TWAS hub - FAM119A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0350	0.0178	8.1e-08	0.025	0.029	0.024	NA	0.029	5.8e-06	1.0e-06	7.3e-06	NA	1.2e-06
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0550	0.0270	3.5e-08	0.064	0.064	0.062	NA	0.058	9.2e-08	1.1e-07	1.6e-07	NA	4.1e-07
3	TCGA	Lung Adenocarcinoma	0.0833	0.0505	9.9e-06	0.039	0.045	0.039	NA	0.028	2.1e-05	5.1e-06	2.1e-05	NA	2.8e-04
4	TCGA	Prostate Adenocarcinoma	0.0868	0.0399	7.8e-12	0.116	0.103	0.092	NA	0.116	3.7e-12	7.4e-11	7.2e-10	NA	4.4e-12
5	TCGA	Rectum Adenocarcinoma	0.2450	0.1950	3.0e-03	0.114	0.058	0.148	NA	0.108	1.3e-03	1.7e-02	2.6e-04	NA	1.7e-03
6	TCGA	Stomach Adenocarcinoma	0.0620	0.0310	1.1e-05	0.083	0.062	0.048	NA	0.073	1.2e-06	2.7e-05	2.1e-04	NA	6.1e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Smoking status: Current	10.4	16.5	22.3	-3.6	-3.9	-4.4	-4.0	-3.6	-4.7
Current tobacco smoking	8.9	14.5	18.8	-3.5	-3.5	-4.1	-3.8	-3.6	-4.3
Bipolar Disorder or Schizophrenia	7.9	19.2	25.8	-3.6	-4.8	-4.4	-4.4	-3.8	-5.1
Loneliness, isolation	7.3	10.1	12.8	-3.6	-3.0	-3.2	-3.5	-2.4	-3.1
Bipolar Disorder (2011)	7.1	6.9	10.8	-2.0	-3.2	-2.0	-2.9	-2.0	-3.3
Schizophrenia (2014)	6.5	14.3	17.4	-3.4	-3.8	-4.0	-3.6	-3.7	-4.2
Schizophrenia (2018)	6.4	13.2	17.7	-3.1	-3.8	-3.5	-3.5	-3.6	-4.2
Hand grip strength (left)	5.8	15.2	17.6	3.7	4.0	4.1	3.8	4.2	3.6
Major Depression (MDD)	5.7	6.9	8.9	-2.8	-3.0	-2.3	-2.9	-2.1	-2.7
Hayfever/allergic rhinitis (self-reported)	5.7	7.6	9.4	2.7	2.8	2.3	2.7	2.8	3.1
Seen a psychiatrist for nerves, anxiety, tension or depression	5.0	6.4	8.2	-2.4	-2.7	-2.8	-2.0	-2.9	-2.4
Average weekly spirits intake	4.9	6.1	9.1	2.9	2.4	3.0	2.1	2.0	2.1
Hand grip strength (right)	4.7	12.9	15.3	3.2	3.8	3.9	3.4	3.8	3.4
Arm fat-free mass (left)	4.7	23.7	30.6	5.5	4.0	4.9	5.3	4.7	4.7
Arm predicted mass (right)	4.5	22.9	28.8	5.4	4.0	4.9	5.3	4.2	4.8
Rheumatoid Arthritis	4.4	6.1	9.9	3.1	2.4	2.3	2.9	1.1	2.5
Sensitivity / hurt feelings	4.4	7.5	9.5	2.3	3.1	3.1	2.5	2.8	2.5
Arm fat-free mass (right)	4.3	22.2	26.9	5.2	3.9	4.8	5.2	4.5	4.7
Arm predicted mass (left)	4.3	22.0	27.6	5.2	3.7	4.7	5.1	4.6	4.6
Whole body fat-free mass	4.1	23.3	28.2	5.3	3.9	5.0	5.0	4.9	4.7
Average weekly fortified wine intake	4.0	4.7	6.5	2.0	2.0	2.5	2.4	2.0	2.0
Waist circumference	4.0	14.7	19.8	4.5	2.9	4.3	4.1	3.2	3.8
Trunk predicted mass	4.0	22.6	26.5	5.2	4.0	4.7	4.9	4.9	4.7
Whole body water mass	4.0	22.7	27.9	5.3	3.8	4.9	5.0	4.8	4.7
Leg predicted mass (right)	4.0	21.5	26.8	5.2	3.5	5.0	4.7	4.8	4.4
Basal metabolic rate	4.0	22.1	27.1	5.2	3.7	5.0	4.9	4.7	4.6
Serious illness, injury or assault to yourself	3.9	4.8	6.7	-2.3	-2.3	-2.6	-2.1	-1.4	-2.3
Leg predicted mass (left)	3.9	20.4	25.1	5.0	3.3	5.0	4.6	4.7	4.3
Trunk fat-free mass	3.9	22.4	26.3	5.1	4.0	4.7	4.9	4.8	4.7
Leg fat-free mass (right)	3.9	21.0	26.1	5.1	3.4	4.9	4.6	4.8	4.4
Leg fat-free mass (left)	3.8	20.3	25.3	5.0	3.3	5.0	4.6	4.7	4.3
Alcohol usually taken with meals	3.7	6.0	11.3	2.1	2.0	2.1	2.3	2.5	3.4
Bipolar Disorder (2018)	3.6	5.6	8.1	-2.0	-2.8	-2.0	-2.7	-1.5	-2.8
BMI	3.6	21.0	28.3	5.3	3.8	5.0	5.1	3.3	4.6
Weight	3.4	16.8	21.7	4.6	3.0	4.7	4.2	3.9	4.0
Comparative body size at age 10	3.4	9.5	14.6	3.5	2.5	3.8	3.2	2.0	3.0
Illnesses of mother	3.3	4.1	6.6	-1.6	-1.8	-2.2	-1.3	-2.6	-2.3
Leg pain on walking	3.3	4.1	5.7	-2.2	-1.2	-2.4	-1.9	-2.4	-1.8
Average weekly beer plus cider intake	3.2	4.6	7.4	-1.9	-2.3	-1.6	-1.9	-2.3	-2.7
Impedance of leg (right)	3.0	14.7	16.9	-4.1	-3.0	-4.0	-3.9	-4.0	-3.8
Ever had hysterectomy (womb removed)	2.9	3.3	4.9	2.2	1.4	2.2	2.0	1.2	1.7
Financial difficulties in last 2 years	2.9	3.9	6.6	-1.9	-2.1	-1.5	-2.3	-1.1	-2.6
Impedance of whole body	2.9	14.7	18.1	-4.2	-3.1	-3.8	-4.2	-3.7	-3.8
Medication: Lansoprazole	2.8	3.2	5.2	-1.5	-2.1	-1.3	-1.5	-2.3	-1.8
Heart disease (mother)	2.8	3.5	5.2	1.6	1.8	2.1	1.5	2.3	1.7
Exposure to tobacco smoke at home	2.6	2.9	5.2	1.8	1.1	1.7	1.6	2.3	1.6
Eye problems/disorders: Cataract	2.6	3.0	4.8	2.2	1.5	1.4	1.9	2.1	1.1
Impedance of leg (left)	2.5	12.3	15.1	-3.7	-2.6	-3.8	-3.5	-3.9	-3.4
Bilateral oophorectomy (both ovaries removed)	2.4	2.8	3.9	1.7	1.5	1.7	1.5	1.6	2.0
Stomach or abdominal pain in last month	2.4	3.0	5.3	-2.3	-1.6	-1.8	-2.0	-1.2	-1.3
Arm fat mass (left)	2.4	9.9	14.2	3.7	2.2	3.8	3.3	2.6	3.0
Leg fat mass (left)	2.4	9.4	13.8	3.7	2.2	3.6	3.4	2.2	2.9
Systolic blood pressure, automated reading	2.3	6.6	14.3	1.9	1.9	2.6	1.8	3.8	2.9
Depression (self-reported)	2.3	2.8	5.4	-1.2	-2.1	-1.3	-1.6	-1.1	-2.3
Length of working week for main job	2.3	2.6	3.9	1.3	2.0	1.5	1.1	1.8	1.7
Waist Hip Ratio (WHR)	2.2	10.1	15.2	3.3	3.9	3.0	3.4	1.4	3.5
Medication: Atenolol	2.2	2.8	4.2	1.3	2.0	1.3	1.6	1.7	2.0
Impedance of arm (right)	2.2	10.2	15.0	-3.4	-2.9	-3.0	-3.9	-2.4	-3.4
Family relationship satisfaction	2.2	2.7	3.5	-1.3	-1.9	-1.6	-1.8	-1.6	-1.7
Commuting to job workplace: Car/motor vehicle	2.2	2.6	3.8	1.9	1.3	1.7	1.5	1.7	1.4
Townsend deprivation index at recruitment	2.1	3.0	4.9	-1.2	-1.6	-1.7	-1.8	-1.7	-2.2
Impedance of arm (left)	2.1	9.7	14.4	-3.5	-2.8	-2.8	-3.8	-2.5	-3.1
Arm fat mass (right)	2.1	8.5	12.5	3.5	1.9	3.5	3.0	2.4	2.7
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.5	7.1	-1.6	-0.9	-1.6	-1.1	-2.7	-0.8
Whole body fat mass	2.1	8.6	13.5	3.6	2.0	3.7	3.1	2.2	2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	3.4	-1.5	-1.3	-1.6	-1.5	-1.8	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.3	7.6	1.9	2.0	2.1	1.4	2.8	2.0
Body mass index (BMI)	2.0	8.5	12.2	3.5	2.1	3.4	3.2	2.3	2.7
Osteoporosis (self-reported)	2.0	2.4	4.2	2.0	1.1	1.9	1.9	0.7	1.2
Supplements: Fish oil (including cod liver oil)	2.0	2.6	4.7	2.2	1.1	1.5	1.9	1.4	1.2
Diastolic blood pressure, automated reading	2.0	6.2	10.3	2.0	2.2	2.6	1.9	2.7	3.2
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	3.2	1.5	0.9	1.8	1.3	1.7	1.4
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	4.6	1.2	2.1	1.0	0.9	2.1	1.5
Birth weight	1.9	4.2	5.9	2.3	1.5	2.2	2.0	1.7	2.4
Alcohol drinker status: Never	1.9	2.3	4.9	-1.4	-1.2	-1.1	-1.2	-2.2	-1.6
Hearing difficulty/problems: Yes	1.8	2.7	5.0	1.5	1.7	1.6	1.7	1.0	2.2
Ever highly irritable/argumentative for 2 days	1.8	2.2	3.0	-1.7	-1.4	-1.4	-1.5	-1.2	-1.7
Leg fat mass (right)	1.8	6.9	10.6	3.2	1.7	3.2	2.9	1.8	2.4
Illness, injury, bereavement, stress in last 2 years	1.8	2.1	3.2	1.8	1.1	1.3	1.6	1.1	1.7
Chronotype (morning person)	1.7	3.8	5.2	-2.2	-1.7	-2.2	-1.6	-2.3	-1.5
Trunk fat mass	1.7	7.2	11.6	3.2	1.8	3.4	2.7	2.1	2.6
Birth weight of first child	1.7	3.1	4.5	1.6	1.7	1.5	1.6	2.1	2.0
HDL Cholesterol	1.6	2.6	5.0	-1.1	-2.1	-1.1	-1.8	-0.8	-2.2
Multivitamins +/- minerals	1.6	2.1	2.9	1.5	1.3	1.7	1.3	1.5	1.3
Illnesses of siblings	1.6	2.2	3.7	-0.8	-1.7	-1.5	-1.0	-1.9	-1.7
Medication: Omeprazole	1.6	1.9	2.5	-1.5	-1.1	-1.6	-1.4	-1.3	-1.4
Eye problems/disorders: Glaucoma	1.6	1.9	4.8	-1.8	-0.4	-2.2	-0.9	-1.3	-0.8
Nervous feelings	1.5	2.9	3.6	-1.3	-1.7	-1.9	-1.4	-1.8	-1.9
Ever unenthusiastic/disinterested for a whole week	1.5	1.9	3.1	-1.6	-1.8	-1.1	-1.4	-0.7	-1.4
Hip circumference	1.5	6.5	9.9	3.0	1.2	3.1	2.6	2.5	2.3
Guilty feelings	1.5	2.3	3.7	1.8	1.0	1.7	1.9	1.1	1.3
Alcohol drinker status: Previous	1.5	1.8	3.2	-1.0	-1.4	-1.1	-0.9	-1.8	-1.5
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	2.3	-0.8	-1.5	-1.5	-1.0	-1.5	-1.2
Worry (Nagel 2018)	1.3	2.7	5.2	-1.2	-2.3	-1.4	-1.3	-1.4	-1.9
Verbal and Numeric Reasoning (VNR)	1.3	3.0	4.8	1.9	1.9	1.3	1.8	0.9	2.2
Systolic Blood Pressure	1.3	6.4	15.8	1.0	2.4	2.3	1.1	4.0	3.1
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	4.7	1.9	0.9	2.2	1.2	2.2	1.3
Medication: Cholesterol lowering	1.3	2.0	3.1	-0.9	-1.2	-1.6	-1.2	-1.8	-1.7
Prospective memory result	1.3	1.6	3.3	-1.2	-1.7	-0.9	-1.1	-0.4	-1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	3.3	-1.3	-1.6	-0.9	-1.6	-1.2	-1.8
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	3.1	1.5	1.4	1.1	1.5	1.8	1.3
Hearing aid user	1.3	1.5	2.6	0.8	1.3	1.0	1.1	1.6	1.4
Unable to work because of sickness or disability	1.3	1.7	2.6	-1.1	-0.8	-1.5	-1.3	-1.6	-1.3
Heart disease (siblings)	1.3	1.6	2.0	1.3	1.4	1.1	1.3	1.0	1.4
Intelligence (Savage-Jansen 2018)	1.2	3.6	4.6	2.0	2.0	1.9	1.8	1.4	2.1
Hair/balding pattern: Pattern 2	1.2	1.6	2.3	-1.3	-0.8	-1.5	-1.5	-0.9	-1.4
Medication: Amlodipine	1.2	1.6	2.4	0.8	1.4	1.2	1.3	1.5	1.2
Chest pain or discomfort	1.2	1.7	3.2	-1.8	-0.5	-1.6	-1.0	-1.6	-1.0
Ever smoked	1.2	2.1	3.6	-1.4	-1.4	-1.9	-1.5	-1.2	-1.2
Alzheimer’s Disease (in father)	1.1	1.2	1.5	1.0	1.1	1.1	1.1	1.2	1.0
Fasting Glucose	1.1	1.3	2.2	-0.9	-1.1	-0.7	-1.2	-1.2	-1.5
Smoking Status	1.1	2.6	4.3	-0.9	-1.7	-2.1	-1.2	-1.7	-1.9
High blood pressure (mother)	1.1	1.6	4.1	0.6	1.0	1.0	0.9	2.0	1.5
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	1.9	1.0	0.9	1.1	1.0	1.4	1.1
Breastfed as a baby	1.1	1.4	2.6	1.6	0.3	0.8	1.6	0.9	1.3
Migraine (self-reported)	1.1	1.4	2.3	-1.2	-1.3	-0.6	-1.5	-1.4	-0.9
Medication: Ibuprofen	1.1	1.3	2.9	0.9	1.4	0.8	0.4	1.7	1.1
Smoking status: Previous	1.1	1.6	3.0	1.4	0.9	0.9	1.7	1.0	1.4
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.7	-0.5	-0.8	-0.3	-1.2	-1.6	-1.6
High cholesterol (Self-reported)	1.1	1.9	3.3	-1.2	-1.2	-1.3	-1.1	-1.8	-1.4
Triglycerides	1.0	1.6	2.1	1.2	1.4	1.3	1.4	0.8	1.4
Medication: Co-codamol	1.0	1.2	3.0	-1.0	-0.9	-0.8	-1.1	-1.7	-0.7
Mouth/teeth dental problems	1.0	1.5	2.6	1.4	0.9	1.4	1.6	0.8	1.1
Falls in the last year	1.0	1.3	2.2	0.9	0.5	1.3	1.0	1.5	1.4
Standing height	1.0	9.8	13.4	3.1	2.7	3.2	2.8	3.7	3.1
Medication: Paracetamol	1.0	1.7	3.2	0.9	1.8	1.0	1.1	1.2	1.5
Ever taken oral contraceptive pill	1.0	1.1	1.4	-0.7	-1.1	-1.1	-1.1	-1.2	-1.2
Medication: Bendroflumethiazide	1.0	1.5	2.2	1.3	1.4	1.1	1.5	0.7	1.3
Number of operations (self-reported)	1.0	1.5	2.3	0.8	1.3	1.1	1.2	1.2	1.5
Irritability	1.0	1.7	3.4	-0.9	-1.5	-1.0	-0.9	-1.9	-1.4
Health satisfaction	0.9	1.2	2.1	1.3	1.4	0.6	1.2	0.8	1.0
Supplements: Vitamin C	0.9	1.0	2.7	-1.1	-0.1	-1.6	-0.9	-1.1	-0.8
Arm fat percentage (left)	0.9	3.5	6.7	2.4	1.0	2.6	1.9	1.2	1.7
Friendships satisfaction	0.9	1.2	2.3	1.5	1.0	1.1	1.1	0.7	0.9
Number of self-reported non-cancer illnesses	0.9	1.6	2.8	1.2	1.3	0.6	1.5	1.0	1.7
Medication: Blood pressure	0.9	1.8	3.9	0.7	1.2	0.9	0.7	2.0	1.8
Medication: Paracetamol	0.9	1.4	2.1	1.0	1.5	0.9	1.1	1.0	1.4
Leg fat percentage (left)	0.9	3.3	5.8	2.4	1.1	2.4	2.0	1.0	1.6
Ever depressed for a whole week	0.9	1.1	1.9	-1.4	-1.1	-0.6	-1.2	-0.6	-1.1
Crohns Disease (2017)	0.8	1.8	3.5	-1.8	-0.9	-0.8	-1.4	-1.9	-0.9
Prostate Cancer	0.8	1.1	2.7	-0.8	-0.9	-0.7	-1.2	0.4	-1.6
Height	0.8	16.0	21.2	4.2	3.4	4.6	3.6	4.5	3.6
Pack years adult smoking proportion	0.8	1.2	2.2	-0.9	-1.1	-0.7	-1.5	-1.1	-1.2
Pain all over the body in last month	0.8	0.9	1.5	1.0	0.5	0.8	1.1	1.2	0.7
Neuroticism score	0.8	1.7	2.3	-1.1	-1.5	-1.3	-1.1	-1.3	-1.4
Worrier / anxious feelings	0.8	1.4	3.0	-0.8	-1.5	-0.8	-1.0	-1.7	-1.2
Pulse rate	0.8	1.3	2.9	-1.0	-0.8	-1.5	-0.7	-1.7	-0.7
Glaucoma (self-reported)	0.8	0.9	3.3	-1.3	0.1	-1.8	-0.4	-0.8	-0.0
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	2.5	1.5	0.9	1.3	1.1	1.6	0.8
Emphysema/chronic bronchitis	0.8	0.9	1.6	-0.6	-1.1	-1.2	-0.6	-1.3	-0.9
Age at last live birth	0.8	1.1	2.2	-0.8	-1.1	-1.0	-1.2	-0.6	-1.5
Medication: Gliclazide	0.8	0.9	1.8	0.8	0.7	1.0	0.8	1.4	0.7
Commuting to job workplace: Cycle	0.8	1.0	2.2	-0.6	-1.3	-1.5	-0.6	-0.8	-0.9
HbA1C	0.7	0.8	1.7	0.7	1.0	0.6	0.5	1.3	0.9
Blood Eosinophil Count	0.7	5.6	8.4	2.8	2.0	2.1	2.9	2.1	2.0
Heel T-Score	0.7	5.9	8.2	2.2	2.9	2.8	2.0	1.9	2.6
Hypothyroidism (self reported)	0.7	1.6	2.7	1.6	1.1	1.4	1.1	1.3	1.1
Angina	0.7	0.9	1.5	-0.7	-1.1	-0.5	-0.8	-1.1	-1.2
Diabetes (mother)	0.7	0.9	1.9	1.1	0.7	1.4	0.8	0.8	0.7
Arm fat percentage (right)	0.7	2.7	5.2	2.2	0.8	2.3	1.6	1.0	1.3
Tense / ‘highly strung’	0.7	1.2	1.7	-0.8	-1.1	-1.3	-0.6	-1.3	-1.2
Peak expiratory flow (PEF)	0.7	1.7	3.8	0.7	2.0	0.6	1.2	1.5	1.4
Body fat percentage	0.7	2.6	5.6	2.0	0.8	2.4	1.6	0.8	1.4
Medication for pain relief, constipation, heartburn	0.7	1.2	2.3	-0.7	-1.5	-0.9	-0.6	-1.4	-1.1
Medication for cholesterol	0.7	1.0	2.5	-0.5	-1.0	-0.3	-0.6	-1.6	-1.4
Myopia	0.7	1.1	2.1	1.2	0.8	0.5	0.9	1.4	1.0
Supplements: Calcium	0.7	0.7	1.3	-0.6	-0.6	-0.8	-0.9	-1.0	-1.1
Body Mass Index (BMI) (2010)	0.6	0.8	1.0	0.8	0.9	1.0	1.0	1.0	0.7
LDL Cholesterol	0.6	0.9	1.3	-0.9	-0.8	-0.8	-0.9	-1.1	-1.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.4	0.9	1.2	1.0	0.6	0.2	0.8
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.1	-1.0	-0.9	-1.0	-0.9	-0.6	-1.1
Trunk fat percentage	0.6	2.3	5.0	1.8	0.8	2.2	1.5	0.8	1.4
Supplements: Glucosamine	0.6	0.8	1.8	-1.4	-1.1	-0.5	-1.1	-0.2	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.2	1.3	0.7	1.5	0.7	1.4	1.1
Time employed in main current job	0.6	0.7	1.1	-0.9	-0.4	-1.0	-0.6	-1.0	-0.9
Alcohol intake versus 10 years previously	0.6	0.9	1.3	0.7	0.9	1.1	0.8	1.0	1.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	4.5	0.8	2.1	0.9	0.9	2.0	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	3.7	1.0	1.9	1.1	0.9	1.8	1.2
Loud music exposure frequency	0.6	0.7	1.4	0.4	1.0	0.3	0.7	1.0	1.2
Angina (self-reported)	0.6	0.8	1.5	-0.5	-1.1	-0.4	-0.7	-1.2	-1.1
Suffer from ‘nerves’	0.6	1.0	2.0	-1.0	-1.4	-0.5	-1.1	-0.8	-0.9
Risk taking	0.6	0.9	1.5	-1.2	-0.7	-1.2	-1.0	-0.6	-0.7
Depressed Affect (Nagel 2018)	0.5	1.0	1.5	-1.1	-1.2	-1.2	-1.0	-0.3	-0.9
Depression (Nagel 2018)	0.5	0.8	1.2	-1.1	-1.1	-0.6	-0.8	-0.2	-1.1
Mean Putamen Volume	0.5	0.5	1.4	-0.8	-0.2	-1.1	-0.2	-1.2	-0.4
Taking other prescription medications	0.5	0.8	1.6	-0.7	-0.8	-0.8	-0.8	-1.3	-0.8
High blood pressure	0.5	1.3	2.2	0.3	1.4	0.5	0.9	1.5	1.5
Forced vital capacity (FVC)	0.5	1.8	3.9	0.7	2.0	0.8	0.7	1.8	1.3
Medication: Ramipril	0.5	0.7	2.1	-0.9	-0.3	-0.6	-0.8	-1.5	-0.3
Hair/balding pattern: Pattern 4	0.5	1.2	2.3	-1.2	-1.2	-0.6	-1.0	-1.5	-0.8
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.0	-1.0	-0.2	-0.6	-1.4	0.1	-0.9
High blood pressure (siblings)	0.5	0.8	1.5	-0.1	1.2	0.9	0.2	1.1	1.1
Leg fat percentage (right)	0.5	1.8	3.6	1.8	0.5	1.9	1.5	0.6	1.0
Comparative height size at age 10	0.5	2.6	5.6	1.7	0.9	1.4	1.4	2.4	1.6
Hypertension (Self-reported)	0.5	1.5	2.6	0.4	1.6	0.7	0.9	1.5	1.6
Back pain experienced in last month	0.5	0.8	1.3	-1.0	-0.9	-1.1	-1.1	-0.2	-0.8
Illnesses of father: None of the above (group 1)	0.5	0.6	2.0	-0.4	-0.3	-0.8	-0.8	-1.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	4.0	0.7	2.0	0.5	0.5	0.8	1.0
Mother’s age at death	0.5	0.6	1.3	0.6	0.4	0.9	0.6	1.2	0.8
Medication: Lisinopril	0.5	0.6	1.4	0.5	0.6	-0.0	0.9	1.0	1.2
Pack years of smoking	0.5	0.7	1.2	-0.5	-0.9	-0.2	-1.1	-0.9	-0.9
Neuroticism (2016)	0.4	0.6	1.1	-0.7	-0.7	-0.8	-0.7	-1.1	-0.5
Blood White Count	0.4	3.2	4.3	1.6	2.1	1.7	1.5	1.9	2.0
Cardiovascular Disease	0.4	1.5	2.7	0.6	1.6	0.9	0.8	1.3	1.5
Tanning	0.4	5.2	7.7	-2.2	-2.8	-2.2	-2.6	-1.7	-2.1
Medication for hormone replacement therapy	0.4	0.5	1.4	0.2	0.9	0.2	0.7	0.5	1.2
Vitamin and mineral supplements	0.4	0.6	0.8	-0.9	-0.9	-0.8	-0.5	-0.4	-0.9
Severe depression (siblings)	0.4	0.4	0.9	0.6	-1.0	0.8	0.2	0.7	0.2
Mouth/teeth dental problems: Dentures	0.4	0.6	1.1	-1.1	-0.5	-1.0	-0.6	-1.0	-0.2
Lung cancer (father)	0.4	0.5	0.9	0.8	0.5	0.8	0.4	-0.9	0.9
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.0	-0.3	-0.4	-0.5	-0.6	-1.4	-0.4
Ever had bowel cancer screening	0.4	0.5	0.8	0.7	0.5	0.4	0.7	-0.8	0.9
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.2	-0.6	-1.1	-0.7	-0.8	-0.9	-0.6
Miserableness	0.4	0.7	1.2	-1.1	-1.1	-0.8	-0.9	-0.0	-0.8
Commuting to job workplace: Public transport	0.4	0.5	0.9	-0.8	0.4	-0.8	-0.7	-0.9	-0.4
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.2	-0.3	-1.1	-0.6	-0.7	-1.5	-1.2
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.2	1.1	0.6	1.1	0.5	0.2	0.5
Schizophrenia vs Biploar Disorder	0.3	0.3	0.7	0.8	0.6	0.6	0.8	0.1	0.3
Irritable Bowel Disease (IBD)	0.3	0.7	1.4	-0.9	-0.5	-0.7	-0.9	-1.2	-0.5
Age at First Birth	0.3	0.5	1.0	-0.8	-0.8	-0.4	-1.0	-0.4	-0.6
Lupus	0.3	0.5	2.5	-0.2	-0.2	-0.6	-0.0	-1.6	-0.2
Primary Biliary Cirrhosis	0.3	0.4	1.2	-0.4	-0.4	-1.1	-0.6	-0.7	-0.6
Ulcerative Colitis	0.3	0.5	0.7	0.8	0.8	0.5	0.6	0.4	0.7
Blood Platelet Count	0.3	3.1	9.1	-3.0	-0.9	-1.8	-2.1	0.4	-1.0
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	-0.5	-0.6	-1.0	-0.8	-0.1	-0.5
Supplements: Zinc	0.3	0.4	0.6	-0.3	-0.7	-0.6	-0.5	-0.8	-0.6
Diabetes (father)	0.3	0.4	0.6	-0.8	-0.5	-0.7	-0.8	-0.1	-0.8
Qualifications: None of the above	0.3	0.6	1.7	-0.8	-0.5	-0.2	-0.7	-1.3	-0.8
Heart attack	0.3	0.4	0.9	0.9	0.5	1.0	0.4	0.2	0.4
Diabetes (self-reported)	0.3	0.4	0.6	0.4	0.7	0.3	0.8	0.8	0.8
Medication: Simvastatin	0.3	0.4	1.4	-0.1	-0.3	-0.6	-0.2	-1.2	-0.6
Number of live births	0.3	0.4	1.8	-0.4	-1.3	-0.5	-0.4	0.3	-0.4
Noisy workplace	0.3	0.3	1.0	-0.4	-0.5	-0.6	-0.4	-1.0	-0.2
Blood clot in the leg (DVT)	0.3	0.3	0.6	-0.3	-0.7	-0.4	-0.5	-0.7	-0.8
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.1	0.5	1.1	0.3	0.1	-0.1	0.8
Exposure to tobacco smoke outside home	0.3	0.4	0.8	-0.9	-0.7	-0.6	-0.8	-0.1	-0.1
Worry too long after embarrassment	0.3	0.4	1.2	0.5	0.8	1.1	0.4	0.4	0.5
Age at first live birth	0.3	0.5	1.1	-0.3	-0.7	-0.3	-0.8	-1.1	-0.8
Shortness of breath walking on level ground	0.3	0.4	0.9	-0.7	-0.1	-0.6	-0.2	-0.9	-0.6
Qualifications: College or University degree	0.3	1.0	1.7	1.1	1.3	0.7	0.8	0.4	1.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.1	-0.7	-0.2	-0.6	-1.0	-0.1	-0.7
Medication: Seretide 50 evohaler	0.3	0.3	0.6	-0.6	-0.8	-0.3	-0.7	-0.3	-0.6
Had major operations	0.3	0.3	0.7	-0.8	-0.3	-0.4	-0.4	-0.8	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	-0.5	-0.7	-0.5	-0.7	0.0	-0.5
Qualifications: nursing, teaching	0.3	0.5	1.4	0.6	0.4	0.7	0.3	1.2	0.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.6	-0.8	-0.5	-0.8	-0.5	-0.6	-0.6
Illnesses of father: High blood pressure	0.3	0.4	1.2	-1.1	-0.2	-0.9	-0.2	-0.5	0.0
Cholesterol lowering medication	0.3	0.4	0.6	0.6	0.8	0.5	0.7	0.8	0.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.6	-0.6	-0.2	-0.8	-0.5	-0.5	-0.8
Alzheimer’s Disease (including proxy)	0.2	0.4	0.8	0.7	0.4	0.9	0.6	0.3	0.6
Reaction Time	0.2	0.3	0.7	0.3	0.4	0.5	0.8	0.3	0.8
Breast Cancer	0.2	0.5	1.3	0.3	1.1	0.4	0.8	0.7	0.5
Ovarian Cancer	0.2	0.3	0.5	-0.7	-0.7	-0.5	-0.4	0.3	-0.2
Allergy or Eczema	0.2	0.4	1.7	0.3	0.3	0.5	0.1	1.3	0.8
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.6	0.5	0.8	0.0	0.7	0.1	0.7
Neuroticism	0.2	0.6	1.3	-0.8	-1.1	-0.6	-0.7	-0.4	-0.8
Number of treatments/medications taken	0.2	0.3	0.7	-0.8	0.3	-0.8	-0.6	-0.4	-0.2
Fed-up feelings	0.2	0.3	0.9	-0.8	-0.4	-1.0	-0.5	0.0	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.4	-0.6	-0.7	-0.2	-0.2	-0.2	-0.6
Medication: Levothyroxine sodium	0.2	0.3	0.6	0.8	0.3	0.4	0.6	0.8	0.1
Sitting height	0.2	1.1	3.3	1.2	0.5	0.7	0.7	1.8	0.7
Hearing difficulty/problems with background noise	0.2	0.3	0.9	-0.7	0.2	-0.5	-0.1	-0.6	1.0
Had menopause	0.2	0.3	0.8	-0.4	-0.9	-0.6	-0.4	-0.1	-0.3
Father’s age at death	0.2	0.2	0.4	-0.3	-0.7	-0.6	0.0	-0.1	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	-0.9	0.4	-0.6	-0.3	0.5	0.6
Headache pain in last month	0.2	0.3	1.0	-0.5	-0.2	-0.4	-0.6	-1.0	0.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.8	0.4	-0.2	0.7	0.2	0.9	0.4
Forced vital capacity (FVC), Best measure	0.2	0.8	2.2	0.4	1.2	0.7	0.2	1.5	0.8
Medication: Blood pressure	0.2	0.4	1.1	-0.3	1.1	-0.5	0.3	-0.7	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.2	0.4	0.5	0.4	0.5	0.4	0.5
Pulse rate, automated reading	0.2	0.7	2.1	-0.2	-0.4	-1.1	-0.1	-1.5	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.8	0.4	0.9	0.3	0.4	0.0	0.8
Knee pain experienced in last month	0.2	0.3	0.7	-0.7	-0.2	-0.8	-0.6	-0.5	0.0
Illnesses of siblings: Diabetes	0.2	0.2	1.0	0.3	-0.3	0.4	-0.1	1.0	-0.1
Mood swings	0.2	0.3	0.9	-0.4	-1.0	-0.7	-0.4	-0.1	-0.6
Long-standing illness, disability or infirmity	0.2	0.3	1.2	-0.5	-0.4	-1.1	-0.3	-0.1	-0.3
Commuting to job workplace: Walk	0.2	0.2	0.6	-0.1	0.0	-0.8	-0.2	-0.7	-0.0
Osteoarthritis (self-reported)	0.2	0.3	0.5	-0.4	-0.5	-0.7	-0.5	-0.6	-0.3
Ever had prostate specific antigen (PSA) test	0.2	0.3	1.0	0.1	-0.1	0.7	-0.1	-1.0	0.1
Fractured/broken bones in last 5 years	0.2	0.2	0.5	-0.7	-0.7	-0.3	-0.5	-0.0	-0.1
Age started oral contraceptive pill	0.2	0.2	0.5	0.7	-0.3	0.1	0.7	-0.2	0.5
Pain experienced in last month	0.2	0.4	1.1	0.6	0.8	0.2	1.1	0.1	0.5
Neuroticism (Nagel 2018)	0.1	0.2	0.7	-0.3	-0.8	-0.3	-0.2	-0.1	-0.6
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	0.3	-0.2	0.5	-0.0	-0.1	0.1
Ulcerative Colitis (UC)	0.1	0.1	0.5	-0.0	-0.2	-0.7	-0.2	-0.2	-0.0
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.1	0.4	-0.1	0.2	0.3	0.2
Respiratory disease	0.1	0.1	0.4	-0.3	0.0	-0.6	0.2	-0.3	0.4
Lung FVC	0.1	0.3	1.0	-1.0	-0.0	-0.2	-0.7	-0.2	-0.0
Relative age of first facial hair	0.1	0.2	0.3	-0.3	-0.5	0.2	-0.1	0.5	-0.6
Maternal smoking around birth	0.1	0.1	0.4	0.5	0.6	0.0	0.3	-0.1	-0.1
Relative age voice broke	0.1	0.1	0.3	0.4	-0.2	0.4	0.2	0.6	0.2
Age when periods started (menarche)	0.1	0.1	0.7	0.2	-0.2	0.1	0.1	0.8	0.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	-0.2	-0.1	0.0	-0.3	0.4	-0.6
Qualifications: CSEs or equivalent	0.1	0.2	0.5	-0.7	0.2	0.1	-0.1	0.7	0.2
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.8	0.4	0.2	0.3	0.2	0.9	0.8
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	0.4	-0.0	0.6	-0.2	0.5	-0.2
Number of incorrect matches in round	0.1	0.2	0.5	0.1	-0.7	-0.2	-0.3	-0.3	-0.7
Past tobacco smoking	0.1	0.2	0.4	-0.1	0.7	0.6	-0.0	0.2	0.5
Had other major operations	0.1	0.2	0.6	-0.3	0.1	-0.7	0.1	0.7	0.1
Allergy	0.1	0.2	0.5	-0.6	-0.3	-0.3	-0.5	-0.5	-0.7
Fluid intelligence score	0.1	0.2	0.6	0.3	0.3	-0.4	0.1	-0.8	0.5
Happiness	0.1	0.1	0.6	0.1	-0.1	-0.1	0.1	-0.8	-0.2
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.4	0.3	-0.1	0.1	0.2	0.1
Pulse wave reflection index	0.1	0.1	0.6	0.0	0.4	0.2	0.1	0.8	0.2
Gout (self-reported)	0.1	0.2	0.4	-0.3	0.6	-0.4	-0.6	-0.0	0.0
Number of full brothers	0.1	0.2	0.6	-0.7	-0.5	0.1	-0.4	0.4	-0.0
Wheeze or whistling in the chest in last year	0.1	0.2	0.6	-0.2	-0.8	-0.2	-0.5	-0.4	0.0
Neck or shoulder pain in last month	0.1	0.1	0.3	0.5	0.5	0.2	-0.1	-0.2	0.2
Medication: Allopurinol	0.1	0.2	0.5	-0.4	0.2	-0.1	-0.5	0.7	-0.1
Mean time to correctly identify matches	0.1	0.1	0.5	-0.5	0.2	-0.0	0.3	0.2	0.7
Number of full sisters	0.1	0.2	0.4	-0.3	-0.3	0.1	-0.3	0.6	-0.5
Overall health rating	0.1	0.1	0.4	-0.2	0.7	-0.2	-0.0	0.2	0.4
Medication: Aspirin	0.1	0.1	0.5	-0.3	-0.1	-0.1	-0.2	-0.7	0.2
Illnesses of father: Heart disease	0.1	0.1	0.4	-0.4	-0.4	-0.1	0.0	0.6	-0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	0.3	0.1	0.1	0.2	-0.0	0.5
Diabetes diagnosed by doctor	0.1	0.2	0.5	0.4	0.5	-0.0	0.7	0.2	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.5	-0.4	-0.0	-0.4	0.2	-0.4
Mineral and other dietary supplements	0.1	0.1	0.3	-0.4	0.3	-0.1	-0.2	-0.6	-0.1
Medication: Aspirin	0.1	0.1	0.3	-0.1	0.2	-0.1	-0.0	-0.5	0.4
Wears glasses or contact lenses	0.1	0.1	0.3	-0.4	-0.2	0.1	-0.4	0.5	-0.1
Medication: Atorvastatin	0.1	0.2	0.3	0.2	0.3	0.4	0.3	0.6	0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	-0.1	-0.5	-0.1	-0.3	-0.6	-0.6
Crohns Disease (2012)	0.0	0.0	0.1	-0.1	0.3	-0.3	0.1	-0.1	0.2
Blood Red Count	0.0	0.2	0.5	-0.2	-0.7	0.0	-0.3	-0.5	-0.3
Lung FEV1/FVC ratio	0.0	0.1	0.3	0.3	0.3	-0.4	0.5	-0.0	0.4
Hair Pigment	0.0	0.9	1.4	-0.4	-1.0	-1.2	-0.6	-1.0	-1.1
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.1	-0.1	0.0	-0.0	-0.3	0.2	0.2
Medication: Metformin	0.0	0.1	0.2	0.0	0.4	-0.0	0.2	-0.0	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.2	0.2	-0.1	0.3	0.0	0.5	-0.2
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	0.0	-0.0	-0.2	0.2	0.0	0.2
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	0.1	-0.2	0.2	-0.2	0.5	0.0
Asthma	0.0	0.1	0.1	0.4	0.1	0.4	0.4	0.0	0.3
Number of children fathered	0.0	0.0	0.1	0.1	0.3	-0.1	0.1	0.1	0.4
Pulse wave peak to peak time	0.0	0.1	0.2	-0.0	0.0	0.4	0.2	0.1	0.3
Eye problems/disorders: None of the above	0.0	0.0	0.1	0.1	0.2	0.3	-0.1	-0.3	-0.1
Alcohol intake frequency.	0.0	0.1	0.3	0.3	0.0	0.5	0.2	0.5	-0.1
Average weekly red wine intake	0.0	0.1	0.3	0.2	-0.1	0.0	0.2	-0.0	0.5
Breast cancer (self-reported)	0.0	0.0	0.2	-0.2	0.0	0.0	-0.1	-0.4	-0.0
Asthma (self-reported)	0.0	0.0	0.1	0.2	-0.3	0.2	0.1	-0.2	-0.0
Average weekly champagne plus white wine intake	0.0	0.0	0.2	-0.1	0.1	-0.1	0.1	-0.0	0.4
Financial situation satisfaction	0.0	0.0	0.1	0.1	0.4	0.2	0.1	-0.1	-0.2
Basal cell carcinoma (self-reported)	0.0	0.0	0.1	0.1	-0.2	0.0	-0.3	0.1	0.2

Hub : Genes

FAM119A

Models

Trait associations