Best TWAS P=6.53e-09 · Best GWAS P=3.28e-10 conditioned to 0.0292
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | BRD3 | 0.24 | 0.06 | enet | 51 | 0.09 | 1.7e-07 | 3.4 | -5.2 | 1.6e-07 | 0.26 | 0.73 | 0.16 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | BRD3 | 0.21 | 0.01 | lasso | 5 | 0.00 | 1.8e-01 | 5.3 | -5.5 | 5.1e-08 | 0.02 | 0.09 | 0.13 | FALSE |
| 3 | GTEx | Artery Aorta | BRD3 | 0.34 | 0.03 | lasso | 9 | 0.09 | 7.9e-06 | 5.5 | -5.7 | 1.5e-08 | -0.04 | 0.29 | 0.48 | FALSE |
| 4 | GTEx | Artery Tibial | BRD3 | 0.17 | 0.03 | enet | 14 | 0.09 | 1.5e-07 | -2.3 | -5.6 | 1.7e-08 | 0.01 | 0.86 | 0.04 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | BRD3 | 0.29 | 0.23 | lasso | 4 | 0.27 | 3.7e-20 | 5.5 | -5.8 | 6.5e-09 | 0.02 | 0.23 | 0.77 | TRUE |
| 6 | GTEx | Muscle Skeletal | RXRA | 0.12 | 0.06 | lasso | 6 | 0.06 | 3.7e-06 | -5.3 | -5.7 | 1.1e-08 | 0.74 | 0.26 | 0.74 | TRUE |
| 7 | GTEx | Nerve Tibial | BRD3 | 0.23 | 0.10 | lasso | 5 | 0.16 | 2.7e-11 | 3.8 | -5.3 | 1.5e-07 | 0.03 | 0.71 | 0.29 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | BRD3 | 0.15 | 0.11 | lasso | 4 | 0.12 | 3.7e-07 | 5.3 | -5.6 | 2.5e-08 | 0.02 | 0.00 | 1.00 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | BRD3 | 0.04 | 0.01 | enet | 14 | 0.03 | 3.1e-04 | 3.8 | -5.4 | 7.4e-08 | 0.08 | 0.03 | 0.52 | FALSE |
| 10 | The Cancer Genome Atlas | Rectum Adenocarcinoma | ABO | 0.48 | 0.23 | enet | 10 | 0.27 | 4.7e-07 | -4.8 | -5.5 | 4.8e-08 | 0.08 | 0.00 | 0.93 | TRUE |