	0.8	0.9	1.8	-1.4	0.1
Neck or shoulder pain in last month	0.8	1.1	1.2	1.0	1.1
Medication: Ibuprofen	0.8	1.0	1.7	-0.6	-1.3
Bipolar Disorder (2018)	0.7	1.0	2.1	-0.1	-1.4
Alzheimer’s Disease (in father)	0.7	0.7	0.9	-1.0	-0.7
Ulcerative Colitis (UC)	0.7	1.3	2.4	1.5	0.5
Schizophrenia (2014)	0.7	1.4	1.6	-1.2	-1.2
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.5	0.5	-1.2
Fed-up feelings	0.7	1.2	1.3	1.2	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.3	1.1	0.7
Relative age voice broke	0.7	1.0	1.5	0.7	1.2
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.4	1.2	0.4
Smoking status: Previous	0.7	1.1	1.7	1.3	0.6
Commuting to job workplace: Walk	0.7	0.7	1.3	-1.2	-0.3
Risk taking	0.7	1.1	1.7	-1.3	-0.6
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.2	-0.6	-1.1
Triglycerides	0.6	1.0	1.8	0.4	1.3
Average weekly spirits intake	0.6	0.7	1.3	1.2	0.4
Medication for hormone replacement therapy	0.6	0.7	1.3	-0.3	-1.1
Supplements: Zinc	0.6	0.7	0.7	-0.8	-0.8
Severe depression (siblings)	0.6	0.6	0.7	-0.8	-0.8
Past tobacco smoking	0.6	1.1	1.8	-1.4	-0.6
Allergy	0.6	1.4	2.8	-0.2	-1.7
Emphysema/chronic bronchitis	0.6	0.6	1.2	1.1	-0.1
Pulse rate, automated reading	0.6	1.9	1.9	-1.4	-1.3
Ever had bowel cancer screening	0.6	0.7	1.1	-0.5	-1.0
Age started oral contraceptive pill	0.6	0.8	1.6	-1.3	0.0
Bipolar Disorder (2011)	0.5	0.5	0.6	0.6	0.8
Diabetes (father)	0.5	0.6	0.8	0.9	-0.6
Townsend deprivation index at recruitment	0.5	0.7	1.1	0.5	1.0
Mouth/teeth dental problems	0.5	0.7	1.1	-1.1	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	0.9	-1.0	-0.5
Depression (self-reported)	0.5	0.6	0.8	0.9	-0.6
Health satisfaction	0.5	0.6	1.2	1.1	0.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.3	1.1	0.2
Illnesses of siblings: Diabetes	0.5	0.6	1.2	0.3	1.1
Smoking status: Current	0.5	0.8	1.2	1.1	0.5
Fractured/broken bones in last 5 years	0.5	0.7	1.1	-0.5	-1.0
Respiratory disease	0.4	0.9	1.1	0.8	1.1
Hair/balding pattern: Pattern 2	0.4	0.6	0.8	-0.9	-0.6
Medication: Lansoprazole	0.4	0.5	0.5	0.6	0.7
Length of working week for main job	0.4	0.5	0.9	0.1	1.0
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.8	-0.3	0.9
Heart disease (mother)	0.4	0.5	0.9	0.2	1.0
Suffer from ‘nerves’	0.4	0.7	1.4	-0.1	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	0.2	1.0
Guilty feelings	0.4	0.7	0.8	-0.9	-0.7
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.9	0.2	-1.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.7	0.6	0.8
Supplements: Calcium	0.4	0.5	0.6	-0.5	-0.8
Impedance of whole body	0.4	1.9	3.4	-1.9	-0.5
HbA1C	0.3	0.3	0.4	0.6	0.6
Ulcerative Colitis	0.3	0.4	0.6	0.5	-0.8
Waist Hip Ratio (WHR)	0.3	1.4	2.5	1.6	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.2	-1.1	-0.4
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	0.0	0.8
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.4	-0.0	1.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.7	0.0	0.9
Pulse rate	0.3	0.5	0.9	-0.4	-0.9
Happiness	0.3	0.3	0.6	0.8	0.2
Noisy workplace	0.3	0.3	0.6	0.1	0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.7	0.8	-0.8	-0.9
Impedance of arm (left)	0.3	1.2	2.2	-1.5	0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	0.7	-0.8	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.8	0.2	-0.9
Commuting to job workplace: Cycle	0.3	0.3	0.4	-0.7	0.4
Alzheimer’s Disease (in mother)	0.2	0.2	0.3	-0.4	-0.5
LDL Cholesterol	0.2	0.3	0.6	0.3	0.7
Lupus	0.2	0.3	0.6	0.8	0.3
Hand grip strength (left)	0.2	0.6	1.1	0.2	1.1
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.4	0.7	0.1
Vitamin and mineral supplements	0.2	0.3	0.3	0.5	0.6
Impedance of leg (right)	0.2	0.8	1.1	-1.0	-0.7
Hand grip strength (right)	0.2	0.6	1.2	-1.1	-0.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.5	-0.7	-0.0
Impedance of leg (left)	0.2	0.8	1.1	-1.0	-0.7
Forced vital capacity (FVC)	0.2	0.7	1.1	-1.1	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.1	-1.0	-0.1
Impedance of arm (right)	0.2	1.1	2.2	-1.5	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.4	0.7	0.3
Falls in the last year	0.2	0.2	0.3	0.4	-0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.0	-1.0	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.3	-1.1	0.2
Exposure to tobacco smoke at home	0.2	0.2	0.3	-0.4	-0.5
Loud music exposure frequency	0.2	0.2	0.4	0.1	-0.6
Forced vital capacity (FVC), Best measure	0.2	0.6	0.7	-0.8	0.8
Comparative body size at age 10	0.2	0.4	0.9	0.1	-0.9
Number of full brothers	0.2	0.3	0.6	0.8	-0.0
Worry too long after embarrassment	0.2	0.3	0.3	-0.5	-0.5
Shortness of breath walking on level ground	0.2	0.2	0.4	0.1	-0.6
Had major operations	0.2	0.3	0.4	-0.6	0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.3	0.6	-0.1
Illnesses of father: Heart disease	0.2	0.3	0.4	0.4	0.6
Wears glasses or contact lenses	0.2	0.3	0.3	-0.6	-0.4
Medication: Atorvastatin	0.2	0.2	0.4	0.6	0.3
Ever smoked	0.2	0.4	0.7	0.1	-0.9
Myopia	0.2	0.3	0.4	0.4	0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.3	-0.4	0.6
Neuroticism (Nagel 2018)	0.1	0.3	0.7	-0.1	-0.8
Crohns Disease (2017)	0.1	0.1	0.2	0.4	0.4
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	0.6	0.2
Prostate Cancer	0.1	0.1	0.2	0.2	0.5
Primary Biliary Cirrhosis	0.1	0.2	0.4	-0.2	-0.6
Heel T-Score	0.1	0.4	0.7	-0.8	-0.4
Hypothyroidism (self reported)	0.1	0.3	0.3	-0.5	-0.6
Lung FEV1/FVC ratio	0.1	0.7	0.9	0.7	-1.0
Neuroticism	0.1	0.3	0.5	-0.1	-0.7
Sensitivity / hurt feelings	0.1	0.1	0.1	0.2	0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.1	-0.1	-0.4
Average weekly fortified wine intake	0.1	0.2	0.2	-0.4	-0.3
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.5	0.3
Neuroticism score	0.1	0.2	0.4	-0.1	-0.7
Time employed in main current job	0.1	0.1	0.1	-0.2	-0.4
Number of live births	0.1	0.1	0.1	-0.4	0.2
Asthma	0.1	0.2	0.3	-0.5	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.4	0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.1	0.1	-0.4
Exposure to tobacco smoke outside home	0.1	0.1	0.1	0.2	0.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.3	0.6	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	0.1	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.2	0.5	0.3
Number of full sisters	0.1	0.1	0.1	-0.3	-0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	-0.2	-0.3
Qualifications: nursing, teaching	0.1	0.2	0.4	0.2	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.1	-0.2	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.1	0.4
Mineral and other dietary supplements	0.1	0.2	0.2	0.5	0.3
Breast cancer (self-reported)	0.1	0.1	0.2	0.1	0.4
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.5	0.1
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.2	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	0.4	0.3
Number of operations (self-reported)	0.1	0.1	0.2	0.2	-0.5
Unable to work because of sickness or disability	0.1	0.1	0.1	0.2	0.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.3	-0.5
Crohns Disease (2012)	0.0	0.0	0.0	-0.0	0.1
Blood Red Count	0.0	0.3	0.5	-0.7	0.4
Allergy or Eczema	0.0	0.1	0.1	-0.1	0.4
Hair Pigment	0.0	1.1	2.0	-1.4	-0.4
Tanning	0.0	0.6	1.1	0.2	1.1
Maternal smoking around birth	0.0	0.1	0.1	-0.2	0.3
Age when periods started (menarche)	0.0	0.0	0.1	-0.3	-0.0
Multivitamins +/- minerals	0.0	0.0	0.1	0.0	-0.3
Medication: Levothyroxine sodium	0.0	0.0	0.0	-0.2	-0.0
Nervous feelings	0.0	0.1	0.1	0.2	-0.3
Pain all over the body in last month	0.0	0.0	0.0	0.1	-0.1
Birth weight of first child	0.0	0.0	0.1	-0.2	-0.2
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	0.1	0.0
Gout (self-reported)	0.0	0.1	0.1	0.3	0.2
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.0	-0.1	0.2
Medication: Allopurinol	0.0	0.0	0.1	0.3	0.1
Mood swings	0.0	0.0	0.0	0.0	-0.0
Loneliness, isolation	0.0	0.0	0.0	0.2	-0.2
Friendships satisfaction	0.0	0.0	0.0	0.2	0.2
Asthma (self-reported)	0.0	0.1	0.1	-0.4	-0.1
Illnesses of father: High blood pressure	0.0	0.0	0.0	-0.1	-0.1

Hub : Genes

SGCB

Models

Trait associations