Best TWAS P=1.64e-36 · Best GWAS P=1.47e-35 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | AMZ1 | 0.19 | 0.12 | enet | 22 | 0.13 | 5.7e-16 | 6.1 | 7.7 | 1.0e-14 | -0.43 | 1.00 | 0.00 | TRUE |
2 | GTEx | Adipose Subcutaneous | GNA12 | 0.11 | 0.08 | lasso | 4 | 0.07 | 1.3e-06 | -7.6 | -8.4 | 3.6e-17 | 0.72 | 0.35 | 0.65 | FALSE |
3 | GTEx | Artery Tibial | GNA12 | 0.24 | 0.13 | enet | 20 | 0.22 | 3.5e-17 | -12.4 | -10.6 | 2.0e-26 | 0.86 | 0.02 | 0.98 | FALSE |
4 | GTEx | Breast Mammary Tissue (Male) | EIF3B | 0.38 | -0.01 | enet | 28 | 0.12 | 1.3e-03 | 6.5 | -5.2 | 2.4e-07 | 0.06 | 0.04 | 0.06 | TRUE |
5 | GTEx | Cells EBV-transformed lymphocytes | GNA12 | 0.46 | 0.51 | lasso | 5 | 0.50 | 7.9e-19 | -12.3 | -12.3 | 1.1e-34 | 0.90 | 0.02 | 0.98 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | GNA12 | 0.21 | 0.11 | lasso | 11 | 0.15 | 1.7e-11 | -12.4 | -9.9 | 2.5e-23 | 0.87 | 0.01 | 0.99 | FALSE |
7 | GTEx | Colon Sigmoid | GNA12 | 0.14 | 0.05 | lasso | 3 | 0.03 | 3.6e-02 | -7.6 | -10.2 | 2.0e-24 | 0.82 | 0.04 | 0.88 | FALSE |
8 | GTEx | Colon Transverse | GNA12 | 0.19 | 0.08 | lasso | 4 | 0.10 | 2.3e-05 | 6.5 | -7.3 | 2.0e-13 | 0.62 | 0.21 | 0.77 | FALSE |
9 | GTEx | Esophagus Gastroesophageal Junction | GNA12 | 0.20 | 0.12 | lasso | 6 | 0.12 | 3.4e-05 | -7.6 | -10.2 | 1.5e-24 | 0.82 | 0.05 | 0.93 | FALSE |
10 | GTEx | Esophagus Mucosa | GNA12 | 0.16 | 0.13 | lasso | 3 | 0.13 | 3.0e-09 | -12.3 | -11.3 | 1.3e-29 | 0.93 | 0.01 | 0.99 | FALSE |
11 | GTEx | Esophagus Muscularis | GNA12 | 0.32 | 0.31 | lasso | 3 | 0.34 | 2.1e-21 | -12.4 | -11.9 | 7.9e-33 | 0.93 | 0.01 | 0.99 | TRUE |
12 | GTEx | Lung | GNA12 | 0.16 | 0.08 | enet | 21 | 0.12 | 1.2e-09 | -12.3 | -9.9 | 5.5e-23 | 0.78 | 0.01 | 0.99 | FALSE |
13 | GTEx | Nerve Tibial | GNA12 | 0.31 | 0.34 | lasso | 7 | 0.36 | 9.6e-27 | -7.7 | -10.1 | 9.1e-24 | 0.83 | 0.89 | 0.11 | FALSE |
14 | GTEx | Skin Not Sun Exposed Suprapubic | GNA12 | 0.10 | 0.15 | lasso | 3 | 0.12 | 4.2e-07 | 6.0 | -6.6 | 4.3e-11 | 0.55 | 0.36 | 0.62 | FALSE |
15 | GTEx | Skin Sun Exposed Lower leg | GNA12 | 0.17 | 0.16 | lasso | 3 | 0.18 | 1.3e-14 | -7.4 | -10.0 | 2.2e-23 | 0.85 | 0.16 | 0.84 | FALSE |
16 | GTEx | Skin Sun Exposed Lower leg | AC004840.9 | 0.18 | 0.01 | enet | 36 | 0.02 | 3.7e-03 | 2.6 | -5.4 | 6.8e-08 | 0.15 | 0.18 | 0.21 | TRUE |
17 | GTEx | Small Intestine Terminal Ileum | GNA12 | 0.34 | 0.20 | lasso | 5 | 0.16 | 2.4e-04 | -7.6 | -8.3 | 9.5e-17 | 0.74 | 0.08 | 0.74 | TRUE |
18 | GTEx | Stomach | GNA12 | 0.18 | 0.16 | lasso | 2 | 0.13 | 6.6e-07 | -7.6 | -7.7 | 1.7e-14 | 0.68 | 0.54 | 0.44 | FALSE |
19 | GTEx | Whole Blood | GNA12 | 0.09 | 0.01 | enet | 4 | 0.00 | 3.3e-01 | -12.0 | -12.1 | 1.7e-33 | 0.90 | 0.02 | 0.90 | FALSE |
20 | METSIM | Adipose | GNA12 | 0.07 | 0.05 | lasso | 3 | 0.05 | 3.3e-08 | -7.6 | -7.7 | 1.1e-14 | 0.75 | 0.37 | 0.63 | FALSE |
21 | NTR | Blood | GNA12 | 0.07 | 0.03 | bslmm | 597 | 0.06 | 1.3e-17 | -9.2 | -8.9 | 4.3e-19 | 0.58 | 0.94 | 0.06 | FALSE |
22 | ROSMAP | Brain Pre-frontal Cortex | AMZ1 | 0.09 | 0.05 | lasso | 6 | 0.04 | 2.4e-06 | -12.4 | 12.6 | 1.6e-36 | -0.89 | 0.01 | 0.99 | TRUE |
23 | YFS | Blood | GNA12 | 0.23 | 0.15 | bslmm | 570 | 0.25 | 4.5e-82 | 5.9 | -8.0 | 1.3e-15 | 0.47 | 1.00 | 0.00 | TRUE |
24 | The Cancer Genome Atlas | Esophageal Carcinoma | AMZ1 | 0.18 | 0.05 | blup | 69 | 0.05 | 1.4e-02 | 7.6 | -10.3 | 7.3e-25 | 0.75 | 0.01 | 0.67 | FALSE |
25 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GNA12 | 0.03 | 0.04 | lasso | 1 | 0.04 | 3.0e-05 | -7.6 | -7.6 | 3.8e-14 | 0.68 | 0.07 | 0.79 | FALSE |
26 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AMZ1 | 0.04 | 0.04 | lasso | 3 | 0.02 | 1.3e-03 | 7.6 | 8.8 | 1.1e-18 | -0.67 | 0.03 | 0.93 | FALSE |
27 | The Cancer Genome Atlas | Lung Adenocarcinoma | GNA12 | 0.03 | 0.01 | enet | 7 | 0.02 | 1.5e-03 | 4.8 | -9.8 | 6.7e-23 | 0.76 | 0.06 | 0.74 | FALSE |
28 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AMZ1 | 0.08 | 0.01 | blup | 71 | 0.05 | 1.3e-05 | -7.6 | 5.2 | 1.8e-07 | -0.66 | 0.03 | 0.84 | FALSE |
29 | The Cancer Genome Atlas | Thyroid Carcinoma | AMZ1 | 0.32 | 0.04 | enet | 19 | 0.20 | 3.3e-19 | -9.2 | 5.6 | 2.6e-08 | -0.57 | 0.15 | 0.85 | TRUE |