[Hub]/) : Traits : Trunk fat-free mass :

chr6:79,927,081-81,872,212

Best TWAS P=3.59e-24 · Best GWAS P=1.52e-19 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Visceral Omentum RP11-250B2.6 0.16 0.05 lasso 6 0.06 7.8e-04 7.3 -8.0 1.2e-15 -0.57 0.22 0.44 FALSE
2 GTEx Artery Aorta BCKDHB 0.14 0.14 lasso 1 0.13 9.8e-08 6.0 6.0 1.7e-09 0.15 1.00 0.00 FALSE
3 GTEx Artery Aorta ELOVL4 0.11 0.13 lasso 2 0.11 1.7e-06 5.4 5.4 8.0e-08 0.45 0.94 0.00 TRUE
4 GTEx Artery Tibial BCKDHB 0.16 0.16 lasso 11 0.15 4.9e-12 6.2 5.8 5.0e-09 0.15 1.00 0.00 FALSE
5 GTEx Brain Cerebellum RP11-250B2.5 0.43 0.11 lasso 5 0.14 4.7e-05 -8.2 -8.2 1.7e-16 -0.76 0.08 0.82 TRUE
6 GTEx Cells EBV-transformed lymphocytes RP11-250B2.6 0.21 0.03 enet 37 0.13 4.7e-05 6.2 -7.2 5.6e-13 -0.23 0.14 0.07 FALSE
7 GTEx Cells Transformed fibroblasts BCKDHB 0.16 0.02 enet 42 0.04 3.7e-04 5.5 9.0 1.6e-19 0.49 0.25 0.64 FALSE
8 GTEx Cells Transformed fibroblasts RP11-250B2.6 0.11 0.01 lasso 7 0.00 1.4e-01 -8.0 -5.9 3.4e-09 -0.51 0.35 0.09 FALSE
9 GTEx Colon Transverse RP11-250B2.5 0.13 0.02 enet 3 0.01 6.3e-02 -2.9 -5.8 5.9e-09 -0.61 0.06 0.48 TRUE
10 GTEx Esophagus Mucosa RP11-250B2.6 0.20 0.16 lasso 7 0.23 3.3e-15 -8.0 -8.1 5.9e-16 -0.65 0.94 0.06 FALSE
11 GTEx Esophagus Muscularis BCKDHB 0.18 0.07 enet 25 0.06 2.4e-04 6.1 5.8 5.1e-09 0.15 0.94 0.01 TRUE
12 GTEx Heart Atrial Appendage RP11-250B2.6 0.20 0.00 enet 17 0.03 2.6e-02 -4.7 -10.1 3.6e-24 -0.41 0.05 0.48 TRUE
13 GTEx Heart Left Ventricle RP11-250B2.6 0.09 0.00 enet 6 0.02 2.0e-02 8.0 -7.6 2.6e-14 -0.82 0.06 0.68 FALSE
14 GTEx Lung BCKDHB 0.09 0.06 enet 10 0.05 1.8e-04 6.1 6.1 9.8e-10 0.15 0.89 0.02 FALSE
15 GTEx Lung RP11-250B2.6 0.09 0.05 enet 16 0.07 5.3e-06 5.6 -8.0 1.9e-15 -0.36 0.83 0.02 FALSE
16 GTEx Muscle Skeletal RP11-250B2.6 0.07 0.04 lasso 5 0.04 4.2e-05 8.7 -8.9 4.1e-19 -0.94 0.02 0.98 FALSE
17 GTEx Nerve Tibial BCKDHB 0.18 0.11 lasso 9 0.10 2.4e-07 6.2 6.2 4.7e-10 0.15 1.00 0.00 FALSE
18 GTEx Skin Not Sun Exposed Suprapubic RP11-250B2.6 0.08 0.05 lasso 4 0.01 8.1e-02 5.6 -5.2 2.5e-07 -0.07 0.21 0.11 FALSE
19 GTEx Testis RP11-250B2.5 0.13 0.17 lasso 3 0.14 7.0e-07 -8.1 -7.8 4.0e-15 -0.88 0.04 0.96 FALSE
20 GTEx Testis RP11-250B2.6 0.09 0.05 lasso 6 0.04 6.9e-03 5.6 -5.2 1.9e-07 -0.10 0.42 0.03 TRUE
21 GTEx Thyroid BCKDHB 0.17 0.06 lasso 8 0.10 3.4e-08 5.6 7.4 1.2e-13 0.46 0.98 0.02 TRUE
22 GTEx Thyroid RP11-250B2.6 0.11 0.10 lasso 2 0.07 3.2e-06 5.5 -5.5 3.4e-08 -0.13 1.00 0.00 FALSE
23 METSIM Adipose BCKDHB 0.05 0.03 blup 558 0.05 1.1e-07 -8.1 5.5 3.7e-08 0.55 0.88 0.12 FALSE
24 METSIM Adipose RP11-250B2.6 0.04 0.04 lasso 12 0.02 1.7e-04 7.8 -6.9 5.3e-12 -0.60 0.68 0.10 FALSE
25 ROSMAP Brain Pre-frontal Cortex BCKDHB 0.18 0.13 lasso 6 0.14 2.9e-17 6.2 5.3 1.3e-07 0.18 1.00 0.00 TRUE
26 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma BCKDHB 0.12 0.06 lasso 4 0.06 4.2e-07 6.9 -6.3 2.4e-10 -0.75 0.54 0.45 FALSE
27 The Cancer Genome Atlas Testicular Germ Cell Tumors BCKDHB 0.19 0.02 blup 137 0.06 2.6e-03 6.1 5.2 1.5e-07 0.02 0.03 0.05 TRUE