Best TWAS P=6.2e-11 · Best GWAS P=5.47e-10 conditioned to 0.0567
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | BMP8A | 0.05 | 0.03 | lasso | 3 | 0.02 | 8.8e-04 | 5.7 | 5.8 | 6.9e-09 | 0.70 | 0.06 | 0.89 | FALSE |
| 2 | GTEx | Adrenal Gland | PABPC4 | 0.20 | 0.09 | lasso | 8 | 0.06 | 3.0e-03 | 5.5 | -6.5 | 6.2e-11 | -0.76 | 0.03 | 0.87 | TRUE |
| 3 | GTEx | Artery Tibial | PABPC4 | 0.10 | 0.10 | lasso | 4 | 0.10 | 3.4e-08 | 5.5 | -5.5 | 4.9e-08 | -0.69 | 0.15 | 0.85 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | PABPC4 | 0.13 | 0.02 | enet | 14 | 0.04 | 3.4e-03 | 5.7 | -5.7 | 1.4e-08 | -0.68 | 0.07 | 0.82 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Female) | PABPC4 | 0.10 | 0.00 | enet | 9 | 0.01 | 1.5e-01 | 5.8 | -6.2 | 5.2e-10 | -0.77 | 0.04 | 0.35 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | PABPC4 | 0.07 | 0.09 | lasso | 1 | 0.06 | 2.7e-05 | 5.5 | -5.5 | 2.9e-08 | -0.66 | 0.07 | 0.92 | FALSE |
| 7 | GTEx | Esophagus Mucosa | PABPC4 | 0.06 | 0.06 | lasso | 3 | 0.08 | 7.3e-06 | 5.7 | -5.6 | 1.7e-08 | -0.71 | 0.11 | 0.87 | FALSE |
| 8 | GTEx | Nerve Tibial | PABPC4 | 0.17 | 0.08 | enet | 12 | 0.05 | 2.7e-04 | 5.5 | -5.3 | 9.7e-08 | -0.69 | 0.09 | 0.90 | FALSE |
| 9 | GTEx | Nerve Tibial | RP11-69E11.8 | 0.05 | 0.00 | lasso | 3 | 0.01 | 6.9e-02 | 5.5 | -5.8 | 8.2e-09 | -0.71 | 0.04 | 0.83 | FALSE |
| 10 | GTEx | Skin Not Sun Exposed Suprapubic | PABPC4 | 0.12 | 0.10 | lasso | 3 | 0.05 | 1.0e-03 | 5.7 | -5.8 | 8.9e-09 | -0.69 | 0.09 | 0.80 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | PABPC4 | 0.11 | 0.09 | lasso | 7 | 0.08 | 2.7e-07 | 5.7 | -5.5 | 4.4e-08 | -0.74 | 0.06 | 0.94 | FALSE |
| 12 | METSIM | Adipose | PABPC4 | 0.05 | 0.02 | lasso | 6 | 0.03 | 6.0e-05 | 5.7 | -5.3 | 1.4e-07 | -0.69 | 0.08 | 0.92 | FALSE |
| 13 | NTR | Blood | PABPC4 | 0.01 | 0.00 | blup | 383 | 0.00 | 2.8e-02 | 5.5 | -5.9 | 3.7e-09 | -0.65 | 0.02 | 0.77 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PABPC4 | 0.03 | 0.03 | lasso | 2 | 0.04 | 1.3e-08 | 5.5 | -5.3 | 1.1e-07 | -0.60 | 0.00 | 1.00 | FALSE |
| 15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | BMP8A | 0.04 | 0.03 | blup | 48 | 0.04 | 3.5e-05 | 3.9 | 5.2 | 2.4e-07 | 0.66 | 0.03 | 0.95 | FALSE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PABPC4 | 0.03 | 0.01 | enet | 4 | 0.02 | 4.3e-03 | 5.5 | -5.4 | 6.8e-08 | -0.61 | 0.00 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BMP8A | 0.05 | 0.01 | blup | 48 | 0.04 | 6.8e-05 | 5.5 | 5.6 | 2.5e-08 | 0.66 | 0.00 | 0.98 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Adenocarcinoma | PABPC4 | 0.04 | 0.03 | enet | 8 | 0.04 | 4.5e-05 | 5.7 | -5.6 | 2.8e-08 | -0.61 | 0.00 | 1.00 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | PABPC4 | 0.09 | 0.07 | enet | 5 | 0.08 | 4.1e-08 | 5.5 | -5.9 | 3.1e-09 | -0.51 | 0.00 | 1.00 | FALSE |