Best TWAS P=1.2e-09 · Best GWAS P=2.25e-11 conditioned to 2.74e-11
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | MPHOSPH6 | 0.32 | 0.14 | lasso | 4 | 0.17 | 3.5e-09 | 5.1 | 5.5 | 4.7e-08 | -0.01 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Adrenal Gland | MPHOSPH6 | 0.34 | 0.25 | lasso | 3 | 0.26 | 8.4e-10 | 5.7 | 5.3 | 1.3e-07 | -0.01 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Tibial | MPHOSPH6 | 0.36 | 0.24 | enet | 9 | 0.27 | 1.9e-21 | 5.7 | 5.6 | 2.1e-08 | -0.01 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | MPHOSPH6 | 0.49 | 0.30 | enet | 12 | 0.31 | 8.5e-09 | 5.7 | 5.3 | 9.5e-08 | -0.01 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Brain Cerebellum | MPHOSPH6 | 0.40 | 0.36 | enet | 10 | 0.39 | 1.8e-12 | 4.4 | 5.2 | 1.5e-07 | -0.03 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Colon Transverse | MPHOSPH6 | 0.21 | 0.16 | lasso | 3 | 0.17 | 1.4e-08 | 5.7 | 5.6 | 2.1e-08 | -0.01 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Esophagus Gastroesophageal Junction | MPHOSPH6 | 0.43 | 0.19 | enet | 30 | 0.19 | 1.8e-07 | 5.5 | 5.2 | 1.8e-07 | -0.02 | 0.01 | 0.99 | FALSE |
| 8 | GTEx | Esophagus Muscularis | MPHOSPH6 | 0.36 | 0.23 | lasso | 7 | 0.20 | 1.7e-12 | 5.7 | 5.7 | 1.1e-08 | -0.01 | 0.00 | 1.00 | FALSE |
| 9 | GTEx | Heart Atrial Appendage | MPHOSPH6 | 0.33 | 0.19 | enet | 27 | 0.21 | 5.4e-10 | 5.7 | 5.2 | 2.3e-07 | -0.02 | 0.01 | 0.99 | FALSE |
| 10 | GTEx | Heart Left Ventricle | MPHOSPH6 | 0.28 | 0.24 | lasso | 3 | 0.24 | 8.9e-13 | 5.7 | 5.7 | 1.1e-08 | -0.01 | 0.00 | 1.00 | FALSE |
| 11 | GTEx | Lung | MPHOSPH6 | 0.16 | 0.10 | lasso | 4 | 0.11 | 8.3e-09 | 5.7 | 5.5 | 3.9e-08 | -0.02 | 0.01 | 0.99 | FALSE |
| 12 | GTEx | Muscle Skeletal | MPHOSPH6 | 0.27 | 0.19 | lasso | 7 | 0.23 | 1.4e-22 | 5.7 | 5.2 | 1.9e-07 | -0.01 | 0.00 | 1.00 | FALSE |
| 13 | GTEx | Nerve Tibial | MPHOSPH6 | 0.40 | 0.22 | lasso | 7 | 0.28 | 1.0e-19 | 5.7 | 6.0 | 1.9e-09 | -0.02 | 0.00 | 1.00 | FALSE |
| 14 | GTEx | Stomach | MPHOSPH6 | 0.41 | 0.10 | lasso | 7 | 0.09 | 3.5e-05 | 4.8 | 6.1 | 1.2e-09 | 0.00 | 0.01 | 0.99 | TRUE |
| 15 | GTEx | Testis | MPHOSPH6 | 0.52 | 0.32 | lasso | 11 | 0.35 | 2.0e-16 | 5.7 | 5.7 | 1.3e-08 | -0.02 | 0.00 | 1.00 | FALSE |
| 16 | GTEx | Thyroid | MPHOSPH6 | 0.31 | 0.21 | lasso | 4 | 0.26 | 4.7e-20 | 5.1 | 5.5 | 3.3e-08 | -0.01 | 0.01 | 0.99 | FALSE |
| 17 | METSIM | Adipose | MPHOSPH6 | 0.12 | 0.07 | bslmm | 741 | 0.08 | 2.0e-11 | 5.5 | 5.2 | 2.4e-07 | -0.05 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MPHOSPH6 | 0.07 | 0.03 | lasso | 4 | 0.06 | 8.0e-07 | 5.6 | 5.2 | 1.6e-07 | -0.04 | 0.01 | 0.98 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | MPHOSPH6 | 0.18 | 0.16 | lasso | 3 | 0.16 | 5.1e-15 | 5.7 | 5.6 | 2.0e-08 | -0.02 | 0.00 | 1.00 | FALSE |