Hub : Genes

RXRA

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.1201	0.0363	0.00069	0.057	NA	0.044	NA	0.055	2.7e-06	NA	3.6e-05	NA	3.7e-06
2	GTEx	Thyroid	0.1750	0.0490	0.00055	0.002	NA	0.024	NA	0.020	2.2e-01	NA	5.4e-03	NA	1.0e-02
3	YFS	Blood	0.0265	0.0108	0.00480	0.046	0	0.044	0.043	0.044	6.7e-15	0.22	3.4e-14	5.9e-14	2.8e-14

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	2.3	3.6	9.3	-3.1	1.3	0.0
Bipolar Disorder or Schizophrenia	1.3	3.1	4.7	-2.1	2.2	0.0
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	0.7	-0.2	-0.2
Depression (Nagel 2018)	0.6	0.9	1.3	1.1	-0.4	1.1
Intelligence (Savage-Jansen 2018)	1.0	3.2	8.4	-1.1	2.9	-0.5
Neuroticism (Nagel 2018)	0.1	0.3	0.6	0.4	-0.8	0.4
Schizophrenia (2018)	0.5	1.1	3.2	-0.3	1.8	0.0
Schizophrenia vs Biploar Disorder	1.2	1.6	4.6	2.2	-0.2	0.0
Worry (Nagel 2018)	0.2	0.3	0.8	0.9	-0.2	0.3
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	0.1	0.0	0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.3	-0.6	0.1	-0.2
Alzheimer’s Disease (including proxy)	0.0	0.1	0.2	-0.1	-0.2	0.4
Crohns Disease (2017)	0.7	1.5	2.8	-0.9	1.7	-0.9
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	-0.9	0.1	-0.4
Ulcerative Colitis (UC)	0.3	0.5	1.2	-0.5	-1.1	0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	1.6	3.1	5.3	2.3	-1.5	-1.3
Verbal and Numeric Reasoning (VNR)	1.1	2.8	7.4	-0.7	2.7	-0.6
Breast Cancer	1.0	2.4	3.3	1.6	-1.2	-1.8
Ovarian Cancer	0.7	0.9	1.7	0.9	1.3	0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.9	1.2	2.8	1.7	0.9	-0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.8	1.1	1.6	0.9	-1.3	-1.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	-0.0	0.0
Crohns Disease (2012)	0.4	0.6	1.7	-0.2	1.3	-0.3
Mean Putamen Volume	1.0	1.1	2.4	-1.6	0.5	0.8
Fasting Glucose	0.9	1.1	2.2	-1.0	-0.1	1.5
HbA1C	1.2	1.4	3.3	0.7	0.6	-1.8
HDL Cholesterol	0.5	0.8	1.1	1.1	-0.7	0.9
LDL Cholesterol	0.2	0.3	0.4	-0.7	-0.4	-0.6
Lupus	0.1	0.1	0.4	0.1	0.2	-0.6
Neuroticism (2016)	0.3	0.5	0.8	-0.7	-0.9	0.1
Primary Biliary Cirrhosis	0.5	0.7	1.8	0.4	1.3	0.4
Rheumatoid Arthritis	0.3	0.4	0.7	-0.6	0.3	0.8
Schizophrenia (2014)	0.2	0.5	1.6	-0.2	1.3	0.0
Triglycerides	1.2	2.0	3.6	-1.4	0.5	-1.9
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.3	-0.2	-1.5	-0.4
Ulcerative Colitis	0.0	0.0	0.1	0.3	-0.2	0.0
Blood Eosinophil Count	0.1	0.7	2.0	0.1	1.4	-0.1
Blood Platelet Count	0.5	6.2	12.2	-2.3	3.5	-1.1
Blood Red Count	0.8	8.2	19.1	4.4	-1.7	1.6
Blood White Count	0.1	0.9	1.1	-1.1	-1.0	-0.7
Heel T-Score	0.5	4.0	9.5	-3.1	0.8	-1.3
BMI	0.2	0.9	2.5	-0.4	-1.6	-0.0
Height	0.3	5.7	15.6	-4.0	1.2	0.4
Waist Hip Ratio (WHR)	0.1	0.3	0.7	0.4	-0.8	0.4
Systolic Blood Pressure	0.1	0.6	1.4	-1.2	-0.6	0.4
Smoking Status	0.3	0.8	1.6	-0.5	-1.3	-0.7
Allergy or Eczema	0.5	1.4	3.2	0.9	-1.8	0.4
Cardiovascular Disease	0.0	0.1	0.3	0.1	0.2	0.6
Hypothyroidism (self reported)	0.2	0.4	0.8	0.4	0.9	-0.4
Respiratory disease	0.5	1.2	2.2	1.2	0.1	1.5
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.1	-0.8	-0.8	-1.0
Lung FEV1/FVC ratio	0.9	4.8	7.3	-2.6	-0.7	2.7
Lung FVC	0.1	0.6	1.3	-1.2	0.2	-0.5
Neuroticism	0.3	0.6	1.5	-1.2	-0.1	0.5
Chronotype (morning person)	1.6	3.6	10.2	-3.2	0.0	0.8
Hair Pigment	0.0	0.9	1.7	-1.0	-0.1	1.3
Tanning	0.1	1.6	3.8	1.0	-0.2	-2.0
Hand grip strength (left)	0.7	1.9	4.8	-2.2	1.0	0.1
Number of treatments/medications taken	0.1	0.2	0.4	0.4	0.6	0.2
Average weekly spirits intake	0.3	0.3	0.7	-0.5	-0.8	-0.2
Sensitivity / hurt feelings	0.5	0.9	2.5	-0.4	0.2	1.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.1	-1.1	0.5	0.8
Hearing difficulty/problems: Yes	0.4	0.6	1.3	0.4	1.2	0.5
Relative age of first facial hair	0.2	0.4	0.6	0.8	0.7	-0.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.3	-1.1	-0.5	1.1
Ever used hormone-replacement therapy (HRT)	1.9	2.5	5.4	1.4	-2.3	0.4
Ever had hysterectomy (womb removed)	2.7	3.0	4.2	1.2	-2.0	1.9
Systolic blood pressure, automated reading	0.2	0.7	1.1	0.5	-1.1	0.9
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.1	-0.1	0.4	-1.1
Angina	0.2	0.2	0.5	-0.7	0.3	-0.2
Medication for hormone replacement therapy	0.2	0.2	0.7	0.8	-0.1	-0.1
Vitamin and mineral supplements	0.5	0.7	1.8	0.0	1.4	0.3
Supplements: Zinc	0.8	0.8	1.1	-0.7	-1.0	-1.0
Medication: Co-codamol	0.7	0.9	2.3	1.5	-0.0	-0.5
Medication: Metformin	0.4	0.6	1.6	-1.3	0.3	-0.0
Diabetes (father)	0.4	0.5	0.8	-0.1	-0.9	0.9
Diabetes (mother)	0.8	1.0	2.3	0.7	-0.1	-1.5
Severe depression (siblings)	0.5	0.5	0.8	0.8	-0.5	0.9
Pack years adult smoking proportion	0.7	1.1	1.9	1.4	-1.1	-0.4
Impedance of leg (right)	0.6	2.7	6.5	2.5	-0.4	-1.3
Leg fat-free mass (left)	0.6	3.2	9.4	-3.1	-0.2	0.2
Trunk fat percentage	2.4	9.8	19.0	4.4	-3.2	0.0
Hand grip strength (right)	0.4	1.0	2.1	-1.4	1.0	-0.0
Townsend deprivation index at recruitment	0.0	0.0	0.1	0.2	0.3	-0.0
Current tobacco smoking	1.3	2.1	5.3	-0.3	-2.3	-1.0
Average weekly fortified wine intake	0.5	0.5	1.3	-1.2	-0.5	-0.1
Maternal smoking around birth	0.2	0.4	0.7	-0.3	-0.5	0.8
Fed-up feelings	0.5	0.9	1.5	1.2	0.2	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.7	3.7	1.9	-0.4	1.1
Relative age voice broke	1.1	1.7	2.7	1.6	-1.6	0.2
Taking other prescription medications	0.5	0.7	1.6	-1.3	0.0	-0.7
Age when periods started (menarche)	0.7	1.8	4.9	-2.2	0.6	-0.3
Bilateral oophorectomy (both ovaries removed)	1.3	1.4	2.0	1.2	-1.4	0.9
Heel bone mineral density (BMD) T-score, automated (left)	3.9	8.9	25.7	-5.1	1.0	0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.7	0.7	-0.8	-0.6
Qualifications: CSEs or equivalent	1.8	2.4	4.1	2.0	-1.4	-1.0
Serious illness, injury or assault to yourself	0.1	0.1	0.2	0.5	-0.2	-0.3
High blood pressure	0.3	0.8	1.3	0.8	-0.8	1.1
Hayfever, allergic rhinitis or eczema	0.3	0.8	1.2	0.9	-1.1	0.5
Multivitamins +/- minerals	0.6	0.7	1.4	-0.1	-1.2	-0.8
Stomach or abdominal pain in last month	3.2	4.0	6.5	-2.3	2.5	-0.5
Supplements: Glucosamine	0.1	0.1	0.1	-0.2	-0.3	-0.3
Diverticular disease/diverticulitis (self-reported)	3.3	3.9	6.2	-2.5	2.3	0.1
Medication: Atenolol	0.4	0.4	0.8	-0.4	0.6	0.9
Medication: Levothyroxine sodium	0.4	0.6	0.8	0.9	0.8	0.6
Sitting height	1.3	9.0	26.7	-5.2	0.2	-0.5
Chronic bronchitis/emphysema (father)	0.5	0.6	0.8	0.7	-0.9	-0.6
High blood pressure (mother)	0.8	1.2	1.5	-1.2	0.8	-1.2
Body mass index (BMI)	0.2	0.9	2.0	0.8	-1.4	-0.1
Impedance of leg (left)	0.6	2.7	7.2	2.7	-0.1	-1.0
Leg predicted mass (left)	0.6	3.2	9.6	-3.1	-0.2	0.3
Trunk fat mass	1.1	4.9	7.6	2.6	-2.8	-0.1
Waist circumference	0.4	1.5	3.5	1.0	-1.9	-0.3
Number of incorrect matches in round	0.3	0.5	1.4	-1.2	0.3	0.2
Past tobacco smoking	0.4	0.8	1.3	-0.4	1.1	0.9
Alcohol usually taken with meals	0.2	0.2	0.4	-0.6	0.3	-0.5
Nervous feelings	1.1	2.0	3.3	1.4	-0.8	-1.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.2	-0.5	1.1	0.2
Hearing difficulty/problems with background noise	0.1	0.2	0.3	-0.6	0.3	-0.3
Hair/balding pattern: Pattern 2	0.6	0.8	2.0	0.4	0.4	-1.4
Had menopause	1.3	1.7	2.5	1.4	-1.6	0.8
Had other major operations	0.1	0.1	0.2	-0.1	-0.2	-0.4
Forced vital capacity (FVC)	1.7	6.6	17.4	-4.2	1.3	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	3.4	7.8	22.7	-4.8	0.9	-0.1
Ever unenthusiastic/disinterested for a whole week	1.5	1.9	3.1	-1.8	0.8	1.3
Qualifications: None of the above	3.3	7.0	13.3	3.6	-2.7	-0.6
Financial difficulties in last 2 years	1.3	1.8	3.9	-1.2	2.0	-0.4
Mouth/teeth dental problems	0.1	0.1	0.2	0.0	-0.4	-0.4
Heart attack	0.7	0.9	2.5	-0.0	-0.3	-1.6
Allergy	0.3	0.7	1.0	-1.0	0.2	-1.0
Pain all over the body in last month	1.5	1.6	4.8	0.3	-0.1	2.2
Diabetes (self-reported)	0.8	1.2	2.8	-1.7	-0.1	0.8
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.4	0.6	0.1	0.4
Medication: Ramipril	0.4	0.6	0.8	-0.9	-0.5	0.8
Medication: Simvastatin	0.2	0.3	0.5	0.1	0.7	-0.6
Fluid intelligence score	0.7	1.5	2.2	-0.4	1.5	1.5
Illnesses of siblings	1.2	1.7	3.2	1.3	-1.8	-0.3
Neuroticism score	0.1	0.1	0.2	0.5	-0.2	0.4
Weight	0.1	0.6	1.0	-0.8	-1.0	-0.1
Impedance of arm (right)	1.4	6.6	19.7	4.4	-0.2	0.3
Arm fat percentage (right)	1.4	5.3	12.6	3.5	-1.8	0.2
Trunk fat-free mass	1.9	11.0	32.6	-5.7	0.7	0.1
Hip circumference	0.3	1.2	1.8	1.3	-1.1	-0.8
Time employed in main current job	0.4	0.5	0.8	-0.9	0.2	-0.8
Alcohol intake versus 10 years previously	0.2	0.2	0.3	-0.5	-0.6	-0.3
Father’s age at death	0.1	0.1	0.2	-0.4	0.2	-0.2
Worrier / anxious feelings	0.2	0.3	0.6	0.8	-0.1	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	0.9	1.0	0.7	-0.8
Falls in the last year	0.9	1.2	1.4	-1.0	-1.1	-1.2
Hair/balding pattern: Pattern 3	1.2	1.8	2.9	0.5	-1.5	1.7
Number of live births	1.5	2.2	3.3	-1.2	1.3	-1.8
Forced expiratory volume in 1-second (FEV1)	2.1	7.0	19.7	-4.4	1.1	-0.1
Pulse rate	1.0	1.6	3.8	2.0	-0.2	1.0
Happiness	1.1	1.4	4.0	-0.3	-2.0	0.1
Noisy workplace	0.4	0.4	0.6	-0.7	0.7	-0.5
Qualifications: A levels/AS levels or equivalent	1.1	2.3	3.5	-1.8	1.9	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.2	-0.6	0.5	-1.1
Mouth/teeth dental problems: Dentures	0.6	1.0	1.5	1.2	-1.2	0.4
Asthma	0.4	0.8	1.3	1.1	0.2	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	3.9	0.1	0.8	-2.0
Medication: Cholesterol lowering	0.1	0.2	0.5	0.7	-0.2	-0.0
Depression (self-reported)	1.6	1.9	4.7	-0.9	-2.2	0.5
Medication: Lansoprazole	0.6	0.7	1.2	-0.5	1.1	0.8
Prospective memory result	0.2	0.2	0.5	-0.7	0.2	0.4
Lung cancer (father)	1.4	1.6	4.5	-2.1	0.3	0.4
Illnesses of mother	0.6	0.7	1.2	1.0	1.1	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	6.9	18.7	-4.3	1.4	0.3
Pulse wave Arterial Stiffness index	0.8	0.9	1.6	0.9	-1.3	0.6
Impedance of arm (left)	1.6	7.5	21.8	4.7	-0.3	0.7
Arm fat mass (right)	0.4	1.7	3.4	1.3	-1.9	0.1
Trunk predicted mass	1.9	11.1	32.7	-5.7	0.7	0.2
Standing height	0.6	6.3	18.6	-4.3	0.6	-0.2
Length of working week for main job	0.7	0.8	1.5	-1.2	-0.8	-0.3
Exposure to tobacco smoke at home	0.1	0.1	0.3	0.2	0.6	-0.0
Breastfed as a baby	0.5	0.6	1.3	-1.1	-0.6	-0.4
Tense / ‘highly strung’	0.3	0.5	0.9	-0.6	-0.9	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.7	0.3	-0.2
Hair/balding pattern: Pattern 4	0.3	0.7	1.0	1.0	0.3	1.0
Birth weight of first child	1.3	2.3	4.2	-2.0	1.7	-0.3
Peak expiratory flow (PEF)	1.6	3.6	9.6	-3.1	1.1	0.3
Pulse wave reflection index	0.7	0.9	2.8	-1.7	0.1	0.0
Ever highly irritable/argumentative for 2 days	1.9	2.2	5.0	-2.2	1.3	0.3
Loud music exposure frequency	0.5	0.6	0.9	0.3	-0.9	-0.9
Qualifications: O levels/GCSEs or equivalent	2.4	3.8	5.4	-2.3	0.9	2.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.8	-0.1	1.4	-0.5
Blood clot in the leg (DVT)	0.5	0.6	1.0	0.8	-1.0	-0.4
Medication: Paracetamol	0.3	0.4	0.7	0.3	-0.8	-0.8
Headache pain in last month	0.8	1.3	2.7	0.9	-0.6	-1.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.8	-0.8	-0.4	-0.9
Glaucoma (self-reported)	0.3	0.3	0.5	0.6	0.7	0.3
Gout (self-reported)	4.5	6.2	18.2	-4.3	0.1	-0.5
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.9	0.0	1.7	-0.6
Medication: Amlodipine	0.8	1.1	2.2	1.5	-0.4	0.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	0.9	-0.5	0.4
Birth weight	0.3	0.6	1.1	-0.8	0.2	-1.1
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.4	0.9	-0.5	1.6
High blood pressure (siblings)	2.5	3.5	6.0	-1.7	2.5	1.2
Forced vital capacity (FVC), Best measure	1.8	6.7	17.7	-4.2	1.5	-0.4
Body fat percentage	2.2	8.6	18.0	4.2	-2.7	-0.5
Leg fat percentage (right)	1.1	4.2	8.7	3.0	-1.9	-0.6
Arm fat-free mass (right)	1.5	7.5	22.6	-4.8	-0.1	-0.1
Exposure to tobacco smoke outside home	0.2	0.3	0.6	-0.5	0.8	-0.0
Comparative body size at age 10	0.7	2.1	5.6	-2.4	0.2	-0.7
Number of full brothers	0.7	0.8	1.9	-0.4	0.7	-1.4
Worry too long after embarrassment	0.7	1.2	1.3	1.1	-1.1	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.4	0.2	0.6	0.6
Wheeze or whistling in the chest in last year	0.5	0.8	2.1	1.5	-0.6	0.1
Number of children fathered	2.0	2.3	4.8	-2.2	1.3	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.2	0.1	-0.6	-1.1
Age at first live birth	0.5	0.9	2.4	-1.5	0.3	0.4
Pulse wave peak to peak time	0.8	0.9	1.3	-1.1	1.2	-0.5
Health satisfaction	0.4	0.5	0.9	0.6	-0.9	-0.5
Shortness of breath walking on level ground	1.2	1.5	4.0	-0.2	-0.6	-2.0
Qualifications: College or University degree	1.1	3.5	6.2	-2.5	1.7	-1.1
Eye problems/disorders: None of the above	0.3	0.3	0.6	-0.1	0.6	-0.8
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.9	-0.2	0.7	-1.0
Emphysema/chronic bronchitis	1.4	1.5	3.8	2.0	0.8	-0.3
Medication for pain relief, constipation, heartburn	0.5	0.8	2.4	-0.1	0.2	1.5
Neck or shoulder pain in last month	0.2	0.3	0.8	0.9	-0.2	0.4
Medication: Blood pressure	0.8	1.4	3.5	0.8	0.3	1.9
Angina (self-reported)	0.2	0.2	0.6	-0.8	0.1	0.2
Migraine (self-reported)	0.7	0.9	2.4	-1.6	0.4	-0.4
Medication: Ibuprofen	0.5	0.6	1.3	-0.3	0.5	-1.1
Medication: Allopurinol	3.6	4.9	11.6	-3.4	1.0	-1.4
Medication: Omeprazole	0.5	0.6	0.9	0.4	-0.9	-0.9
Medication: Seretide 50 evohaler	0.0	0.1	0.1	0.2	0.3	-0.2
Mean time to correctly identify matches	1.5	2.9	4.1	2.0	-2.0	-0.8
Heart disease (mother)	0.9	1.1	2.9	-0.5	-1.7	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.1	-0.1	1.5	-0.6
Whole body fat mass	0.8	3.5	6.2	2.0	-2.5	-0.4
Leg fat mass (right)	0.5	1.8	3.0	1.4	-1.7	-0.4
Arm predicted mass (right)	1.4	7.3	21.9	-4.7	0.0	-0.2
Pulse rate, automated reading	1.6	5.1	8.8	3.0	-1.4	2.1
Alcohol intake frequency.	0.1	0.3	0.6	0.8	0.2	0.4
Comparative height size at age 10	0.2	1.0	1.9	0.7	-1.4	0.7
Number of full sisters	0.2	0.3	0.4	-0.4	0.5	0.6
Suffer from ‘nerves’	1.1	1.8	4.0	2.0	1.1	0.6
Overall health rating	0.4	0.8	2.2	1.5	0.2	0.3
Chest pain or discomfort	0.6	0.9	2.6	-0.1	-0.3	1.6
Had major operations	0.1	0.1	0.2	-0.5	0.4	0.1
Age at last live birth	1.9	2.8	6.7	-2.6	1.3	-0.2
Family relationship satisfaction	0.3	0.4	1.0	0.3	0.3	-1.0
Leg pain on walking	0.3	0.4	0.7	-0.1	0.6	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	1.3	-0.7	-0.9	-1.1
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.2	0.8	-1.4	-1.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.8	-0.9	0.3	0.0
Medication: Aspirin	0.1	0.1	0.2	0.0	0.4	-0.2
Supplements: Vitamin C	0.6	0.7	1.5	1.2	-0.5	0.6
Knee pain experienced in last month	0.2	0.3	0.4	0.6	-0.3	0.5
Hypertension (Self-reported)	0.3	0.9	1.9	0.7	-0.5	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.8	-0.8	0.4	-1.7
Illnesses of father: Heart disease	1.1	1.5	2.7	1.7	-0.7	1.1
Illnesses of siblings: Diabetes	0.7	0.9	1.2	-0.8	0.9	1.1
Smoking status: Previous	0.3	0.5	1.1	1.1	-0.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.2	-2.0	0.6	0.1
Whole body fat-free mass	1.4	8.1	24.2	-4.9	0.4	0.1
Leg fat-free mass (right)	0.6	3.4	10.1	-3.2	0.1	0.4
Arm fat percentage (left)	1.3	5.3	13.4	3.7	-1.6	0.3
Average weekly red wine intake	0.9	1.4	2.1	1.5	0.2	-1.4
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.7	-0.1	-0.8	0.2
Mood swings	0.2	0.4	1.0	-0.3	1.0	0.0
Loneliness, isolation	0.8	1.2	3.3	1.8	0.4	0.0
Long-standing illness, disability or infirmity	0.1	0.2	0.3	-0.5	0.5	0.4
Ever had bowel cancer screening	1.3	1.6	1.7	-1.3	-1.2	-1.3
Diabetes diagnosed by doctor	0.7	1.1	2.3	-1.5	-0.5	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	1.8	-0.8	1.1	-1.4
Friendships satisfaction	0.2	0.3	0.5	0.7	-0.5	0.2
Qualifications: nursing, teaching	1.9	2.9	6.8	-2.6	1.4	0.1
Commuting to job workplace: Walk	0.6	0.7	1.0	-0.3	1.0	1.0
Eye problems/disorders: Cataract	2.1	2.4	4.3	-0.9	-1.4	2.1
Mouth/teeth dental problems: Mouth ulcers	2.4	3.8	8.1	-1.8	2.8	0.3
Medication for cholesterol	0.1	0.2	0.6	0.8	-0.1	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.3	-0.6	0.2	0.4
Back pain experienced in last month	0.6	0.9	1.8	0.1	-0.9	-1.3
Mineral and other dietary supplements	0.4	0.5	1.6	0.1	1.3	0.1
Breast cancer (self-reported)	1.0	1.2	1.6	-0.8	-1.2	-1.2
Asthma (self-reported)	0.6	1.2	2.6	0.9	0.4	1.6
Osteoporosis (self-reported)	0.5	0.6	1.5	1.2	0.2	0.5
Osteoarthritis (self-reported)	1.5	2.0	4.5	1.2	-0.1	2.1
Medication: Aspirin	0.2	0.2	0.6	0.4	0.8	0.1
Medication: Gliclazide	1.6	1.8	3.8	-0.8	-1.0	-1.9
Illnesses of father: None of the above (group 1)	0.4	0.5	0.7	-0.6	0.8	-0.7
Smoking status: Current	1.7	2.7	4.2	-1.2	-2.0	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.7	10.6	-3.3	0.7	0.4
Whole body water mass	1.4	7.7	23.1	-4.8	0.2	0.2
Leg predicted mass (right)	0.7	3.6	10.7	-3.3	0.2	0.3
Arm fat mass (left)	0.5	2.0	3.4	1.6	-1.8	0.2
Number of self-reported non-cancer illnesses	0.1	0.2	0.7	0.8	0.1	-0.1
Average weekly champagne plus white wine intake	1.2	1.6	3.2	-1.3	1.8	0.0
Miserableness	0.3	0.5	1.1	-0.3	0.4	-1.1
Guilty feelings	0.1	0.1	0.1	-0.2	-0.3	-0.3
Wears glasses or contact lenses	0.1	0.2	0.3	0.6	0.4	-0.1
Ever taken oral contraceptive pill	0.1	0.2	0.5	-0.0	0.7	-0.0
Hearing aid user	1.9	2.2	4.5	1.0	-1.0	-2.1
Mother’s age at death	0.6	0.7	1.6	-0.6	0.6	1.2
Financial situation satisfaction	0.1	0.1	0.4	-0.0	-0.6	-0.0
Tinnitus: Yes, now most or all of the time	3.0	3.6	10.1	3.2	-0.7	-0.3
Commuting to job workplace: Public transport	4.1	4.9	8.8	-0.6	2.4	3.0
Eye problems/disorders: Glaucoma	0.3	0.3	0.8	0.5	0.9	0.2
Medication: Blood pressure	0.1	0.3	0.7	-0.8	-0.2	-0.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	0.6	0.5	0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.5	0.6	-0.8	-0.8	-0.4
High cholesterol (Self-reported)	0.1	0.2	0.5	-0.7	-0.1	-0.2
Medication: Bendroflumethiazide	0.4	0.6	0.8	-0.7	0.7	0.9
Medication: Paracetamol	0.2	0.3	0.5	-0.4	-0.5	0.7
Medication: Lisinopril	0.5	0.6	1.8	1.3	-0.1	0.2
Medication: Atorvastatin	0.5	0.6	1.3	-0.2	0.6	1.1
Illnesses of father: High blood pressure	0.6	0.8	1.6	-1.2	0.9	-0.0
Alcohol drinker status: Never	0.3	0.3	0.6	0.8	0.1	-0.5
Ever smoked	0.8	1.4	3.0	0.3	-1.7	-1.0
Basal metabolic rate	0.9	5.1	15.4	-3.9	0.1	0.1
Leg fat percentage (left)	1.1	3.8	8.4	2.9	-1.7	-0.5
Arm fat-free mass (left)	1.3	6.6	19.7	-4.4	-0.2	-0.2
Number of operations (self-reported)	0.4	0.6	1.3	-1.2	0.7	-0.2
Average weekly beer plus cider intake	0.2	0.2	0.4	0.6	-0.4	-0.4
Irritability	0.3	0.6	1.6	0.0	-1.3	-0.4
Risk taking	3.7	5.4	13.8	-3.7	0.4	1.5
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.5	0.2	-0.7	-0.5
Fractured/broken bones in last 5 years	1.3	1.6	4.5	0.6	0.2	-2.1
Age started oral contraceptive pill	3.8	4.8	13.7	-0.1	-0.8	3.7
Diastolic blood pressure, automated reading	0.4	1.2	2.0	0.9	-1.4	0.9
Ever depressed for a whole week	2.4	3.0	5.9	-2.4	1.2	1.3
Unable to work because of sickness or disability	0.0	0.0	0.1	0.3	-0.1	-0.0
Commuting to job workplace: Cycle	1.8	2.2	3.3	-1.5	1.8	-1.1
Myopia	0.3	0.4	0.6	0.7	-0.7	-0.1
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	-0.3	-0.4	-0.8
Cholesterol lowering medication	0.0	0.1	0.1	-0.4	-0.1	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.0	0.1	-0.4	-1.0
Pain experienced in last month	0.2	0.3	0.6	-0.4	0.7	-0.3
Supplements: Calcium	2.8	3.1	4.3	1.9	-2.1	-1.1
Basal cell carcinoma (self-reported)	0.8	0.9	1.2	-0.8	1.1	-1.0
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.8	-0.1	-0.8	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.7	1.0	1.7	0.9	-1.3	-0.5
Heart disease (siblings)	0.2	0.3	0.6	0.4	0.4	0.8
Alcohol drinker status: Previous	0.7	0.8	0.9	0.8	-1.0	0.9
Pack years of smoking	0.8	1.2	2.0	1.2	-1.4	-0.2
Impedance of whole body	1.2	6.3	18.4	4.3	-0.6	-0.4
Leg fat mass (left)	0.4	1.6	2.6	1.4	-1.6	-0.4
Arm predicted mass (left)	1.4	7.3	21.8	-4.7	-0.4	-0.3