Hub : Genes

ELOVL4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1130	0.0400	5.0e-04	0.126	NA	0.100	NA	0.107	2.0e-07	NA	3.9e-06	NA	1.8e-06
2	GTEx	Artery Tibial	0.1331	0.0388	1.9e-05	0.115	NA	0.099	NA	0.103	2.8e-09	NA	3.4e-08	NA	2.0e-08
3	GTEx	Cells Transformed fibroblasts	0.0910	0.0400	6.3e-03	0.047	NA	0.057	NA	0.060	2.0e-04	NA	4.2e-05	NA	2.8e-05
4	GTEx	Esophagus Mucosa	0.3490	0.0690	6.9e-08	0.101	NA	0.206	NA	0.102	3.1e-07	NA	7.8e-14	NA	2.5e-07
5	GTEx	Esophagus Muscularis	0.1650	0.0460	9.8e-06	0.054	NA	0.110	NA	0.103	3.4e-04	NA	3.4e-07	NA	8.5e-07
6	GTEx	Testis	0.3080	0.0760	2.0e-05	0.192	NA	0.154	NA	0.181	6.5e-09	NA	2.5e-07	NA	1.9e-08
7	METSIM	Adipose	0.0588	0.0187	5.4e-06	0.033	0.036	0.022	0.036	0.034	8.0e-06	3.6e-06	2.3e-04	3.2e-06	5.9e-06
8	ROSMAP	Brain Pre-frontal Cortex	0.0570	0.0242	4.6e-03	0.049	0.025	0.029	0.028	0.039	6.7e-07	2.6e-04	9.9e-05	1.3e-04	8.9e-06
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0376	0.0205	8.5e-03	0.005	0.011	0.002	NA	0.001	7.4e-02	2.0e-02	1.8e-01	NA	2.4e-01
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0900	0.0404	5.6e-03	0.036	0.006	0.021	NA	0.006	5.5e-05	5.7e-02	1.9e-03	NA	6.6e-02
11	TCGA	Thyroid Carcinoma	0.2280	0.0670	8.4e-07	0.004	0.079	0.058	NA	0.041	1.3e-01	3.7e-08	2.3e-06	NA	7.2e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.5	0.8	2.6	-0.1	0.1	-0.1	-1.2	-0.3	0.4	-0.3	1.6	-1.5	0.4	1.2
Bipolar Disorder or Schizophrenia	0.5	1.2	2.1	0.7	0.9	1.1	-0.7	-0.3	-1.4	1.4	1.4	-1.0	1.1	1.4
Depressed Affect (Nagel 2018)	0.3	0.5	2.1	0.6	0.6	-0.7	0.1	0.7	-0.3	-0.1	-0.7	0.8	1.0	1.4
Depression (Nagel 2018)	0.4	0.6	1.3	1.2	1.1	0.6	-0.0	0.9	-1.2	0.7	0.4	0.4	1.0	-0.2
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.2	0.1	0.2	0.8	0.4	0.2	0.5	-0.9	1.5	-1.5	-0.5	-0.4
Neuroticism (Nagel 2018)	0.2	0.4	1.0	0.2	0.2	-1.0	-0.2	0.3	-0.7	0.1	-0.8	1.0	0.5	0.9
Schizophrenia (2018)	0.7	1.4	4.6	1.1	1.1	1.6	0.1	-0.1	-2.1	2.0	0.5	-0.1	1.1	0.7
Schizophrenia vs Biploar Disorder	2.5	3.3	7.9	2.5	2.1	1.6	2.2	1.3	-1.2	2.8	-0.4	1.1	1.6	1.7
Worry (Nagel 2018)	0.2	0.4	2.2	-0.7	-0.5	-1.5	0.0	-0.6	-0.5	0.3	0.8	-0.1	-0.2	-0.4
Alzheimer’s Disease (in mother)	0.9	1.1	2.0	1.0	1.0	1.4	-0.9	0.7	-0.1	1.2	1.4	-1.3	0.9	1.0
Alzheimer’s Disease (in father)	1.5	1.6	3.9	-1.1	-1.2	-1.6	2.0	-1.3	-0.0	-0.3	0.7	-0.3	-1.9	-1.6
Alzheimer’s Disease (including proxy)	0.3	0.4	1.0	0.4	0.4	0.5	0.9	0.5	0.4	0.6	1.0	-0.9	0.1	-0.3
Crohns Disease (2017)	0.3	0.7	3.6	-0.5	-0.5	-1.1	-0.4	0.4	-0.6	-0.5	1.9	-1.1	-0.1	0.3
Irritable Bowel Disease (IBD)	0.2	0.5	1.6	-0.1	0.1	-0.3	-0.5	1.3	-0.8	-0.3	0.6	0.3	0.7	1.3
Ulcerative Colitis (UC)	0.4	0.7	2.1	0.0	0.3	0.2	-0.9	1.5	-0.9	-0.6	-0.3	1.1	0.8	1.3
Major Depression (MDD)	0.4	0.5	1.6	-0.3	-0.1	-0.3	0.0	-0.1	1.1	-1.0	-1.3	0.4	0.1	1.1
Reaction Time	0.5	0.9	3.0	-0.7	-0.7	0.6	1.7	-0.4	0.1	-1.2	1.0	-0.8	-0.7	1.5
Verbal and Numeric Reasoning (VNR)	0.3	0.6	2.0	-0.9	-0.6	-0.1	0.5	0.3	-0.9	-1.2	1.4	-0.8	-0.9	-0.1
Breast Cancer	1.1	2.7	8.1	-2.4	-2.3	-1.1	1.7	-1.0	-0.4	-2.9	-0.4	-0.2	-2.2	0.3
Ovarian Cancer	0.5	0.7	2.6	0.4	0.3	1.6	-0.5	0.6	-0.2	-0.2	1.4	-0.9	0.6	1.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.4	0.6	1.8	-0.2	-0.9	-0.3	-0.3	0.5	-1.0	-0.7	1.2	-0.8	-0.5	-1.3
Bipolar Disorder (2011)	1.0	1.0	2.4	-1.0	-0.9	-0.3	-1.3	-0.8	1.0	-1.3	-1.1	0.2	-0.1	1.6
Body Mass Index (BMI) (2010)	0.4	0.6	3.2	-0.1	-0.1	-0.7	-1.8	-0.6	1.3	-0.4	-0.0	-0.5	-0.4	-0.0
Coronary Artery Disease (CAD)	0.5	0.6	2.0	-0.9	-0.8	-1.0	-0.4	-0.3	-0.3	-1.4	0.1	0.9	-0.7	-0.2
Crohns Disease (2012)	0.4	0.6	1.9	0.3	0.1	-0.7	-0.5	1.0	-1.1	-0.1	1.4	-1.2	0.4	-0.1
Mean Putamen Volume	0.4	0.4	1.8	0.7	0.5	-0.0	1.3	0.7	-0.3	-0.3	-0.9	0.6	0.0	0.1
Fasting Glucose	0.8	1.0	2.6	-0.7	-0.1	-0.7	-1.5	-1.4	1.0	-1.3	-1.6	0.5	-0.4	0.2
HbA1C	0.9	1.0	3.6	-1.1	-0.8	-1.9	-1.5	-0.7	0.3	-1.4	-0.2	0.1	-0.3	0.8
HDL Cholesterol	0.2	0.3	1.2	0.5	0.6	0.0	0.4	-0.1	0.0	1.1	-0.6	0.6	0.4	-0.1
LDL Cholesterol	1.2	1.9	5.4	-0.8	-0.9	-1.9	-1.9	-0.6	2.3	-2.0	-0.1	-0.8	-0.9	-1.0
Lupus	0.7	1.1	5.5	-0.2	0.2	-1.1	0.3	0.5	0.7	-1.9	0.7	-0.3	-0.5	-2.4
Neuroticism (2016)	0.3	0.4	1.5	0.2	0.3	-1.2	-0.4	0.3	0.8	-0.2	-0.2	-0.4	0.6	-1.1
Primary Biliary Cirrhosis	0.2	0.3	1.5	-0.1	0.2	-0.3	-0.5	-0.0	1.2	0.2	0.7	-1.0	0.2	0.5
Rheumatoid Arthritis	0.5	0.7	3.9	-0.5	-0.3	-0.5	1.2	-0.3	-0.4	-0.0	-1.0	2.0	-0.4	0.6
Schizophrenia (2014)	1.0	2.1	4.1	1.1	1.2	1.8	-0.7	-0.7	-1.6	2.0	2.0	-1.2	1.3	1.8
Triglycerides	0.3	0.5	0.9	-1.0	-0.8	-0.3	-0.9	-0.7	0.8	-0.9	0.8	-0.4	-0.8	-0.3
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.4	1.1	1.3	-0.1	-0.6	1.6	-0.9	0.5	-0.2	0.5	1.3	0.1
Ulcerative Colitis	0.1	0.2	1.1	-0.2	0.2	0.3	-1.1	0.5	0.5	-0.5	0.2	0.3	0.2	-0.3
Blood Eosinophil Count	0.1	0.4	1.5	0.2	0.2	0.8	0.7	0.5	-1.1	0.4	-0.2	1.2	0.6	-0.3
Blood Platelet Count	0.2	2.0	5.1	-2.3	-2.2	-1.5	0.4	-1.4	-0.8	-1.9	-0.1	-0.1	-1.9	-0.5
Blood Red Count	0.0	0.4	1.6	0.0	0.0	-0.2	-0.3	-1.0	1.2	0.4	0.8	-1.3	-0.1	0.0
Blood White Count	0.1	1.0	4.3	-0.3	-0.2	-0.7	2.1	0.0	-1.8	0.5	0.6	0.8	0.3	-1.1
Heel T-Score	0.4	3.0	10.6	1.9	1.6	0.5	-2.0	2.2	0.3	3.3	-0.7	1.4	1.8	-0.8
BMI	0.2	1.3	8.8	0.2	0.2	-1.4	-1.1	0.4	3.0	-0.3	-1.5	0.5	0.2	-0.0
Height	2.1	40.6	79.4	8.1	7.2	6.4	1.4	6.7	-7.4	8.4	-2.5	4.8	8.9	2.7
Waist Hip Ratio (WHR)	1.7	7.7	39.4	2.5	2.1	2.3	2.5	2.2	-6.3	0.6	-1.3	2.8	2.1	1.9
Systolic Blood Pressure	1.0	5.1	11.4	3.3	3.1	1.4	2.0	3.4	-1.7	2.5	-0.2	1.4	2.4	1.1
Smoking Status	0.3	0.8	4.2	-0.1	-0.3	0.0	2.1	-0.6	-0.9	-0.6	-0.4	1.0	-0.1	1.3
Allergy or Eczema	0.5	1.3	2.5	1.1	1.5	1.3	-1.1	1.0	0.6	0.3	1.5	-0.9	1.6	0.9
Cardiovascular Disease	0.2	0.8	2.6	1.2	1.1	-1.6	-0.2	1.4	-0.7	-0.1	0.6	0.4	0.8	0.0
Hypothyroidism (self reported)	1.2	2.8	6.0	-1.8	-1.5	-0.4	-0.1	-2.5	2.1	-1.3	1.3	-2.4	-2.2	-0.9
Respiratory disease	0.2	0.5	1.2	-1.0	-0.6	-0.8	-1.1	-0.7	-0.2	-0.1	-0.3	0.3	-0.5	-1.1
Type 2 Diabetes (T2D) (2018)	2.6	4.9	11.2	3.3	3.3	2.5	0.3	2.5	-0.8	1.2	-0.5	1.2	3.3	2.2
Lung FEV1/FVC ratio	0.5	2.4	6.0	1.9	2.2	1.9	0.1	2.4	-0.6	0.8	1.4	-0.1	2.5	0.3
Lung FVC	0.7	3.5	6.6	2.2	2.4	2.2	1.8	2.6	-0.8	0.9	-2.0	2.0	1.7	1.3
Neuroticism	0.2	0.5	3.1	-0.7	-0.6	-1.8	-0.1	-0.4	-0.1	-0.7	0.7	-0.9	-0.2	0.1
Chronotype (morning person)	0.2	0.6	2.1	0.8	0.6	-0.0	0.7	0.3	-0.8	0.2	-1.0	1.4	0.6	0.6
Hair Pigment	0.1	2.1	5.1	2.3	1.8	1.4	0.1	1.2	-0.1	2.2	-1.3	0.5	1.9	0.8
Tanning	0.2	2.2	5.2	-1.1	-1.0	-0.8	-2.3	-2.0	1.9	0.6	1.2	-2.2	-0.7	-0.9
Hand grip strength (left)	0.9	2.5	6.1	1.8	1.6	1.0	-0.3	1.5	0.2	2.5	-2.0	1.6	1.9	1.3
Number of treatments/medications taken	0.4	0.8	1.7	1.0	1.1	-0.4	-0.9	1.2	0.1	1.3	-0.6	0.5	1.3	-0.1
Average weekly spirits intake	1.0	1.3	7.3	-0.5	-0.6	-1.3	-1.2	-0.8	2.7	-0.7	-1.0	0.3	-0.5	-1.0
Sensitivity / hurt feelings	0.1	0.2	0.9	-0.6	-0.5	-0.9	-0.1	-0.2	-0.3	0.2	-0.2	0.0	0.0	0.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.4	0.1	-0.0	0.3	0.1	-0.7	-1.1	-1.2	-0.1	0.6	-0.1	-0.2
Hearing difficulty/problems: Yes	3.0	4.6	10.7	-2.5	-2.7	-2.9	-0.6	-3.3	2.2	-1.8	-1.5	0.9	-2.5	-0.8
Relative age of first facial hair	0.3	0.6	3.3	0.6	0.4	-0.1	-1.8	-0.4	1.0	0.4	0.1	-0.0	0.3	1.3
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	4.3	-0.9	-0.5	-0.5	-0.1	-0.2	-0.2	-1.3	2.1	-1.0	-1.2	-0.8
Ever used hormone-replacement therapy (HRT)	2.2	2.8	10.1	2.1	2.1	1.0	1.7	1.8	-0.1	3.2	0.7	-0.1	2.0	-0.4
Ever had hysterectomy (womb removed)	0.8	0.9	4.6	0.2	0.0	-0.1	0.1	-0.4	-0.1	-1.2	2.1	-1.8	-0.4	-0.1
Systolic blood pressure, automated reading	0.6	1.8	4.1	1.6	1.8	0.4	0.7	1.5	0.9	2.0	-1.3	1.6	1.2	-0.8
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.8	-0.4	-0.3	-0.4	-1.4	-0.7	-0.1	-0.7	0.8	-1.0	-0.4	-0.7
Angina	0.4	0.6	2.2	0.7	1.0	0.4	-1.5	0.2	0.4	0.1	0.2	-0.4	0.6	1.1
Medication for hormone replacement therapy	1.8	2.0	3.9	-2.0	-1.8	-1.6	1.3	-1.3	0.4	-0.8	1.5	-1.3	-1.4	-1.4
Vitamin and mineral supplements	1.4	1.8	7.0	0.9	0.7	0.8	1.3	1.1	-2.2	0.2	-1.8	2.6	0.3	0.3
Supplements: Zinc	0.3	0.3	1.2	-0.3	-0.2	0.1	0.9	0.5	-1.1	-0.4	-0.6	0.9	-0.2	0.1
Medication: Co-codamol	0.2	0.3	0.7	-0.6	-0.5	-0.6	-0.9	-0.2	0.4	-0.7	0.0	-0.5	-0.4	0.2
Medication: Metformin	3.4	4.8	11.2	3.4	3.1	2.1	1.7	2.1	-1.4	2.0	-0.4	1.2	2.9	2.0
Diabetes (father)	0.7	0.8	4.0	0.7	0.5	-0.2	0.6	0.9	-1.1	0.8	-0.7	2.0	0.9	0.1
Diabetes (mother)	0.9	1.1	5.1	0.5	0.4	-0.2	-0.9	0.9	-0.2	0.5	2.2	-1.9	0.6	0.7
Severe depression (siblings)	0.4	0.4	1.6	0.3	0.6	0.7	-0.7	0.6	1.3	0.3	-0.5	0.1	0.7	-0.7
Pack years adult smoking proportion	0.2	0.3	1.9	-0.0	-0.0	-0.8	0.1	-0.1	-0.0	0.5	-0.4	0.5	0.0	1.4
Impedance of leg (right)	0.6	2.7	5.7	-2.4	-2.0	0.1	-0.2	-1.4	-0.9	-1.7	2.4	-2.0	-2.1	-0.8
Leg fat-free mass (left)	1.3	6.7	14.7	3.8	3.2	1.5	0.2	2.9	-1.7	3.6	-1.7	2.5	3.5	1.2
Trunk fat percentage	0.2	0.9	3.8	-0.0	0.0	-0.9	-1.0	-0.4	2.0	0.6	0.5	-1.4	-0.3	-1.2
Hand grip strength (right)	1.2	3.2	6.6	1.9	1.7	1.5	-0.1	1.5	1.3	1.9	-2.6	2.3	2.3	1.3
Townsend deprivation index at recruitment	2.0	2.8	7.5	-2.4	-2.4	-1.3	0.7	-1.9	-0.9	-2.7	0.1	0.3	-2.2	-0.2
Current tobacco smoking	0.8	1.3	4.1	-0.5	-0.6	-0.4	2.0	-0.1	-1.4	0.5	-0.8	1.8	-0.3	1.9
Average weekly fortified wine intake	0.9	1.1	5.8	-1.1	-0.7	-0.8	0.4	-0.7	-2.4	-0.5	-0.5	0.9	-0.9	-1.1
Maternal smoking around birth	0.2	0.4	1.6	0.3	0.2	1.3	-0.1	0.5	-0.2	-0.7	0.7	0.1	0.7	-0.6
Fed-up feelings	0.3	0.5	1.4	0.1	-0.1	-0.4	1.2	0.0	-1.0	-0.9	0.8	-0.5	0.2	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.8	-0.0	-0.1	-0.3	0.4	-0.4	-0.5	-0.3	-0.0	0.4	-0.4	-1.3
Relative age voice broke	0.3	0.4	1.9	0.4	0.3	0.6	-0.6	0.8	0.1	0.3	-0.3	0.7	0.2	1.4
Taking other prescription medications	0.3	0.5	2.5	-0.5	-0.5	-0.6	-0.8	-0.5	-0.0	-0.5	0.5	0.1	-0.6	-1.6
Age when periods started (menarche)	0.7	1.7	6.2	-1.6	-1.6	-1.0	-0.2	-2.5	0.7	-0.7	-0.2	-0.8	-1.6	-1.4
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.3	0.7	0.6	-0.5	1.5	-1.5	1.0	0.4	1.2	-0.5	0.3	0.1
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.6	9.9	3.0	2.8	2.4	-1.7	2.6	1.0	2.7	-0.2	0.5	3.1	-0.3
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	3.6	1.0	0.9	1.0	-0.2	-0.0	1.7	1.3	1.9	-1.7	0.9	1.0
Qualifications: CSEs or equivalent	0.4	0.6	1.8	-0.2	-0.5	-1.1	-0.4	0.6	0.1	-1.2	0.8	-0.5	-0.3	1.4
Serious illness, injury or assault to yourself	1.0	1.2	2.8	1.1	1.2	1.3	-1.3	1.7	1.3	-0.6	0.9	-0.5	0.8	-0.1
High blood pressure	0.3	0.8	4.7	0.5	0.3	-2.2	0.9	0.5	0.0	-0.3	0.1	0.4	0.0	-1.6
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.5	0.5	0.8	1.0	-0.3	1.1	-0.8	-0.2	1.2	-0.3	1.0	1.1
Multivitamins +/- minerals	0.9	1.2	3.5	0.9	1.1	0.5	-0.2	0.7	0.6	1.4	1.8	-1.9	1.2	-0.1
Stomach or abdominal pain in last month	0.4	0.5	1.5	-0.7	-0.5	-1.1	0.4	-0.4	0.3	-1.2	-0.3	0.4	-0.5	-0.8
Supplements: Glucosamine	1.3	1.7	6.5	1.3	1.2	1.2	0.5	1.5	0.1	1.9	0.4	-0.1	1.3	2.5
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	3.8	0.5	0.5	-0.5	0.6	-0.3	0.7	-0.2	1.9	-1.4	0.4	0.6
Medication: Atenolol	0.6	0.7	1.7	1.2	1.1	-0.7	0.5	0.4	-0.2	1.3	-0.7	1.0	0.9	0.4
Medication: Levothyroxine sodium	0.7	1.2	3.6	-0.9	-0.9	-0.0	-0.4	-1.1	1.6	-0.6	0.3	-1.3	-1.3	-1.9
Sitting height	6.6	46.7	98.8	9.7	8.6	6.6	0.4	7.6	-5.2	9.6	-2.2	4.0	9.9	2.4
Chronic bronchitis/emphysema (father)	0.9	1.0	6.1	0.1	-0.6	-1.0	2.5	-0.2	-1.5	-0.7	-0.2	0.8	-0.2	-0.3
High blood pressure (mother)	0.3	0.4	2.0	0.4	0.8	-0.3	0.5	0.6	0.5	1.4	-0.0	-0.3	0.8	0.4
Body mass index (BMI)	0.2	1.0	5.1	0.7	0.7	-1.2	-0.5	0.5	2.3	0.8	-1.2	0.5	0.5	0.1
Impedance of leg (left)	0.6	2.8	5.5	-2.3	-2.0	0.5	0.1	-1.5	-0.9	-2.1	2.2	-2.1	-2.1	-0.1
Leg predicted mass (left)	1.3	7.1	15.5	3.9	3.3	1.5	0.3	3.0	-1.7	3.8	-1.7	2.4	3.5	1.2
Trunk fat mass	0.2	0.9	3.0	1.4	1.3	-0.1	-0.5	0.8	0.9	1.7	0.0	-0.4	1.1	-0.4
Waist circumference	0.9	3.2	8.7	3.0	2.7	0.9	0.8	2.2	-1.0	2.3	-0.5	0.8	2.2	0.6
Number of incorrect matches in round	0.2	0.4	1.1	0.4	0.6	0.9	-1.0	-0.1	-1.0	0.6	0.0	-0.1	0.4	0.3
Past tobacco smoking	0.4	0.8	2.5	0.1	0.4	-0.3	-1.6	1.3	1.6	0.8	-0.7	0.3	0.7	0.2
Alcohol usually taken with meals	0.9	1.5	2.8	1.7	1.6	1.0	0.1	1.4	-0.1	0.9	1.6	-1.5	1.4	0.7
Nervous feelings	0.4	0.7	2.7	-0.8	-0.6	-0.8	-0.1	-1.1	0.5	0.5	1.7	-1.1	-0.1	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	0.4	0.3	-0.7	1.0	-0.2	-0.8	-0.2	0.7	0.1	0.6	-0.4
Hearing difficulty/problems with background noise	0.4	0.6	2.6	-0.2	-0.1	-0.8	-0.2	-1.2	1.0	-0.1	-1.6	0.4	0.2	0.5
Hair/balding pattern: Pattern 2	0.3	0.3	1.3	-0.1	0.1	-1.1	0.1	1.1	-0.2	0.5	0.8	-0.3	-0.1	-0.5
Had menopause	0.3	0.4	1.5	-0.3	-0.2	-0.4	1.2	-0.3	-1.1	0.8	-0.2	0.3	-0.1	-0.8
Had other major operations	2.6	3.1	6.5	-1.7	-1.9	-2.3	-0.2	-2.6	1.2	-1.8	1.9	-1.3	-2.4	-0.8
Forced vital capacity (FVC)	1.3	5.1	10.4	2.8	2.7	3.2	0.8	3.1	-2.5	1.4	-0.5	1.4	2.6	1.9
Heel bone mineral density (BMD) T-score, automated (right)	2.6	6.0	16.2	3.2	3.1	2.5	-1.9	2.6	1.1	4.0	-0.2	0.4	3.3	0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.8	-0.1	0.0	-0.6	1.7	-0.1	-0.7	0.6	-0.6	1.3	-0.4	-1.3
Qualifications: None of the above	0.5	1.0	4.3	-0.5	-0.8	-1.4	-0.4	-0.4	0.2	-1.0	-2.1	1.6	-0.2	0.4
Financial difficulties in last 2 years	0.6	0.8	3.4	-0.6	-0.6	-0.4	0.7	-0.1	-0.6	0.1	-1.9	1.5	-0.5	-0.9
Mouth/teeth dental problems	0.8	1.2	4.7	-1.5	-1.4	-0.4	-1.6	0.1	1.0	-2.2	-0.0	-0.4	-1.0	-0.4
Heart attack	0.3	0.4	1.0	0.5	0.6	0.3	-0.5	0.4	1.0	-0.6	0.6	-0.5	0.2	-1.0
Allergy	0.3	0.7	3.6	-0.1	-0.3	-0.4	-0.3	-0.8	1.5	-0.6	-0.6	-0.1	-0.5	-1.9
Pain all over the body in last month	0.4	0.5	1.0	1.0	0.6	0.5	0.3	0.2	0.6	0.9	0.9	-0.9	0.4	-0.6
Diabetes (self-reported)	1.6	2.5	6.2	2.4	2.5	1.7	0.7	1.1	-0.0	1.0	-0.4	0.3	2.5	1.8
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.8	0.4	0.7	0.4	-1.2	-0.3	-0.5	0.1	1.7	-1.7	0.5	-0.1
Medication: Ramipril	0.6	0.7	2.1	0.0	0.2	-1.5	1.1	-0.7	0.9	-0.4	0.5	-1.1	-0.5	-1.2
Medication: Simvastatin	0.8	1.2	3.8	0.9	1.4	0.4	0.5	1.5	0.2	2.0	-0.9	1.3	1.1	0.2
Fluid intelligence score	0.2	0.4	1.4	0.5	0.7	0.7	1.2	0.8	-0.7	0.4	-0.1	0.3	0.4	0.0
Illnesses of siblings	0.7	1.0	3.8	0.1	0.2	1.7	-1.4	0.2	1.1	0.4	0.6	-1.9	0.6	0.8
Neuroticism score	0.2	0.4	1.1	-0.5	-0.4	-1.0	-0.8	-0.2	0.1	-0.6	0.7	-1.0	0.1	0.1
Weight	0.8	4.1	10.1	3.2	2.8	0.9	0.1	2.5	-0.6	2.9	-0.9	1.3	2.8	1.0
Impedance of arm (right)	0.7	3.5	7.7	-2.8	-2.3	-0.7	-0.5	-2.1	-0.7	-1.7	1.3	-1.8	-2.1	-2.7
Arm fat percentage (right)	0.3	1.1	6.1	-0.1	-0.0	-1.3	-0.9	-0.2	2.5	0.4	-0.9	-0.3	-0.2	-1.5
Trunk fat-free mass	2.4	13.8	28.8	5.4	4.7	3.1	0.7	4.5	-3.5	4.2	-1.4	3.0	4.9	2.5
Hip circumference	0.2	0.7	1.9	1.3	1.1	-0.5	0.2	1.2	0.4	1.4	0.2	0.2	0.7	0.4
Time employed in main current job	0.1	0.2	0.9	0.1	0.1	0.0	-0.8	-0.1	-0.1	0.3	0.0	-0.2	0.4	-1.0
Alcohol intake versus 10 years previously	0.5	0.7	2.4	0.5	0.2	0.0	-1.4	0.3	0.2	-0.6	1.6	-1.5	0.1	-0.5
Father’s age at death	1.5	2.0	4.0	-1.6	-1.7	-0.9	-1.3	-1.0	0.3	-1.5	2.0	-1.7	-1.4	-1.2
Worrier / anxious feelings	0.4	0.8	2.9	-0.5	-0.3	-0.4	-1.7	-1.4	0.5	-0.0	0.6	-1.2	-0.2	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.7	-0.3	-0.4	-1.2	1.3	-1.1	-0.9	-0.1	0.7	-0.4	-0.5	-0.1
Falls in the last year	0.7	0.9	3.3	-0.8	-0.8	-1.4	0.7	-0.6	-0.6	-0.2	-1.4	1.8	-0.6	0.5
Hair/balding pattern: Pattern 3	0.6	0.9	3.0	1.1	1.1	1.7	0.5	-0.0	0.0	0.5	1.3	-1.1	0.9	0.6
Number of live births	1.7	2.4	8.2	-1.9	-1.8	-1.6	-0.8	-2.0	-0.4	-1.7	0.6	-0.3	-2.9	-0.8
Forced expiratory volume in 1-second (FEV1)	1.3	4.3	11.7	2.5	2.6	3.4	0.3	2.8	-1.8	0.6	-0.2	1.0	2.5	1.6
Pulse rate	1.5	2.5	7.6	-1.8	-1.7	-1.6	-0.1	-1.8	0.2	-0.9	1.1	-1.8	-1.6	-2.8
Happiness	0.9	1.1	2.2	1.0	1.1	0.9	0.9	0.2	-1.4	1.5	1.4	-0.5	1.1	0.3
Noisy workplace	1.7	2.1	6.3	-1.5	-1.4	-0.8	1.4	-0.8	-0.6	-1.3	-2.5	2.4	-0.7	-0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	0.3	1.0	0.2	0.1	0.5	-0.8	1.1	-0.3	0.3	0.8	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.1	0.5	0.2	-0.7	1.0	-0.4	-0.0	-0.2	-0.6	0.3	0.4	-1.0
Mouth/teeth dental problems: Dentures	0.5	0.9	4.4	0.3	0.2	-0.5	1.9	-0.1	-2.1	0.6	-0.0	1.0	0.2	-0.3
Asthma	0.2	0.5	1.1	-0.7	-0.5	-0.9	-0.0	-0.5	-0.5	1.0	0.2	0.6	-0.9	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.1	0.7	0.7	1.4	-1.3	0.8	1.2	-0.4	0.3	-1.2	0.5	-0.2
Medication: Cholesterol lowering	0.9	1.4	4.4	1.5	1.9	0.3	0.2	2.1	0.4	0.4	-0.1	0.2	2.0	0.7
Depression (self-reported)	0.3	0.4	1.2	0.6	1.1	0.6	-0.1	0.8	-0.4	0.1	-0.3	0.8	1.1	0.1
Medication: Lansoprazole	0.3	0.3	0.9	-0.4	-0.6	-0.2	-0.8	-0.8	0.7	0.3	-0.6	0.9	-0.4	-0.2
Prospective memory result	1.3	1.6	4.2	-1.2	-1.2	-1.5	1.1	-2.1	-0.4	-1.8	-1.2	0.7	-1.1	-0.9
Lung cancer (father)	2.1	2.5	5.2	2.3	2.2	1.2	-1.9	1.3	1.0	1.1	1.6	-2.0	1.4	0.4
Illnesses of mother	1.1	1.3	3.3	-1.7	-1.8	-0.3	-0.2	-1.2	-0.4	-1.7	-0.7	-0.1	-1.8	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	2.6	8.2	20.4	3.4	3.7	4.5	0.4	4.0	-2.5	1.3	-0.3	1.7	3.7	2.0
Pulse wave Arterial Stiffness index	0.5	0.6	1.7	-1.0	-1.3	-1.1	-0.4	0.0	0.1	-0.2	0.1	0.3	-1.2	-1.0
Impedance of arm (left)	1.0	4.7	9.0	-3.0	-2.6	-1.0	-1.0	-2.5	0.3	-1.8	1.9	-2.4	-2.5	-3.0
Arm fat mass (right)	0.2	1.0	1.9	1.3	1.2	-0.5	-0.5	0.9	1.2	1.4	-1.4	0.8	1.1	0.0
Trunk predicted mass	2.4	13.7	29.3	5.4	4.7	3.0	0.6	4.5	-3.4	4.2	-1.4	2.9	4.9	2.5
Standing height	1.9	19.2	41.5	5.8	5.1	4.7	1.2	4.7	-6.4	5.0	0.2	2.2	5.5	2.3
Length of working week for main job	0.8	0.9	4.7	0.5	0.5	-0.5	-0.3	0.0	0.1	-0.3	-2.2	1.8	0.5	0.9
Exposure to tobacco smoke at home	0.3	0.3	1.6	0.2	-0.1	-0.0	1.3	0.4	-0.1	-0.4	-0.6	0.8	-0.2	0.6
Breastfed as a baby	0.8	1.0	3.4	0.5	0.8	1.1	1.5	0.1	-0.6	0.4	1.6	-1.8	0.6	0.3
Tense / ‘highly strung’	0.4	0.7	2.0	-1.1	-0.9	-1.2	0.4	-1.4	-0.2	-0.4	0.6	-0.3	-1.0	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	0.3	0.6	-0.1	0.0	-0.2	-1.0	-0.4	0.1	0.8	0.7	0.5
Hair/balding pattern: Pattern 4	0.5	1.1	2.4	-1.0	-1.1	-0.7	0.9	-1.3	-1.1	-0.9	-1.1	1.6	-1.0	0.5
Birth weight of first child	0.6	1.1	4.4	-0.4	0.1	-0.3	-2.1	0.2	0.3	0.0	1.1	-1.5	0.4	-2.0
Peak expiratory flow (PEF)	0.6	1.3	2.7	1.2	1.3	1.1	1.1	1.5	-1.4	0.6	0.1	0.9	1.0	1.6
Pulse wave reflection index	0.4	0.5	1.4	0.2	-0.2	0.2	-0.6	1.2	0.9	0.4	0.7	-0.6	-0.5	-1.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.2	-0.9	-1.2	-1.2	0.3	-0.1	-0.5	-1.5	0.6	0.1	-0.9	-0.2
Loud music exposure frequency	0.7	0.7	2.7	0.4	0.4	0.2	0.2	0.6	-1.5	0.5	-1.0	1.6	1.0	0.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.1	-0.2	0.1	0.3	0.7	0.2	-0.5	0.3	-1.0	1.1	0.2	0.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.9	0.2	0.2	0.0	-0.5	-1.4	0.2	1.0	-0.2	0.0	-0.2	0.0
Blood clot in the leg (DVT)	0.4	0.6	2.1	-1.0	-0.9	-0.3	-0.0	-0.5	-1.4	-0.3	-0.6	0.8	-1.0	0.2
Medication: Paracetamol	0.2	0.4	1.7	0.3	0.3	0.7	-0.4	0.3	-0.8	-0.5	1.3	-0.7	0.2	0.5
Headache pain in last month	0.5	0.8	2.6	-1.1	-0.8	-0.5	0.7	-1.3	-0.5	-1.6	0.4	-0.4	-1.1	-0.3
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	3.4	-1.4	-1.4	0.2	0.1	-1.8	-1.3	-0.8	-0.1	0.8	-1.6	-0.1
Glaucoma (self-reported)	1.0	1.2	5.1	0.9	1.1	0.2	1.6	0.5	-2.3	0.2	-0.2	1.4	0.8	0.4
Gout (self-reported)	2.0	2.7	5.4	2.3	2.3	2.3	-0.8	2.2	0.1	1.2	-0.6	1.2	1.5	1.8
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	4.5	-1.8	-1.6	-0.9	-0.1	-2.1	1.2	-1.5	0.5	-1.4	-2.1	-1.9
Medication: Amlodipine	0.8	1.1	2.5	1.2	0.8	-0.3	1.3	1.1	-0.4	1.6	0.1	0.6	1.3	-1.3
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.2	-0.2	-0.1	-0.5	-0.6	0.4	-0.1	0.5	1.1	-0.9	0.2	-0.5
Birth weight	0.8	1.8	4.0	1.6	1.6	0.7	-0.2	1.4	-1.0	1.7	2.0	-1.3	1.7	0.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	6.1	-0.8	-1.1	-1.5	-1.0	-1.4	2.5	-0.7	-0.2	-0.5	-0.6	-0.9
High blood pressure (siblings)	0.5	0.7	3.0	-0.0	-0.0	-1.2	1.7	0.5	-0.7	-0.0	-0.5	1.4	-0.2	-0.6
Forced vital capacity (FVC), Best measure	2.7	9.7	19.3	3.8	4.0	4.4	1.1	4.3	-2.7	1.9	-0.9	2.0	3.9	2.5
Body fat percentage	0.3	1.0	5.6	-0.2	-0.1	-1.1	-1.1	-0.5	2.4	0.5	0.2	-1.2	-0.5	-1.1
Leg fat percentage (right)	0.3	1.0	5.1	-0.5	-0.4	-1.6	-0.5	-0.5	2.2	0.1	0.3	-1.1	-0.9	-0.8
Arm fat-free mass (right)	1.9	9.6	21.7	4.7	4.1	2.5	0.2	3.7	-2.2	3.6	-0.9	2.0	4.2	2.6
Exposure to tobacco smoke outside home	2.1	2.8	7.6	-2.5	-2.8	-1.4	1.5	-1.2	0.4	-2.0	-1.4	0.6	-1.9	-0.8
Comparative body size at age 10	1.8	4.9	13.6	2.7	2.4	1.5	-0.8	2.0	1.0	3.7	-2.2	2.0	2.5	2.2
Number of full brothers	3.2	4.1	10.4	-2.4	-2.2	-1.9	-0.6	-2.7	1.7	-3.2	0.3	-1.0	-2.7	-1.1
Worry too long after embarrassment	1.4	2.3	5.1	1.5	1.7	1.7	0.2	2.2	-1.3	1.0	1.2	-0.4	2.3	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.4	1.2	1.6	1.2	-0.4	1.1	-1.4	1.3	1.1	0.3	1.2	-0.0
Wheeze or whistling in the chest in last year	0.9	1.7	4.6	1.3	1.5	0.6	-0.4	1.4	-0.9	2.2	-1.1	1.6	1.5	0.1
Number of children fathered	1.0	1.2	2.8	1.2	1.1	0.3	0.1	1.6	0.4	1.2	-1.7	1.2	1.3	0.4
Reason for reducing amount of alcohol drunk: Health precaution	2.5	3.0	6.1	1.9	1.8	1.7	0.2	1.8	-2.1	2.5	-1.2	2.0	1.8	0.8
Age at first live birth	0.5	0.8	6.5	-0.4	-0.1	0.5	0.1	0.4	-0.7	0.3	0.9	-0.8	-0.2	-2.5
Pulse wave peak to peak time	1.0	1.2	3.2	1.5	1.8	1.5	0.4	0.4	-0.6	0.6	-0.0	-0.2	1.7	1.3
Health satisfaction	0.4	0.5	3.0	-0.2	-0.0	0.1	-0.7	-0.4	-0.7	0.6	0.7	-0.0	0.4	1.7
Shortness of breath walking on level ground	0.6	0.7	2.2	-0.8	-0.8	-1.3	1.5	0.3	-1.0	-1.1	0.6	-0.2	-0.1	0.3
Qualifications: College or University degree	0.2	0.5	1.2	-0.3	0.2	1.0	-1.1	-0.7	0.1	-0.6	0.8	-1.0	-0.2	-0.7
Eye problems/disorders: None of the above	0.6	0.7	2.8	-0.8	-1.0	0.1	-1.2	-0.7	1.7	-0.4	-1.0	0.3	-0.6	0.4
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.3	0.9	0.7	1.1	-0.3	0.8	-0.0	1.5	-1.2	1.0	0.7	1.4
Emphysema/chronic bronchitis	0.3	0.4	2.8	-0.6	-0.3	-0.0	-1.7	-0.3	-0.4	0.2	0.3	-0.4	-0.1	-0.2
Medication for pain relief, constipation, heartburn	0.1	0.2	0.6	-0.3	-0.3	-0.2	0.6	-0.8	0.7	0.6	-0.6	-0.2	0.1	-0.1
Neck or shoulder pain in last month	0.4	0.5	1.7	0.4	0.4	-0.1	0.3	0.6	-0.7	1.2	-1.0	1.3	0.7	-0.1
Medication: Blood pressure	0.4	0.7	2.0	0.8	0.7	-0.7	0.4	0.6	1.4	0.6	0.1	-1.2	0.8	-1.0
Angina (self-reported)	0.5	0.7	2.0	0.9	1.2	0.6	-1.3	0.6	0.2	0.2	0.3	-0.3	0.9	1.4
Migraine (self-reported)	0.1	0.1	0.4	-0.2	-0.0	0.1	-0.4	-0.2	0.4	0.5	0.6	-0.7	-0.4	-0.1
Medication: Ibuprofen	0.4	0.4	2.0	0.0	0.2	0.7	-0.9	0.4	1.4	-0.3	0.1	-1.1	0.1	-0.2
Medication: Allopurinol	4.3	5.7	13.2	3.5	3.6	2.9	-0.9	3.1	-0.2	2.1	-1.0	1.0	2.6	2.3
Medication: Omeprazole	0.6	0.7	2.0	-1.3	-0.9	-1.2	0.4	1.0	-0.6	0.1	0.0	0.1	-0.6	-1.4
Medication: Seretide 50 evohaler	1.9	2.2	6.1	-2.1	-2.0	-2.5	-0.7	-0.9	0.5	-0.6	-1.2	-0.0	-1.5	-2.0
Mean time to correctly identify matches	0.2	0.5	2.9	0.1	0.0	0.6	1.7	0.1	-0.2	-0.0	0.8	-0.5	-0.2	0.8
Heart disease (mother)	2.9	3.5	6.5	2.5	2.2	1.5	1.7	2.5	-1.2	1.9	-0.7	2.4	2.1	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.4	-0.1	0.2	0.8	1.6	-0.4	0.9	0.2	1.4	-1.1	-0.2	0.4
Whole body fat mass	0.2	0.9	2.5	1.4	1.3	-0.2	-0.6	0.8	1.2	1.6	-0.5	-0.0	1.1	0.1
Leg fat mass (right)	0.2	0.6	1.4	1.0	0.9	-0.6	-0.3	0.9	1.1	1.2	-0.6	0.2	0.6	-0.0
Arm predicted mass (right)	2.3	11.7	25.5	5.0	4.4	2.7	0.5	4.1	-2.7	3.9	-1.0	2.4	4.6	3.1
Pulse rate, automated reading	0.7	2.3	4.8	-1.5	-1.5	-1.7	-1.4	-2.2	1.5	-0.5	0.8	-1.8	-1.3	-2.0
Alcohol intake frequency.	1.5	3.5	6.7	-1.4	-1.4	-2.5	0.2	-2.1	0.3	-2.6	2.4	-1.6	-2.0	-2.0
Comparative height size at age 10	1.3	7.0	15.8	3.5	3.3	2.3	0.4	3.0	-4.0	2.4	-0.5	2.1	3.6	0.5
Number of full sisters	1.6	2.0	5.8	-2.1	-2.1	-0.4	0.3	-0.8	-1.8	-1.5	0.6	0.3	-2.4	-0.6
Suffer from ‘nerves’	0.3	0.4	2.0	-0.5	-0.3	-0.7	-0.8	0.1	-0.4	0.3	1.4	-0.7	0.2	-0.6
Overall health rating	0.2	0.4	2.0	0.0	-0.0	-0.8	0.6	0.1	-1.1	-0.1	-0.4	1.4	0.4	0.2
Chest pain or discomfort	1.0	1.4	4.3	1.0	1.2	-0.3	0.5	0.9	-0.6	2.1	-1.5	1.5	1.7	0.7
Had major operations	0.3	0.3	0.7	0.5	0.5	0.4	0.7	-0.6	0.8	-0.7	-0.8	0.2	0.3	0.3
Age at last live birth	0.6	0.9	3.1	0.6	0.6	0.4	1.3	0.7	-1.5	0.6	1.2	0.0	0.2	-1.8
Family relationship satisfaction	0.9	1.1	3.1	1.4	1.5	1.6	-0.3	0.3	-0.1	1.8	0.7	-0.4	1.3	0.0
Leg pain on walking	0.4	0.5	4.7	0.0	0.1	-0.5	2.2	-0.6	-0.0	-0.3	0.5	-0.3	-0.0	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.5	-0.3	-0.6	-0.1	1.2	0.3	-0.8	-0.1	0.0	0.4	-0.2	0.2
Commuting to job workplace: Car/motor vehicle	0.5	0.6	5.1	0.2	0.0	-0.7	2.2	0.5	-0.6	-0.4	-0.3	0.6	-0.0	-0.1
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.5	-1.6	-1.5	-0.6	0.1	-1.5	0.5	-0.2	0.5	-0.7	-1.3	0.3
Medication: Aspirin	0.9	1.2	3.5	1.9	1.7	0.4	0.4	1.3	-0.3	0.8	-0.2	1.4	1.5	0.2
Supplements: Vitamin C	1.4	1.7	3.4	-1.7	-1.6	-1.2	-1.8	-1.4	1.5	-1.3	0.3	-0.8	-1.2	-0.5
Knee pain experienced in last month	0.4	0.6	2.6	0.2	0.2	-0.7	0.1	0.0	-0.3	-0.1	-1.6	1.6	0.5	-0.2
Hypertension (Self-reported)	0.3	0.9	5.6	0.6	0.4	-2.4	0.6	0.2	0.4	-0.1	-0.1	0.4	0.1	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.5	-1.3	-1.2	-1.2	0.3	-0.5	-0.5	-1.9	-1.7	1.7	-1.0	-0.4
Illnesses of father: Heart disease	0.8	1.0	3.6	1.4	1.3	0.2	-0.5	0.9	-0.2	1.9	-0.4	0.9	1.0	-1.1
Illnesses of siblings: Diabetes	0.6	0.7	3.1	0.5	0.4	-0.4	0.3	0.2	-1.3	-0.4	-0.5	1.8	0.1	-1.2
Smoking status: Previous	0.6	0.9	2.5	-0.3	-0.5	0.0	0.9	-1.6	-1.0	-1.0	1.2	-1.2	-0.9	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.0	16.6	2.3	2.0	2.0	2.2	2.9	-4.1	1.3	1.7	0.2	2.0	1.7
Whole body fat-free mass	1.9	10.9	23.7	4.9	4.2	2.5	0.5	3.9	-2.8	4.0	-1.3	2.6	4.4	2.2
Leg fat-free mass (right)	1.2	6.6	14.9	3.9	3.1	1.6	0.4	2.8	-1.8	3.4	-1.6	2.4	3.4	1.5
Arm fat percentage (left)	0.3	1.4	7.8	-0.3	-0.2	-1.5	-1.2	-0.5	2.8	0.3	-0.6	-0.6	-0.4	-1.4
Average weekly red wine intake	1.0	1.5	3.4	1.4	1.3	1.7	-0.0	1.0	-0.5	1.6	1.8	-0.9	1.2	0.8
Handedness (chirality/laterality): Left-handed	0.6	0.7	3.0	-0.6	-1.0	-0.5	0.3	-0.7	-1.7	-1.3	-0.7	0.4	-0.8	-0.1
Mood swings	0.4	0.7	2.6	-1.1	-1.0	-0.9	-1.2	-0.8	-0.2	-1.6	0.1	0.1	-0.5	0.6
Loneliness, isolation	0.4	0.6	3.0	0.1	0.1	-0.5	1.7	0.0	-0.1	-0.2	-1.0	1.4	0.5	0.0
Long-standing illness, disability or infirmity	0.1	0.2	0.6	-0.3	-0.2	-0.7	-0.2	0.2	-0.3	-0.2	-0.4	0.8	-0.3	-0.6
Ever had bowel cancer screening	0.3	0.4	0.9	0.6	0.6	0.6	-0.1	0.2	0.4	0.9	-0.8	0.4	0.5	-0.9
Diabetes diagnosed by doctor	2.3	3.8	9.5	2.9	3.1	2.3	0.5	1.5	-0.4	2.0	0.3	0.0	3.0	1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.2	-1.3	-1.3	-1.6	1.2	-0.9	-1.4	-1.5	-1.0	1.8	-1.1	-0.9
Friendships satisfaction	1.5	1.8	3.5	1.5	1.5	1.3	1.6	0.8	-1.3	1.9	0.9	0.3	1.6	1.3
Qualifications: nursing, teaching	0.3	0.5	1.4	-0.2	0.3	0.8	1.2	0.6	1.2	0.3	0.8	-0.2	-0.3	-0.6
Commuting to job workplace: Walk	1.0	1.1	3.6	-0.9	-0.6	0.6	-1.9	-1.2	1.2	-0.8	0.3	-0.6	-0.6	1.4
Eye problems/disorders: Cataract	1.3	1.6	4.7	1.3	1.3	0.6	0.6	1.6	-2.2	1.2	1.8	-0.4	1.1	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	3.6	-0.0	-0.0	-0.8	1.9	0.2	-0.2	-0.1	0.2	0.3	0.2	0.2
Medication for cholesterol	0.4	0.7	1.8	0.4	0.2	1.3	-1.3	0.3	-0.4	-1.1	0.9	-1.2	-0.1	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.8	4.9	-0.1	0.1	-0.7	1.3	0.9	-2.2	0.2	0.5	0.3	-0.2	-0.3
Back pain experienced in last month	1.5	2.1	5.6	-1.9	-2.0	-2.4	-0.7	-1.2	1.4	-1.5	-0.4	-0.4	-1.4	-1.2
Mineral and other dietary supplements	1.8	2.4	3.8	-1.8	-1.6	-1.8	1.1	-1.5	0.1	-2.0	-1.8	1.4	-1.5	-1.7
Breast cancer (self-reported)	0.3	0.4	2.3	0.6	0.4	-0.2	-1.5	0.2	-0.7	0.5	0.1	-0.2	0.4	-0.1
Asthma (self-reported)	0.2	0.3	1.1	-0.6	-0.4	-0.6	-0.2	-0.5	-0.4	1.0	0.2	0.5	-0.8	0.6
Osteoporosis (self-reported)	1.1	1.4	2.9	-1.1	-1.2	-1.2	-1.0	-1.3	0.3	-1.3	0.7	-0.9	-1.7	-1.6
Osteoarthritis (self-reported)	1.2	1.6	7.2	0.6	0.8	-0.4	2.7	0.9	-1.5	0.9	1.8	-0.9	0.6	-0.9
Medication: Aspirin	1.4	1.8	4.6	2.1	2.1	0.5	0.6	1.4	-0.5	1.3	-0.4	1.6	1.9	0.4
Medication: Gliclazide	0.9	1.1	2.6	1.6	1.6	1.6	-0.9	1.2	-0.2	0.3	0.7	-0.3	1.2	0.2
Illnesses of father: None of the above (group 1)	0.9	1.1	4.9	0.7	1.0	1.2	-0.2	0.8	-0.0	0.3	0.2	-1.2	1.4	2.2
Smoking status: Current	1.1	1.7	5.2	0.1	-0.0	-0.0	2.2	0.4	-1.4	1.0	-1.3	2.3	0.4	2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	6.9	1.8	2.3	2.4	0.6	2.6	-0.9	0.2	-0.3	1.3	1.7	0.1
Whole body water mass	1.9	10.7	23.3	4.8	4.1	2.4	0.5	3.9	-2.7	3.9	-1.5	2.7	4.4	2.2
Leg predicted mass (right)	1.3	6.8	15.2	3.9	3.2	1.6	0.4	2.8	-1.8	3.5	-1.7	2.4	3.4	1.5
Arm fat mass (left)	0.3	1.1	2.2	1.4	1.2	-0.5	-0.6	0.8	1.5	1.4	-1.1	0.5	1.1	0.0
Number of self-reported non-cancer illnesses	0.4	0.7	2.6	-0.5	-0.5	-1.4	0.1	-0.5	-0.6	-0.6	0.9	-0.4	-1.0	-1.6
Average weekly champagne plus white wine intake	0.4	0.6	2.4	0.4	0.6	-0.3	-1.6	1.1	-0.3	0.7	-0.2	0.3	1.1	-0.7
Miserableness	0.4	0.6	1.5	-0.4	-0.4	-1.2	-1.0	-0.3	1.1	-0.8	-0.9	0.1	-0.2	1.1
Guilty feelings	0.5	0.7	2.9	0.8	0.8	-0.5	-0.5	0.3	0.9	0.6	-1.7	1.0	1.0	-0.0
Wears glasses or contact lenses	0.9	1.1	4.1	0.1	0.2	-0.5	-0.1	-0.1	-0.8	-0.3	2.0	-2.0	-0.2	-1.6
Ever taken oral contraceptive pill	0.3	0.4	1.5	0.6	0.9	0.1	-0.1	0.2	-0.7	0.3	0.6	0.1	0.5	1.2
Hearing aid user	0.4	0.4	1.5	0.8	0.8	0.3	-0.1	1.0	0.2	0.3	0.4	0.5	1.2	0.2
Mother’s age at death	0.4	0.5	1.9	-0.3	-0.3	-0.6	1.4	0.7	-0.5	0.3	0.6	-0.9	-0.3	-0.6
Financial situation satisfaction	0.1	0.1	0.4	-0.2	-0.1	-0.6	0.3	-0.6	0.2	0.0	-0.1	-0.6	0.0	0.6
Tinnitus: Yes, now most or all of the time	0.6	0.7	3.1	0.1	0.2	-1.0	0.0	0.6	-0.0	0.4	-1.6	1.8	0.5	-0.3
Commuting to job workplace: Public transport	0.3	0.4	2.3	0.1	0.1	0.6	-0.5	-0.3	0.4	1.5	0.7	-0.7	0.3	-0.2
Eye problems/disorders: Glaucoma	0.7	0.9	3.5	1.1	1.2	0.1	1.1	0.6	-1.9	-0.1	-0.3	1.0	0.8	-0.5
Medication: Blood pressure	0.3	0.6	2.7	0.2	0.2	-1.6	1.1	0.0	-0.0	0.7	-0.7	1.2	0.1	-0.5
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.7	0.1	0.2	1.0	-1.6	0.7	0.5	-0.8	0.8	-0.7	0.2	0.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.6	0.5	0.4	0.6	-1.2	0.4	-0.1	0.7	1.3	-1.1	0.6	-0.1
High cholesterol (Self-reported)	0.4	0.7	1.7	0.8	1.0	-0.4	0.3	0.8	0.1	1.1	-1.2	1.3	0.7	0.9
Medication: Bendroflumethiazide	0.3	0.4	2.4	-0.2	-0.1	-1.2	0.4	-0.2	0.7	0.1	-0.4	0.1	-0.2	-1.6
Medication: Paracetamol	0.1	0.2	0.8	0.4	0.3	0.3	-0.4	0.6	0.1	-0.3	-0.3	0.4	0.6	0.9
Medication: Lisinopril	0.8	1.0	5.1	0.4	0.3	-0.7	-1.2	-0.4	2.3	1.1	0.1	-1.3	0.8	-0.3
Medication: Atorvastatin	0.4	0.5	1.0	1.0	0.9	0.2	-0.1	0.2	0.8	-0.8	-0.9	0.9	0.7	0.9
Illnesses of father: High blood pressure	0.7	0.8	4.2	-1.0	-1.0	-0.7	-0.2	-0.1	-0.4	-0.5	-1.1	2.0	-0.7	0.2
Alcohol drinker status: Never	0.7	0.9	3.7	-1.0	-0.8	-0.1	-0.0	-1.1	0.7	-1.9	-0.2	0.7	-1.5	-0.1
Ever smoked	0.7	1.3	5.4	-0.8	-0.9	0.2	1.6	-1.3	-2.3	-1.0	0.5	0.2	-1.2	-0.3
Basal metabolic rate	1.6	8.6	18.7	4.3	3.7	2.1	0.4	3.5	-2.3	3.6	-1.4	2.4	3.9	2.0
Leg fat percentage (left)	0.2	0.8	5.6	-0.2	-0.2	-1.1	-0.3	-0.5	2.4	0.1	0.1	-0.9	-0.7	-0.2
Arm fat-free mass (left)	2.2	11.0	23.7	4.9	4.2	2.6	0.4	4.1	-2.4	3.8	-1.2	2.5	4.4	3.0
Number of operations (self-reported)	1.8	2.6	6.6	-1.3	-1.1	-1.5	0.3	-2.6	1.5	-2.4	1.8	-1.9	-1.5	-0.6
Average weekly beer plus cider intake	1.7	2.4	5.6	-2.4	-2.0	-1.9	-0.8	-2.0	0.7	-1.7	0.3	-1.3	-1.6	-1.3
Irritability	0.7	1.1	4.1	-0.9	-1.0	-1.5	-0.5	-0.5	-0.7	-2.0	-1.3	0.8	-0.4	-0.9
Risk taking	0.6	0.8	2.1	-0.9	-0.7	-1.4	-0.3	-1.3	1.0	-0.8	-0.2	-0.4	-1.0	-1.1
Ever had prostate specific antigen (PSA) test	0.7	0.8	3.6	-0.6	-0.6	-0.4	-1.9	0.6	1.1	-1.0	0.4	-1.1	-0.0	-0.1
Fractured/broken bones in last 5 years	1.1	1.4	7.9	-0.5	-0.4	-0.7	-2.8	-0.8	1.4	0.4	-0.5	-0.7	-0.2	-1.7
Age started oral contraceptive pill	1.6	2.1	5.7	1.6	1.9	1.2	0.5	1.6	0.3	2.4	-1.0	1.4	1.7	0.0
Diastolic blood pressure, automated reading	0.3	0.9	2.6	-1.1	-0.8	-0.7	-0.1	0.1	1.4	-1.1	0.2	-0.1	-1.1	-1.6
Ever depressed for a whole week	1.5	1.8	6.6	-1.9	-1.7	-1.6	0.2	-2.6	0.7	-0.3	0.3	-0.6	-1.6	-1.0
Unable to work because of sickness or disability	0.5	0.7	2.0	-1.2	-0.9	-0.6	-0.5	-0.4	-0.0	-1.4	-0.5	0.9	-0.6	-1.0
Commuting to job workplace: Cycle	1.0	1.2	5.2	-0.2	0.0	0.1	-2.0	-1.4	2.3	0.1	-0.5	-0.2	0.3	1.4
Myopia	2.4	3.5	5.8	-2.3	-2.4	-2.0	-1.4	-1.7	1.3	-2.0	0.3	-1.5	-2.3	-2.3
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.9	-1.0	-0.8	1.7	-0.8	-1.1	-0.0	-0.1	-0.1	-0.5	-0.5	1.4
Cholesterol lowering medication	0.6	0.9	5.5	1.1	1.2	-0.1	0.0	0.5	0.8	2.3	-0.2	0.8	0.6	0.2
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.4	-1.5	-1.1	-1.6	1.2	0.6	-0.6	0.5	-0.2	0.6	-1.0	-1.5
Pain experienced in last month	1.2	2.0	5.5	1.8	1.7	2.3	0.5	0.6	-1.2	2.0	0.8	-0.8	1.2	1.3
Supplements: Calcium	0.6	0.7	1.9	0.6	0.8	0.5	0.4	0.5	0.9	1.0	0.3	-0.6	1.3	1.4
Basal cell carcinoma (self-reported)	0.5	0.6	1.6	-0.2	-0.5	0.7	-1.3	-0.5	1.0	-0.8	0.6	-1.0	-0.8	-0.7
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.7	0.5	0.6	0.4	-0.6	0.3	1.3	-0.6	0.4	-0.5	0.2	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.1	-1.5	-1.3	-0.9	0.2	-0.9	-1.3	-0.8	-0.2	0.5	-1.4	0.2
Heart disease (siblings)	0.4	0.5	1.5	1.2	1.0	0.7	-0.3	0.7	-0.5	0.6	0.5	0.2	0.9	0.5
Alcohol drinker status: Previous	0.7	0.7	2.4	0.4	0.6	-1.4	-0.3	-0.5	-1.3	-0.3	1.6	-0.7	0.7	-0.8
Pack years of smoking	0.1	0.2	0.8	0.1	0.1	-0.7	-0.4	0.1	0.3	0.5	-0.4	0.3	0.2	0.9
Impedance of whole body	0.8	3.8	7.8	-2.8	-2.4	-0.4	-0.7	-2.2	-0.3	-1.9	2.2	-2.4	-2.4	-1.8
Leg fat mass (left)	0.2	0.7	1.4	1.2	1.0	-0.3	-0.1	0.9	1.1	1.2	-0.7	0.4	0.7	0.3
Arm predicted mass (left)	2.2	11.4	24.6	5.0	4.3	2.8	0.6	4.1	-2.3	3.7	-1.4	2.6	4.5	2.9