Best TWAS P=4.39e-10 · Best GWAS P=1.19e-12 conditioned to 6.5e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | HIVEP3 | 0.23 | 0.16 | lasso | 6 | 0.19 | 2.8e-06 | 3.4 | 5.2 | 1.6e-07 | 0.68 | 0.10 | 0.84 | FALSE |
| 2 | GTEx | Pituitary | ZMYND12 | 0.18 | 0.01 | enet | 22 | 0.04 | 3.9e-02 | -5.1 | -5.5 | 3.2e-08 | -0.37 | 0.06 | 0.26 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | RIMKLA | 0.06 | 0.06 | bslmm | 341 | 0.05 | 1.3e-07 | -3.7 | 6.2 | 4.4e-10 | 0.41 | 0.97 | 0.01 | TRUE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RIMKLA | 0.03 | 0.02 | blup | 53 | 0.01 | 2.8e-02 | 4.8 | 5.5 | 3.1e-08 | 0.33 | 0.00 | 0.84 | FALSE |