TWAS hub - EPB41L2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1510	0.0350	6.9e-12	0.068	0.091	0.074	0.092	0.072	1.1e-08	3.5e-11	2.4e-09	2.8e-11	3.7e-09
2	GTEx	Artery Aorta	0.0980	0.0430	7.5e-03	0.005	NA	0.003	NA	0.008	1.6e-01	NA	2.2e-01	NA	1.1e-01
3	GTEx	Esophagus Muscularis	0.0930	0.0420	8.1e-03	0.003	NA	-0.001	NA	0.001	2.0e-01	NA	3.6e-01	NA	2.9e-01
4	NTR	Blood	0.0329	0.0102	1.6e-05	0.013	0.016	0.017	0.017	0.018	2.6e-05	4.2e-06	1.9e-06	2.2e-06	1.5e-06
5	ROSMAP	Brain Pre-frontal Cortex	0.1178	0.0278	7.1e-11	0.115	0.101	0.088	0.100	0.098	1.4e-14	6.5e-13	1.9e-11	8.4e-13	1.4e-12
6	TCGA	Breast Invasive Carcinoma	0.0228	0.0123	9.2e-04	0.009	0.005	0.016	NA	0.005	4.8e-03	2.4e-02	2.4e-04	NA	2.5e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Suffer from ‘nerves’	5.7	8.9	19.3	-2.6	-4.4	-3.6	-2.9	-2.3	-0.6
Hair/balding pattern: Pattern 4	5.5	13.2	19.8	-4.5	-3.4	-3.2	3.5	-2.7	4.2
Tense / ‘highly strung’	5.3	8.7	13.9	-3.4	-3.7	-3.6	-1.1	-3.0	1.8
Frequency of tenseness / restlessness in last 2 weeks	5.2	8.1	14.8	-3.0	-3.8	-3.7	-2.2	-2.4	-0.1
Nervous feelings	4.5	8.4	18.6	-3.1	-3.5	-4.3	-1.3	-2.5	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	4.5	6.8	14.2	-3.8	-3.5	-2.5	-1.3	-2.5	0.4
Worry (Nagel 2018)	4.4	9.3	18.1	-3.4	-3.6	-4.3	-2.0	-2.9	1.0
Neuroticism score	4.0	8.3	15.3	-3.6	-3.9	-3.7	-1.5	-2.3	0.5
Neuroticism (2016)	3.7	5.3	10.3	-2.7	-2.1	-3.2	-0.4	-2.7	1.7
Ever had stillbirth, spontaneous miscarriage or termination	3.7	3.9	6.7	-2.5	-1.4	-2.6	0.3	-2.1	2.1
Supplements: Glucosamine	3.6	4.7	9.6	3.1	2.3	2.0	1.2	2.8	0.4
Forced vital capacity (FVC), Best measure	3.6	13.1	26.8	3.6	2.7	4.9	2.5	5.2	-1.3
Frequency of depressed mood in last 2 weeks	3.5	4.9	11.5	-2.1	-3.4	-3.1	-1.1	-1.6	0.4
Forced vital capacity (FVC)	3.5	13.6	30.0	3.8	1.8	4.9	2.8	5.5	-1.2
Neuroticism (Nagel 2018)	3.3	7.7	14.2	-3.1	-3.8	-3.5	-2.2	-2.3	0.5
Maternal smoking around birth	3.1	4.5	11.1	-2.0	-1.8	-0.3	3.3	-1.5	2.6
Angina (self-reported)	3.1	4.0	7.9	-2.0	-2.3	-2.0	0.9	-2.8	1.5
Loneliness, isolation	3.1	4.2	9.7	-2.6	-3.1	-2.6	0.1	-1.3	0.9
Commuting to job workplace: Walk	3.1	3.4	8.1	-1.4	-0.4	-2.2	0.8	-2.1	2.8
Medication for hormone replacement therapy	3.0	3.3	7.4	-2.5	-1.0	-1.9	1.1	-2.7	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	3.0	3.9	8.5	-2.1	-2.9	-2.6	-1.1	-1.6	0.2
Depression (Nagel 2018)	2.9	4.3	6.8	-2.4	-2.6	-2.6	-1.7	-1.9	0.3
Fluid intelligence score	2.9	6.0	10.3	1.1	2.4	2.6	-2.1	2.8	-3.2
Bipolar Disorder or Schizophrenia	2.8	6.9	13.2	-2.4	-2.8	-3.6	-1.7	-3.1	1.6
Worrier / anxious feelings	2.8	5.2	9.7	-2.8	-2.8	-3.1	0.5	-1.7	1.7
Bipolar Disorder (2018)	2.7	4.3	7.1	-2.1	-1.6	-2.7	-0.2	-2.4	2.4
Heel T-Score	2.7	21.5	52.0	2.2	0.7	6.8	7.2	5.0	-0.4
Lung FVC	2.7	13.6	41.0	3.6	3.1	6.4	2.0	3.4	-1.6
Systolic blood pressure, automated reading	2.7	7.8	16.3	-1.7	-3.4	-4.0	0.8	-3.3	2.1
Angina	2.7	3.6	7.5	-1.9	-2.0	-2.1	0.6	-2.7	1.4
Mean time to correctly identify matches	2.7	5.1	10.6	-2.7	-1.5	-2.5	-2.0	-3.3	0.9
Heel bone mineral density (BMD) T-score, automated (left)	2.6	6.0	23.4	0.1	-0.9	2.9	4.8	1.4	1.2
Forced expiratory volume in 1-second (FEV1)	2.6	8.7	17.8	3.3	1.5	3.9	2.1	4.2	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	2.6	8.3	15.4	3.0	2.3	3.9	1.9	3.8	-1.1
Pulse wave peak to peak time	2.6	3.0	5.2	2.3	1.2	1.8	-1.4	1.5	-2.0
Commuting to job workplace: Car/motor vehicle	2.6	3.0	6.6	1.9	2.6	2.3	0.4	1.3	-0.8
Guilty feelings	2.6	3.8	9.3	-1.4	-2.4	-2.3	-3.0	-0.8	-0.3
Severe depression (siblings)	2.5	2.8	7.9	-0.8	-2.1	-2.8	-1.6	-1.0	-0.1
Systolic Blood Pressure	2.4	12.2	24.2	-3.0	-3.3	-4.9	1.9	-4.3	2.7
Diabetes (father)	2.4	2.9	6.9	0.6	2.6	1.6	0.4	2.4	-1.3
Major Depression (MDD)	2.3	2.8	6.7	-2.1	-1.5	-1.6	-0.3	-2.6	1.0
Fed-up feelings	2.3	4.2	17.0	-1.1	-4.1	-2.3	-0.8	-0.8	0.7
Lung cancer (father)	2.3	2.6	6.3	1.4	1.4	1.0	-0.9	1.9	-2.5
Reaction Time	2.2	4.3	8.1	-2.6	-1.2	-2.2	-2.1	-2.8	0.2
Hand grip strength (right)	2.2	6.0	8.1	2.6	2.7	2.6	2.8	2.7	0.0
Hip circumference	2.2	9.3	26.2	3.0	1.7	2.8	1.0	5.1	-3.0
Qualifications: O levels/GCSEs or equivalent	2.2	3.5	5.9	2.3	2.2	1.5	-0.9	2.4	-1.4
Birth weight	2.2	4.7	9.5	3.1	1.4	1.7	-1.1	2.6	-2.4
Mineral and other dietary supplements	2.2	3.0	8.1	-1.7	-2.9	-0.8	0.4	-2.4	0.7
Neuroticism	2.1	5.0	9.4	-3.1	-2.0	-2.9	-1.8	-2.3	0.4
Age at first live birth	2.1	3.7	7.1	2.7	1.6	2.2	0.8	2.6	-0.3
Hearing difficulty/problems with background noise	2.0	3.1	7.3	-2.7	0.4	-1.2	0.4	-2.1	2.3
Pulse wave Arterial Stiffness index	2.0	2.3	3.8	-2.0	-1.2	-1.6	1.4	-0.9	1.8
Comparative body size at age 10	2.0	5.5	9.9	3.1	1.9	2.9	1.4	2.1	-2.1
Chest pain or discomfort	2.0	2.9	7.1	-2.7	-2.6	-1.0	0.9	-0.2	1.1
Schizophrenia (2014)	1.9	4.2	8.2	-1.5	-2.2	-2.9	-2.3	-2.1	-0.0
Hearing difficulty/problems: Yes	1.9	2.9	8.1	-2.3	-0.0	0.2	1.5	-1.3	2.9
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.4	13.6	0.7	-0.5	3.0	3.7	1.8	-0.1
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	3.2	-1.6	-1.5	-1.7	-0.8	-1.5	1.8
High blood pressure (siblings)	1.9	2.8	5.1	-1.9	-0.4	-2.2	1.2	-1.4	2.1
Body Mass Index (BMI) (2010)	1.8	2.4	5.7	1.6	0.4	1.9	-1.2	1.2	-2.4
Friendships satisfaction	1.8	2.3	6.0	-0.4	-1.9	-1.1	-2.5	-1.1	-1.2
Vascular/heart problems diagnosed by doctor	1.8	4.8	9.7	2.1	1.6	2.6	-1.1	3.1	-2.1
Schizophrenia (2018)	1.7	3.5	6.4	-1.3	-2.2	-2.5	-1.9	-2.0	0.1
Bipolar Disorder (2011)	1.7	1.7	3.3	-1.2	-1.4	0.1	1.5	-1.0	1.8
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	3.8	-1.1	-0.7	-2.0	0.7	-1.9	1.2
Stomach or abdominal pain in last month	1.7	2.1	4.5	-1.1	-2.1	-1.8	-1.1	-1.0	1.2
Happiness	1.7	2.1	3.0	-1.6	-1.5	-1.7	-1.4	-1.6	0.1
Financial situation satisfaction	1.7	2.1	4.2	-1.3	-1.0	-1.8	-2.1	-0.6	-1.4
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	5.5	1.5	-0.5	2.0	2.4	0.8	0.1
Exposure to tobacco smoke at home	1.6	1.8	3.8	-1.9	0.7	-1.1	0.6	-1.4	1.7
Wheeze or whistling in the chest in last year	1.6	2.8	6.0	-2.3	-2.4	-1.4	0.9	-0.9	1.4
Migraine (self-reported)	1.6	2.0	4.4	0.0	-2.0	1.6	2.1	0.1	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	9.1	2.3	1.8	3.0	0.8	0.9	-1.1
Ever taken oral contraceptive pill	1.6	1.8	5.4	-1.3	-1.5	0.7	-0.9	0.2	-2.3
Waist Hip Ratio (WHR)	1.5	6.6	11.4	-2.7	-2.5	-3.1	-0.1	-3.4	2.2
Hand grip strength (left)	1.5	3.9	7.3	2.0	2.7	1.3	2.6	1.6	0.9
Sitting height	1.5	10.8	41.1	2.3	0.5	2.6	3.3	6.4	-0.8
Pain all over the body in last month	1.5	1.6	3.4	-0.3	-1.8	0.0	1.7	-0.9	1.5
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	6.4	1.2	2.5	1.6	-0.7	1.7	-1.0
Worry too long after embarrassment	1.5	2.5	6.0	-1.6	-1.0	-2.2	-2.4	-0.8	-0.3
Rheumatoid Arthritis	1.4	1.9	4.2	-1.6	-0.9	-2.0	1.0	-1.5	1.0
Cardiovascular Disease	1.4	4.5	8.2	-1.1	-2.4	-2.8	0.4	-2.9	2.1
Weight	1.4	6.8	24.4	2.6	0.8	1.9	1.3	4.9	-2.0
Falls in the last year	1.4	1.8	3.1	0.7	-1.5	-1.8	0.7	-1.4	1.7
Depression (self-reported)	1.4	1.7	4.7	-1.9	-2.2	-0.9	0.2	-0.7	0.7
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.8	-2.2	-0.1	0.5	2.0	-0.6	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	4.8	-1.1	-2.2	-1.7	-0.9	0.2	1.2
Supplements: Vitamin C	1.4	1.6	5.0	1.4	2.2	1.1	0.5	0.9	-0.7
Leg fat-free mass (right)	1.4	7.5	26.4	3.0	1.5	1.7	1.0	5.1	-1.8
Long-standing illness, disability or infirmity	1.4	2.2	9.2	-0.9	-3.0	-1.3	-1.0	-0.7	-0.1
Leg predicted mass (right)	1.4	7.2	25.7	2.9	1.6	1.7	0.9	5.1	-1.8
Basal metabolic rate	1.4	7.7	28.8	2.8	1.5	1.6	1.2	5.4	-1.9
Arm fat-free mass (left)	1.4	7.2	25.6	2.7	1.7	1.7	1.3	5.1	-1.7
Blood Platelet Count	1.3	14.5	44.5	-1.5	-1.9	-3.7	-6.7	-3.7	-3.1
Leg fat-free mass (left)	1.3	6.9	25.1	2.8	1.4	1.6	1.1	5.0	-1.7
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	7.3	-0.0	-2.7	-0.8	0.8	0.0	-0.4
Leg predicted mass (left)	1.3	7.0	25.0	2.9	1.6	1.6	1.0	5.0	-1.7
Hair/balding pattern: Pattern 2	1.3	1.6	4.4	1.0	2.1	0.7	-1.1	0.5	-1.6
Medication: Cholesterol lowering	1.3	2.0	5.2	-1.2	-1.5	0.1	2.3	-1.5	1.1
Prospective memory result	1.3	1.6	3.5	-0.7	-1.7	-1.1	0.7	-0.9	1.9
Whole body fat-free mass	1.3	7.2	26.7	2.6	1.8	1.4	1.1	5.2	-1.6
Medication for cholesterol	1.3	2.0	3.4	1.5	0.3	1.7	-1.9	1.7	-0.5
Whole body water mass	1.3	7.5	27.9	2.8	1.8	1.5	1.0	5.3	-1.7
Wears glasses or contact lenses	1.3	1.5	2.7	0.7	-1.0	1.0	-1.6	1.2	-1.5
Arm predicted mass (left)	1.3	6.7	23.2	2.6	1.8	1.5	1.0	4.8	-1.9
Ulcerative Colitis (UC)	1.2	2.3	3.9	1.5	1.7	0.6	-1.4	1.5	-2.0
Average weekly fortified wine intake	1.2	1.5	3.7	0.2	1.9	1.0	1.6	1.0	0.7
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	6.4	0.5	2.5	0.4	-0.9	-0.2	-0.8
High blood pressure (mother)	1.2	1.6	4.7	-0.7	0.8	-0.9	1.7	-0.3	2.2
Trunk fat mass	1.2	5.0	14.8	1.9	0.5	2.2	0.6	3.9	-2.5
Illnesses of siblings	1.2	1.7	4.0	1.0	0.4	1.3	-1.6	1.1	-2.0
Trunk fat-free mass	1.2	6.8	26.3	2.4	1.8	1.4	1.1	5.1	-1.5
Trunk predicted mass	1.2	6.9	26.6	2.4	1.9	1.4	1.2	5.2	-1.4
Length of working week for main job	1.2	1.3	3.0	-1.2	-0.6	-1.1	-1.7	-1.3	-0.3
Mouth/teeth dental problems: Loose teeth	1.2	1.4	5.5	-2.3	0.7	-1.0	-1.1	0.1	-0.5
Comparative height size at age 10	1.2	6.5	29.5	2.4	-0.2	1.4	1.1	5.4	-0.8
Smoking status: Previous	1.2	1.8	3.9	-0.3	1.6	2.0	1.6	1.3	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.4	-1.8	-0.5	-0.9	-0.8	-1.8	-0.1
Medication: Aspirin	1.2	1.5	3.9	-1.1	-2.0	-0.8	-0.1	-1.8	0.0
Hearing aid user	1.2	1.4	2.4	-1.1	-0.6	-0.7	1.6	-1.4	1.3
Depressed Affect (Nagel 2018)	1.1	2.3	6.9	-1.5	-2.6	-1.5	-1.3	-0.9	-0.1
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.0	-1.2	-0.6	-1.3	0.9	-1.7	0.7
Sensitivity / hurt feelings	1.1	1.9	4.3	-2.1	-1.6	-1.6	-0.2	-1.3	0.2
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.4	0.2	-1.9	-0.9	-0.0	-0.2	1.6
High blood pressure	1.1	3.1	6.3	-1.6	-1.3	-2.5	0.7	-2.3	1.5
Past tobacco smoking	1.1	2.0	5.8	0.5	-1.3	-2.4	-1.4	-1.6	0.1
Headache pain in last month	1.1	2.0	4.7	-1.1	-1.5	-1.4	0.7	-1.0	2.2
Arm fat-free mass (right)	1.1	5.5	20.3	2.2	1.5	1.2	1.6	4.5	-1.2
Whole body fat mass	1.1	4.8	13.7	2.1	0.5	2.0	0.6	3.7	-2.4
Arm predicted mass (right)	1.1	5.5	20.9	2.1	1.6	1.1	1.7	4.6	-1.0
Family relationship satisfaction	1.1	1.4	2.4	-1.6	-1.5	-1.3	-1.1	-0.8	-0.0
Leg pain on walking	1.1	1.3	6.2	-1.0	-0.8	0.1	0.3	-0.2	2.5
Asthma (self-reported)	1.1	2.2	6.6	-2.6	-2.0	-1.3	0.5	-0.7	0.6
Tinnitus: Yes, now most or all of the time	1.1	1.2	2.3	1.5	0.8	1.1	1.5	1.0	0.4
High cholesterol (Self-reported)	1.1	1.9	2.8	-1.7	-1.6	-0.5	1.5	-1.6	1.0
Irritability	1.1	1.9	3.2	-1.6	-0.6	-1.7	-1.8	-0.5	-1.5
Commuting to job workplace: Cycle	1.1	1.3	4.2	-0.8	1.0	0.4	2.1	0.6	1.3
Respiratory disease	1.0	2.2	4.7	-2.2	-2.0	-0.9	1.4	-0.7	0.9
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.6	-1.6	0.1	-1.1	0.7	-1.5	1.0
Pack years adult smoking proportion	1.0	1.5	3.8	-1.9	-0.6	-1.3	1.1	-1.4	0.3
Qualifications: CSEs or equivalent	1.0	1.3	4.1	0.5	-1.2	-2.0	0.6	-0.2	1.3
Heart attack	1.0	1.2	3.2	-0.4	-1.4	-0.3	0.5	-1.8	1.2
Asthma	1.0	2.0	6.7	-2.6	-1.8	-1.2	0.4	-0.8	0.4
Illnesses of mother	1.0	1.2	2.3	1.2	0.6	1.4	-0.9	0.4	-1.5
Arm fat mass (right)	1.0	4.2	10.3	2.2	0.7	1.9	0.5	3.2	-2.5
Standing height	1.0	10.2	45.8	2.2	0.7	1.7	2.6	6.8	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.5	-0.4	0.7	-1.6	0.5	-0.5	1.9
Leg fat mass (right)	1.0	3.8	10.0	2.0	0.4	1.9	1.1	3.2	-2.0
Had major operations	1.0	1.1	2.5	1.4	-0.1	-0.1	-1.6	0.5	-1.5
Hypertension (Self-reported)	1.0	2.9	6.3	-1.4	-1.2	-2.5	0.7	-2.2	1.4
Osteoporosis (self-reported)	1.0	1.2	4.5	-0.3	-1.1	-0.6	-2.1	-0.8	-0.7
Arm fat mass (left)	1.0	4.2	11.6	2.1	0.7	1.7	0.5	3.4	-2.3
Eye problems/disorders: Glaucoma	1.0	1.2	2.1	-0.9	-1.2	-1.4	-0.1	-1.4	0.8
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.6	0.9	1.8	0.5	-0.1	1.9	-0.3
Medication: Lisinopril	1.0	1.2	4.2	-0.5	-2.0	-1.3	0.4	-0.7	0.7
Ever smoked	1.0	1.7	5.2	-0.4	0.6	2.3	0.0	1.7	-1.2
Heart disease (siblings)	1.0	1.3	3.7	-0.3	-0.6	-1.4	-1.2	-1.9	-0.2
Leg fat mass (left)	1.0	3.8	9.8	2.0	0.3	1.9	0.8	3.1	-2.1
Blood Red Count	0.9	8.4	15.1	-2.9	-2.3	-2.3	3.4	-2.4	3.9
Height	0.9	17.4	78.1	2.0	1.2	2.3	3.9	8.8	-0.3
Medication: Metformin	0.9	1.2	2.4	0.2	-1.5	-1.3	0.7	-0.7	1.6
Had menopause	0.9	1.1	2.2	-1.5	-0.6	-1.1	0.2	-1.3	1.0
Mouth/teeth dental problems	0.9	1.3	3.7	1.9	0.8	0.5	-1.5	0.9	-0.6
Father’s age at death	0.9	1.3	2.8	1.2	1.1	1.7	0.4	1.4	-0.2
Peak expiratory flow (PEF)	0.9	2.2	6.0	1.9	0.4	0.7	-0.4	2.5	-1.6
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.4	-1.5	0.0	-1.5	0.4	-1.0	0.9
Medication: Ventolin 100micrograms inhaler	0.9	1.1	1.8	-1.3	-1.2	-1.0	-1.4	-0.6	-0.7
Medication: Blood pressure	0.9	1.6	2.7	-1.4	-1.6	-1.5	0.3	-1.4	0.9
Medication: Ibuprofen	0.9	1.1	3.3	-0.2	0.8	1.8	1.5	0.8	0.1
Back pain experienced in last month	0.9	1.4	3.4	0.6	1.8	1.2	-0.3	1.3	-1.1
Miserableness	0.9	1.6	5.4	-1.3	-2.3	-1.5	-0.4	0.0	0.2
Medication: Blood pressure	0.9	1.7	2.6	-1.4	0.1	-1.6	1.6	-1.6	1.0
Age started oral contraceptive pill	0.9	1.1	3.4	1.8	-0.2	0.9	-0.4	0.9	-1.1
Diastolic blood pressure, automated reading	0.9	2.9	8.8	-0.2	-3.0	-2.3	0.3	-1.5	0.8
Pack years of smoking	0.9	1.4	2.4	-1.5	-0.9	-1.3	1.3	-1.3	0.5
Ulcerative Colitis	0.8	1.2	2.3	1.3	0.6	1.2	-0.4	1.5	-1.1
Medication: Co-codamol	0.8	1.0	2.2	1.5	0.1	0.0	-1.2	0.4	-1.4
Trunk fat percentage	0.8	3.0	7.3	1.4	-0.0	2.0	0.5	2.7	-2.1
Multivitamins +/- minerals	0.8	1.0	2.6	-0.1	1.2	-0.4	1.3	1.6	0.2
Medication: Atenolol	0.8	1.0	2.9	-1.7	-1.1	0.0	-0.3	-1.2	-0.1
Medication: Levothyroxine sodium	0.8	1.4	2.5	1.3	1.4	1.6	1.5	0.3	0.4
Waist circumference	0.8	2.9	8.6	1.8	0.1	1.2	0.3	2.9	-2.0
Loud music exposure frequency	0.8	0.9	2.2	0.8	1.0	0.9	1.5	0.7	0.1
Medication: Omeprazole	0.8	0.9	3.5	0.4	-0.5	1.3	1.9	-0.2	0.2
Medication: Aspirin	0.8	1.1	3.3	-0.8	-1.8	-0.8	-0.4	-1.4	-0.1
Illnesses of father: Heart disease	0.8	1.1	1.8	-1.3	-0.6	-1.0	0.7	-1.3	1.2
Mood swings	0.8	1.4	5.0	-1.0	-2.2	-1.4	-0.3	-0.7	-0.1
Osteoarthritis (self-reported)	0.8	1.1	3.2	1.5	-0.2	0.9	0.1	1.8	-0.5
Commuting to job workplace: Public transport	0.8	0.9	3.0	-1.2	1.7	-0.0	0.5	-0.7	0.5
Medication: Bendroflumethiazide	0.8	1.2	3.5	0.4	-1.6	-1.9	-0.1	-0.1	1.1
Medication: Atorvastatin	0.8	1.0	3.5	-0.1	-1.9	-1.2	0.1	-0.9	0.1
Myopia	0.8	1.2	4.7	-0.7	0.1	-0.6	-2.2	-0.1	-1.3
Schizophrenia vs Biploar Disorder	0.7	0.9	2.3	0.6	-1.1	1.1	-0.4	0.1	-1.5
Lupus	0.7	1.0	2.4	-1.2	-1.0	-1.6	-0.5	-0.9	0.3
BMI	0.7	4.1	7.1	2.6	1.8	1.2	-1.0	2.3	-2.7
Smoking Status	0.7	1.8	6.7	-0.5	1.0	2.6	1.4	0.8	-0.3
Supplements: Zinc	0.7	0.7	2.0	0.7	1.4	0.0	0.8	1.0	-0.6
Financial difficulties in last 2 years	0.7	1.0	3.1	-1.3	-1.8	-0.8	0.1	-0.5	0.3
Medication: Ramipril	0.7	0.9	1.9	-1.1	-0.8	-0.9	-0.3	-1.4	0.8
Medication: Simvastatin	0.7	1.0	2.0	-1.0	-1.4	-1.0	0.5	-1.2	0.6
Arm fat percentage (right)	0.7	2.7	6.2	1.6	0.4	1.8	-0.3	1.9	-2.5
Alcohol intake versus 10 years previously	0.7	1.1	4.2	-0.3	-2.1	-1.2	0.2	-0.6	0.7
Birth weight of first child	0.7	1.3	4.0	1.1	0.7	2.0	0.4	0.9	-1.1
Glaucoma (self-reported)	0.7	0.8	3.5	-0.3	-1.9	-0.9	0.6	-0.5	0.2
Number of full brothers	0.7	0.8	1.6	-1.0	-1.2	-1.2	-0.7	-0.8	0.3
Number of self-reported non-cancer illnesses	0.7	1.3	4.9	-0.4	-2.2	-0.5	1.3	-0.7	0.4
Mother’s age at death	0.7	0.9	1.4	0.7	1.1	1.1	1.2	1.1	0.1
Alcohol drinker status: Never	0.7	0.9	1.3	1.0	-1.1	0.5	-1.1	-1.1	-0.3
Fractured/broken bones in last 5 years	0.7	0.9	2.4	0.9	1.0	0.5	0.6	1.5	-0.7
Cholesterol lowering medication	0.7	1.1	2.4	-0.5	-0.7	-1.3	1.0	-0.9	1.5
Supplements: Calcium	0.7	0.8	1.9	1.0	0.8	0.1	1.0	1.4	-0.2
Coronary Artery Disease (CAD)	0.6	0.8	3.7	1.9	0.7	0.6	-0.1	-0.2	-0.1
Blood White Count	0.6	4.3	8.1	-0.3	-1.8	-2.8	-2.7	-2.7	-0.5
Taking other prescription medications	0.6	1.0	3.9	2.0	-0.2	1.1	0.5	0.5	-0.5
Serious illness, injury or assault to yourself	0.6	0.7	1.8	-0.3	-1.3	-0.6	0.8	0.6	0.9
Qualifications: None of the above	0.6	1.2	2.8	-1.0	-0.6	-1.4	-0.8	-1.7	0.8
Noisy workplace	0.6	0.7	1.3	-1.1	-0.6	-0.6	-0.5	-1.0	1.2
Medication: Amlodipine	0.6	0.9	2.2	-1.5	-0.7	-0.8	-0.7	-1.0	-0.3
Body fat percentage	0.6	2.5	5.1	1.3	-0.1	1.9	0.5	2.2	-2.1
Number of children fathered	0.6	0.6	2.4	-0.9	-0.2	1.6	0.7	-0.2	-0.1
Emphysema/chronic bronchitis	0.6	0.6	2.3	-0.2	-1.5	-0.8	-0.3	-0.8	0.2
Medication: Seretide 50 evohaler	0.6	0.7	2.6	-0.2	0.2	-1.6	-0.9	-0.7	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.7	0.4	1.3	0.4	-0.5	1.1	-0.9
Illnesses of siblings: Diabetes	0.6	0.7	1.5	1.2	-0.7	0.5	-0.3	0.8	-1.2
Diabetes diagnosed by doctor	0.6	1.0	2.8	-0.0	-1.7	-1.1	1.2	0.1	0.8
Illnesses of father: None of the above (group 1)	0.6	0.7	2.8	0.7	1.7	-0.0	-0.7	0.5	-0.5
Average weekly champagne plus white wine intake	0.6	0.9	1.9	0.3	0.8	1.0	1.4	1.2	-0.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.5	-0.3	-1.1	-0.1	0.2	-1.6	0.9
Alzheimer’s Disease (in mother)	0.5	0.6	1.9	-1.4	-0.6	-0.7	0.7	0.1	0.5
Irritable Bowel Disease (IBD)	0.5	1.2	2.9	0.7	1.1	0.7	-1.3	0.6	-1.7
LDL Cholesterol	0.5	0.8	3.8	0.3	0.3	0.4	-0.2	1.9	-0.9
Lung FEV1/FVC ratio	0.5	2.4	6.4	-0.6	0.5	-2.2	-1.6	-2.5	-0.3
Chronotype (morning person)	0.5	1.0	2.6	1.6	0.8	1.4	1.0	0.0	0.2
Number of treatments/medications taken	0.5	0.8	1.9	-0.0	-1.4	-0.2	0.7	-1.3	0.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	3.0	-0.2	-1.7	-1.0	-0.1	0.4	0.1
Vitamin and mineral supplements	0.5	0.6	2.7	0.1	-1.6	0.1	-0.1	-0.9	0.5
Diabetes (mother)	0.5	0.6	1.2	-0.9	0.3	-1.1	-0.5	-1.0	-0.5
Body mass index (BMI)	0.5	2.3	4.8	1.8	0.5	1.1	0.0	2.0	-2.2
Hair/balding pattern: Pattern 3	0.5	0.7	1.3	-0.4	0.9	-1.1	1.0	-0.1	1.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.3	0.5	-0.6	0.3	0.0	1.5	-0.6
Eye problems/disorders: None of the above	0.5	0.6	2.2	0.0	1.5	0.4	-0.0	1.1	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.6	-0.6	-1.3	-0.2	-1.1	-0.6	-0.2
Overall health rating	0.5	1.0	4.9	0.4	-2.2	0.0	-0.4	-0.1	-1.0
Arm fat percentage (left)	0.5	2.1	4.7	1.3	0.2	1.5	0.1	1.9	-2.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.7	-0.7	-1.3	-0.6	0.5	-1.1	0.8
Medication: Gliclazide	0.5	0.6	2.1	0.3	-0.9	-1.4	-0.2	-0.0	0.6
Leg fat percentage (left)	0.5	1.7	3.3	0.9	0.2	1.6	0.6	1.7	-1.8
Average weekly beer plus cider intake	0.5	0.7	2.5	-0.5	-0.2	1.6	1.0	0.3	-0.3
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.3	-0.2	0.5	-0.2	-0.7	0.6	-1.5
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.3	-1.4	-0.8	0.6	1.8	0.9	0.8
Alzheimer’s Disease (including proxy)	0.4	0.6	1.0	-1.0	-0.9	-1.0	0.7	-0.1	0.2
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.4	-0.3	0.7	1.8	-0.1	1.0	-0.5
Age at First Birth	0.4	0.6	1.2	0.9	0.6	1.1	-0.0	0.9	0.3
HDL Cholesterol	0.4	0.7	2.3	-0.7	-0.7	-0.7	0.2	-0.8	1.5
Triglycerides	0.4	0.6	2.8	-0.0	-1.7	-0.6	-0.2	-0.2	-0.5
Blood Eosinophil Count	0.4	3.3	5.9	-2.4	-1.7	-2.4	-1.1	-2.0	0.3
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.1	0.3	-0.9	-1.5	0.6	0.9	-0.4
Relative age of first facial hair	0.4	0.7	2.7	-0.7	0.4	0.8	0.5	-0.5	1.6
Ever had hysterectomy (womb removed)	0.4	0.4	1.5	1.2	-0.5	-0.1	0.8	0.1	-0.3
Impedance of leg (right)	0.4	1.9	3.2	-1.8	-1.6	-0.4	0.5	-1.5	1.8
Relative age voice broke	0.4	0.6	1.7	-1.0	-0.4	0.6	-0.0	-0.6	1.3
Chronic bronchitis/emphysema (father)	0.4	0.4	1.3	-0.5	-0.7	0.1	-1.1	0.2	-0.8
Impedance of leg (left)	0.4	2.1	3.8	-2.0	-1.4	-0.1	0.6	-1.7	1.9
Number of incorrect matches in round	0.4	0.7	1.4	1.0	1.2	-0.6	-0.9	-0.6	0.4
Alcohol usually taken with meals	0.4	0.6	1.5	0.1	1.1	0.4	-0.7	1.2	-0.6
Allergy	0.4	0.9	2.2	-0.4	1.5	-0.4	1.3	-0.4	0.9
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	-0.7	-0.2	-0.9	0.7	0.2	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.9	-0.6	-0.8	-0.9	-1.4	0.1	-0.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.8	1.3	0.6	0.8	-0.7	1.3	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.9	0.2	0.4	-0.3	-0.5	1.4	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.6	-0.2	0.6	1.3	0.5	0.8	-0.0
Medication: Lansoprazole	0.4	0.4	0.8	0.7	-0.8	-0.9	-0.1	-0.2	0.7
Impedance of arm (left)	0.4	1.8	4.8	-1.5	-1.5	-0.3	0.9	-0.7	2.2
Pulse wave reflection index	0.4	0.5	1.3	0.0	-1.1	-0.3	1.1	-0.3	0.5
Medication: Paracetamol	0.4	0.7	1.9	0.3	1.3	0.7	-1.4	-0.2	-0.3
Leg fat percentage (right)	0.4	1.3	2.5	0.8	-0.0	1.4	0.8	1.5	-1.6
Shortness of breath walking on level ground	0.4	0.5	1.0	-0.9	-1.0	-0.0	-0.8	-0.7	0.1
Medication: Allopurinol	0.4	0.5	1.2	0.4	-1.1	0.5	0.3	0.9	-0.8
Heart disease (mother)	0.4	0.5	1.4	1.1	-0.6	-0.3	-1.2	-0.2	-0.1
Age at last live birth	0.4	0.6	1.7	1.3	0.3	0.8	0.8	0.7	0.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.3	0.4	-0.8	0.3	-1.2	-0.1	-0.9
Ever had bowel cancer screening	0.4	0.5	2.0	-1.4	0.6	-0.3	0.2	-0.2	0.7
Qualifications: nursing, teaching	0.4	0.6	1.7	1.3	1.0	0.2	-1.0	0.1	-0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.6	0.8	-0.7	-0.0	-0.8	0.8	-0.7
Medication: Paracetamol	0.4	0.6	2.0	0.2	1.1	1.4	-0.3	-0.6	0.1
Number of operations (self-reported)	0.4	0.7	3.2	0.5	-1.8	-0.3	-0.2	0.6	-0.1
Alzheimer’s Disease (in father)	0.3	0.3	1.0	0.9	-1.0	-0.1	-0.3	-0.0	-0.3
Crohns Disease (2017)	0.3	0.6	1.7	-0.9	0.1	0.0	-0.9	-1.3	-0.3
Mean Putamen Volume	0.3	0.4	1.6	-0.4	-0.2	0.1	-0.5	-1.3	-0.1
Fasting Glucose	0.3	0.3	1.1	-0.0	0.4	-1.0	0.2	-0.5	0.7
Hair Pigment	0.3	7.8	25.5	3.9	-0.6	-0.7	-5.0	0.6	-2.3
Average weekly spirits intake	0.3	0.4	1.8	-0.3	0.2	0.4	1.3	0.1	0.2
Current tobacco smoking	0.3	0.5	1.2	-1.1	-0.7	0.8	0.9	-0.3	0.1
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.6	0.8	-0.4	0.3	-1.6	0.6	-0.7
Had other major operations	0.3	0.3	1.3	-0.4	-1.2	0.6	0.3	0.2	0.2
Diabetes (self-reported)	0.3	0.4	1.5	0.4	-0.5	-0.7	1.2	0.3	0.4
Mouth/teeth dental problems: Dentures	0.3	0.5	0.8	-0.9	0.6	-0.7	0.3	-0.9	-0.6
Breastfed as a baby	0.3	0.4	0.9	-0.8	0.7	0.5	-0.2	0.9	-0.5
Knee pain experienced in last month	0.3	0.5	2.0	-0.1	-0.5	-0.8	-1.4	-0.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.6	-0.7	0.6	-0.2	-0.1	1.6	0.5
Average weekly red wine intake	0.3	0.4	0.9	-0.8	-0.3	-0.9	-0.9	-0.2	0.2
Breast cancer (self-reported)	0.3	0.4	1.3	-0.6	-0.2	0.4	0.1	0.7	1.1
Smoking status: Current	0.3	0.5	1.4	-1.2	-0.4	0.8	0.6	-0.4	0.1
Illnesses of father: High blood pressure	0.3	0.3	1.2	-0.3	-0.0	-0.6	1.1	-0.3	0.3
Pain experienced in last month	0.3	0.4	1.3	0.9	0.3	1.1	0.4	0.5	-0.2
Basal cell carcinoma (self-reported)	0.3	0.3	0.6	0.8	0.3	-0.6	-0.5	0.7	-0.3
Alcohol drinker status: Previous	0.3	0.4	0.8	-0.9	-0.8	-0.4	-0.6	-0.3	-0.3
Impedance of whole body	0.3	1.8	4.3	-1.6	-1.4	-0.2	0.6	-1.3	2.1
Ovarian Cancer	0.2	0.2	0.5	0.7	0.3	0.2	-0.7	-0.3	0.3
Hypothyroidism (self reported)	0.2	0.5	1.0	0.8	1.0	-0.1	-1.0	0.2	-0.5
Townsend deprivation index at recruitment	0.2	0.3	1.1	-1.1	-0.3	-0.2	0.1	0.3	0.5
Age when periods started (menarche)	0.2	0.5	2.1	-0.8	-0.1	1.4	0.2	0.5	-0.5
Time employed in main current job	0.2	0.2	0.3	0.6	-0.5	0.4	0.6	0.3	0.0
Blood clot in the leg (DVT)	0.2	0.3	1.3	0.2	-1.1	0.1	-0.3	-0.5	0.2
Exposure to tobacco smoke outside home	0.2	0.3	1.0	0.4	-0.5	0.1	-0.2	1.0	-0.6
Health satisfaction	0.2	0.2	0.7	0.1	-0.2	-0.7	-0.8	0.1	-0.2
Qualifications: College or University degree	0.2	0.6	1.3	0.4	0.5	0.9	1.1	1.2	-0.2
Medication for pain relief, constipation, heartburn	0.2	0.4	0.9	-0.1	0.1	-0.4	0.9	0.7	0.9
Alcohol intake frequency.	0.2	0.4	0.7	0.5	-0.8	-0.6	-0.7	-0.1	-0.5
Number of full sisters	0.2	0.2	1.0	-0.2	-0.5	-0.0	0.1	1.0	-0.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	-0.3	0.3	0.9	0.2	-0.7	-0.0
Risk taking	0.2	0.2	0.6	-0.1	0.5	0.4	0.6	0.2	0.8
Ever depressed for a whole week	0.2	0.3	0.5	0.3	-0.7	0.6	0.1	-0.4	0.7
Unable to work because of sickness or disability	0.2	0.3	0.7	0.1	-0.3	-0.5	-0.9	-0.0	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.9	0.3	-0.9	0.3	-0.5	-0.5	0.2
Breast Cancer	0.1	0.3	0.8	-0.7	0.3	0.7	0.4	0.9	0.2
Crohns Disease (2012)	0.1	0.2	0.9	-0.2	-0.0	0.5	-0.9	-0.2	-0.4
Primary Biliary Cirrhosis	0.1	0.2	0.5	-0.2	-0.5	0.1	-0.2	0.7	-0.7
Allergy or Eczema	0.1	0.3	0.7	0.9	0.2	0.1	-0.7	0.6	-0.3
Tanning	0.1	1.4	4.6	-2.1	0.4	-0.9	-0.6	-1.6	0.2
Impedance of arm (right)	0.1	0.7	1.7	-0.7	-1.0	0.6	0.3	-0.5	1.3
Number of live births	0.1	0.2	0.7	0.6	-0.1	-0.1	0.1	0.3	0.8
Pulse rate	0.1	0.2	0.9	-0.2	-0.1	-0.4	-0.5	-0.9	-0.4
Gout (self-reported)	0.1	0.2	0.9	-0.1	-0.3	0.1	-0.3	0.1	-0.9
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	1.0	1.0	0.6	0.6	0.0	0.3	0.0
Neck or shoulder pain in last month	0.1	0.1	0.4	-0.0	-0.6	-0.3	-0.3	-0.2	-0.5
Pulse rate, automated reading	0.1	0.3	0.6	-0.7	-0.5	0.1	-0.0	-0.8	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.0	-0.1	-0.3	0.2	-0.3	0.4
Eye problems/disorders: Cataract	0.1	0.2	0.5	0.5	-0.3	0.0	-0.7	0.1	0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HbA1C	0.0	0.0	0.1	-0.3	0.2	-0.0	-0.2	0.3	0.0

Hub : Genes

EPB41L2

Models

Trait associations