Best TWAS P=2.4e-18 · Best GWAS P=4.13e-15 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | FAM208A | 0.12 | 0.09 | enet | 11 | 0.12 | 1.1e-09 | -4.1 | 6.5 | 6.7e-11 | -0.86 | 0.03 | 0.97 | FALSE |
| 2 | GTEx | Brain Hippocampus | CCDC66 | 0.23 | 0.23 | lasso | 3 | 0.20 | 2.1e-05 | -6.0 | 5.7 | 1.6e-08 | -0.63 | 0.25 | 0.17 | TRUE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | CCDC66 | 0.45 | 0.27 | enet | 37 | 0.29 | 3.7e-10 | -6.5 | -5.5 | 3.5e-08 | 0.34 | 0.98 | 0.01 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | FAM208A | 0.10 | 0.00 | lasso | 4 | 0.00 | 1.3e-01 | -7.9 | 7.3 | 3.6e-13 | -0.94 | 0.01 | 0.97 | FALSE |
| 5 | GTEx | Pituitary | CCDC66 | 0.16 | 0.16 | enet | 31 | 0.12 | 6.8e-04 | -3.4 | 6.3 | 2.4e-10 | -0.78 | 0.02 | 0.92 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | FAM208A | 0.06 | 0.04 | lasso | 2 | 0.03 | 2.0e-03 | -5.8 | 5.8 | 7.3e-09 | -0.60 | 0.20 | 0.48 | TRUE |
| 7 | YFS | Blood | CCDC66 | 0.11 | 0.09 | lasso | 8 | 0.11 | 6.0e-34 | -6.5 | -6.6 | 5.6e-11 | 0.49 | 0.99 | 0.01 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CCDC66 | 0.09 | 0.03 | lasso | 8 | 0.05 | 4.2e-11 | -5.6 | -7.7 | 2.0e-14 | 0.65 | 0.20 | 0.80 | FALSE |
| 9 | The Cancer Genome Atlas | Colon Adenocarcinoma | CCDC66 | 0.14 | 0.12 | lasso | 2 | 0.10 | 1.2e-06 | -5.6 | -5.5 | 3.2e-08 | 0.42 | 0.62 | 0.16 | FALSE |
| 10 | The Cancer Genome Atlas | Glioblastoma Multiforme | CCDC66 | 0.19 | 0.02 | enet | 14 | 0.12 | 1.7e-04 | 2.3 | -5.6 | 2.3e-08 | 0.24 | 0.04 | 0.07 | TRUE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CCDC66 | 0.05 | 0.05 | blup | 56 | 0.06 | 1.0e-07 | -7.8 | -8.7 | 4.8e-18 | 0.81 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C3orf63 | 0.03 | 0.01 | enet | 4 | 0.01 | 1.3e-02 | -7.8 | 7.1 | 1.1e-12 | -0.94 | 0.01 | 0.89 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC66 | 0.09 | 0.05 | blup | 56 | 0.06 | 5.3e-07 | -6.4 | -6.7 | 2.8e-11 | 0.59 | 0.83 | 0.17 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CCDC66 | 0.16 | 0.13 | enet | 12 | 0.16 | 3.1e-17 | -6.5 | -6.2 | 4.5e-10 | 0.29 | 0.98 | 0.02 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Adenocarcinoma | CCDC66 | 0.05 | 0.06 | blup | 56 | 0.05 | 9.7e-07 | -7.8 | -8.7 | 2.4e-18 | 0.79 | 0.00 | 1.00 | TRUE |
| 16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CCDC66 | 0.03 | 0.03 | blup | 56 | 0.03 | 9.6e-05 | -5.6 | -7.1 | 1.0e-12 | 0.56 | 0.34 | 0.26 | FALSE |
| 17 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CCDC66 | 0.08 | 0.01 | blup | 56 | 0.07 | 7.2e-04 | -6.5 | -6.3 | 2.8e-10 | 0.36 | 0.12 | 0.07 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CCDC66 | 0.15 | 0.10 | enet | 11 | 0.13 | 7.3e-14 | -5.6 | -6.3 | 2.2e-10 | 0.39 | 0.99 | 0.01 | TRUE |
| 19 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CCDC66 | 0.05 | 0.01 | blup | 57 | 0.02 | 8.4e-03 | -5.6 | -7.2 | 7.1e-13 | 0.64 | 0.07 | 0.57 | FALSE |