Hub : Genes

FAM160B2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1800	0.0470	1.1e-05	0.092	NA	0.098	NA	0.103	2.0e-07	NA	9.1e-08	NA	4.0e-08
2	GTEx	Colon Transverse	0.3290	0.0890	2.6e-04	0.045	NA	0.088	NA	0.080	3.3e-03	NA	5.7e-05	NA	1.2e-04
3	GTEx	Esophagus Mucosa	0.1520	0.0530	5.1e-03	0.053	NA	0.088	NA	0.071	1.9e-04	NA	1.7e-06	NA	1.7e-05
4	METSIM	Adipose	0.0590	0.0197	1.7e-04	0.034	0.028	0.040	0.036	0.030	6.2e-06	3.8e-05	1.2e-06	4.0e-06	2.5e-05
5	ROSMAP	Brain Pre-frontal Cortex	0.0726	0.0277	7.1e-04	0.014	0.035	0.029	0.035	0.008	4.9e-03	2.2e-05	9.6e-05	2.3e-05	2.6e-02
6	YFS	Blood	0.0534	0.0158	3.7e-06	0.031	0.023	0.032	0.028	0.031	2.0e-10	3.6e-08	1.0e-10	1.3e-09	1.5e-10
7	TCGA	Bladder Urothelial Carcinoma	0.0520	0.0320	6.7e-03	0.001	0.016	-0.003	NA	0.000	2.5e-01	1.5e-02	8.6e-01	NA	3.0e-01
8	TCGA	Colon Adenocarcinoma	0.0620	0.0320	1.8e-03	0.074	0.055	0.049	NA	0.060	4.7e-05	4.3e-04	7.6e-04	NA	2.3e-04
9	TCGA	Brain Lower Grade Glioma	0.0351	0.0197	2.1e-03	0.010	0.008	0.002	NA	0.009	2.4e-02	3.7e-02	1.9e-01	NA	2.6e-02
10	TCGA	Lung Squamous Cell Carcinoma	0.0245	0.0132	2.9e-03	0.021	0.021	0.016	NA	0.003	1.6e-03	1.8e-03	5.7e-03	NA	1.2e-01
11	TCGA	Prostate Adenocarcinoma	0.0468	0.0222	9.9e-05	0.007	0.033	0.034	NA	0.028	5.2e-02	1.8e-04	1.7e-04	NA	5.7e-04
12	TCGA	Stomach Adenocarcinoma	0.0370	0.0210	8.0e-03	0.015	0.013	0.011	NA	0.013	2.8e-02	3.5e-02	5.2e-02	NA	3.9e-02
13	TCGA	Thyroid Carcinoma	0.0790	0.0350	2.4e-05	0.056	0.033	0.038	NA	0.049	3.7e-06	3.5e-04	1.3e-04	NA	1.4e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	2.7	4.2	9.6	-2.1	-0.0	-2.1	-1.7	-2.9	1.5	-3.1	-2.3	-1.8	-1.9	0.0	-2.5	-2.0
Bipolar Disorder or Schizophrenia	1.9	4.6	14.4	-2.0	-0.7	-2.2	-0.7	-3.8	1.1	-3.3	-1.6	-2.1	-1.8	0.0	-2.8	-2.3
Depressed Affect (Nagel 2018)	6.9	14.5	22.3	4.1	0.8	4.3	3.7	3.0	-2.8	4.7	3.6	3.9	4.5	3.6	4.2	4.5
Depression (Nagel 2018)	4.3	6.5	12.1	2.9	0.4	2.9	3.5	-0.0	-2.2	2.5	3.1	2.5	3.3	1.9	2.3	2.9
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.3	-1.1	0.9	-0.1	-0.5	0.9	0.9	-0.3	-0.6	-0.9	-0.5	-1.0	-0.6	-0.7
Neuroticism (Nagel 2018)	4.4	10.4	17.2	3.7	0.8	3.1	3.8	1.3	-2.9	4.0	3.2	3.1	4.2	2.8	3.6	3.6
Schizophrenia (2018)	0.7	1.4	5.9	-0.8	-0.8	-1.1	0.5	-2.4	0.2	-1.7	-0.2	-1.3	-0.8	0.0	-1.5	-1.3
Schizophrenia vs Biploar Disorder	0.8	1.1	4.3	1.9	0.9	2.1	1.9	1.0	-0.4	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Worry (Nagel 2018)	1.4	2.9	5.9	2.2	0.5	1.2	1.5	-0.1	-2.0	2.2	1.1	1.7	2.4	1.4	2.1	1.8
Alzheimer’s Disease (in mother)	0.5	0.6	1.4	1.1	-0.6	-0.3	0.7	-0.6	-0.9	-0.3	0.4	1.1	1.2	0.2	0.6	1.0
Alzheimer’s Disease (in father)	1.5	1.7	5.5	0.8	2.3	1.6	2.0	0.4	-0.9	1.2	0.8	0.4	2.0	0.1	1.2	0.5
Alzheimer’s Disease (including proxy)	0.7	1.1	3.1	1.4	0.5	0.3	1.4	-0.7	-1.4	0.2	0.8	1.0	1.8	0.3	0.9	0.9
Crohns Disease (2017)	0.2	0.4	2.8	0.6	-1.7	-0.5	0.0	-0.9	-0.6	0.3	-0.1	0.1	-0.0	0.6	0.5	0.1
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	0.7	-0.6	0.1	0.5	-0.4	-0.6	0.3	0.2	0.4	0.3	0.5	0.8	0.3
Ulcerative Colitis (UC)	0.1	0.2	0.6	0.4	0.4	0.4	0.4	0.1	-0.3	0.2	0.4	0.3	0.6	0.3	0.8	0.1
Major Depression (MDD)	0.1	0.1	1.3	0.0	-1.1	0.0	0.0	0.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.8	1.6	8.7	1.2	-2.9	-0.9	-1.4	0.9	-1.7	1.0	-0.1	0.6	-0.1	1.2	1.0	0.5
Verbal and Numeric Reasoning (VNR)	0.3	0.8	6.8	-0.0	0.2	0.5	0.1	2.6	-0.4	1.3	0.6	-0.4	0.5	0.3	0.9	-0.3
Breast Cancer	0.4	0.9	4.0	0.5	-0.3	0.5	0.0	2.0	-0.1	1.2	-0.2	1.1	0.4	1.4	1.1	0.7
Ovarian Cancer	1.0	1.3	3.0	1.1	0.7	1.7	0.7	0.4	-1.0	1.5	1.0	1.2	1.2	1.4	1.3	1.1
Prostate Cancer	1.6	2.2	9.6	0.9	0.7	1.7	-0.2	0.4	-0.6	3.1	1.7	1.4	0.2	2.5	1.4	1.2
Age at First Birth	0.3	0.4	2.3	-0.5	1.5	0.6	-0.7	-0.0	0.0	0.2	0.8	-0.4	0.4	0.9	0.4	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.2	1.0	-0.2	0.1	-0.3	0.3	-1.0	-0.1	-0.0	0.3	-0.3	-0.6	0.0	-0.6	-0.4
Coronary Artery Disease (CAD)	0.3	0.3	3.2	0.1	1.0	-0.1	0.3	-1.8	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.2	0.4	1.8	0.2	-0.2	0.1	0.9	-1.3	0.1	1.4	0.3	0.0	-0.2	-0.2	0.1	0.3
Mean Putamen Volume	0.7	0.8	2.4	0.4	1.6	1.1	1.0	-0.5	0.5	0.8	1.0	0.5	0.8	0.7	0.8	1.1
Fasting Glucose	2.1	2.5	6.2	2.1	-0.4	0.9	0.5	0.7	-2.2	1.1	0.8	1.4	2.2	2.1	2.5	1.2
HbA1C	0.3	0.4	1.2	-0.4	-0.7	-0.7	-0.7	-0.5	-0.1	-1.1	-1.0	0.1	-0.7	-0.4	-0.3	-0.3
HDL Cholesterol	0.3	0.5	1.3	0.9	0.2	0.2	-0.2	0.8	-1.1	0.5	0.2	1.0	0.8	1.1	0.6	0.9
LDL Cholesterol	0.5	0.8	3.9	-0.5	2.0	0.9	0.8	0.1	1.6	-0.1	-0.1	0.2	0.8	-0.7	0.5	0.3
Lupus	0.2	0.3	1.6	0.1	-0.6	-0.9	-0.7	-1.3	-0.7	-0.1	0.5	-0.4	-0.0	0.3	0.2	-0.2
Neuroticism (2016)	0.2	0.3	2.2	0.5	0.0	0.7	0.1	0.2	-0.1	1.5	-0.1	0.1	0.2	-0.6	0.3	0.4
Primary Biliary Cirrhosis	0.4	0.5	3.3	-0.1	-0.4	-0.3	0.5	-1.8	-0.5	0.0	1.1	-0.5	-0.5	0.4	-0.5	-0.6
Rheumatoid Arthritis	0.3	0.4	3.4	-0.0	-0.6	-0.1	-0.2	1.8	0.2	0.3	-0.8	-0.2	0.4	0.0	0.5	-0.3
Schizophrenia (2014)	0.6	1.2	8.4	-0.4	-1.1	-1.1	0.4	-2.9	-0.1	-1.5	-0.7	-0.2	-0.6	0.0	-1.3	-0.6
Triglycerides	0.1	0.2	0.8	0.4	0.9	0.7	0.7	-0.1	-0.5	0.2	0.4	-0.1	0.3	0.0	0.3	-0.1
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.0	0.4	1.0	0.8	0.5	-0.2	-0.4	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.4	0.6	3.4	-0.0	1.9	0.9	1.5	0.9	0.0	0.4	0.6	0.0	0.2	0.0	0.5	0.0
Blood Eosinophil Count	0.2	1.7	6.7	1.1	1.7	2.6	1.0	0.4	-1.2	1.4	1.9	0.5	0.7	1.0	0.8	0.5
Blood Platelet Count	0.4	4.2	21.2	1.2	-0.9	-0.6	-3.7	4.6	-1.4	0.6	-2.5	1.1	0.9	1.2	2.2	0.5
Blood Red Count	0.2	1.6	10.8	0.6	-3.3	-0.4	-0.3	1.9	-1.7	-0.6	-0.1	-0.1	0.6	0.4	1.0	-0.9
Blood White Count	0.7	4.9	9.9	2.6	0.0	2.2	0.7	3.1	-2.0	2.1	1.7	1.9	2.8	2.2	2.9	2.2
Heel T-Score	0.1	0.7	4.5	-0.9	0.1	-0.5	-0.8	-0.3	0.4	0.0	0.1	-1.0	-2.1	0.2	-1.2	-0.9
BMI	2.0	11.6	18.9	3.4	3.1	4.3	3.9	0.6	-2.4	2.5	4.2	3.0	4.1	3.8	3.7	3.6
Height	0.1	1.3	11.1	0.2	-0.4	0.5	1.3	3.3	-0.2	0.5	0.8	-0.6	0.3	-1.4	-0.4	-0.2
Waist Hip Ratio (WHR)	0.7	3.2	12.1	1.0	-3.5	-1.4	-1.7	3.2	-1.1	-1.4	-2.4	0.7	1.4	-0.6	1.1	-0.1
Systolic Blood Pressure	0.2	1.2	3.6	0.9	-1.4	-0.1	-0.9	-1.9	-1.9	1.5	-0.5	-0.1	0.4	0.6	1.0	-0.7
Smoking Status	1.8	4.3	7.9	1.4	1.9	2.8	2.7	2.6	-0.8	2.1	2.8	1.4	1.9	1.3	1.9	2.1
Allergy or Eczema	1.0	2.5	14.4	-1.0	1.4	-0.3	-0.6	-3.8	0.6	-1.3	-0.5	-1.2	-1.3	-2.1	-1.8	-1.4
Cardiovascular Disease	3.3	10.8	18.7	3.8	2.2	4.0	2.7	1.0	-3.8	3.3	3.0	2.5	4.3	3.4	4.1	3.0
Hypothyroidism (self reported)	0.0	0.1	0.6	0.4	-0.2	0.8	-0.1	0.5	-0.4	0.1	0.0	0.4	-0.0	-0.1	0.2	0.1
Respiratory disease	0.9	1.9	6.5	0.6	2.1	1.9	2.5	-1.4	-0.6	0.3	2.2	0.5	1.3	-0.0	0.1	0.6
Type 2 Diabetes (T2D) (2018)	0.8	1.5	4.9	1.0	2.2	1.3	0.4	0.8	-0.2	-0.4	-0.0	1.7	1.8	0.8	1.2	1.8
Lung FEV1/FVC ratio	0.1	0.5	4.4	0.4	-0.9	0.3	-0.2	2.1	-0.5	-0.1	0.4	0.2	-0.5	0.4	-0.2	0.2
Lung FVC	0.2	1.2	5.4	-1.8	0.5	-0.5	-0.3	0.1	2.3	-0.1	-0.8	-1.1	-0.6	-1.6	-1.0	-0.5
Neuroticism	3.6	8.8	15.8	3.4	0.0	2.6	3.4	2.0	-3.0	4.0	3.2	2.7	3.4	2.5	3.4	3.0
Chronotype (morning person)	0.9	2.1	5.5	-1.5	-0.2	-1.5	-2.1	-0.7	1.4	-1.1	-2.4	-1.5	-1.4	-1.2	-1.1	-1.6
Hair Pigment	0.1	4.0	9.2	1.0	3.0	3.0	1.2	0.5	-0.7	3.0	2.7	0.6	1.7	2.0	2.4	1.0
Tanning	0.1	0.8	2.3	0.9	0.5	0.5	0.0	0.9	-0.1	0.3	-0.1	1.5	0.8	1.4	0.9	1.5
Hand grip strength (left)	0.2	0.5	2.9	-0.1	-0.0	0.9	0.2	1.7	0.0	1.3	0.8	-0.3	-0.5	0.6	-0.0	-0.2
Number of treatments/medications taken	2.8	5.1	12.5	2.5	1.7	2.4	1.4	-0.3	-2.4	3.5	2.4	2.0	1.6	2.9	2.5	2.2
Average weekly spirits intake	0.5	0.6	2.0	1.1	-0.2	0.2	0.8	0.2	-1.4	0.1	1.2	0.9	0.5	0.7	0.4	0.7
Sensitivity / hurt feelings	0.5	0.9	3.0	0.3	1.7	0.8	1.1	-1.3	0.2	0.8	1.1	0.4	1.2	0.6	1.0	0.8
Frequency of depressed mood in last 2 weeks	5.4	7.6	13.6	2.9	1.0	3.1	3.6	2.0	-2.3	2.7	3.0	2.2	3.7	2.2	3.3	2.7
Hearing difficulty/problems: Yes	2.9	4.4	8.9	2.2	1.9	2.3	2.9	-0.3	-1.8	1.8	1.8	2.0	3.0	1.5	2.2	2.2
Relative age of first facial hair	0.7	1.4	4.7	-0.1	2.2	1.6	-0.6	1.3	0.6	0.9	0.0	-0.3	1.7	0.8	2.1	-0.1
Other serious medical condition/disability diagnosed by doctor	1.7	2.3	5.6	1.9	0.9	1.8	2.3	-0.1	-1.8	1.2	2.4	1.4	1.0	1.0	0.8	1.4
Ever used hormone-replacement therapy (HRT)	2.9	3.7	6.4	2.0	1.9	2.5	1.8	-2.0	-1.2	2.1	1.7	2.3	1.6	1.8	1.8	2.0
Ever had hysterectomy (womb removed)	2.7	3.0	7.0	1.8	1.3	2.1	1.3	-0.9	-1.0	2.6	1.7	1.8	1.2	2.1	1.9	1.9
Systolic blood pressure, automated reading	0.4	1.1	9.5	0.7	-0.3	0.4	0.3	-3.1	-1.3	1.3	0.2	0.2	0.4	0.6	0.6	-0.2
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.9	0.8	1.7	1.4	1.2	1.1	0.1	-0.2	0.9	1.0	1.1	0.5	0.6	1.5
Angina	0.2	0.2	0.6	0.7	-0.3	-0.1	0.3	0.6	-0.7	-0.8	0.5	0.5	0.2	0.1	-0.2	0.6
Medication for hormone replacement therapy	0.2	0.2	1.0	0.2	0.5	0.7	0.0	-0.4	0.1	0.0	-0.1	1.0	0.3	-0.2	0.2	0.6
Vitamin and mineral supplements	0.5	0.7	2.8	-1.0	1.7	0.5	0.8	0.9	1.0	0.5	0.6	-1.0	0.1	-0.3	-0.1	-0.6
Supplements: Zinc	3.3	3.5	7.2	-1.4	-2.7	-2.2	-2.7	-1.5	1.0	-1.6	-2.3	-1.3	-2.1	-1.1	-1.5	-2.0
Medication: Co-codamol	0.2	0.2	1.0	0.0	0.5	0.4	-0.3	-1.0	0.3	-0.0	-0.4	0.7	-0.1	0.1	0.3	0.5
Medication: Metformin	0.4	0.5	2.2	0.5	1.3	0.7	-0.0	-1.5	-0.2	-0.3	0.1	0.9	0.7	0.4	0.2	0.9
Diabetes (father)	1.1	1.4	2.9	1.4	1.6	1.4	1.2	-0.3	-0.6	0.2	0.8	1.7	1.6	0.2	0.9	1.7
Diabetes (mother)	0.5	0.6	1.8	-0.5	-0.4	-0.7	-1.3	0.8	0.4	1.3	-0.4	-0.7	-1.2	0.7	0.3	-0.6
Severe depression (siblings)	0.1	0.1	0.5	0.3	-0.2	0.2	-0.6	0.3	-0.4	-0.1	-0.7	-0.0	-0.3	-0.0	-0.1	-0.2
Pack years adult smoking proportion	7.8	11.9	22.5	4.0	2.4	3.7	3.5	2.6	-2.9	3.3	2.9	3.3	4.7	2.9	4.2	3.8
Impedance of leg (right)	0.1	0.3	0.7	0.8	-0.6	-0.4	-0.6	-0.1	-0.8	0.3	-0.6	0.6	-0.2	-0.2	-0.0	0.2
Leg fat-free mass (left)	0.5	2.8	10.2	1.0	0.7	2.2	2.0	3.2	-0.8	1.1	1.9	0.6	2.0	1.3	1.8	1.0
Trunk fat percentage	5.7	22.8	33.4	5.4	3.3	5.5	5.1	0.5	-4.2	4.3	5.8	4.8	5.1	5.3	4.9	5.5
Hand grip strength (right)	0.3	0.8	4.1	-1.0	0.3	0.2	-0.4	2.0	0.8	0.1	-0.2	-1.1	-1.1	-0.3	-0.7	-0.9
Townsend deprivation index at recruitment	1.1	1.5	11.5	0.5	-0.2	0.7	0.1	3.4	-0.9	0.9	0.4	0.4	1.7	0.5	1.3	0.5
Current tobacco smoking	1.3	2.2	8.4	0.0	2.9	2.3	2.2	1.8	0.9	0.3	1.8	-0.2	1.4	-0.1	0.7	0.6
Average weekly fortified wine intake	0.8	0.9	1.9	-0.7	-0.4	-1.4	-0.9	-0.7	-0.1	-1.0	-1.0	-0.8	-1.2	-0.9	-1.0	-1.4
Maternal smoking around birth	1.7	2.4	6.0	2.0	0.6	1.1	1.1	0.9	-1.0	1.5	0.5	1.9	2.4	1.3	2.5	1.8
Fed-up feelings	1.9	3.5	7.2	1.9	-1.2	1.7	1.7	2.1	-1.2	1.7	1.2	1.6	2.7	1.7	2.6	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.5	3.3	6.0	1.8	-0.1	2.4	2.4	0.8	-1.5	1.9	2.4	1.1	2.4	1.5	2.0	1.5
Relative age voice broke	0.5	0.7	4.1	-0.4	2.0	1.1	0.5	-0.3	0.0	0.6	0.6	-1.0	0.9	-0.1	0.6	-0.7
Taking other prescription medications	7.2	11.2	20.4	3.5	3.4	3.5	2.8	-2.6	-3.2	4.5	3.7	2.8	2.8	3.8	3.4	2.9
Age when periods started (menarche)	0.7	1.7	5.9	-1.6	1.2	-0.4	-0.1	0.5	2.4	-1.8	-0.9	-1.5	-0.3	-2.1	-0.9	-0.8
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	4.2	0.9	0.6	0.5	-0.7	1.9	-0.6	2.0	0.2	1.2	0.5	1.4	1.3	1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	5.2	-2.0	-0.9	-1.4	-1.9	-0.3	1.7	-1.6	-2.0	-1.7	-2.3	-1.8	-2.0	-1.6
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	2.3	1.4	1.0	1.5	0.9	0.9	-1.4	1.4	1.2	1.3	1.5	1.4	1.3	1.1
Qualifications: CSEs or equivalent	0.7	0.9	5.3	0.8	-2.3	-1.1	-1.1	-0.4	-1.5	0.3	-0.1	0.2	0.2	0.8	0.7	-0.0
Serious illness, injury or assault to yourself	3.1	3.8	8.0	2.7	0.9	1.5	1.4	0.3	-2.2	1.6	2.0	2.4	1.9	2.0	2.2	2.8
High blood pressure	1.0	2.7	5.0	2.1	1.2	2.0	1.3	-0.7	-2.2	1.4	1.4	1.4	1.9	1.5	1.8	1.6
Hayfever, allergic rhinitis or eczema	0.7	1.5	12.4	-0.4	1.8	0.3	0.2	-3.5	0.3	-0.4	0.5	-0.8	-0.5	-1.2	-0.9	-0.7
Multivitamins +/- minerals	0.2	0.3	1.0	0.3	-0.6	-0.5	-1.0	-0.3	-0.2	-0.2	-0.8	0.6	0.2	0.3	0.4	0.4
Stomach or abdominal pain in last month	9.4	11.7	17.5	4.1	1.6	3.4	3.3	1.7	-2.8	3.3	2.8	3.9	4.1	3.8	4.2	4.2
Supplements: Glucosamine	1.9	2.5	6.4	-1.4	-1.1	-1.7	-2.5	-0.2	1.3	-1.6	-2.2	-1.1	-1.5	-1.7	-1.5	-1.2
Diverticular disease/diverticulitis (self-reported)	2.6	3.1	4.7	2.0	0.7	1.9	1.4	1.2	-1.8	1.9	2.0	1.5	2.1	2.2	2.2	1.7
Medication: Atenolol	0.2	0.2	1.4	-0.4	0.2	1.2	0.3	-0.0	0.7	0.4	-0.1	-0.3	0.4	-0.3	0.3	-0.0
Medication: Levothyroxine sodium	0.3	0.5	1.3	-0.6	1.0	1.1	0.5	0.1	0.5	-0.2	0.4	-1.1	-0.3	-0.8	-0.4	-1.0
Sitting height	0.5	3.4	9.2	-0.5	2.9	2.9	2.5	3.0	1.0	1.6	2.2	-0.8	1.2	-0.4	0.9	0.1
Chronic bronchitis/emphysema (father)	1.4	1.7	5.9	1.3	-0.3	0.1	-0.7	-0.7	-1.5	2.4	1.0	1.6	0.3	2.0	1.1	1.4
High blood pressure (mother)	0.1	0.2	0.7	0.2	-0.2	-0.4	-0.6	-0.0	-0.8	0.8	-0.0	-0.1	0.4	0.5	0.5	-0.4
Body mass index (BMI)	3.8	16.2	23.1	4.2	3.0	4.7	4.1	0.1	-3.0	3.5	4.8	4.0	4.6	4.6	4.5	4.6
Impedance of leg (left)	0.0	0.2	0.6	0.5	-0.7	-0.5	-0.8	0.0	-0.4	0.2	-0.7	0.2	-0.5	-0.4	-0.3	0.1
Leg predicted mass (left)	0.5	2.8	9.4	1.0	0.7	2.2	2.0	3.1	-0.8	1.1	2.0	0.6	2.0	1.3	1.8	1.0
Trunk fat mass	4.5	19.3	27.5	4.9	2.8	5.1	4.7	1.4	-3.8	3.9	5.2	4.3	4.8	4.8	4.7	5.0
Waist circumference	3.8	13.9	21.4	4.5	1.4	3.7	3.3	1.8	-3.3	3.1	3.7	4.1	4.6	4.2	4.5	4.4
Number of incorrect matches in round	2.2	3.6	8.3	-1.1	-2.4	-2.9	-2.8	-1.7	0.7	-1.8	-2.9	-0.6	-1.9	-0.9	-1.4	-1.3
Past tobacco smoking	1.6	2.9	8.8	-1.1	-1.3	-1.9	-1.5	-0.3	1.6	-3.0	-2.6	-1.0	-0.7	-2.3	-1.6	-1.1
Alcohol usually taken with meals	2.6	4.2	9.1	-1.7	-2.3	-3.0	-1.9	-0.9	1.0	-1.6	-2.6	-1.6	-2.9	-1.5	-2.3	-2.2
Nervous feelings	0.4	0.8	7.1	0.4	-0.4	-0.7	0.7	-2.7	-0.6	0.3	-0.5	0.0	0.2	-1.1	-0.1	-0.0
Frequency of tenseness / restlessness in last 2 weeks	1.9	2.9	7.1	1.6	1.8	1.9	2.7	1.2	-1.0	1.1	1.7	0.9	2.6	0.9	1.9	1.5
Hearing difficulty/problems with background noise	3.0	4.8	13.1	2.6	1.2	2.1	3.0	-0.0	-1.9	1.1	1.6	2.5	3.6	1.0	2.5	2.6
Hair/balding pattern: Pattern 2	1.1	1.3	3.6	1.5	0.1	1.2	0.8	-0.9	-0.9	1.0	0.8	1.9	0.6	1.2	0.9	1.9
Had menopause	0.4	0.4	3.4	0.4	-0.3	-0.1	0.8	-1.8	-0.6	0.7	0.4	0.1	-0.3	-0.2	-0.5	-0.1
Had other major operations	1.3	1.6	7.5	0.4	2.7	2.0	0.8	-0.0	-0.2	1.7	0.8	0.3	1.3	0.9	1.4	0.4
Forced vital capacity (FVC)	0.4	1.4	9.6	-1.0	-0.8	-0.4	-0.7	3.1	1.3	0.4	-1.2	-0.9	-0.1	-1.0	-0.1	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.4	5.2	-1.9	-0.9	-1.2	-1.5	-0.7	1.9	-0.9	-1.6	-1.9	-2.3	-1.3	-1.5	-1.7
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.1	0.8	-0.3	0.6	-0.3	0.6	-0.1	0.8	0.3	1.3	-0.2	1.4	0.7	1.3
Qualifications: None of the above	0.1	0.3	1.0	0.0	0.4	0.1	0.4	0.1	0.6	-0.5	-0.4	1.0	0.4	-0.3	-0.1	1.0
Financial difficulties in last 2 years	7.3	9.8	16.7	3.6	0.6	3.5	3.3	2.7	-3.4	2.5	3.3	2.6	4.1	3.1	3.8	2.7
Mouth/teeth dental problems	1.9	3.0	5.3	-2.2	-1.0	-1.2	-1.3	0.8	1.5	-1.4	-1.2	-2.2	-2.2	-1.8	-2.1	-2.3
Heart attack	2.2	2.8	7.5	2.1	-0.3	0.9	1.9	1.0	-2.7	0.9	1.9	1.6	2.0	1.7	1.8	1.4
Allergy	0.6	1.3	7.2	-0.1	-2.1	-1.0	-1.2	2.7	-0.0	0.6	-0.8	0.0	-0.4	1.1	0.7	-0.0
Pain all over the body in last month	1.1	1.2	5.3	-0.6	2.1	1.2	1.1	-2.3	1.1	-0.8	0.2	-0.3	0.6	-0.2	-0.1	0.2
Diabetes (self-reported)	0.9	1.4	5.6	0.9	2.4	1.8	1.0	0.6	-0.2	0.1	1.1	1.2	1.1	1.1	0.8	1.5
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	11.7	0.1	-0.2	-1.0	0.1	-3.4	-0.0	-1.2	0.1	-0.3	-0.8	-0.6	-0.9	-0.3
Medication: Ramipril	0.2	0.2	0.6	-0.2	0.1	-0.3	-0.4	-0.7	-0.0	-0.7	0.6	-0.1	-0.8	0.4	-0.5	0.2
Medication: Simvastatin	0.4	0.6	3.1	-0.1	1.8	1.3	1.2	-0.4	0.3	0.7	1.0	-0.2	0.3	0.4	0.5	0.0
Fluid intelligence score	0.2	0.5	5.2	-0.3	-0.5	-0.0	-0.0	2.3	0.1	0.3	-0.1	-0.4	0.1	-0.2	-0.0	-0.4
Illnesses of siblings	0.6	0.8	5.9	-0.8	-0.6	0.0	0.5	2.4	0.4	-0.6	0.7	-1.0	-0.3	-0.6	-0.4	-0.8
Neuroticism score	1.5	3.1	6.6	1.7	0.0	1.6	2.6	1.4	-1.4	2.4	1.9	1.2	2.3	0.9	2.1	1.6
Weight	2.6	12.9	18.0	3.8	2.1	4.2	3.8	2.5	-2.8	3.2	4.2	3.3	4.2	3.8	4.1	3.9
Impedance of arm (right)	0.1	0.5	1.6	1.1	0.3	0.1	0.8	-0.9	-1.3	0.4	0.5	1.0	0.3	0.3	0.1	0.7
Arm fat percentage (right)	5.8	22.7	31.5	5.4	3.1	5.1	5.0	-0.4	-4.2	4.1	5.6	5.1	5.2	5.4	4.9	5.6
Trunk fat-free mass	0.4	2.0	16.4	0.8	-0.5	1.1	1.1	4.0	-0.7	0.9	1.1	0.0	1.5	0.5	1.3	0.4
Hip circumference	4.3	18.7	29.9	4.6	3.3	4.8	4.8	1.1	-3.5	4.2	5.5	4.1	4.7	4.7	4.6	4.8
Time employed in main current job	0.3	0.4	2.1	0.3	0.4	0.5	1.3	-0.3	-0.5	0.2	1.4	-0.3	-0.1	0.3	-0.3	-0.2
Alcohol intake versus 10 years previously	1.0	1.5	6.0	1.5	-0.0	0.6	1.3	-0.6	-2.5	0.7	1.5	1.3	1.2	1.2	0.9	0.9
Father’s age at death	1.0	1.3	2.8	-1.3	-0.3	-1.1	-1.6	0.2	1.5	-0.5	-1.7	-1.1	-1.1	-1.3	-1.0	-1.1
Worrier / anxious feelings	0.4	0.7	1.9	1.0	1.0	0.6	1.2	0.0	-0.8	1.0	0.2	0.6	1.4	-0.5	0.9	0.6
Frequency of tiredness / lethargy in last 2 weeks	5.6	9.1	14.9	3.1	1.1	3.3	3.3	-0.3	-2.2	3.2	3.6	2.8	3.9	3.3	3.7	3.3
Falls in the last year	0.6	0.8	3.6	1.3	-0.4	0.4	0.2	-0.6	-0.5	-0.3	0.1	1.9	0.5	0.8	0.6	1.7
Hair/balding pattern: Pattern 3	0.2	0.4	1.3	0.1	-0.0	0.2	-1.1	0.6	-0.0	1.1	-0.3	0.1	0.5	0.8	0.9	0.1
Number of live births	0.8	1.1	4.3	-1.3	1.9	0.4	0.2	-0.6	2.1	-0.9	-1.1	-0.9	0.0	-1.1	-0.3	-0.5
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	9.6	-1.0	-1.2	-0.7	-1.2	3.1	1.2	0.1	-1.4	-1.0	-0.3	-0.9	-0.1	-0.8
Pulse rate	0.2	0.3	1.2	-0.2	-1.1	-0.3	-0.8	0.3	-0.3	-0.0	-0.3	-0.4	-0.9	-0.1	-0.6	-0.4
Happiness	0.8	1.0	1.5	1.1	-1.2	0.5	1.2	0.9	-0.9	0.4	1.2	0.9	1.1	1.2	0.8	1.2
Noisy workplace	0.1	0.1	0.5	0.0	-0.4	0.0	-0.1	0.3	-0.1	-0.2	-0.2	-0.1	0.7	0.2	0.5	-0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.8	-0.5	-0.3	-0.7	-0.3	0.8	-0.2	-1.4	-0.5	-0.8	-0.4	-0.4	-0.7	-1.0
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.6	4.5	2.0	1.2	1.4	1.9	-0.1	-2.1	1.4	2.1	0.9	1.8	1.8	1.7	1.4
Mouth/teeth dental problems: Dentures	0.1	0.1	0.5	-0.1	0.6	-0.1	0.5	-0.7	-0.1	0.1	0.2	-0.2	0.0	-0.2	-0.3	-0.1
Asthma	1.1	2.1	6.3	1.1	2.0	1.8	2.5	-0.9	-0.7	0.8	2.3	0.9	1.5	0.8	0.7	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	5.1	2.0	0.5	0.8	0.4	0.6	-2.3	1.8	1.2	1.3	2.0	1.9	2.3	1.4
Medication: Cholesterol lowering	0.7	1.1	3.5	0.6	1.7	1.3	1.9	0.4	-0.6	0.2	1.4	0.6	0.8	0.9	0.6	0.8
Depression (self-reported)	2.5	3.0	5.4	2.2	0.5	1.6	1.5	-0.9	-1.7	2.1	1.2	2.0	1.6	1.9	1.9	2.3
Medication: Lansoprazole	0.6	0.6	2.4	0.5	1.5	0.6	0.6	0.2	-0.6	0.7	1.4	0.7	0.4	0.6	0.3	1.0
Prospective memory result	0.5	0.6	3.6	-0.1	-0.0	-0.9	0.5	-1.9	0.0	-1.2	-0.3	0.2	-0.8	-0.6	-0.7	0.1
Lung cancer (father)	0.8	1.0	4.0	-1.0	0.3	-0.3	-1.4	-1.3	2.0	-0.3	-1.0	0.2	-1.3	-0.3	-0.6	0.2
Illnesses of mother	0.6	0.8	1.8	-1.0	1.3	0.6	0.4	1.0	1.3	-1.1	0.1	-0.9	-0.5	-1.0	-0.8	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	9.3	-0.9	-0.7	-0.3	-0.8	3.1	1.2	0.4	-1.2	-0.5	-0.1	-1.0	-0.0	-0.4
Pulse wave Arterial Stiffness index	0.3	0.3	1.1	0.5	-0.7	-0.3	0.0	-1.1	-0.8	0.9	0.4	-0.5	-0.3	0.5	0.3	-0.4
Impedance of arm (left)	0.0	0.2	0.5	0.3	0.4	-0.1	0.4	-0.7	-0.6	-0.4	0.1	0.2	-0.3	-0.2	-0.6	-0.0
Arm fat mass (right)	4.7	19.5	26.0	5.0	2.6	5.0	4.5	1.0	-3.9	4.0	5.1	4.5	5.0	5.0	4.9	5.0
Trunk predicted mass	0.4	2.2	16.9	0.9	-0.5	1.2	1.2	4.1	-0.8	1.0	1.2	0.1	1.5	0.6	1.4	0.5
Standing height	0.3	2.8	27.6	-0.5	-1.5	-0.4	-0.0	5.3	0.1	-0.3	-0.5	-1.3	-0.1	-1.4	-0.5	-1.2
Length of working week for main job	1.0	1.1	2.6	-1.1	-0.7	-1.2	-1.0	-0.1	0.4	-1.6	-0.8	-1.2	-0.3	-1.6	-1.0	-1.4
Exposure to tobacco smoke at home	4.2	4.7	9.8	1.9	3.1	3.0	2.8	-0.5	-1.3	1.8	2.2	1.6	2.8	1.3	2.0	2.1
Breastfed as a baby	0.3	0.4	1.2	-0.5	-0.0	-0.7	-0.7	-1.1	0.1	-0.5	-0.8	0.0	-1.0	-0.3	-0.9	-0.4
Tense / ‘highly strung’	0.4	0.7	2.0	0.8	0.7	0.7	0.8	-0.6	-0.5	1.0	0.0	0.6	1.3	0.7	1.4	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	2.6	4.0	8.3	2.1	0.4	2.5	1.7	-0.9	-1.6	2.9	1.6	1.9	2.0	2.6	2.6	2.0
Hair/balding pattern: Pattern 4	0.8	2.0	3.5	-1.3	-1.4	-1.9	-1.3	0.2	1.0	-0.7	-1.5	-1.6	-1.6	-1.8	-1.6	-1.6
Birth weight of first child	0.4	0.8	2.0	0.1	1.4	1.2	1.0	1.1	0.6	0.8	1.3	0.4	0.6	0.5	0.5	1.0
Peak expiratory flow (PEF)	0.2	0.4	2.1	-0.3	-0.6	-0.2	-1.1	1.5	0.5	0.3	-0.7	-0.6	0.1	0.0	0.5	-0.5
Pulse wave reflection index	0.6	0.7	1.5	0.6	0.5	0.7	1.0	-0.2	-0.3	1.2	1.0	0.3	0.8	1.1	1.2	0.7
Ever highly irritable/argumentative for 2 days	3.8	4.5	8.0	2.8	-0.8	1.9	2.2	1.5	-2.1	2.1	1.8	2.6	2.2	1.9	2.1	2.7
Loud music exposure frequency	0.7	0.8	2.1	1.2	0.1	0.8	0.3	0.5	-0.7	0.8	0.4	1.5	1.2	0.8	1.1	1.2
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.2	-0.7	-1.4	-1.5	-1.3	1.1	0.0	-1.5	-0.9	-1.1	-1.2	-0.5	-0.9	-1.3
Mouth/teeth dental problems: Bleeding gums	5.6	7.2	13.8	3.7	0.0	1.7	1.6	0.1	-2.5	2.3	1.9	3.6	3.2	3.3	3.6	3.6
Blood clot in the leg (DVT)	0.3	0.4	2.3	0.3	-0.3	-0.5	-0.5	-1.5	-0.5	-0.7	-1.0	0.2	-0.2	-0.6	-0.7	0.1
Medication: Paracetamol	1.4	2.3	4.9	1.7	0.5	0.8	0.8	1.5	-1.5	1.4	1.0	1.8	1.7	2.1	2.2	1.7
Headache pain in last month	8.7	14.9	22.8	4.8	1.3	3.6	3.3	1.0	-4.2	4.5	4.3	4.3	3.4	4.8	4.0	4.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	3.2	0.4	-1.8	-1.0	-1.3	-0.3	-0.2	-0.6	-1.3	0.6	-0.1	-0.3	-0.2	0.3
Glaucoma (self-reported)	1.5	1.8	3.8	-2.0	0.4	-0.9	-1.2	-0.8	1.9	-1.2	-1.0	-1.6	-1.5	-1.2	-1.3	-1.3
Gout (self-reported)	0.8	1.1	3.2	-1.0	-1.3	-0.8	-1.1	1.8	1.1	-0.6	-1.5	-0.8	-0.3	-1.1	-0.3	-0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	-0.7	0.4	0.3	-0.4	-0.2	0.7	-0.4	-0.4	-0.7	-1.0	-0.9	-0.8	-0.8
Medication: Amlodipine	0.4	0.5	1.5	0.5	-0.4	-0.3	-1.2	-0.8	-1.1	1.0	0.0	-0.2	-0.0	1.2	0.8	-0.2
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.6	0.2	1.4	0.3	0.8	-1.6	-0.3	0.3	1.2	-0.1	1.1	0.6	0.7	-0.2
Birth weight	0.3	0.7	1.8	-0.7	1.1	0.1	1.3	-0.8	1.3	-0.8	0.5	-0.1	-1.0	-0.4	-1.1	0.0
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.7	0.1	-1.3	-0.2	-1.0	0.6	0.5	-0.0	-1.1	0.3	0.3	0.2	0.6	0.3
High blood pressure (siblings)	0.9	1.3	4.0	-0.5	-1.1	-1.8	-1.6	-2.0	-0.0	-1.1	-1.5	-0.5	-0.4	-0.7	-0.7	-0.9
Forced vital capacity (FVC), Best measure	0.3	1.0	7.5	-0.8	-0.5	-0.1	-0.2	2.7	1.2	0.7	-1.1	-0.5	0.1	-1.2	-0.0	-0.3
Body fat percentage	5.9	23.3	32.3	5.5	3.3	5.5	5.2	0.2	-4.2	4.2	5.7	5.1	5.2	5.3	5.0	5.7
Leg fat percentage (right)	5.8	21.0	29.8	5.4	2.8	4.9	4.3	-0.7	-4.2	4.2	4.9	5.3	4.9	5.2	5.0	5.5
Arm fat-free mass (right)	0.6	2.8	17.4	0.9	0.3	2.0	1.4	4.2	-0.5	1.4	1.7	0.1	1.8	1.0	1.7	0.7
Exposure to tobacco smoke outside home	2.1	2.8	5.6	2.3	1.1	1.9	1.0	-0.2	-1.4	1.6	1.4	1.9	1.7	1.9	2.0	2.4
Comparative body size at age 10	2.4	6.7	11.5	-3.3	-0.7	-2.2	-1.5	1.2	2.9	-2.7	-1.9	-3.4	-3.1	-2.9	-3.2	-2.9
Number of full brothers	2.0	2.5	6.2	1.1	2.1	2.5	1.5	0.9	-0.5	1.5	1.5	1.2	1.6	1.7	1.8	1.5
Worry too long after embarrassment	0.3	0.4	2.8	0.4	-0.3	-0.2	1.3	1.7	-0.5	0.5	0.6	0.2	0.2	-0.4	0.0	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	4.3	1.8	1.4	1.7	1.3	-0.6	-1.0	2.1	1.2	1.4	1.8	1.7	2.0	1.9
Wheeze or whistling in the chest in last year	4.2	7.4	15.8	2.3	3.0	4.0	3.1	-0.0	-1.7	2.4	3.5	2.4	3.2	2.5	2.8	2.4
Number of children fathered	1.1	1.2	2.9	-1.5	-0.1	-0.5	-0.8	-0.1	1.7	-0.8	-1.0	-1.6	-0.8	-1.2	-0.9	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.9	0.5	-0.4	0.0	0.5	0.2	-1.0	-0.0	0.9	0.5	0.5	0.3	0.3	0.5
Age at first live birth	0.3	0.5	1.0	-0.8	-0.5	-0.2	-0.8	0.6	0.5	-0.8	-0.2	-1.0	-1.0	-0.4	-1.0	-0.9
Pulse wave peak to peak time	0.3	0.4	2.2	-0.4	0.5	0.2	-0.0	1.5	0.7	-0.9	-0.4	0.5	0.3	-0.6	-0.2	0.3
Health satisfaction	4.3	5.6	11.4	2.6	0.9	2.7	3.4	-1.3	-2.0	2.6	3.4	2.0	1.9	2.0	2.0	2.6
Shortness of breath walking on level ground	4.8	5.7	13.9	2.0	3.1	3.0	2.5	0.1	0.0	1.9	2.3	3.3	2.4	1.5	2.0	3.7
Qualifications: College or University degree	0.4	1.2	3.6	-0.8	-0.3	-1.2	0.3	1.1	0.0	-1.9	0.1	-1.1	-1.1	-1.1	-1.6	-1.4
Eye problems/disorders: None of the above	0.5	0.6	3.3	0.9	-1.0	-0.9	0.6	-1.8	-0.9	-0.1	-0.2	0.4	0.0	-0.2	-0.1	0.3
Mouth/teeth dental problems: Loose teeth	0.8	0.9	3.5	0.6	1.0	1.9	1.0	0.3	0.3	0.9	0.5	0.8	1.4	0.6	1.0	1.2
Emphysema/chronic bronchitis	3.2	3.6	6.7	1.2	2.4	2.6	0.9	2.0	-0.8	2.3	1.4	1.4	2.4	2.0	2.5	1.4
Medication for pain relief, constipation, heartburn	5.3	9.1	13.2	-3.0	-2.7	-3.6	-2.9	-0.1	3.0	-3.5	-3.6	-2.7	-2.6	-3.6	-3.2	-2.8
Neck or shoulder pain in last month	4.7	6.6	11.0	3.3	0.5	2.3	2.3	0.8	-3.1	2.8	2.5	2.9	2.4	3.3	2.9	2.7
Medication: Blood pressure	0.7	1.2	2.7	-1.4	0.5	-0.7	-0.2	-1.1	1.1	-1.1	-0.2	-1.2	-1.6	-1.2	-1.5	-1.1
Angina (self-reported)	0.1	0.2	0.5	0.6	-0.2	-0.1	0.1	0.5	-0.6	-0.7	0.5	0.4	0.3	0.2	-0.1	0.5
Migraine (self-reported)	2.9	3.6	6.3	2.1	0.7	2.0	2.0	1.5	-2.1	2.0	2.5	1.7	1.3	2.3	1.6	2.1
Medication: Ibuprofen	3.0	3.6	7.3	2.2	1.0	1.3	0.7	1.3	-2.4	2.4	1.8	1.4	2.3	2.3	2.7	1.4
Medication: Allopurinol	1.5	1.9	5.9	-1.5	-1.2	-1.1	-1.8	2.4	1.4	-0.8	-1.7	-1.5	-0.8	-0.9	-0.4	-1.3
Medication: Omeprazole	1.2	1.4	3.3	0.6	1.8	1.7	1.4	-1.6	0.0	1.2	1.6	0.6	-0.0	1.2	0.3	1.0
Medication: Seretide 50 evohaler	0.7	0.8	3.2	-0.1	-1.8	-1.4	0.5	-0.4	-0.5	-0.6	0.2	-0.2	-1.1	-0.8	-1.3	-0.6
Mean time to correctly identify matches	0.8	1.6	10.7	0.7	-3.3	-1.9	-1.6	-0.6	-1.1	0.1	-0.8	0.3	-1.1	0.2	-0.3	0.1
Heart disease (mother)	0.6	0.7	3.7	0.1	1.9	1.4	1.2	-0.2	0.0	0.3	0.5	0.1	1.1	0.3	0.7	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	4.8	-0.3	2.2	0.8	0.7	-0.9	0.3	1.1	1.3	-0.1	-0.3	0.5	0.1	-0.1
Whole body fat mass	5.0	20.9	28.4	5.1	2.8	5.3	4.8	1.5	-3.9	4.0	5.3	4.6	5.2	4.9	5.0	5.2
Leg fat mass (right)	4.2	16.3	22.3	4.5	2.5	4.7	4.0	1.1	-3.4	3.7	4.6	4.1	4.6	4.6	4.6	4.5
Arm predicted mass (right)	0.5	2.5	15.5	1.0	0.0	1.8	1.3	3.9	-0.6	1.2	1.6	0.2	1.6	1.1	1.6	0.8
Pulse rate, automated reading	0.2	0.6	2.4	-0.5	-0.4	-0.2	0.2	-1.3	0.6	-0.7	0.1	-0.4	-1.5	-0.5	-1.6	-0.0
Alcohol intake frequency.	0.3	0.6	4.1	0.6	0.0	-1.0	-0.3	-2.0	-1.1	-0.6	-0.5	0.5	0.4	0.1	0.2	0.2
Comparative height size at age 10	0.7	3.7	8.3	-1.3	-2.9	-2.5	-1.6	2.8	-0.1	-0.7	-1.4	-2.0	-2.0	-1.4	-1.9	-2.3
Number of full sisters	1.1	1.3	2.1	1.1	0.4	0.9	1.1	-0.6	-0.9	1.3	1.1	1.5	1.4	1.3	1.4	1.2
Suffer from ‘nerves’	0.7	1.1	3.3	-0.9	-1.0	-1.3	-1.2	-1.8	1.0	-0.1	-1.5	-1.0	-0.5	-1.1	-0.3	-0.8
Overall health rating	6.5	14.1	25.2	4.5	2.3	4.2	3.6	0.1	-2.9	2.6	3.5	4.6	4.7	3.6	4.3	5.0
Chest pain or discomfort	2.4	3.5	7.3	1.9	0.9	2.1	2.5	-0.9	-1.8	1.8	2.7	1.4	2.4	1.4	1.9	1.6
Had major operations	0.2	0.2	1.3	-0.4	1.2	0.3	0.2	-0.6	0.1	0.9	0.5	0.2	-0.0	0.3	-0.1	0.1
Age at last live birth	0.4	0.6	1.4	-0.9	-0.4	-0.2	-1.0	1.2	0.5	-0.2	-0.6	-0.9	-1.0	-0.5	-0.7	-1.1
Family relationship satisfaction	1.1	1.3	3.8	0.9	-1.1	0.7	-0.2	1.9	-0.8	1.7	-0.0	1.0	0.9	1.4	1.7	0.8
Leg pain on walking	4.8	6.0	11.6	2.6	1.6	2.7	1.8	2.0	-1.5	1.8	1.9	2.9	3.4	2.3	3.0	3.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.5	0.4	-0.2	0.7	-0.3	-0.5	-0.5	0.4	0.1	0.2	0.5	0.3	0.6	0.0
Commuting to job workplace: Car/motor vehicle	1.0	1.2	3.3	-0.9	-1.3	-1.2	-1.8	-0.7	0.9	-0.8	-1.5	-0.7	-1.0	-0.9	-0.9	-1.0
Illness, injury, bereavement, stress in last 2 years	7.1	8.6	15.2	-2.9	-3.2	-3.9	-2.8	-0.0	2.0	-3.1	-3.3	-2.4	-3.3	-3.0	-3.2	-3.1
Medication: Aspirin	5.6	7.4	15.9	2.4	2.8	3.5	3.4	0.1	-2.0	2.5	4.0	2.4	2.1	3.2	2.3	2.5
Supplements: Vitamin C	1.8	2.1	12.6	1.1	-3.5	-1.7	-1.9	0.3	-1.8	-0.3	-1.8	0.3	-0.1	-0.0	0.0	-0.5
Knee pain experienced in last month	0.4	0.7	2.3	0.8	-1.5	-0.9	-0.1	0.6	-0.7	-1.1	-0.4	1.0	0.8	0.2	0.5	0.8
Hypertension (Self-reported)	1.4	3.9	6.0	2.4	1.5	2.4	1.8	-0.7	-2.5	1.9	2.0	1.8	2.1	2.0	2.0	2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.8	0.1	1.7	1.2	1.2	-0.8	0.3	0.4	1.5	0.1	0.1	-0.0	-0.5	0.4
Illnesses of father: Heart disease	2.7	3.7	6.7	2.1	1.2	1.8	1.9	1.3	-1.3	0.9	1.7	2.6	2.4	2.1	2.3	2.6
Illnesses of siblings: Diabetes	0.6	0.8	8.3	0.3	1.0	-0.0	-0.1	-2.9	0.2	0.5	-0.1	0.3	0.2	0.1	-0.0	0.3
Smoking status: Previous	0.5	0.8	3.9	0.5	-0.2	0.4	0.3	-0.5	-1.2	2.0	1.0	0.7	-0.2	1.4	0.8	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	4.9	-0.5	0.8	1.0	0.4	2.2	0.5	0.9	0.4	-0.9	0.8	-0.6	0.8	-0.7
Whole body fat-free mass	0.4	2.3	14.6	0.8	-0.0	1.6	1.5	3.8	-0.7	1.0	1.5	0.1	1.7	0.8	1.5	0.5
Leg fat-free mass (right)	0.4	2.1	10.2	0.6	0.5	1.9	1.6	3.2	-0.4	0.9	1.7	0.1	1.7	1.0	1.4	0.7
Arm fat percentage (left)	5.4	21.6	31.0	5.2	3.1	5.2	4.9	-0.3	-4.1	4.0	5.6	4.9	5.0	5.3	4.8	5.4
Average weekly red wine intake	2.3	3.4	8.0	-1.2	-2.8	-2.3	-1.9	1.6	1.2	-1.6	-2.5	-0.9	-2.3	-1.4	-1.9	-1.2
Handedness (chirality/laterality): Left-handed	1.0	1.3	1.9	1.4	-0.1	0.8	1.3	-0.8	-1.4	1.1	1.4	1.3	0.9	1.2	1.2	1.2
Mood swings	1.1	2.0	4.3	1.2	0.5	1.7	1.0	1.7	-0.2	1.8	1.0	1.2	1.7	1.3	2.1	1.8
Loneliness, isolation	10.0	13.8	21.3	4.5	1.3	4.0	4.2	1.9	-3.2	3.4	3.4	4.2	4.6	3.4	4.0	4.6
Long-standing illness, disability or infirmity	3.5	5.4	9.1	3.0	1.6	2.2	2.4	-1.0	-2.9	2.2	2.5	2.7	2.3	2.2	2.2	2.4
Ever had bowel cancer screening	0.4	0.4	3.0	0.2	0.3	-0.4	-1.0	-1.7	-0.5	0.5	-0.4	0.4	-0.3	0.6	-0.1	0.2
Diabetes diagnosed by doctor	1.3	2.1	6.1	1.1	2.5	1.9	0.7	0.3	-0.3	0.6	1.2	1.6	1.6	1.8	1.5	2.0
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	5.7	0.0	2.4	1.0	1.4	-0.8	-0.1	0.5	1.5	-0.2	0.3	-0.0	-0.2	-0.1
Friendships satisfaction	0.8	1.0	3.1	1.2	-1.6	-1.0	-1.0	0.6	-1.8	0.5	-0.1	0.3	1.1	0.9	1.0	-0.0
Qualifications: nursing, teaching	0.7	1.1	3.8	-0.7	0.0	-1.2	-0.6	-0.3	0.6	-1.9	-0.7	-0.8	-1.4	-1.0	-1.7	-0.6
Commuting to job workplace: Walk	3.3	3.6	6.2	-2.5	-0.6	-1.4	-1.9	0.1	2.2	-1.9	-2.4	-2.3	-1.5	-2.2	-1.8	-2.1
Eye problems/disorders: Cataract	0.3	0.3	2.2	-0.3	-0.7	0.4	-0.5	1.5	-0.3	0.0	-0.1	-0.6	0.0	0.0	0.3	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.8	0.8	0.5	1.0	0.7	0.0	-0.3	1.5	1.4	0.9	0.5	1.9	1.4	1.0
Medication for cholesterol	1.7	2.5	5.3	-1.6	-0.7	-2.3	-1.1	-0.0	1.2	-1.9	-0.9	-1.8	-2.0	-1.7	-2.2	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.1	0.4	1.3	0.4	0.8	-0.2	0.1	-1.5	0.3	0.1	0.5	-0.9	-0.3	0.5
Back pain experienced in last month	2.3	3.4	8.7	2.0	-0.7	1.2	0.8	2.7	-1.7	0.8	0.8	2.0	3.0	1.5	2.7	1.9
Mineral and other dietary supplements	1.5	2.1	6.8	0.3	2.6	2.0	2.6	1.2	0.4	0.3	1.9	0.3	1.5	0.5	0.8	0.9
Breast cancer (self-reported)	0.4	0.4	3.7	0.2	-0.3	0.1	-0.7	1.9	-0.2	0.3	-0.2	-0.1	0.4	0.7	0.7	-0.1
Asthma (self-reported)	1.3	2.6	6.8	1.5	2.0	1.9	2.6	-1.0	-1.1	0.9	2.4	1.2	1.8	0.9	1.0	1.4
Osteoporosis (self-reported)	0.7	0.9	7.3	-0.5	2.7	1.2	0.5	-0.4	0.7	0.8	1.2	-0.1	-0.3	0.0	-0.1	-0.0
Osteoarthritis (self-reported)	0.2	0.2	1.0	0.5	-0.4	-0.4	-0.1	1.0	-0.7	-0.5	0.1	0.2	0.5	0.4	0.7	0.0
Medication: Aspirin	4.1	5.4	12.5	2.1	2.4	3.1	3.2	-0.4	-1.7	2.0	3.5	2.1	1.6	2.4	1.7	2.1
Medication: Gliclazide	0.3	0.3	0.8	0.6	0.9	0.8	0.4	-0.6	-0.4	-0.5	-0.1	0.8	0.7	0.3	0.1	0.7
Illnesses of father: None of the above (group 1)	3.1	3.8	6.7	-2.3	-0.6	-1.5	-1.0	-0.8	2.0	-2.4	-1.3	-2.6	-2.1	-2.5	-2.4	-2.4
Smoking status: Current	1.5	2.3	9.7	0.0	3.1	2.3	2.3	1.8	0.8	0.2	1.9	-0.3	1.4	-0.2	0.6	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	6.9	0.5	-2.6	-0.9	-1.2	0.6	-0.7	0.7	-0.8	0.7	-0.5	0.2	0.2	0.3
Whole body water mass	0.4	2.2	15.0	0.7	0.0	1.6	1.4	3.9	-0.5	0.9	1.4	0.0	1.6	0.8	1.4	0.5
Leg predicted mass (right)	0.4	1.9	9.8	0.6	0.5	1.8	1.6	3.1	-0.4	0.8	1.6	0.1	1.6	0.9	1.4	0.6
Arm fat mass (left)	4.9	20.1	28.2	4.9	3.0	5.3	4.6	1.2	-3.8	3.9	5.2	4.4	5.0	5.1	4.9	5.1
Number of self-reported non-cancer illnesses	1.6	2.7	4.5	1.9	1.4	1.8	1.0	-2.0	-1.9	1.9	1.6	1.3	1.0	2.1	1.4	1.5
Average weekly champagne plus white wine intake	0.7	0.9	2.7	0.8	0.5	1.2	0.3	1.7	0.0	1.6	0.4	1.0	0.5	0.8	1.0	1.1
Miserableness	2.8	4.9	8.8	2.1	-0.4	2.3	2.3	3.0	-0.8	3.0	1.9	1.7	2.3	2.0	2.8	2.5
Guilty feelings	0.9	1.4	8.6	1.1	0.3	1.3	2.9	0.4	-1.2	0.5	1.4	0.3	1.2	-0.0	0.5	0.7
Wears glasses or contact lenses	1.0	1.2	3.4	-1.1	0.3	-1.3	-0.2	-1.8	0.8	-0.1	0.1	-1.2	-1.8	-0.6	-1.4	-1.3
Ever taken oral contraceptive pill	0.0	0.0	0.2	0.3	0.1	-0.3	-0.1	-0.4	-0.3	0.1	0.1	0.2	-0.1	-0.2	-0.2	0.0
Hearing aid user	0.3	0.3	1.0	-0.3	0.6	0.2	-0.1	-1.0	0.9	-0.8	-0.6	-0.2	0.3	-0.9	-0.3	0.1
Mother’s age at death	0.5	0.6	2.1	-0.2	-1.1	-1.2	-0.4	-1.2	0.1	-0.3	-0.4	-0.0	-1.4	-0.3	-1.1	-0.1
Financial situation satisfaction	0.9	1.1	3.5	1.4	-1.9	0.2	0.5	1.8	-0.9	-0.1	0.6	0.9	1.0	0.5	1.0	1.0
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.1	0.8	-0.5	0.4	0.7	0.0	-0.8	0.2	0.8	0.9	1.0	0.9	1.0	0.8
Commuting to job workplace: Public transport	0.4	0.5	3.3	0.0	0.0	-0.1	-0.3	0.8	0.2	-1.8	-0.9	0.8	-0.1	-0.1	-0.2	0.6
Eye problems/disorders: Glaucoma	1.6	1.9	3.7	-1.9	-0.1	-1.3	-1.6	-0.8	1.7	-1.4	-1.3	-1.4	-1.4	-1.5	-1.4	-1.3
Medication: Blood pressure	1.8	3.4	6.5	2.4	-0.6	1.5	1.0	0.5	-2.5	1.7	1.4	1.9	2.4	2.2	2.4	1.7
Pain type(s) experienced in last month: Hip pain	1.7	2.1	5.4	2.2	-0.4	0.8	1.0	-0.2	-1.7	1.5	1.0	2.3	1.2	1.1	1.1	2.3
Supplements: Fish oil (including cod liver oil)	1.3	1.7	5.9	-0.6	-2.3	-1.8	-2.4	-0.2	-0.1	-0.8	-1.9	-0.2	-0.9	-1.0	-0.7	-1.0
High cholesterol (Self-reported)	0.5	0.9	2.8	0.4	1.7	1.4	0.8	0.5	0.1	0.4	0.5	0.5	1.3	0.9	1.3	1.0
Medication: Bendroflumethiazide	0.3	0.5	2.9	0.6	-1.7	0.2	-0.4	-0.8	-0.7	0.9	-0.6	0.4	-0.1	0.4	0.4	0.1
Medication: Paracetamol	1.3	2.1	4.6	1.4	0.8	1.0	1.2	1.6	-1.3	1.5	1.1	1.1	1.9	1.7	2.1	1.2
Medication: Lisinopril	0.4	0.6	2.3	0.1	0.5	1.3	1.5	0.8	0.2	0.5	1.1	-0.1	-0.3	-0.4	-0.7	0.4
Medication: Atorvastatin	0.4	0.5	1.5	-0.5	0.2	0.8	1.1	0.8	0.3	-1.2	0.5	-0.6	0.2	-0.9	-0.7	-0.5
Illnesses of father: High blood pressure	3.1	3.8	7.9	2.2	0.6	2.0	1.2	2.8	-2.4	1.3	1.0	1.7	2.6	1.8	2.6	1.6
Alcohol drinker status: Never	0.2	0.3	0.5	0.7	0.6	-0.0	0.1	-0.5	-0.6	0.1	-0.1	0.6	0.7	0.5	0.6	0.7
Ever smoked	0.9	1.6	6.0	0.2	1.8	1.7	1.5	0.2	-0.7	2.0	2.4	0.1	0.2	1.3	0.6	0.3
Basal metabolic rate	0.7	3.7	13.2	1.5	0.5	2.2	2.0	3.6	-1.1	1.5	2.1	0.9	2.3	1.6	2.1	1.4
Leg fat percentage (left)	5.4	19.5	28.1	5.2	2.6	4.8	4.1	-0.7	-3.9	4.1	4.9	5.0	4.7	5.1	4.8	5.3
Arm fat-free mass (left)	0.7	3.6	15.4	1.5	0.4	2.2	1.8	3.9	-0.9	1.7	2.0	0.7	2.2	1.5	2.1	1.3
Number of operations (self-reported)	2.6	3.9	8.0	1.6	2.1	2.2	1.3	0.2	-1.2	2.8	2.0	2.0	1.9	2.5	2.3	1.9
Average weekly beer plus cider intake	0.4	0.6	2.2	0.0	0.4	1.1	-0.0	0.3	0.6	0.1	0.7	0.0	1.3	1.2	1.5	0.3
Irritability	2.1	3.6	6.9	2.2	-0.9	1.5	2.5	2.0	-1.4	1.4	1.7	2.1	2.6	1.0	2.0	2.4
Risk taking	2.7	4.0	7.0	2.1	2.6	2.6	1.5	1.3	-1.5	1.3	1.3	2.3	2.4	1.9	2.1	2.2
Ever had prostate specific antigen (PSA) test	0.4	0.5	2.6	0.0	1.0	-0.3	0.5	-1.6	-0.2	0.1	0.5	0.8	-0.5	0.2	-0.8	0.6
Fractured/broken bones in last 5 years	1.7	2.2	4.6	1.9	0.1	1.3	1.4	0.7	-1.7	0.7	1.6	1.8	2.1	1.3	1.4	1.7
Age started oral contraceptive pill	0.8	0.9	4.1	0.7	-1.1	-1.4	0.5	-2.0	-1.0	-1.0	-0.2	-0.2	-0.3	-1.0	-1.1	-0.2
Diastolic blood pressure, automated reading	0.5	1.6	4.3	1.4	-0.3	1.4	0.9	-1.1	-2.1	1.9	1.4	0.7	1.0	1.4	1.4	0.3
Ever depressed for a whole week	0.2	0.3	1.2	0.2	0.1	0.1	-1.0	-0.6	-0.0	0.8	-0.5	0.3	-0.4	1.1	0.5	0.2
Unable to work because of sickness or disability	3.0	3.8	6.3	2.3	1.8	2.3	2.3	0.5	-1.6	1.2	2.2	2.0	2.4	1.4	2.1	2.5
Commuting to job workplace: Cycle	0.2	0.3	1.5	0.2	-0.8	-0.5	-0.4	1.2	-0.4	-0.8	-0.3	0.1	0.5	-0.2	0.2	0.0
Myopia	0.3	0.4	1.5	0.3	0.3	0.7	0.5	-1.0	-0.0	1.2	-0.0	0.4	0.5	1.1	0.9	0.0
Vascular/heart problems diagnosed by doctor	1.2	3.2	5.8	-2.2	-1.3	-2.3	-1.6	0.2	2.4	-1.7	-1.8	-1.5	-1.9	-1.8	-1.9	-1.7
Cholesterol lowering medication	0.3	0.5	1.4	0.3	1.2	1.0	0.1	-0.9	0.1	1.0	0.0	0.4	0.7	0.6	1.0	0.4
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	4.0	1.1	1.7	2.0	1.6	-1.3	-0.9	1.8	1.9	1.2	0.5	1.8	1.0	1.3
Pain experienced in last month	3.6	5.9	9.5	-2.9	-0.7	-2.3	-1.7	-1.7	2.1	-2.7	-1.9	-2.8	-2.7	-2.9	-3.1	-2.9
Supplements: Calcium	3.2	3.5	7.6	2.5	1.1	2.4	1.8	-1.5	-1.4	1.6	1.5	2.6	1.6	1.2	1.3	2.8
Basal cell carcinoma (self-reported)	1.6	1.9	4.8	1.3	1.0	1.4	1.5	-0.1	-0.2	1.5	0.7	2.2	1.4	1.4	1.3	2.0
Heart attack/myocardial infarction (self-reported)	2.0	2.6	7.5	2.0	-0.5	0.7	1.7	1.2	-2.7	0.8	1.8	1.6	1.9	1.7	1.7	1.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	2.2	0.7	-0.2	-0.2	-0.2	-1.5	-0.7	-0.2	-0.6	0.7	0.2	-0.1	-0.1	0.5
Heart disease (siblings)	3.2	4.0	7.1	2.5	1.2	2.1	1.2	0.1	-1.7	2.0	0.8	2.6	2.6	1.9	2.5	2.7
Alcohol drinker status: Previous	0.3	0.3	0.9	-0.3	-0.9	-1.0	-0.0	-0.9	0.1	-0.8	0.0	-0.2	-0.7	-0.0	-0.5	-0.4
Pack years of smoking	8.8	12.9	24.0	4.2	2.6	3.8	3.8	2.5	-3.0	3.1	3.0	3.7	4.9	3.1	4.2	4.1
Impedance of whole body	0.0	0.1	0.4	0.5	-0.2	-0.4	-0.2	-0.2	-0.6	0.0	-0.3	0.3	-0.5	-0.3	-0.4	0.1
Leg fat mass (left)	4.2	16.3	22.5	4.5	2.5	4.7	4.0	1.1	-3.4	3.6	4.6	4.1	4.6	4.6	4.6	4.5
Arm predicted mass (left)	0.8	4.1	17.6	1.6	0.3	2.3	1.8	4.2	-1.2	2.0	2.1	0.8	2.3	1.5	2.3	1.4