Best TWAS P=4.45e-18 · Best GWAS P=9.9e-20 conditioned to 0.0111
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | TSEN15 | 0.23 | 0.18 | lasso | 9 | 0.18 | 4.7e-21 | 8.8 | 8.7 | 4.5e-18 | 0.90 | 0.01 | 0.99 | TRUE |
2 | GTEx | Adipose Subcutaneous | RP11-181K3.4 | 0.09 | 0.11 | enet | 9 | 0.09 | 6.7e-08 | 5.9 | 5.9 | 4.7e-09 | 0.04 | 0.11 | 0.89 | FALSE |
3 | GTEx | Adipose Visceral Omentum | RP11-181K3.4 | 0.13 | 0.06 | lasso | 3 | 0.14 | 8.3e-08 | 5.9 | 6.1 | 1.1e-09 | 0.04 | 0.05 | 0.95 | FALSE |
4 | GTEx | Artery Aorta | RP11-181K3.4 | 0.17 | 0.01 | enet | 16 | 0.02 | 2.3e-02 | 5.9 | 5.8 | 8.7e-09 | 0.06 | 0.07 | 0.91 | FALSE |
5 | GTEx | Artery Tibial | LAMC1 | 0.10 | 0.10 | lasso | 5 | 0.10 | 2.2e-08 | 5.9 | -6.0 | 1.7e-09 | -0.03 | 0.08 | 0.92 | FALSE |
6 | GTEx | Artery Tibial | RP11-181K3.4 | 0.07 | 0.07 | lasso | 15 | 0.05 | 1.1e-04 | 5.9 | 6.1 | 1.4e-09 | 0.06 | 0.10 | 0.89 | FALSE |
7 | GTEx | Brain Cerebellar Hemisphere | LAMC1 | 0.50 | 0.16 | enet | 13 | 0.13 | 3.8e-04 | 6.2 | 6.0 | 1.4e-09 | 0.04 | 0.05 | 0.93 | FALSE |
8 | GTEx | Brain Cerebellar Hemisphere | TSEN15 | 0.38 | 0.08 | lasso | 13 | 0.16 | 5.3e-05 | 8.8 | 8.3 | 7.0e-17 | 0.83 | 0.01 | 0.96 | FALSE |
9 | GTEx | Brain Cerebellum | LAMC1 | 0.27 | 0.36 | enet | 29 | 0.29 | 3.5e-09 | 6.2 | 6.1 | 1.4e-09 | 0.00 | 0.04 | 0.96 | FALSE |
10 | GTEx | Brain Cerebellum | COLGALT2 | 0.49 | 0.05 | lasso | 8 | 0.10 | 9.2e-04 | 6.1 | -5.4 | 7.7e-08 | -0.39 | 0.10 | 0.19 | FALSE |
11 | GTEx | Colon Transverse | TSEN15 | 0.17 | 0.05 | enet | 18 | 0.06 | 7.2e-04 | 4.7 | 5.4 | 7.8e-08 | 0.63 | 0.16 | 0.71 | FALSE |
12 | GTEx | Esophagus Muscularis | LAMC1 | 0.11 | 0.08 | enet | 9 | 0.03 | 4.4e-03 | 6.1 | -6.1 | 8.4e-10 | -0.02 | 0.05 | 0.93 | FALSE |
13 | GTEx | Esophagus Muscularis | RP11-181K3.4 | 0.05 | 0.09 | lasso | 1 | 0.07 | 3.9e-05 | 6.2 | 6.2 | 6.1e-10 | 0.03 | 0.05 | 0.94 | TRUE |
14 | GTEx | Lung | LAMC1 | 0.18 | 0.20 | enet | 33 | 0.19 | 2.3e-14 | 6.2 | -6.0 | 2.4e-09 | -0.04 | 0.05 | 0.95 | FALSE |
15 | GTEx | Nerve Tibial | LAMC1 | 0.07 | 0.08 | enet | 30 | 0.05 | 1.1e-04 | 6.2 | 5.8 | 4.8e-09 | 0.07 | 0.04 | 0.96 | FALSE |
16 | GTEx | Nerve Tibial | RP11-181K3.4 | 0.18 | 0.24 | enet | 30 | 0.24 | 2.9e-17 | 6.2 | 6.1 | 1.4e-09 | 0.03 | 0.04 | 0.96 | FALSE |
17 | GTEx | Thyroid | RP11-181K3.4 | 0.12 | 0.07 | lasso | 4 | 0.05 | 5.7e-05 | 5.8 | 5.9 | 3.0e-09 | 0.05 | 0.08 | 0.91 | FALSE |
18 | GTEx | Whole Blood | LAMC1 | 0.08 | 0.05 | enet | 21 | 0.04 | 1.0e-04 | 5.9 | 5.6 | 2.7e-08 | 0.05 | 0.06 | 0.94 | FALSE |
19 | METSIM | Adipose | TSEN15 | 0.06 | 0.02 | enet | 28 | 0.04 | 1.3e-06 | 8.8 | 8.0 | 1.5e-15 | 0.76 | 0.01 | 0.99 | FALSE |
20 | NTR | Blood | LAMC1 | 0.05 | 0.07 | lasso | 11 | 0.07 | 3.7e-21 | -4.6 | 5.3 | 1.1e-07 | -0.03 | 0.66 | 0.34 | FALSE |
21 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GLT25D2 | 0.05 | 0.01 | enet | 10 | 0.04 | 6.3e-05 | 4.0 | -8.0 | 1.8e-15 | -0.69 | 0.01 | 0.93 | FALSE |
22 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GLT25D2 | 0.11 | 0.02 | blup | 119 | 0.05 | 5.1e-06 | -1.7 | -6.0 | 2.5e-09 | -0.50 | 0.14 | 0.32 | FALSE |
23 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LAMC1 | 0.04 | 0.03 | blup | 108 | 0.04 | 1.2e-05 | 6.2 | -5.9 | 3.5e-09 | -0.04 | 0.05 | 0.95 | FALSE |
24 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TSEN15 | 0.11 | 0.08 | blup | 52 | 0.10 | 6.7e-12 | 8.8 | 7.6 | 3.9e-14 | 0.78 | 0.01 | 0.99 | FALSE |
25 | The Cancer Genome Atlas | Thyroid Carcinoma | LAMC1 | 0.06 | 0.04 | blup | 109 | 0.05 | 1.3e-05 | 5.9 | -5.8 | 7.3e-09 | -0.07 | 0.05 | 0.95 | FALSE |