Hub : Genes

ELOVL4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.1130 0.0400 5.0e-04 0.126 NA 0.100 NA 0.107 2.0e-07 NA 3.9e-06 NA 1.8e-06
2 GTEx Artery Tibial 0.1331 0.0388 1.9e-05 0.115 NA 0.099 NA 0.103 2.8e-09 NA 3.4e-08 NA 2.0e-08
3 GTEx Cells Transformed fibroblasts 0.0910 0.0400 6.3e-03 0.047 NA 0.057 NA 0.060 2.0e-04 NA 4.2e-05 NA 2.8e-05
4 GTEx Esophagus Mucosa 0.3490 0.0690 6.9e-08 0.101 NA 0.206 NA 0.102 3.1e-07 NA 7.8e-14 NA 2.5e-07
5 GTEx Esophagus Muscularis 0.1650 0.0460 9.8e-06 0.054 NA 0.110 NA 0.103 3.4e-04 NA 3.4e-07 NA 8.5e-07
6 GTEx Testis 0.3080 0.0760 2.0e-05 0.192 NA 0.154 NA 0.181 6.5e-09 NA 2.5e-07 NA 1.9e-08
7 METSIM Adipose 0.0588 0.0187 5.4e-06 0.033 0.036 0.022 0.036 0.034 8.0e-06 3.6e-06 2.3e-04 3.2e-06 5.9e-06
8 ROSMAP Brain Pre-frontal Cortex 0.0570 0.0242 4.6e-03 0.049 0.025 0.029 0.028 0.039 6.7e-07 2.6e-04 9.9e-05 1.3e-04 8.9e-06
9 TCGA Head and Neck Squamous Cell Carcinoma 0.0376 0.0205 8.5e-03 0.005 0.011 0.002 NA 0.001 7.4e-02 2.0e-02 1.8e-01 NA 2.4e-01
10 TCGA Kidney Renal Clear Cell Carcinoma 0.0900 0.0404 5.6e-03 0.036 0.006 0.021 NA 0.006 5.5e-05 5.7e-02 1.9e-03 NA 6.6e-02
11 TCGA Thyroid Carcinoma 0.2280 0.0670 8.4e-07 0.004 0.079 0.058 NA 0.041 1.3e-01 3.7e-08 2.3e-06 NA 7.2e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.5 0.8 2.6 -0.1 0.1 -0.1 -1.2 -0.3 0.4 -0.3 1.6 -1.5 0.4 1.2
Bipolar Disorder or Schizophrenia 0.5 1.2 2.1 0.7 0.9 1.1 -0.7 -0.3 -1.4 1.4 1.4 -1.0 1.1 1.4
Depressed Affect (Nagel 2018) 0.3 0.5 2.1 0.6 0.6 -0.7 0.1 0.7 -0.3 -0.1 -0.7 0.8 1.0 1.4
Depression (Nagel 2018) 0.4 0.6 1.3 1.2 1.1 0.6 -0.0 0.9 -1.2 0.7 0.4 0.4 1.0 -0.2
Intelligence (Savage-Jansen 2018) 0.2 0.6 2.2 0.1 0.2 0.8 0.4 0.2 0.5 -0.9 1.5 -1.5 -0.5 -0.4
Neuroticism (Nagel 2018) 0.2 0.4 1.0 0.2 0.2 -1.0 -0.2 0.3 -0.7 0.1 -0.8 1.0 0.5 0.9
Schizophrenia (2018) 0.7 1.4 4.6 1.1 1.1 1.6 0.1 -0.1 -2.1 2.0 0.5 -0.1 1.1 0.7
Schizophrenia vs Biploar Disorder 2.5 3.3 7.9 2.5 2.1 1.6 2.2 1.3 -1.2 2.8 -0.4 1.1 1.6 1.7
Worry (Nagel 2018) 0.2 0.4 2.2 -0.7 -0.5 -1.5 0.0 -0.6 -0.5 0.3 0.8 -0.1 -0.2 -0.4
Alzheimer’s Disease (in mother) 0.9 1.1 2.0 1.0 1.0 1.4 -0.9 0.7 -0.1 1.2 1.4 -1.3 0.9 1.0
Alzheimer’s Disease (in father) 1.5 1.6 3.9 -1.1 -1.2 -1.6 2.0 -1.3 -0.0 -0.3 0.7 -0.3 -1.9 -1.6
Alzheimer’s Disease (including proxy) 0.3 0.4 1.0 0.4 0.4 0.5 0.9 0.5 0.4 0.6 1.0 -0.9 0.1 -0.3
Crohns Disease (2017) 0.3 0.7 3.6 -0.5 -0.5 -1.1 -0.4 0.4 -0.6 -0.5 1.9 -1.1 -0.1 0.3
Irritable Bowel Disease (IBD) 0.2 0.5 1.6 -0.1 0.1 -0.3 -0.5 1.3 -0.8 -0.3 0.6 0.3 0.7 1.3
Ulcerative Colitis (UC) 0.4 0.7 2.1 0.0 0.3 0.2 -0.9 1.5 -0.9 -0.6 -0.3 1.1 0.8 1.3
Major Depression (MDD) 0.4 0.5 1.6 -0.3 -0.1 -0.3 0.0 -0.1 1.1 -1.0 -1.3 0.4 0.1 1.1
Reaction Time 0.5 0.9 3.0 -0.7 -0.7 0.6 1.7 -0.4 0.1 -1.2 1.0 -0.8 -0.7 1.5
Verbal and Numeric Reasoning (VNR) 0.3 0.6 2.0 -0.9 -0.6 -0.1 0.5 0.3 -0.9 -1.2 1.4 -0.8 -0.9 -0.1
Breast Cancer 1.1 2.7 8.1 -2.4 -2.3 -1.1 1.7 -1.0 -0.4 -2.9 -0.4 -0.2 -2.2 0.3
Ovarian Cancer 0.5 0.7 2.6 0.4 0.3 1.6 -0.5 0.6 -0.2 -0.2 1.4 -0.9 0.6 1.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.4 0.6 1.8 -0.2 -0.9 -0.3 -0.3 0.5 -1.0 -0.7 1.2 -0.8 -0.5 -1.3
Bipolar Disorder (2011) 1.0 1.0 2.4 -1.0 -0.9 -0.3 -1.3 -0.8 1.0 -1.3 -1.1 0.2 -0.1 1.6
Body Mass Index (BMI) (2010) 0.4 0.6 3.2 -0.1 -0.1 -0.7 -1.8 -0.6 1.3 -0.4 -0.0 -0.5 -0.4 -0.0
Coronary Artery Disease (CAD) 0.5 0.6 2.0 -0.9 -0.8 -1.0 -0.4 -0.3 -0.3 -1.4 0.1 0.9 -0.7 -0.2
Crohns Disease (2012) 0.4 0.6 1.9 0.3 0.1 -0.7 -0.5 1.0 -1.1 -0.1 1.4 -1.2 0.4 -0.1
Mean Putamen Volume 0.4 0.4 1.8 0.7 0.5 -0.0 1.3 0.7 -0.3 -0.3 -0.9 0.6 0.0 0.1
Fasting Glucose 0.8 1.0 2.6 -0.7 -0.1 -0.7 -1.5 -1.4 1.0 -1.3 -1.6 0.5 -0.4 0.2
HbA1C 0.9 1.0 3.6 -1.1 -0.8 -1.9 -1.5 -0.7 0.3 -1.4 -0.2 0.1 -0.3 0.8
HDL Cholesterol 0.2 0.3 1.2 0.5 0.6 0.0 0.4 -0.1 0.0 1.1 -0.6 0.6 0.4 -0.1
LDL Cholesterol 1.2 1.9 5.4 -0.8 -0.9 -1.9 -1.9 -0.6 2.3 -2.0 -0.1 -0.8 -0.9 -1.0
Lupus 0.7 1.1 5.5 -0.2 0.2 -1.1 0.3 0.5 0.7 -1.9 0.7 -0.3 -0.5 -2.4
Neuroticism (2016) 0.3 0.4 1.5 0.2 0.3 -1.2 -0.4 0.3 0.8 -0.2 -0.2 -0.4 0.6 -1.1
Primary Biliary Cirrhosis 0.2 0.3 1.5 -0.1 0.2 -0.3 -0.5 -0.0 1.2 0.2 0.7 -1.0 0.2 0.5
Rheumatoid Arthritis 0.5 0.7 3.9 -0.5 -0.3 -0.5 1.2 -0.3 -0.4 -0.0 -1.0 2.0 -0.4 0.6
Schizophrenia (2014) 1.0 2.1 4.1 1.1 1.2 1.8 -0.7 -0.7 -1.6 2.0 2.0 -1.2 1.3 1.8
Triglycerides 0.3 0.5 0.9 -1.0 -0.8 -0.3 -0.9 -0.7 0.8 -0.9 0.8 -0.4 -0.8 -0.3
Type 2 Diabetes (T2D) (2012) 0.7 0.8 2.4 1.1 1.3 -0.1 -0.6 1.6 -0.9 0.5 -0.2 0.5 1.3 0.1
Ulcerative Colitis 0.1 0.2 1.1 -0.2 0.2 0.3 -1.1 0.5 0.5 -0.5 0.2 0.3 0.2 -0.3
Blood Eosinophil Count 0.1 0.4 1.5 0.2 0.2 0.8 0.7 0.5 -1.1 0.4 -0.2 1.2 0.6 -0.3
Blood Platelet Count 0.2 2.0 5.1 -2.3 -2.2 -1.5 0.4 -1.4 -0.8 -1.9 -0.1 -0.1 -1.9 -0.5
Blood Red Count 0.0 0.4 1.6 0.0 0.0 -0.2 -0.3 -1.0 1.2 0.4 0.8 -1.3 -0.1 0.0
Blood White Count 0.1 1.0 4.3 -0.3 -0.2 -0.7 2.1 0.0 -1.8 0.5 0.6 0.8 0.3 -1.1
Heel T-Score 0.4 3.0 10.6 1.9 1.6 0.5 -2.0 2.2 0.3 3.3 -0.7 1.4 1.8 -0.8
BMI 0.2 1.3 8.8 0.2 0.2 -1.4 -1.1 0.4 3.0 -0.3 -1.5 0.5 0.2 -0.0
Height 2.1 40.6 79.4 8.1 7.2 6.4 1.4 6.7 -7.4 8.4 -2.5 4.8 8.9 2.7
Waist Hip Ratio (WHR) 1.7 7.7 39.4 2.5 2.1 2.3 2.5 2.2 -6.3 0.6 -1.3 2.8 2.1 1.9
Systolic Blood Pressure 1.0 5.1 11.4 3.3 3.1 1.4 2.0 3.4 -1.7 2.5 -0.2 1.4 2.4 1.1
Smoking Status 0.3 0.8 4.2 -0.1 -0.3 0.0 2.1 -0.6 -0.9 -0.6 -0.4 1.0 -0.1 1.3
Allergy or Eczema 0.5 1.3 2.5 1.1 1.5 1.3 -1.1 1.0 0.6 0.3 1.5 -0.9 1.6 0.9
Cardiovascular Disease 0.2 0.8 2.6 1.2 1.1 -1.6 -0.2 1.4 -0.7 -0.1 0.6 0.4 0.8 0.0
Hypothyroidism (self reported) 1.2 2.8 6.0 -1.8 -1.5 -0.4 -0.1 -2.5 2.1 -1.3 1.3 -2.4 -2.2 -0.9
Respiratory disease 0.2 0.5 1.2 -1.0 -0.6 -0.8 -1.1 -0.7 -0.2 -0.1 -0.3 0.3 -0.5 -1.1
Type 2 Diabetes (T2D) (2018) 2.6 4.9 11.2 3.3 3.3 2.5 0.3 2.5 -0.8 1.2 -0.5 1.2 3.3 2.2
Lung FEV1/FVC ratio 0.5 2.4 6.0 1.9 2.2 1.9 0.1 2.4 -0.6 0.8 1.4 -0.1 2.5 0.3
Lung FVC 0.7 3.5 6.6 2.2 2.4 2.2 1.8 2.6 -0.8 0.9 -2.0 2.0 1.7 1.3
Neuroticism 0.2 0.5 3.1 -0.7 -0.6 -1.8 -0.1 -0.4 -0.1 -0.7 0.7 -0.9 -0.2 0.1
Chronotype (morning person) 0.2 0.6 2.1 0.8 0.6 -0.0 0.7 0.3 -0.8 0.2 -1.0 1.4 0.6 0.6
Hair Pigment 0.1 2.1 5.1 2.3 1.8 1.4 0.1 1.2 -0.1 2.2 -1.3 0.5 1.9 0.8
Tanning 0.2 2.2 5.2 -1.1 -1.0 -0.8 -2.3 -2.0 1.9 0.6 1.2 -2.2 -0.7 -0.9
Hand grip strength (left) 0.9 2.5 6.1 1.8 1.6 1.0 -0.3 1.5 0.2 2.5 -2.0 1.6 1.9 1.3
Number of treatments/medications taken 0.4 0.8 1.7 1.0 1.1 -0.4 -0.9 1.2 0.1 1.3 -0.6 0.5 1.3 -0.1
Average weekly spirits intake 1.0 1.3 7.3 -0.5 -0.6 -1.3 -1.2 -0.8 2.7 -0.7 -1.0 0.3 -0.5 -1.0
Sensitivity / hurt feelings 0.1 0.2 0.9 -0.6 -0.5 -0.9 -0.1 -0.2 -0.3 0.2 -0.2 0.0 0.0 0.6
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.4 0.1 -0.0 0.3 0.1 -0.7 -1.1 -1.2 -0.1 0.6 -0.1 -0.2
Hearing difficulty/problems: Yes 3.0 4.6 10.7 -2.5 -2.7 -2.9 -0.6 -3.3 2.2 -1.8 -1.5 0.9 -2.5 -0.8
Relative age of first facial hair 0.3 0.6 3.3 0.6 0.4 -0.1 -1.8 -0.4 1.0 0.4 0.1 -0.0 0.3 1.3
Other serious medical condition/disability diagnosed by doctor 0.7 1.0 4.3 -0.9 -0.5 -0.5 -0.1 -0.2 -0.2 -1.3 2.1 -1.0 -1.2 -0.8
Ever used hormone-replacement therapy (HRT) 2.2 2.8 10.1 2.1 2.1 1.0 1.7 1.8 -0.1 3.2 0.7 -0.1 2.0 -0.4
Ever had hysterectomy (womb removed) 0.8 0.9 4.6 0.2 0.0 -0.1 0.1 -0.4 -0.1 -1.2 2.1 -1.8 -0.4 -0.1
Systolic blood pressure, automated reading 0.6 1.8 4.1 1.6 1.8 0.4 0.7 1.5 0.9 2.0 -1.3 1.6 1.2 -0.8
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.8 -0.4 -0.3 -0.4 -1.4 -0.7 -0.1 -0.7 0.8 -1.0 -0.4 -0.7
Angina 0.4 0.6 2.2 0.7 1.0 0.4 -1.5 0.2 0.4 0.1 0.2 -0.4 0.6 1.1
Medication for hormone replacement therapy 1.8 2.0 3.9 -2.0 -1.8 -1.6 1.3 -1.3 0.4 -0.8 1.5 -1.3 -1.4 -1.4
Vitamin and mineral supplements 1.4 1.8 7.0 0.9 0.7 0.8 1.3 1.1 -2.2 0.2 -1.8 2.6 0.3 0.3
Supplements: Zinc 0.3 0.3 1.2 -0.3 -0.2 0.1 0.9 0.5 -1.1 -0.4 -0.6 0.9 -0.2 0.1
Medication: Co-codamol 0.2 0.3 0.7 -0.6 -0.5 -0.6 -0.9 -0.2 0.4 -0.7 0.0 -0.5 -0.4 0.2
Medication: Metformin 3.4 4.8 11.2 3.4 3.1 2.1 1.7 2.1 -1.4 2.0 -0.4 1.2 2.9 2.0
Diabetes (father) 0.7 0.8 4.0 0.7 0.5 -0.2 0.6 0.9 -1.1 0.8 -0.7 2.0 0.9 0.1
Diabetes (mother) 0.9 1.1 5.1 0.5 0.4 -0.2 -0.9 0.9 -0.2 0.5 2.2 -1.9 0.6 0.7
Severe depression (siblings) 0.4 0.4 1.6 0.3 0.6 0.7 -0.7 0.6 1.3 0.3 -0.5 0.1 0.7 -0.7
Pack years adult smoking proportion 0.2 0.3 1.9 -0.0 -0.0 -0.8 0.1 -0.1 -0.0 0.5 -0.4 0.5 0.0 1.4
Impedance of leg (right) 0.6 2.7 5.7 -2.4 -2.0 0.1 -0.2 -1.4 -0.9 -1.7 2.4 -2.0 -2.1 -0.8
Leg fat-free mass (left) 1.3 6.7 14.7 3.8 3.2 1.5 0.2 2.9 -1.7 3.6 -1.7 2.5 3.5 1.2
Trunk fat percentage 0.2 0.9 3.8 -0.0 0.0 -0.9 -1.0 -0.4 2.0 0.6 0.5 -1.4 -0.3 -1.2
Hand grip strength (right) 1.2 3.2 6.6 1.9 1.7 1.5 -0.1 1.5 1.3 1.9 -2.6 2.3 2.3 1.3
Townsend deprivation index at recruitment 2.0 2.8 7.5 -2.4 -2.4 -1.3 0.7 -1.9 -0.9 -2.7 0.1 0.3 -2.2 -0.2
Current tobacco smoking 0.8 1.3 4.1 -0.5 -0.6 -0.4 2.0 -0.1 -1.4 0.5 -0.8 1.8 -0.3 1.9
Average weekly fortified wine intake 0.9 1.1 5.8 -1.1 -0.7 -0.8 0.4 -0.7 -2.4 -0.5 -0.5 0.9 -0.9 -1.1
Maternal smoking around birth 0.2 0.4 1.6 0.3 0.2 1.3 -0.1 0.5 -0.2 -0.7 0.7 0.1 0.7 -0.6
Fed-up feelings 0.3 0.5 1.4 0.1 -0.1 -0.4 1.2 0.0 -1.0 -0.9 0.8 -0.5 0.2 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 1.8 -0.0 -0.1 -0.3 0.4 -0.4 -0.5 -0.3 -0.0 0.4 -0.4 -1.3
Relative age voice broke 0.3 0.4 1.9 0.4 0.3 0.6 -0.6 0.8 0.1 0.3 -0.3 0.7 0.2 1.4
Taking other prescription medications 0.3 0.5 2.5 -0.5 -0.5 -0.6 -0.8 -0.5 -0.0 -0.5 0.5 0.1 -0.6 -1.6
Age when periods started (menarche) 0.7 1.7 6.2 -1.6 -1.6 -1.0 -0.2 -2.5 0.7 -0.7 -0.2 -0.8 -1.6 -1.4
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.3 0.7 0.6 -0.5 1.5 -1.5 1.0 0.4 1.2 -0.5 0.3 0.1
Heel bone mineral density (BMD) T-score, automated (left) 2.0 4.6 9.9 3.0 2.8 2.4 -1.7 2.6 1.0 2.7 -0.2 0.5 3.1 -0.3
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 3.6 1.0 0.9 1.0 -0.2 -0.0 1.7 1.3 1.9 -1.7 0.9 1.0
Qualifications: CSEs or equivalent 0.4 0.6 1.8 -0.2 -0.5 -1.1 -0.4 0.6 0.1 -1.2 0.8 -0.5 -0.3 1.4
Serious illness, injury or assault to yourself 1.0 1.2 2.8 1.1 1.2 1.3 -1.3 1.7 1.3 -0.6 0.9 -0.5 0.8 -0.1
High blood pressure 0.3 0.8 4.7 0.5 0.3 -2.2 0.9 0.5 0.0 -0.3 0.1 0.4 0.0 -1.6
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.5 0.5 0.8 1.0 -0.3 1.1 -0.8 -0.2 1.2 -0.3 1.0 1.1
Multivitamins +/- minerals 0.9 1.2 3.5 0.9 1.1 0.5 -0.2 0.7 0.6 1.4 1.8 -1.9 1.2 -0.1
Stomach or abdominal pain in last month 0.4 0.5 1.5 -0.7 -0.5 -1.1 0.4 -0.4 0.3 -1.2 -0.3 0.4 -0.5 -0.8
Supplements: Glucosamine 1.3 1.7 6.5 1.3 1.2 1.2 0.5 1.5 0.1 1.9 0.4 -0.1 1.3 2.5
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 3.8 0.5 0.5 -0.5 0.6 -0.3 0.7 -0.2 1.9 -1.4 0.4 0.6
Medication: Atenolol 0.6 0.7 1.7 1.2 1.1 -0.7 0.5 0.4 -0.2 1.3 -0.7 1.0 0.9 0.4
Medication: Levothyroxine sodium 0.7 1.2 3.6 -0.9 -0.9 -0.0 -0.4 -1.1 1.6 -0.6 0.3 -1.3 -1.3 -1.9
Sitting height 6.6 46.7 98.8 9.7 8.6 6.6 0.4 7.6 -5.2 9.6 -2.2 4.0 9.9 2.4
Chronic bronchitis/emphysema (father) 0.9 1.0 6.1 0.1 -0.6 -1.0 2.5 -0.2 -1.5 -0.7 -0.2 0.8 -0.2 -0.3
High blood pressure (mother) 0.3 0.4 2.0 0.4 0.8 -0.3 0.5 0.6 0.5 1.4 -0.0 -0.3 0.8 0.4
Body mass index (BMI) 0.2 1.0 5.1 0.7 0.7 -1.2 -0.5 0.5 2.3 0.8 -1.2 0.5 0.5 0.1
Impedance of leg (left) 0.6 2.8 5.5 -2.3 -2.0 0.5 0.1 -1.5 -0.9 -2.1 2.2 -2.1 -2.1 -0.1
Leg predicted mass (left) 1.3 7.1 15.5 3.9 3.3 1.5 0.3 3.0 -1.7 3.8 -1.7 2.4 3.5 1.2
Trunk fat mass 0.2 0.9 3.0 1.4 1.3 -0.1 -0.5 0.8 0.9 1.7 0.0 -0.4 1.1 -0.4
Waist circumference 0.9 3.2 8.7 3.0 2.7 0.9 0.8 2.2 -1.0 2.3 -0.5 0.8 2.2 0.6
Number of incorrect matches in round 0.2 0.4 1.1 0.4 0.6 0.9 -1.0 -0.1 -1.0 0.6 0.0 -0.1 0.4 0.3
Past tobacco smoking 0.4 0.8 2.5 0.1 0.4 -0.3 -1.6 1.3 1.6 0.8 -0.7 0.3 0.7 0.2
Alcohol usually taken with meals 0.9 1.5 2.8 1.7 1.6 1.0 0.1 1.4 -0.1 0.9 1.6 -1.5 1.4 0.7
Nervous feelings 0.4 0.7 2.7 -0.8 -0.6 -0.8 -0.1 -1.1 0.5 0.5 1.7 -1.1 -0.1 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.0 0.4 0.3 -0.7 1.0 -0.2 -0.8 -0.2 0.7 0.1 0.6 -0.4
Hearing difficulty/problems with background noise 0.4 0.6 2.6 -0.2 -0.1 -0.8 -0.2 -1.2 1.0 -0.1 -1.6 0.4 0.2 0.5
Hair/balding pattern: Pattern 2 0.3 0.3 1.3 -0.1 0.1 -1.1 0.1 1.1 -0.2 0.5 0.8 -0.3 -0.1 -0.5
Had menopause 0.3 0.4 1.5 -0.3 -0.2 -0.4 1.2 -0.3 -1.1 0.8 -0.2 0.3 -0.1 -0.8
Had other major operations 2.6 3.1 6.5 -1.7 -1.9 -2.3 -0.2 -2.6 1.2 -1.8 1.9 -1.3 -2.4 -0.8
Forced vital capacity (FVC) 1.3 5.1 10.4 2.8 2.7 3.2 0.8 3.1 -2.5 1.4 -0.5 1.4 2.6 1.9
Heel bone mineral density (BMD) T-score, automated (right) 2.6 6.0 16.2 3.2 3.1 2.5 -1.9 2.6 1.1 4.0 -0.2 0.4 3.3 0.2
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 2.8 -0.1 0.0 -0.6 1.7 -0.1 -0.7 0.6 -0.6 1.3 -0.4 -1.3
Qualifications: None of the above 0.5 1.0 4.3 -0.5 -0.8 -1.4 -0.4 -0.4 0.2 -1.0 -2.1 1.6 -0.2 0.4
Financial difficulties in last 2 years 0.6 0.8 3.4 -0.6 -0.6 -0.4 0.7 -0.1 -0.6 0.1 -1.9 1.5 -0.5 -0.9
Mouth/teeth dental problems 0.8 1.2 4.7 -1.5 -1.4 -0.4 -1.6 0.1 1.0 -2.2 -0.0 -0.4 -1.0 -0.4
Heart attack 0.3 0.4 1.0 0.5 0.6 0.3 -0.5 0.4 1.0 -0.6 0.6 -0.5 0.2 -1.0
Allergy 0.3 0.7 3.6 -0.1 -0.3 -0.4 -0.3 -0.8 1.5 -0.6 -0.6 -0.1 -0.5 -1.9
Pain all over the body in last month 0.4 0.5 1.0 1.0 0.6 0.5 0.3 0.2 0.6 0.9 0.9 -0.9 0.4 -0.6
Diabetes (self-reported) 1.6 2.5 6.2 2.4 2.5 1.7 0.7 1.1 -0.0 1.0 -0.4 0.3 2.5 1.8
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.8 0.4 0.7 0.4 -1.2 -0.3 -0.5 0.1 1.7 -1.7 0.5 -0.1
Medication: Ramipril 0.6 0.7 2.1 0.0 0.2 -1.5 1.1 -0.7 0.9 -0.4 0.5 -1.1 -0.5 -1.2
Medication: Simvastatin 0.8 1.2 3.8 0.9 1.4 0.4 0.5 1.5 0.2 2.0 -0.9 1.3 1.1 0.2
Fluid intelligence score 0.2 0.4 1.4 0.5 0.7 0.7 1.2 0.8 -0.7 0.4 -0.1 0.3 0.4 0.0
Illnesses of siblings 0.7 1.0 3.8 0.1 0.2 1.7 -1.4 0.2 1.1 0.4 0.6 -1.9 0.6 0.8
Neuroticism score 0.2 0.4 1.1 -0.5 -0.4 -1.0 -0.8 -0.2 0.1 -0.6 0.7 -1.0 0.1 0.1
Weight 0.8 4.1 10.1 3.2 2.8 0.9 0.1 2.5 -0.6 2.9 -0.9 1.3 2.8 1.0
Impedance of arm (right) 0.7 3.5 7.7 -2.8 -2.3 -0.7 -0.5 -2.1 -0.7 -1.7 1.3 -1.8 -2.1 -2.7
Arm fat percentage (right) 0.3 1.1 6.1 -0.1 -0.0 -1.3 -0.9 -0.2 2.5 0.4 -0.9 -0.3 -0.2 -1.5
Trunk fat-free mass 2.4 13.8 28.8 5.4 4.7 3.1 0.7 4.5 -3.5 4.2 -1.4 3.0 4.9 2.5
Hip circumference 0.2 0.7 1.9 1.3 1.1 -0.5 0.2 1.2 0.4 1.4 0.2 0.2 0.7 0.4
Time employed in main current job 0.1 0.2 0.9 0.1 0.1 0.0 -0.8 -0.1 -0.1 0.3 0.0 -0.2 0.4 -1.0
Alcohol intake versus 10 years previously 0.5 0.7 2.4 0.5 0.2 0.0 -1.4 0.3 0.2 -0.6 1.6 -1.5 0.1 -0.5
Father’s age at death 1.5 2.0 4.0 -1.6 -1.7 -0.9 -1.3 -1.0 0.3 -1.5 2.0 -1.7 -1.4 -1.2
Worrier / anxious feelings 0.4 0.8 2.9 -0.5 -0.3 -0.4 -1.7 -1.4 0.5 -0.0 0.6 -1.2 -0.2 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.6 1.7 -0.3 -0.4 -1.2 1.3 -1.1 -0.9 -0.1 0.7 -0.4 -0.5 -0.1
Falls in the last year 0.7 0.9 3.3 -0.8 -0.8 -1.4 0.7 -0.6 -0.6 -0.2 -1.4 1.8 -0.6 0.5
Hair/balding pattern: Pattern 3 0.6 0.9 3.0 1.1 1.1 1.7 0.5 -0.0 0.0 0.5 1.3 -1.1 0.9 0.6
Number of live births 1.7 2.4 8.2 -1.9 -1.8 -1.6 -0.8 -2.0 -0.4 -1.7 0.6 -0.3 -2.9 -0.8
Forced expiratory volume in 1-second (FEV1) 1.3 4.3 11.7 2.5 2.6 3.4 0.3 2.8 -1.8 0.6 -0.2 1.0 2.5 1.6
Pulse rate 1.5 2.5 7.6 -1.8 -1.7 -1.6 -0.1 -1.8 0.2 -0.9 1.1 -1.8 -1.6 -2.8
Happiness 0.9 1.1 2.2 1.0 1.1 0.9 0.9 0.2 -1.4 1.5 1.4 -0.5 1.1 0.3
Noisy workplace 1.7 2.1 6.3 -1.5 -1.4 -0.8 1.4 -0.8 -0.6 -1.3 -2.5 2.4 -0.7 -0.9
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.1 0.3 1.0 0.2 0.1 0.5 -0.8 1.1 -0.3 0.3 0.8 -0.3
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 1.1 0.5 0.2 -0.7 1.0 -0.4 -0.0 -0.2 -0.6 0.3 0.4 -1.0
Mouth/teeth dental problems: Dentures 0.5 0.9 4.4 0.3 0.2 -0.5 1.9 -0.1 -2.1 0.6 -0.0 1.0 0.2 -0.3
Asthma 0.2 0.5 1.1 -0.7 -0.5 -0.9 -0.0 -0.5 -0.5 1.0 0.2 0.6 -0.9 0.7
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 2.1 0.7 0.7 1.4 -1.3 0.8 1.2 -0.4 0.3 -1.2 0.5 -0.2
Medication: Cholesterol lowering 0.9 1.4 4.4 1.5 1.9 0.3 0.2 2.1 0.4 0.4 -0.1 0.2 2.0 0.7
Depression (self-reported) 0.3 0.4 1.2 0.6 1.1 0.6 -0.1 0.8 -0.4 0.1 -0.3 0.8 1.1 0.1
Medication: Lansoprazole 0.3 0.3 0.9 -0.4 -0.6 -0.2 -0.8 -0.8 0.7 0.3 -0.6 0.9 -0.4 -0.2
Prospective memory result 1.3 1.6 4.2 -1.2 -1.2 -1.5 1.1 -2.1 -0.4 -1.8 -1.2 0.7 -1.1 -0.9
Lung cancer (father) 2.1 2.5 5.2 2.3 2.2 1.2 -1.9 1.3 1.0 1.1 1.6 -2.0 1.4 0.4
Illnesses of mother 1.1 1.3 3.3 -1.7 -1.8 -0.3 -0.2 -1.2 -0.4 -1.7 -0.7 -0.1 -1.8 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 2.6 8.2 20.4 3.4 3.7 4.5 0.4 4.0 -2.5 1.3 -0.3 1.7 3.7 2.0
Pulse wave Arterial Stiffness index 0.5 0.6 1.7 -1.0 -1.3 -1.1 -0.4 0.0 0.1 -0.2 0.1 0.3 -1.2 -1.0
Impedance of arm (left) 1.0 4.7 9.0 -3.0 -2.6 -1.0 -1.0 -2.5 0.3 -1.8 1.9 -2.4 -2.5 -3.0
Arm fat mass (right) 0.2 1.0 1.9 1.3 1.2 -0.5 -0.5 0.9 1.2 1.4 -1.4 0.8 1.1 0.0
Trunk predicted mass 2.4 13.7 29.3 5.4 4.7 3.0 0.6 4.5 -3.4 4.2 -1.4 2.9 4.9 2.5
Standing height 1.9 19.2 41.5 5.8 5.1 4.7 1.2 4.7 -6.4 5.0 0.2 2.2 5.5 2.3
Length of working week for main job 0.8 0.9 4.7 0.5 0.5 -0.5 -0.3 0.0 0.1 -0.3 -2.2 1.8 0.5 0.9
Exposure to tobacco smoke at home 0.3 0.3 1.6 0.2 -0.1 -0.0 1.3 0.4 -0.1 -0.4 -0.6 0.8 -0.2 0.6
Breastfed as a baby 0.8 1.0 3.4 0.5 0.8 1.1 1.5 0.1 -0.6 0.4 1.6 -1.8 0.6 0.3
Tense / ‘highly strung’ 0.4 0.7 2.0 -1.1 -0.9 -1.2 0.4 -1.4 -0.2 -0.4 0.6 -0.3 -1.0 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.0 0.3 0.6 -0.1 0.0 -0.2 -1.0 -0.4 0.1 0.8 0.7 0.5
Hair/balding pattern: Pattern 4 0.5 1.1 2.4 -1.0 -1.1 -0.7 0.9 -1.3 -1.1 -0.9 -1.1 1.6 -1.0 0.5
Birth weight of first child 0.6 1.1 4.4 -0.4 0.1 -0.3 -2.1 0.2 0.3 0.0 1.1 -1.5 0.4 -2.0
Peak expiratory flow (PEF) 0.6 1.3 2.7 1.2 1.3 1.1 1.1 1.5 -1.4 0.6 0.1 0.9 1.0 1.6
Pulse wave reflection index 0.4 0.5 1.4 0.2 -0.2 0.2 -0.6 1.2 0.9 0.4 0.7 -0.6 -0.5 -1.1
Ever highly irritable/argumentative for 2 days 0.6 0.7 2.2 -0.9 -1.2 -1.2 0.3 -0.1 -0.5 -1.5 0.6 0.1 -0.9 -0.2
Loud music exposure frequency 0.7 0.7 2.7 0.4 0.4 0.2 0.2 0.6 -1.5 0.5 -1.0 1.6 1.0 0.5
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 1.1 -0.2 0.1 0.3 0.7 0.2 -0.5 0.3 -1.0 1.1 0.2 0.9
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 1.9 0.2 0.2 0.0 -0.5 -1.4 0.2 1.0 -0.2 0.0 -0.2 0.0
Blood clot in the leg (DVT) 0.4 0.6 2.1 -1.0 -0.9 -0.3 -0.0 -0.5 -1.4 -0.3 -0.6 0.8 -1.0 0.2
Medication: Paracetamol 0.2 0.4 1.7 0.3 0.3 0.7 -0.4 0.3 -0.8 -0.5 1.3 -0.7 0.2 0.5
Headache pain in last month 0.5 0.8 2.6 -1.1 -0.8 -0.5 0.7 -1.3 -0.5 -1.6 0.4 -0.4 -1.1 -0.3
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 3.4 -1.4 -1.4 0.2 0.1 -1.8 -1.3 -0.8 -0.1 0.8 -1.6 -0.1
Glaucoma (self-reported) 1.0 1.2 5.1 0.9 1.1 0.2 1.6 0.5 -2.3 0.2 -0.2 1.4 0.8 0.4
Gout (self-reported) 2.0 2.7 5.4 2.3 2.3 2.3 -0.8 2.2 0.1 1.2 -0.6 1.2 1.5 1.8
Hypothyroidism/myxoedema (self-reported) 1.2 2.3 4.5 -1.8 -1.6 -0.9 -0.1 -2.1 1.2 -1.5 0.5 -1.4 -2.1 -1.9
Medication: Amlodipine 0.8 1.1 2.5 1.2 0.8 -0.3 1.3 1.1 -0.4 1.6 0.1 0.6 1.3 -1.3
Medication: Ventolin 100micrograms inhaler 0.2 0.3 1.2 -0.2 -0.1 -0.5 -0.6 0.4 -0.1 0.5 1.1 -0.9 0.2 -0.5
Birth weight 0.8 1.8 4.0 1.6 1.6 0.7 -0.2 1.4 -1.0 1.7 2.0 -1.3 1.7 0.2
Chronic bronchitis/emphysema (mother) 1.2 1.4 6.1 -0.8 -1.1 -1.5 -1.0 -1.4 2.5 -0.7 -0.2 -0.5 -0.6 -0.9
High blood pressure (siblings) 0.5 0.7 3.0 -0.0 -0.0 -1.2 1.7 0.5 -0.7 -0.0 -0.5 1.4 -0.2 -0.6
Forced vital capacity (FVC), Best measure 2.7 9.7 19.3 3.8 4.0 4.4 1.1 4.3 -2.7 1.9 -0.9 2.0 3.9 2.5
Body fat percentage 0.3 1.0 5.6 -0.2 -0.1 -1.1 -1.1 -0.5 2.4 0.5 0.2 -1.2 -0.5 -1.1
Leg fat percentage (right) 0.3 1.0 5.1 -0.5 -0.4 -1.6 -0.5 -0.5 2.2 0.1 0.3 -1.1 -0.9 -0.8
Arm fat-free mass (right) 1.9 9.6 21.7 4.7 4.1 2.5 0.2 3.7 -2.2 3.6 -0.9 2.0 4.2 2.6
Exposure to tobacco smoke outside home 2.1 2.8 7.6 -2.5 -2.8 -1.4 1.5 -1.2 0.4 -2.0 -1.4 0.6 -1.9 -0.8
Comparative body size at age 10 1.8 4.9 13.6 2.7 2.4 1.5 -0.8 2.0 1.0 3.7 -2.2 2.0 2.5 2.2
Number of full brothers 3.2 4.1 10.4 -2.4 -2.2 -1.9 -0.6 -2.7 1.7 -3.2 0.3 -1.0 -2.7 -1.1
Worry too long after embarrassment 1.4 2.3 5.1 1.5 1.7 1.7 0.2 2.2 -1.3 1.0 1.2 -0.4 2.3 1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 2.4 1.2 1.6 1.2 -0.4 1.1 -1.4 1.3 1.1 0.3 1.2 -0.0
Wheeze or whistling in the chest in last year 0.9 1.7 4.6 1.3 1.5 0.6 -0.4 1.4 -0.9 2.2 -1.1 1.6 1.5 0.1
Number of children fathered 1.0 1.2 2.8 1.2 1.1 0.3 0.1 1.6 0.4 1.2 -1.7 1.2 1.3 0.4
Reason for reducing amount of alcohol drunk: Health precaution 2.5 3.0 6.1 1.9 1.8 1.7 0.2 1.8 -2.1 2.5 -1.2 2.0 1.8 0.8
Age at first live birth 0.5 0.8 6.5 -0.4 -0.1 0.5 0.1 0.4 -0.7 0.3 0.9 -0.8 -0.2 -2.5
Pulse wave peak to peak time 1.0 1.2 3.2 1.5 1.8 1.5 0.4 0.4 -0.6 0.6 -0.0 -0.2 1.7 1.3
Health satisfaction 0.4 0.5 3.0 -0.2 -0.0 0.1 -0.7 -0.4 -0.7 0.6 0.7 -0.0 0.4 1.7
Shortness of breath walking on level ground 0.6 0.7 2.2 -0.8 -0.8 -1.3 1.5 0.3 -1.0 -1.1 0.6 -0.2 -0.1 0.3
Qualifications: College or University degree 0.2 0.5 1.2 -0.3 0.2 1.0 -1.1 -0.7 0.1 -0.6 0.8 -1.0 -0.2 -0.7
Eye problems/disorders: None of the above 0.6 0.7 2.8 -0.8 -1.0 0.1 -1.2 -0.7 1.7 -0.4 -1.0 0.3 -0.6 0.4
Mouth/teeth dental problems: Loose teeth 0.8 1.0 2.3 0.9 0.7 1.1 -0.3 0.8 -0.0 1.5 -1.2 1.0 0.7 1.4
Emphysema/chronic bronchitis 0.3 0.4 2.8 -0.6 -0.3 -0.0 -1.7 -0.3 -0.4 0.2 0.3 -0.4 -0.1 -0.2
Medication for pain relief, constipation, heartburn 0.1 0.2 0.6 -0.3 -0.3 -0.2 0.6 -0.8 0.7 0.6 -0.6 -0.2 0.1 -0.1
Neck or shoulder pain in last month 0.4 0.5 1.7 0.4 0.4 -0.1 0.3 0.6 -0.7 1.2 -1.0 1.3 0.7 -0.1
Medication: Blood pressure 0.4 0.7 2.0 0.8 0.7 -0.7 0.4 0.6 1.4 0.6 0.1 -1.2 0.8 -1.0
Angina (self-reported) 0.5 0.7 2.0 0.9 1.2 0.6 -1.3 0.6 0.2 0.2 0.3 -0.3 0.9 1.4
Migraine (self-reported) 0.1 0.1 0.4 -0.2 -0.0 0.1 -0.4 -0.2 0.4 0.5 0.6 -0.7 -0.4 -0.1
Medication: Ibuprofen 0.4 0.4 2.0 0.0 0.2 0.7 -0.9 0.4 1.4 -0.3 0.1 -1.1 0.1 -0.2
Medication: Allopurinol 4.3 5.7 13.2 3.5 3.6 2.9 -0.9 3.1 -0.2 2.1 -1.0 1.0 2.6 2.3
Medication: Omeprazole 0.6 0.7 2.0 -1.3 -0.9 -1.2 0.4 1.0 -0.6 0.1 0.0 0.1 -0.6 -1.4
Medication: Seretide 50 evohaler 1.9 2.2 6.1 -2.1 -2.0 -2.5 -0.7 -0.9 0.5 -0.6 -1.2 -0.0 -1.5 -2.0
Mean time to correctly identify matches 0.2 0.5 2.9 0.1 0.0 0.6 1.7 0.1 -0.2 -0.0 0.8 -0.5 -0.2 0.8
Heart disease (mother) 2.9 3.5 6.5 2.5 2.2 1.5 1.7 2.5 -1.2 1.9 -0.7 2.4 2.1 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 2.4 -0.1 0.2 0.8 1.6 -0.4 0.9 0.2 1.4 -1.1 -0.2 0.4
Whole body fat mass 0.2 0.9 2.5 1.4 1.3 -0.2 -0.6 0.8 1.2 1.6 -0.5 -0.0 1.1 0.1
Leg fat mass (right) 0.2 0.6 1.4 1.0 0.9 -0.6 -0.3 0.9 1.1 1.2 -0.6 0.2 0.6 -0.0
Arm predicted mass (right) 2.3 11.7 25.5 5.0 4.4 2.7 0.5 4.1 -2.7 3.9 -1.0 2.4 4.6 3.1
Pulse rate, automated reading 0.7 2.3 4.8 -1.5 -1.5 -1.7 -1.4 -2.2 1.5 -0.5 0.8 -1.8 -1.3 -2.0
Alcohol intake frequency. 1.5 3.5 6.7 -1.4 -1.4 -2.5 0.2 -2.1 0.3 -2.6 2.4 -1.6 -2.0 -2.0
Comparative height size at age 10 1.3 7.0 15.8 3.5 3.3 2.3 0.4 3.0 -4.0 2.4 -0.5 2.1 3.6 0.5
Number of full sisters 1.6 2.0 5.8 -2.1 -2.1 -0.4 0.3 -0.8 -1.8 -1.5 0.6 0.3 -2.4 -0.6
Suffer from ‘nerves’ 0.3 0.4 2.0 -0.5 -0.3 -0.7 -0.8 0.1 -0.4 0.3 1.4 -0.7 0.2 -0.6
Overall health rating 0.2 0.4 2.0 0.0 -0.0 -0.8 0.6 0.1 -1.1 -0.1 -0.4 1.4 0.4 0.2
Chest pain or discomfort 1.0 1.4 4.3 1.0 1.2 -0.3 0.5 0.9 -0.6 2.1 -1.5 1.5 1.7 0.7
Had major operations 0.3 0.3 0.7 0.5 0.5 0.4 0.7 -0.6 0.8 -0.7 -0.8 0.2 0.3 0.3
Age at last live birth 0.6 0.9 3.1 0.6 0.6 0.4 1.3 0.7 -1.5 0.6 1.2 0.0 0.2 -1.8
Family relationship satisfaction 0.9 1.1 3.1 1.4 1.5 1.6 -0.3 0.3 -0.1 1.8 0.7 -0.4 1.3 0.0
Leg pain on walking 0.4 0.5 4.7 0.0 0.1 -0.5 2.2 -0.6 -0.0 -0.3 0.5 -0.3 -0.0 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 1.5 -0.3 -0.6 -0.1 1.2 0.3 -0.8 -0.1 0.0 0.4 -0.2 0.2
Commuting to job workplace: Car/motor vehicle 0.5 0.6 5.1 0.2 0.0 -0.7 2.2 0.5 -0.6 -0.4 -0.3 0.6 -0.0 -0.1
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 2.5 -1.6 -1.5 -0.6 0.1 -1.5 0.5 -0.2 0.5 -0.7 -1.3 0.3
Medication: Aspirin 0.9 1.2 3.5 1.9 1.7 0.4 0.4 1.3 -0.3 0.8 -0.2 1.4 1.5 0.2
Supplements: Vitamin C 1.4 1.7 3.4 -1.7 -1.6 -1.2 -1.8 -1.4 1.5 -1.3 0.3 -0.8 -1.2 -0.5
Knee pain experienced in last month 0.4 0.6 2.6 0.2 0.2 -0.7 0.1 0.0 -0.3 -0.1 -1.6 1.6 0.5 -0.2
Hypertension (Self-reported) 0.3 0.9 5.6 0.6 0.4 -2.4 0.6 0.2 0.4 -0.1 -0.1 0.4 0.1 -1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 3.5 -1.3 -1.2 -1.2 0.3 -0.5 -0.5 -1.9 -1.7 1.7 -1.0 -0.4
Illnesses of father: Heart disease 0.8 1.0 3.6 1.4 1.3 0.2 -0.5 0.9 -0.2 1.9 -0.4 0.9 1.0 -1.1
Illnesses of siblings: Diabetes 0.6 0.7 3.1 0.5 0.4 -0.4 0.3 0.2 -1.3 -0.4 -0.5 1.8 0.1 -1.2
Smoking status: Previous 0.6 0.9 2.5 -0.3 -0.5 0.0 0.9 -1.6 -1.0 -1.0 1.2 -1.2 -0.9 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 2.4 5.0 16.6 2.3 2.0 2.0 2.2 2.9 -4.1 1.3 1.7 0.2 2.0 1.7
Whole body fat-free mass 1.9 10.9 23.7 4.9 4.2 2.5 0.5 3.9 -2.8 4.0 -1.3 2.6 4.4 2.2
Leg fat-free mass (right) 1.2 6.6 14.9 3.9 3.1 1.6 0.4 2.8 -1.8 3.4 -1.6 2.4 3.4 1.5
Arm fat percentage (left) 0.3 1.4 7.8 -0.3 -0.2 -1.5 -1.2 -0.5 2.8 0.3 -0.6 -0.6 -0.4 -1.4
Average weekly red wine intake 1.0 1.5 3.4 1.4 1.3 1.7 -0.0 1.0 -0.5 1.6 1.8 -0.9 1.2 0.8
Handedness (chirality/laterality): Left-handed 0.6 0.7 3.0 -0.6 -1.0 -0.5 0.3 -0.7 -1.7 -1.3 -0.7 0.4 -0.8 -0.1
Mood swings 0.4 0.7 2.6 -1.1 -1.0 -0.9 -1.2 -0.8 -0.2 -1.6 0.1 0.1 -0.5 0.6
Loneliness, isolation 0.4 0.6 3.0 0.1 0.1 -0.5 1.7 0.0 -0.1 -0.2 -1.0 1.4 0.5 0.0
Long-standing illness, disability or infirmity 0.1 0.2 0.6 -0.3 -0.2 -0.7 -0.2 0.2 -0.3 -0.2 -0.4 0.8 -0.3 -0.6
Ever had bowel cancer screening 0.3 0.4 0.9 0.6 0.6 0.6 -0.1 0.2 0.4 0.9 -0.8 0.4 0.5 -0.9
Diabetes diagnosed by doctor 2.3 3.8 9.5 2.9 3.1 2.3 0.5 1.5 -0.4 2.0 0.3 0.0 3.0 1.4
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 3.2 -1.3 -1.3 -1.6 1.2 -0.9 -1.4 -1.5 -1.0 1.8 -1.1 -0.9
Friendships satisfaction 1.5 1.8 3.5 1.5 1.5 1.3 1.6 0.8 -1.3 1.9 0.9 0.3 1.6 1.3
Qualifications: nursing, teaching 0.3 0.5 1.4 -0.2 0.3 0.8 1.2 0.6 1.2 0.3 0.8 -0.2 -0.3 -0.6
Commuting to job workplace: Walk 1.0 1.1 3.6 -0.9 -0.6 0.6 -1.9 -1.2 1.2 -0.8 0.3 -0.6 -0.6 1.4
Eye problems/disorders: Cataract 1.3 1.6 4.7 1.3 1.3 0.6 0.6 1.6 -2.2 1.2 1.8 -0.4 1.1 -0.0
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 3.6 -0.0 -0.0 -0.8 1.9 0.2 -0.2 -0.1 0.2 0.3 0.2 0.2
Medication for cholesterol 0.4 0.7 1.8 0.4 0.2 1.3 -1.3 0.3 -0.4 -1.1 0.9 -1.2 -0.1 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.8 4.9 -0.1 0.1 -0.7 1.3 0.9 -2.2 0.2 0.5 0.3 -0.2 -0.3
Back pain experienced in last month 1.5 2.1 5.6 -1.9 -2.0 -2.4 -0.7 -1.2 1.4 -1.5 -0.4 -0.4 -1.4 -1.2
Mineral and other dietary supplements 1.8 2.4 3.8 -1.8 -1.6 -1.8 1.1 -1.5 0.1 -2.0 -1.8 1.4 -1.5 -1.7
Breast cancer (self-reported) 0.3 0.4 2.3 0.6 0.4 -0.2 -1.5 0.2 -0.7 0.5 0.1 -0.2 0.4 -0.1
Asthma (self-reported) 0.2 0.3 1.1 -0.6 -0.4 -0.6 -0.2 -0.5 -0.4 1.0 0.2 0.5 -0.8 0.6
Osteoporosis (self-reported) 1.1 1.4 2.9 -1.1 -1.2 -1.2 -1.0 -1.3 0.3 -1.3 0.7 -0.9 -1.7 -1.6
Osteoarthritis (self-reported) 1.2 1.6 7.2 0.6 0.8 -0.4 2.7 0.9 -1.5 0.9 1.8 -0.9 0.6 -0.9
Medication: Aspirin 1.4 1.8 4.6 2.1 2.1 0.5 0.6 1.4 -0.5 1.3 -0.4 1.6 1.9 0.4
Medication: Gliclazide 0.9 1.1 2.6 1.6 1.6 1.6 -0.9 1.2 -0.2 0.3 0.7 -0.3 1.2 0.2
Illnesses of father: None of the above (group 1) 0.9 1.1 4.9 0.7 1.0 1.2 -0.2 0.8 -0.0 0.3 0.2 -1.2 1.4 2.2
Smoking status: Current 1.1 1.7 5.2 0.1 -0.0 -0.0 2.2 0.4 -1.4 1.0 -1.3 2.3 0.4 2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.5 6.9 1.8 2.3 2.4 0.6 2.6 -0.9 0.2 -0.3 1.3 1.7 0.1
Whole body water mass 1.9 10.7 23.3 4.8 4.1 2.4 0.5 3.9 -2.7 3.9 -1.5 2.7 4.4 2.2
Leg predicted mass (right) 1.3 6.8 15.2 3.9 3.2 1.6 0.4 2.8 -1.8 3.5 -1.7 2.4 3.4 1.5
Arm fat mass (left) 0.3 1.1 2.2 1.4 1.2 -0.5 -0.6 0.8 1.5 1.4 -1.1 0.5 1.1 0.0
Number of self-reported non-cancer illnesses 0.4 0.7 2.6 -0.5 -0.5 -1.4 0.1 -0.5 -0.6 -0.6 0.9 -0.4 -1.0 -1.6
Average weekly champagne plus white wine intake 0.4 0.6 2.4 0.4 0.6 -0.3 -1.6 1.1 -0.3 0.7 -0.2 0.3 1.1 -0.7
Miserableness 0.4 0.6 1.5 -0.4 -0.4 -1.2 -1.0 -0.3 1.1 -0.8 -0.9 0.1 -0.2 1.1
Guilty feelings 0.5 0.7 2.9 0.8 0.8 -0.5 -0.5 0.3 0.9 0.6 -1.7 1.0 1.0 -0.0
Wears glasses or contact lenses 0.9 1.1 4.1 0.1 0.2 -0.5 -0.1 -0.1 -0.8 -0.3 2.0 -2.0 -0.2 -1.6
Ever taken oral contraceptive pill 0.3 0.4 1.5 0.6 0.9 0.1 -0.1 0.2 -0.7 0.3 0.6 0.1 0.5 1.2
Hearing aid user 0.4 0.4 1.5 0.8 0.8 0.3 -0.1 1.0 0.2 0.3 0.4 0.5 1.2 0.2
Mother’s age at death 0.4 0.5 1.9 -0.3 -0.3 -0.6 1.4 0.7 -0.5 0.3 0.6 -0.9 -0.3 -0.6
Financial situation satisfaction 0.1 0.1 0.4 -0.2 -0.1 -0.6 0.3 -0.6 0.2 0.0 -0.1 -0.6 0.0 0.6
Tinnitus: Yes, now most or all of the time 0.6 0.7 3.1 0.1 0.2 -1.0 0.0 0.6 -0.0 0.4 -1.6 1.8 0.5 -0.3
Commuting to job workplace: Public transport 0.3 0.4 2.3 0.1 0.1 0.6 -0.5 -0.3 0.4 1.5 0.7 -0.7 0.3 -0.2
Eye problems/disorders: Glaucoma 0.7 0.9 3.5 1.1 1.2 0.1 1.1 0.6 -1.9 -0.1 -0.3 1.0 0.8 -0.5
Medication: Blood pressure 0.3 0.6 2.7 0.2 0.2 -1.6 1.1 0.0 -0.0 0.7 -0.7 1.2 0.1 -0.5
Pain type(s) experienced in last month: Hip pain 0.5 0.6 2.7 0.1 0.2 1.0 -1.6 0.7 0.5 -0.8 0.8 -0.7 0.2 0.0
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.6 0.5 0.4 0.6 -1.2 0.4 -0.1 0.7 1.3 -1.1 0.6 -0.1
High cholesterol (Self-reported) 0.4 0.7 1.7 0.8 1.0 -0.4 0.3 0.8 0.1 1.1 -1.2 1.3 0.7 0.9
Medication: Bendroflumethiazide 0.3 0.4 2.4 -0.2 -0.1 -1.2 0.4 -0.2 0.7 0.1 -0.4 0.1 -0.2 -1.6
Medication: Paracetamol 0.1 0.2 0.8 0.4 0.3 0.3 -0.4 0.6 0.1 -0.3 -0.3 0.4 0.6 0.9
Medication: Lisinopril 0.8 1.0 5.1 0.4 0.3 -0.7 -1.2 -0.4 2.3 1.1 0.1 -1.3 0.8 -0.3
Medication: Atorvastatin 0.4 0.5 1.0 1.0 0.9 0.2 -0.1 0.2 0.8 -0.8 -0.9 0.9 0.7 0.9
Illnesses of father: High blood pressure 0.7 0.8 4.2 -1.0 -1.0 -0.7 -0.2 -0.1 -0.4 -0.5 -1.1 2.0 -0.7 0.2
Alcohol drinker status: Never 0.7 0.9 3.7 -1.0 -0.8 -0.1 -0.0 -1.1 0.7 -1.9 -0.2 0.7 -1.5 -0.1
Ever smoked 0.7 1.3 5.4 -0.8 -0.9 0.2 1.6 -1.3 -2.3 -1.0 0.5 0.2 -1.2 -0.3
Basal metabolic rate 1.6 8.6 18.7 4.3 3.7 2.1 0.4 3.5 -2.3 3.6 -1.4 2.4 3.9 2.0
Leg fat percentage (left) 0.2 0.8 5.6 -0.2 -0.2 -1.1 -0.3 -0.5 2.4 0.1 0.1 -0.9 -0.7 -0.2
Arm fat-free mass (left) 2.2 11.0 23.7 4.9 4.2 2.6 0.4 4.1 -2.4 3.8 -1.2 2.5 4.4 3.0
Number of operations (self-reported) 1.8 2.6 6.6 -1.3 -1.1 -1.5 0.3 -2.6 1.5 -2.4 1.8 -1.9 -1.5 -0.6
Average weekly beer plus cider intake 1.7 2.4 5.6 -2.4 -2.0 -1.9 -0.8 -2.0 0.7 -1.7 0.3 -1.3 -1.6 -1.3
Irritability 0.7 1.1 4.1 -0.9 -1.0 -1.5 -0.5 -0.5 -0.7 -2.0 -1.3 0.8 -0.4 -0.9
Risk taking 0.6 0.8 2.1 -0.9 -0.7 -1.4 -0.3 -1.3 1.0 -0.8 -0.2 -0.4 -1.0 -1.1
Ever had prostate specific antigen (PSA) test 0.7 0.8 3.6 -0.6 -0.6 -0.4 -1.9 0.6 1.1 -1.0 0.4 -1.1 -0.0 -0.1
Fractured/broken bones in last 5 years 1.1 1.4 7.9 -0.5 -0.4 -0.7 -2.8 -0.8 1.4 0.4 -0.5 -0.7 -0.2 -1.7
Age started oral contraceptive pill 1.6 2.1 5.7 1.6 1.9 1.2 0.5 1.6 0.3 2.4 -1.0 1.4 1.7 0.0
Diastolic blood pressure, automated reading 0.3 0.9 2.6 -1.1 -0.8 -0.7 -0.1 0.1 1.4 -1.1 0.2 -0.1 -1.1 -1.6
Ever depressed for a whole week 1.5 1.8 6.6 -1.9 -1.7 -1.6 0.2 -2.6 0.7 -0.3 0.3 -0.6 -1.6 -1.0
Unable to work because of sickness or disability 0.5 0.7 2.0 -1.2 -0.9 -0.6 -0.5 -0.4 -0.0 -1.4 -0.5 0.9 -0.6 -1.0
Commuting to job workplace: Cycle 1.0 1.2 5.2 -0.2 0.0 0.1 -2.0 -1.4 2.3 0.1 -0.5 -0.2 0.3 1.4
Myopia 2.4 3.5 5.8 -2.3 -2.4 -2.0 -1.4 -1.7 1.3 -2.0 0.3 -1.5 -2.3 -2.3
Vascular/heart problems diagnosed by doctor 0.3 0.8 2.9 -1.0 -0.8 1.7 -0.8 -1.1 -0.0 -0.1 -0.1 -0.5 -0.5 1.4
Cholesterol lowering medication 0.6 0.9 5.5 1.1 1.2 -0.1 0.0 0.5 0.8 2.3 -0.2 0.8 0.6 0.2
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.4 -1.5 -1.1 -1.6 1.2 0.6 -0.6 0.5 -0.2 0.6 -1.0 -1.5
Pain experienced in last month 1.2 2.0 5.5 1.8 1.7 2.3 0.5 0.6 -1.2 2.0 0.8 -0.8 1.2 1.3
Supplements: Calcium 0.6 0.7 1.9 0.6 0.8 0.5 0.4 0.5 0.9 1.0 0.3 -0.6 1.3 1.4
Basal cell carcinoma (self-reported) 0.5 0.6 1.6 -0.2 -0.5 0.7 -1.3 -0.5 1.0 -0.8 0.6 -1.0 -0.8 -0.7
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.7 0.5 0.6 0.4 -0.6 0.3 1.3 -0.6 0.4 -0.5 0.2 -0.7
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.1 -1.5 -1.3 -0.9 0.2 -0.9 -1.3 -0.8 -0.2 0.5 -1.4 0.2
Heart disease (siblings) 0.4 0.5 1.5 1.2 1.0 0.7 -0.3 0.7 -0.5 0.6 0.5 0.2 0.9 0.5
Alcohol drinker status: Previous 0.7 0.7 2.4 0.4 0.6 -1.4 -0.3 -0.5 -1.3 -0.3 1.6 -0.7 0.7 -0.8
Pack years of smoking 0.1 0.2 0.8 0.1 0.1 -0.7 -0.4 0.1 0.3 0.5 -0.4 0.3 0.2 0.9
Impedance of whole body 0.8 3.8 7.8 -2.8 -2.4 -0.4 -0.7 -2.2 -0.3 -1.9 2.2 -2.4 -2.4 -1.8
Leg fat mass (left) 0.2 0.7 1.4 1.2 1.0 -0.3 -0.1 0.9 1.1 1.2 -0.7 0.4 0.7 0.3
Arm predicted mass (left) 2.2 11.4 24.6 5.0 4.3 2.8 0.6 4.1 -2.3 3.7 -1.4 2.6 4.5 2.9