Best TWAS P=6.54e-14 · Best GWAS P=2.12e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ARFGEF2 | 0.09 | 0.05 | lasso | 8 | 0.10 | 9.2e-13 | 6.9 | -7.1 | 1.5e-12 | -0.82 | 0.04 | 0.96 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | STAU1 | 0.08 | 0.03 | lasso | 6 | 0.02 | 2.3e-02 | 5.9 | 6.6 | 5.5e-11 | 0.85 | 0.07 | 0.80 | FALSE |
| 3 | GTEx | Colon Sigmoid | ARFGEF2 | 0.15 | 0.12 | lasso | 1 | 0.07 | 2.3e-03 | 5.3 | -5.3 | 9.1e-08 | -0.60 | 0.07 | 0.52 | FALSE |
| 4 | GTEx | Colon Sigmoid | CSE1L | 0.18 | 0.12 | lasso | 11 | 0.09 | 4.4e-04 | 6.2 | -6.3 | 2.5e-10 | -0.80 | 0.09 | 0.87 | FALSE |
| 5 | GTEx | Esophagus Mucosa | CSE1L | 0.09 | 0.06 | lasso | 4 | 0.06 | 6.9e-05 | 6.7 | -6.2 | 4.7e-10 | -0.80 | 0.14 | 0.83 | FALSE |
| 6 | GTEx | Esophagus Mucosa | ZFAS1 | 0.15 | 0.01 | enet | 16 | 0.01 | 8.9e-02 | 7.3 | 5.4 | 8.2e-08 | 0.69 | 0.01 | 0.95 | FALSE |
| 7 | GTEx | Lung | CSE1L | 0.10 | 0.09 | lasso | 5 | 0.08 | 6.6e-07 | 6.0 | -5.9 | 4.6e-09 | -0.73 | 0.67 | 0.32 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | CSE1L | 0.08 | 0.03 | lasso | 2 | 0.03 | 9.5e-04 | 6.8 | -6.5 | 8.2e-11 | -0.81 | 0.35 | 0.37 | FALSE |
| 9 | GTEx | Testis | ARFGEF2 | 0.20 | 0.20 | lasso | 7 | 0.24 | 5.4e-11 | 5.9 | -6.8 | 8.4e-12 | -0.91 | 0.08 | 0.92 | FALSE |
| 10 | METSIM | Adipose | ARFGEF2 | 0.04 | 0.03 | lasso | 12 | 0.02 | 9.8e-05 | 7.3 | -7.5 | 9.4e-14 | -0.98 | 0.02 | 0.98 | FALSE |
| 11 | NTR | Blood | NCRNA00275 | 0.07 | 0.06 | lasso | 4 | 0.08 | 9.7e-25 | -4.6 | -6.5 | 9.9e-11 | -0.53 | 1.00 | 0.00 | FALSE |
| 12 | NTR | Blood | SNORD12B | 0.03 | 0.05 | lasso | 8 | 0.05 | 1.9e-14 | 7.3 | -7.5 | 6.5e-14 | -0.96 | 0.01 | 0.99 | TRUE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | CSE1L | 0.04 | 0.02 | enet | 16 | 0.02 | 2.8e-03 | 5.3 | -5.6 | 2.8e-08 | -0.72 | 0.08 | 0.91 | FALSE |
| 14 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CSE1L | 0.03 | 0.05 | lasso | 1 | 0.03 | 9.3e-05 | 5.9 | -5.9 | 3.1e-09 | -0.75 | 0.08 | 0.90 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CSE1L | 0.05 | 0.07 | blup | 50 | 0.07 | 3.2e-08 | 6.2 | -6.2 | 5.0e-10 | -0.80 | 0.05 | 0.95 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ARFGEF2 | 0.05 | 0.04 | lasso | 5 | 0.05 | 3.2e-06 | 6.9 | -7.4 | 1.9e-13 | -0.94 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C20orf199 | 0.04 | 0.00 | enet | 8 | 0.02 | 6.4e-03 | 2.8 | 5.3 | 1.4e-07 | 0.62 | 0.01 | 0.50 | FALSE |
| 18 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C20orf199 | 0.05 | 0.06 | lasso | 4 | 0.06 | 1.0e-04 | 7.3 | 7.3 | 2.9e-13 | 0.92 | 0.00 | 0.96 | FALSE |
| 19 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CSE1L | 0.13 | 0.03 | blup | 50 | 0.07 | 1.4e-03 | 5.9 | -5.7 | 9.6e-09 | -0.60 | 0.02 | 0.44 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | DDX27 | 0.08 | 0.05 | lasso | 3 | 0.05 | 1.9e-05 | 7.3 | 6.4 | 1.9e-10 | 0.85 | 0.01 | 0.98 | FALSE |