Best TWAS P=1.99e-10 · Best GWAS P=6.23e-11 conditioned to 0.00125
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Caudate basal ganglia | SLC22A3 | 0.15 | 0.10 | enet | 39 | 0.11 | 5.6e-04 | -5.7 | -6.4 | 2.0e-10 | 0.64 | 0.20 | 0.51 | TRUE |
| 2 | GTEx | Brain Frontal Cortex BA9 | SLC22A3 | 0.26 | 0.08 | lasso | 6 | 0.05 | 1.5e-02 | -4.2 | -5.3 | 1.3e-07 | 0.62 | 0.10 | 0.71 | FALSE |
| 3 | GTEx | Nerve Tibial | SLC22A3 | 0.20 | 0.10 | lasso | 7 | 0.13 | 3.2e-09 | -5.2 | -5.3 | 9.3e-08 | 0.54 | 0.95 | 0.04 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | SLC22A3 | 0.15 | 0.05 | lasso | 9 | 0.05 | 9.9e-04 | -4.7 | -6.1 | 8.6e-10 | 0.82 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | SLC22A3 | 0.29 | 0.14 | lasso | 10 | 0.20 | 3.7e-16 | 3.5 | -5.5 | 3.4e-08 | 0.52 | 0.99 | 0.01 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | SLC22A3 | 0.14 | 0.20 | lasso | 10 | 0.19 | 2.4e-24 | -4.9 | -5.2 | 1.9e-07 | 0.61 | 0.98 | 0.02 | FALSE |