Best TWAS P=1.69e-13 · Best GWAS P=4.52e-13 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PABPC1L | 0.17 | 0.16 | lasso | 1 | 0.15 | 8.0e-18 | 7.0 | -7.0 | 2.3e-12 | -0.91 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adipose Subcutaneous | YWHAB | 0.13 | 0.17 | lasso | 2 | 0.15 | 2.8e-12 | 7.1 | -7.1 | 1.6e-12 | -0.91 | 0.01 | 0.99 | FALSE |
3 | GTEx | Adipose Visceral Omentum | YWHAB | 0.19 | 0.07 | lasso | 4 | 0.05 | 1.1e-03 | 7.0 | -7.2 | 4.4e-13 | -0.91 | 0.01 | 0.98 | FALSE |
4 | GTEx | Adrenal Gland | PABPC1L | 0.32 | 0.07 | lasso | 8 | 0.07 | 1.9e-03 | 7.0 | -7.0 | 2.7e-12 | -0.80 | 0.01 | 0.94 | FALSE |
5 | GTEx | Adrenal Gland | YWHAB | 0.23 | 0.15 | lasso | 3 | 0.10 | 1.4e-04 | 7.1 | -7.1 | 1.5e-12 | -0.90 | 0.01 | 0.98 | FALSE |
6 | GTEx | Artery Aorta | PABPC1L | 0.14 | 0.10 | lasso | 3 | 0.09 | 1.1e-05 | 5.8 | 5.2 | 1.9e-07 | 0.63 | 0.28 | 0.12 | FALSE |
7 | GTEx | Artery Aorta | YWHAB | 0.29 | 0.17 | lasso | 5 | 0.15 | 1.3e-08 | 7.1 | -7.2 | 4.5e-13 | -0.90 | 0.01 | 0.99 | FALSE |
8 | GTEx | Artery Tibial | YWHAB | 0.17 | 0.15 | lasso | 3 | 0.16 | 3.5e-12 | 7.1 | -7.1 | 9.9e-13 | -0.91 | 0.01 | 0.99 | FALSE |
9 | GTEx | Brain Cerebellar Hemisphere | YWHAB | 0.42 | 0.22 | lasso | 4 | 0.18 | 2.3e-05 | 7.0 | -7.3 | 2.9e-13 | -0.92 | 0.01 | 0.97 | FALSE |
10 | GTEx | Brain Cerebellum | YWHAB | 0.43 | 0.19 | lasso | 7 | 0.16 | 1.7e-05 | 7.0 | -7.3 | 3.4e-13 | -0.89 | 0.01 | 0.98 | FALSE |
11 | GTEx | Brain Nucleus accumbens basal ganglia | YWHAB | 0.22 | 0.11 | lasso | 3 | 0.07 | 6.5e-03 | 7.0 | -7.0 | 1.8e-12 | -0.90 | 0.01 | 0.93 | FALSE |
12 | GTEx | Breast Mammary Tissue | YWHAB | 0.18 | 0.09 | lasso | 6 | 0.08 | 5.2e-05 | 7.1 | -6.6 | 4.5e-11 | -0.88 | 0.01 | 0.99 | FALSE |
13 | GTEx | Cells EBV-transformed lymphocytes | YWHAB | 0.27 | 0.12 | enet | 13 | 0.18 | 1.2e-06 | 6.4 | -7.0 | 3.3e-12 | -0.86 | 0.02 | 0.98 | FALSE |
14 | GTEx | Cells Transformed fibroblasts | PABPC1L | 0.12 | 0.03 | enet | 22 | 0.08 | 2.0e-06 | 4.0 | 5.8 | 8.2e-09 | 0.65 | 0.08 | 0.92 | FALSE |
15 | GTEx | Cells Transformed fibroblasts | YWHAB | 0.29 | 0.20 | enet | 21 | 0.26 | 1.5e-19 | 7.0 | -5.8 | 6.7e-09 | -0.79 | 0.01 | 0.99 | FALSE |
16 | GTEx | Colon Sigmoid | YWHAB | 0.27 | 0.14 | lasso | 4 | 0.10 | 1.7e-04 | 7.0 | -6.2 | 5.4e-10 | -0.85 | 0.01 | 0.97 | FALSE |
17 | GTEx | Esophagus Gastroesophageal Junction | YWHAB | 0.31 | 0.18 | lasso | 5 | 0.14 | 9.9e-06 | 7.2 | -7.3 | 2.6e-13 | -0.99 | 0.01 | 0.99 | FALSE |
18 | GTEx | Esophagus Mucosa | YWHAB | 0.25 | 0.27 | enet | 7 | 0.27 | 4.2e-18 | 7.1 | -7.1 | 1.4e-12 | -0.91 | 0.01 | 0.99 | FALSE |
19 | GTEx | Esophagus Muscularis | YWHAB | 0.16 | 0.11 | lasso | 3 | 0.14 | 1.5e-08 | 5.8 | -6.9 | 7.1e-12 | -0.87 | 0.01 | 0.99 | FALSE |
20 | GTEx | Lung | YWHAB | 0.10 | 0.04 | lasso | 4 | 0.04 | 6.5e-04 | 7.1 | -7.0 | 2.1e-12 | -0.89 | 0.01 | 0.98 | FALSE |
21 | GTEx | Muscle Skeletal | YWHAB | 0.09 | 0.07 | lasso | 5 | 0.07 | 4.5e-07 | 7.0 | -7.3 | 3.5e-13 | -0.97 | 0.01 | 0.99 | FALSE |
22 | GTEx | Nerve Tibial | TOMM34 | 0.11 | 0.02 | lasso | 4 | 0.03 | 6.0e-03 | 4.0 | 5.4 | 7.1e-08 | 0.61 | 0.04 | 0.80 | FALSE |
23 | GTEx | Nerve Tibial | YWHAB | 0.21 | 0.24 | lasso | 2 | 0.23 | 3.3e-16 | 7.2 | -7.3 | 2.6e-13 | -1.00 | 0.00 | 1.00 | FALSE |
24 | GTEx | Skin Not Sun Exposed Suprapubic | YWHAB | 0.33 | 0.24 | lasso | 4 | 0.26 | 1.6e-14 | 7.0 | -7.0 | 2.0e-12 | -0.90 | 0.01 | 0.99 | FALSE |
25 | GTEx | Skin Sun Exposed Lower leg | YWHAB | 0.17 | 0.18 | lasso | 2 | 0.17 | 4.7e-14 | 7.1 | -7.1 | 1.6e-12 | -0.91 | 0.01 | 0.99 | FALSE |
26 | GTEx | Testis | YWHAB | 0.23 | 0.23 | enet | 14 | 0.23 | 1.8e-10 | 7.1 | -7.0 | 3.7e-12 | -0.88 | 0.01 | 0.99 | FALSE |
27 | GTEx | Thyroid | YWHAB | 0.22 | 0.18 | lasso | 2 | 0.17 | 5.3e-13 | 7.1 | -7.1 | 1.6e-12 | -0.91 | 0.01 | 0.99 | FALSE |
28 | GTEx | Whole Blood | YWHAB | 0.20 | 0.10 | lasso | 9 | 0.10 | 1.6e-09 | 7.1 | -6.7 | 2.0e-11 | -0.90 | 0.01 | 0.99 | FALSE |
29 | METSIM | Adipose | TOMM34 | 0.34 | 0.09 | enet | 73 | 0.16 | 2.5e-23 | -4.7 | 5.6 | 2.0e-08 | 0.29 | 1.00 | 0.00 | FALSE |
30 | NTR | Blood | YWHAB | 0.16 | 0.19 | lasso | 5 | 0.19 | 2.2e-58 | 7.0 | -7.0 | 2.3e-12 | -0.91 | 0.01 | 0.99 | FALSE |
31 | ROSMAP | Brain Pre-frontal Cortex | PABPC1L | 0.24 | 0.21 | lasso | 3 | 0.21 | 8.1e-27 | 7.0 | -6.6 | 5.1e-11 | -0.90 | 0.01 | 0.99 | FALSE |
32 | ROSMAP | Brain Pre-frontal Cortex | YWHAB | 0.56 | 0.58 | bslmm | 418 | 0.59 | 7.7e-94 | 7.1 | -7.1 | 1.1e-12 | -0.91 | 0.01 | 0.99 | FALSE |
33 | YFS | Blood | YWHAB | 0.07 | 0.06 | lasso | 4 | 0.07 | 6.8e-21 | 7.2 | 7.4 | 1.7e-13 | 0.98 | 0.00 | 1.00 | TRUE |
34 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PABPC1L | 0.02 | 0.02 | lasso | 4 | 0.02 | 2.2e-04 | 7.0 | -7.0 | 2.2e-12 | -0.91 | 0.01 | 0.99 | FALSE |
35 | The Cancer Genome Atlas | Esophageal Carcinoma | YWHAB | 0.15 | 0.14 | lasso | 5 | 0.10 | 4.6e-04 | 6.4 | -6.5 | 8.7e-11 | -0.79 | 0.03 | 0.86 | FALSE |
36 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PABPC1L | 0.20 | 0.21 | lasso | 3 | 0.21 | 5.5e-23 | 7.0 | -7.0 | 1.9e-12 | -0.91 | 0.01 | 0.99 | FALSE |
37 | The Cancer Genome Atlas | Brain Lower Grade Glioma | YWHAB | 0.06 | 0.07 | enet | 6 | 0.09 | 7.4e-11 | 5.8 | -7.0 | 2.8e-12 | -0.85 | 0.02 | 0.98 | FALSE |
38 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | YWHAB | 0.04 | 0.03 | lasso | 5 | 0.04 | 2.9e-05 | 7.2 | -7.1 | 9.1e-13 | -0.96 | 0.01 | 0.98 | FALSE |
39 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | YWHAB | 0.07 | 0.06 | lasso | 2 | 0.06 | 1.3e-04 | 7.0 | -7.2 | 7.0e-13 | -0.89 | 0.01 | 0.96 | FALSE |
40 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | YWHAB | 0.16 | -0.01 | blup | 52 | 0.03 | 2.1e-02 | -5.0 | -5.4 | 6.4e-08 | -0.63 | 0.02 | 0.55 | FALSE |
41 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PABPC1L | 0.08 | 0.14 | lasso | 4 | 0.14 | 4.2e-14 | 7.0 | -7.0 | 1.9e-12 | -0.91 | 0.01 | 0.99 | FALSE |
42 | The Cancer Genome Atlas | Prostate Adenocarcinoma | YWHAB | 0.07 | 0.06 | lasso | 6 | 0.06 | 3.1e-07 | 7.0 | -7.3 | 3.5e-13 | -0.94 | 0.01 | 0.99 | FALSE |
43 | The Cancer Genome Atlas | Stomach Adenocarcinoma | YWHAB | 0.04 | 0.05 | enet | 10 | 0.03 | 2.3e-03 | 6.4 | -6.8 | 1.2e-11 | -0.82 | 0.01 | 0.88 | FALSE |
44 | The Cancer Genome Atlas | Thyroid Carcinoma | YWHAB | 0.12 | 0.13 | lasso | 5 | 0.12 | 4.3e-12 | 7.0 | -7.0 | 2.2e-12 | -0.91 | 0.01 | 0.99 | FALSE |