Best TWAS P=4.21e-08 · Best GWAS P=5.67e-08 conditioned to 0.445
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells Transformed fibroblasts | NUDT18 | 0.10 | 0.04 | enet | 6 | 0.03 | 4.7e-03 | 5.0 | 5.4 | 5.2e-08 | 0.89 | 0.01 | 0.92 | FALSE |
2 | GTEx | Cells Transformed fibroblasts | AC091171.1 | 0.15 | 0.06 | lasso | 2 | 0.05 | 2.2e-04 | -5.3 | 5.2 | 1.8e-07 | 0.69 | 0.02 | 0.96 | FALSE |
3 | GTEx | Esophagus Mucosa | FAM160B2 | 0.15 | 0.05 | enet | 19 | 0.09 | 1.7e-06 | 5.2 | 5.1 | 2.7e-07 | 0.77 | 0.01 | 0.98 | FALSE |
4 | GTEx | Esophagus Mucosa | AC091171.1 | 0.14 | 0.07 | lasso | 4 | 0.05 | 2.2e-04 | 5.4 | 5.5 | 4.2e-08 | 0.94 | 0.01 | 0.99 | TRUE |
5 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | NUDT18 | 0.09 | 0.03 | blup | 45 | 0.08 | 1.3e-04 | -5.1 | -5.2 | 1.7e-07 | -0.78 | 0.03 | 0.95 | FALSE |
6 | The Cancer Genome Atlas | Colon Adenocarcinoma | FAM160B2 | 0.06 | 0.07 | lasso | 1 | 0.06 | 2.3e-04 | 5.2 | 5.2 | 1.6e-07 | 0.93 | 0.01 | 0.92 | FALSE |
7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NUDT18 | 0.11 | 0.22 | lasso | 6 | 0.22 | 3.6e-24 | -5.3 | -5.2 | 1.9e-07 | -0.78 | 0.02 | 0.98 | FALSE |
8 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | NUDT18 | 0.15 | 0.17 | lasso | 4 | 0.12 | 2.3e-04 | -5.2 | -5.4 | 7.7e-08 | -0.78 | 0.02 | 0.95 | FALSE |