Best TWAS P=5.18e-10 · Best GWAS P=3.97e-08 conditioned to 0.00572
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | METTL21A | 0.10 | 0.02 | lasso | 4 | 0.02 | 1.6e-02 | -4.7 | 5.9 | 4.1e-09 | 0.32 | 0.15 | 0.38 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | CREB1 | 0.15 | 0.00 | enet | 7 | 0.00 | 2.8e-01 | -4.8 | -6.2 | 5.2e-10 | -0.50 | 0.12 | 0.47 | TRUE |
| 3 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CREB1 | 0.03 | 0.01 | blup | 64 | 0.01 | 2.5e-02 | -5.2 | -5.2 | 2.0e-07 | -0.49 | 0.05 | 0.73 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FAM119A | 0.04 | 0.02 | blup | 51 | 0.03 | 1.0e-06 | -4.5 | 5.2 | 2.6e-07 | 0.64 | 0.03 | 0.96 | FALSE |