Best TWAS P=1.1e-75 · Best GWAS P=3.76e-68 conditioned to 0.863
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | L3MBTL3 | 0.20 | 0.08 | lasso | 4 | 0.09 | 1.1e-07 | 17.4 | 18.0 | 1.4e-72 | 0.94 | 0.00 | 1.00 | FALSE |
2 | GTEx | Adipose Visceral Omentum | L3MBTL3 | 0.14 | 0.12 | lasso | 2 | 0.15 | 2.8e-08 | 17.4 | 18.2 | 2.1e-74 | 0.94 | 0.00 | 1.00 | FALSE |
3 | GTEx | Breast Mammary Tissue | L3MBTL3 | 0.31 | 0.25 | lasso | 7 | 0.23 | 2.8e-12 | 17.4 | 18.0 | 8.6e-73 | 0.97 | 0.00 | 1.00 | FALSE |
4 | GTEx | Breast Mammary Tissue | RP11-73O6.3 | 0.27 | 0.22 | lasso | 9 | 0.22 | 1.5e-11 | 17.4 | 17.8 | 7.1e-71 | 0.97 | 0.00 | 1.00 | FALSE |
5 | GTEx | Breast Mammary Tissue (Male) | L3MBTL3 | 0.31 | 0.24 | lasso | 6 | 0.23 | 5.5e-06 | 17.4 | 18.2 | 8.2e-74 | 0.94 | 0.00 | 0.98 | FALSE |
6 | GTEx | Breast Mammary Tissue (Male) | RP11-73O6.3 | 0.33 | 0.17 | lasso | 4 | 0.12 | 1.3e-03 | 17.4 | 17.0 | 5.0e-65 | 0.94 | 0.01 | 0.95 | FALSE |
7 | GTEx | Breast Mammary Tissue (Female) | L3MBTL3 | 0.30 | 0.13 | lasso | 5 | 0.14 | 4.5e-05 | 13.1 | 17.6 | 3.0e-69 | 0.93 | 0.01 | 0.98 | FALSE |
8 | GTEx | Breast Mammary Tissue (Female) | RP11-73O6.3 | 0.29 | 0.08 | lasso | 5 | 0.10 | 5.7e-04 | 14.8 | 17.6 | 5.4e-69 | 0.90 | 0.01 | 0.96 | FALSE |
9 | GTEx | Cells EBV-transformed lymphocytes | L3MBTL3 | 0.28 | 0.08 | lasso | 10 | 0.03 | 4.4e-02 | 17.4 | 16.9 | 2.6e-64 | 0.85 | 0.01 | 0.96 | FALSE |
10 | GTEx | Colon Transverse | L3MBTL3 | 0.27 | 0.13 | lasso | 8 | 0.20 | 8.0e-10 | 17.4 | 17.6 | 2.1e-69 | 0.88 | 0.00 | 1.00 | FALSE |
11 | GTEx | Colon Transverse | RP11-73O6.3 | 0.19 | 0.09 | lasso | 2 | 0.06 | 1.2e-03 | 17.4 | 17.9 | 9.6e-72 | 0.99 | 0.00 | 1.00 | FALSE |
12 | GTEx | Esophagus Mucosa | L3MBTL3 | 0.26 | 0.18 | lasso | 2 | 0.23 | 2.7e-15 | 14.8 | 17.4 | 8.5e-68 | 0.93 | 0.00 | 1.00 | FALSE |
13 | GTEx | Lung | L3MBTL3 | 0.37 | 0.34 | lasso | 4 | 0.38 | 4.1e-30 | 17.4 | 18.3 | 7.5e-75 | 0.96 | 0.00 | 1.00 | FALSE |
14 | GTEx | Lung | RP11-73O6.3 | 0.15 | 0.08 | lasso | 5 | 0.12 | 2.2e-09 | 17.4 | 18.2 | 4.9e-74 | 0.93 | 0.00 | 1.00 | FALSE |
15 | GTEx | Nerve Tibial | L3MBTL3 | 0.30 | 0.23 | lasso | 4 | 0.22 | 2.3e-15 | 17.4 | 18.1 | 3.9e-73 | 0.99 | 0.00 | 1.00 | FALSE |
16 | GTEx | Pancreas | L3MBTL3 | 0.32 | 0.17 | lasso | 4 | 0.23 | 4.4e-10 | 17.4 | 18.2 | 5.1e-74 | 0.98 | 0.00 | 1.00 | FALSE |
17 | GTEx | Pituitary | L3MBTL3 | 0.45 | 0.31 | lasso | 8 | 0.29 | 5.1e-08 | 13.1 | 15.5 | 2.1e-54 | 0.85 | 0.01 | 0.99 | FALSE |
18 | GTEx | Pituitary | RP11-73O6.3 | 0.48 | 0.07 | lasso | 7 | 0.16 | 8.2e-05 | 13.1 | 13.2 | 6.3e-40 | 0.78 | 0.01 | 0.97 | FALSE |
19 | GTEx | Prostate | L3MBTL3 | 0.35 | 0.27 | lasso | 5 | 0.17 | 5.9e-05 | 17.4 | 17.8 | 5.3e-71 | 0.97 | 0.00 | 0.99 | FALSE |
20 | GTEx | Skin Not Sun Exposed Suprapubic | L3MBTL3 | 0.26 | 0.12 | lasso | 4 | 0.12 | 4.0e-07 | 13.7 | 17.2 | 5.3e-66 | 0.92 | 0.00 | 1.00 | FALSE |
21 | GTEx | Skin Sun Exposed Lower leg | L3MBTL3 | 0.25 | 0.25 | lasso | 9 | 0.24 | 1.4e-19 | 17.4 | 17.7 | 4.1e-70 | 0.97 | 0.00 | 1.00 | FALSE |
22 | GTEx | Small Intestine Terminal Ileum | L3MBTL3 | 0.37 | 0.20 | lasso | 4 | 0.17 | 1.3e-04 | 17.4 | 18.0 | 3.6e-72 | 0.98 | 0.00 | 0.98 | FALSE |
23 | GTEx | Spleen | L3MBTL3 | 0.64 | 0.34 | enet | 14 | 0.48 | 6.4e-14 | 14.8 | 17.8 | 5.8e-71 | 0.87 | 0.02 | 0.98 | FALSE |
24 | GTEx | Spleen | RP11-73O6.3 | 0.45 | 0.43 | enet | 21 | 0.42 | 7.7e-12 | 14.9 | 16.5 | 6.0e-61 | 0.82 | 0.06 | 0.94 | FALSE |
25 | GTEx | Stomach | L3MBTL3 | 0.36 | 0.18 | enet | 27 | 0.20 | 1.1e-09 | 17.1 | 16.9 | 9.9e-64 | 0.77 | 0.02 | 0.98 | FALSE |
26 | GTEx | Stomach | RP11-73O6.3 | 0.21 | 0.12 | lasso | 6 | 0.06 | 5.9e-04 | 17.1 | 16.9 | 2.3e-64 | 0.73 | 0.07 | 0.74 | FALSE |
27 | GTEx | Testis | L3MBTL3 | 0.41 | 0.22 | lasso | 8 | 0.30 | 9.2e-14 | 17.4 | 16.9 | 5.0e-64 | 0.90 | 0.00 | 1.00 | FALSE |
28 | GTEx | Thyroid | L3MBTL3 | 0.40 | 0.39 | enet | 9 | 0.43 | 2.8e-35 | 17.4 | 18.4 | 1.1e-75 | 0.95 | 0.00 | 1.00 | TRUE |
29 | GTEx | Thyroid | RP11-73O6.3 | 0.18 | 0.15 | lasso | 3 | 0.20 | 2.3e-15 | 16.0 | 18.2 | 1.1e-73 | 0.91 | 0.00 | 1.00 | FALSE |
30 | GTEx | Whole Blood | L3MBTL3 | 0.22 | 0.20 | lasso | 9 | 0.20 | 5.1e-18 | 17.4 | 18.0 | 4.6e-72 | 0.98 | 0.00 | 1.00 | FALSE |
31 | GTEx | Whole Blood | RP11-73O6.3 | 0.15 | 0.06 | lasso | 8 | 0.04 | 1.1e-04 | 17.4 | 17.9 | 5.0e-72 | 0.97 | 0.00 | 0.99 | FALSE |
32 | METSIM | Adipose | L3MBTL3 | 0.13 | 0.12 | enet | 22 | 0.12 | 4.8e-18 | 14.8 | 13.6 | 4.3e-42 | 0.72 | 0.99 | 0.01 | FALSE |
33 | ROSMAP | Brain Pre-frontal Cortex | EPB41L2 | 0.12 | 0.12 | blup | 522 | 0.10 | 6.5e-13 | 2.9 | 5.2 | 2.5e-07 | 0.00 | 0.92 | 0.00 | TRUE |
34 | ROSMAP | Brain Pre-frontal Cortex | L3MBTL3 | 0.14 | 0.07 | blup | 609 | 0.08 | 3.8e-10 | 17.4 | 14.1 | 3.9e-45 | 0.72 | 0.00 | 1.00 | FALSE |
35 | YFS | Blood | L3MBTL3 | 0.28 | 0.22 | blup | 614 | 0.27 | 1.2e-88 | 14.8 | 14.2 | 5.0e-46 | 0.74 | 1.00 | 0.00 | FALSE |
36 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | L3MBTL3 | 0.05 | 0.00 | blup | 114 | 0.01 | 1.0e-02 | 11.1 | 6.8 | 1.5e-11 | 0.33 | 0.02 | 0.24 | FALSE |
37 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | L3MBTL3 | 0.06 | 0.01 | blup | 114 | 0.04 | 4.0e-03 | 14.8 | 13.9 | 8.1e-44 | 0.77 | 0.02 | 0.84 | FALSE |