Hub : Genes

CREB1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0710 0.0220 7.4e-06 0.066 0.041 0.050 0.054 0.054 1.8e-08 8.8e-06 8.8e-07 3.5e-07 3.2e-07
2 GTEx Adipose Visceral Omentum 0.1430 0.0500 1.5e-03 -0.005 NA 0.020 NA -0.004 9.6e-01 NA 3.1e-02 NA 5.8e-01
3 GTEx Cells Transformed fibroblasts 0.1470 0.0470 9.0e-05 -0.004 NA 0.001 NA -0.003 9.9e-01 NA 2.8e-01 NA 7.4e-01
4 TCGA Bladder Urothelial Carcinoma 0.0330 0.0200 1.9e-03 0.009 0.013 -0.001 NA 0.005 5.3e-02 2.5e-02 4.5e-01 NA 1.1e-01
5 TCGA Breast Invasive Carcinoma 0.0719 0.0381 1.9e-03 0.009 0.010 0.016 NA 0.015 4.1e-03 2.9e-03 2.3e-04 NA 4.0e-04
6 TCGA Head and Neck Squamous Cell Carcinoma 0.3348 0.0835 4.5e-06 0.046 0.029 0.034 NA 0.035 6.1e-06 2.7e-04 9.2e-05 NA 7.2e-05
7 TCGA Kidney Renal Clear Cell Carcinoma 0.1108 0.0511 6.1e-05 0.022 0.018 0.021 NA 0.016 1.3e-03 3.3e-03 1.7e-03 NA 5.9e-03
8 TCGA Lung Squamous Cell Carcinoma 0.0791 0.0610 3.2e-05 0.024 0.024 0.021 NA 0.034 8.6e-04 9.3e-04 1.8e-03 NA 9.1e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 4.4 7.0 9.4 -2.7 1.2 2.0 2.7 3.0 3.0 2.9 3.1
Bipolar Disorder or Schizophrenia 6.8 16.6 27.9 -4.9 0.9 3.0 5.0 4.2 4.3 3.1 5.3
Depressed Affect (Nagel 2018) 0.4 0.9 1.8 -1.0 1.4 -0.5 1.0 0.6 0.7 1.2 1.0
Depression (Nagel 2018) 0.3 0.4 0.8 -0.7 0.7 0.1 0.9 0.3 0.5 0.9 0.7
Intelligence (Savage-Jansen 2018) 1.1 3.5 5.2 1.8 1.5 -1.4 -2.1 -2.2 -2.3 -0.9 -2.3
Neuroticism (Nagel 2018) 0.3 0.6 3.5 -0.6 1.9 -0.1 0.6 0.3 0.4 -0.1 0.5
Schizophrenia (2018) 4.8 9.9 18.4 -4.1 0.2 2.3 4.2 2.9 3.1 1.7 4.3
Schizophrenia vs Biploar Disorder 0.3 0.4 2.0 0.3 0.3 -0.8 -0.3 0.1 0.1 -1.4 -0.1
Worry (Nagel 2018) 0.9 1.8 3.5 -1.9 1.1 1.5 1.8 0.9 0.9 0.4 1.7
Alzheimer’s Disease (in mother) 0.5 0.6 2.9 0.3 1.7 1.0 -0.0 0.6 0.5 0.6 0.1
Alzheimer’s Disease (in father) 0.6 0.7 1.3 0.5 0.4 -0.9 -0.8 -0.8 -1.1 -0.7 -1.1
Alzheimer’s Disease (including proxy) 0.1 0.1 0.5 0.2 0.7 -0.0 -0.4 0.3 0.2 0.6 -0.3
Crohns Disease (2017) 0.5 1.1 3.1 -0.7 0.6 1.5 1.1 0.1 0.7 1.8 1.0
Irritable Bowel Disease (IBD) 0.2 0.4 1.3 -0.4 -0.2 0.8 0.6 0.1 0.6 1.1 0.4
Ulcerative Colitis (UC) 0.1 0.2 0.8 0.0 -0.9 -0.1 -0.1 0.1 0.3 0.5 -0.2
Major Depression (MDD) 4.3 5.2 8.1 -2.8 2.1 1.3 2.7 1.8 1.8 2.6 2.7
Reaction Time 0.3 0.5 1.7 0.1 1.3 -0.7 -0.9 0.2 0.9 0.5 -0.0
Verbal and Numeric Reasoning (VNR) 1.9 4.7 8.5 2.2 0.6 -1.1 -2.4 -2.9 -2.9 -1.1 -2.7
Breast Cancer 0.2 0.6 2.1 0.2 1.5 -0.7 -0.3 -0.0 1.1 0.5 0.5
Ovarian Cancer 0.4 0.5 2.9 0.1 1.7 0.7 -0.1 -0.3 -0.1 0.5 0.4
Prostate Cancer 1.3 1.8 6.5 -1.1 -2.5 0.6 1.7 1.1 0.3 -0.7 1.2
Age at First Birth 0.1 0.2 0.8 -0.2 -0.9 0.1 0.5 0.1 -0.2 0.0 0.4
Bipolar Disorder (2011) 9.7 9.3 14.1 -3.1 1.4 2.4 3.3 3.5 3.4 2.9 3.8
Body Mass Index (BMI) (2010) 1.5 2.0 9.4 0.7 -1.3 -3.1 -0.7 -1.0 -0.9 -1.1 -0.9
Coronary Artery Disease (CAD) 0.2 0.2 1.2 0.4 -0.5 -1.1 0.0 -0.1 0.0 -0.5 -0.1
Crohns Disease (2012) 0.1 0.2 0.4 0.2 0.6 0.5 -0.0 0.4 0.6 0.4 0.3
Mean Putamen Volume 0.4 0.4 1.7 -0.7 0.1 -0.3 0.1 -1.3 -1.1 0.0 -0.0
Fasting Glucose 1.1 1.3 2.5 -1.6 1.2 0.4 1.4 1.2 0.7 0.4 1.3
HbA1C 0.7 0.8 3.8 0.6 0.4 -2.0 -0.8 -0.4 -0.2 -0.7 -0.7
HDL Cholesterol 1.6 2.6 4.8 -2.2 0.8 1.5 1.8 2.1 1.3 0.4 1.9
LDL Cholesterol 0.4 0.7 1.7 -1.1 1.2 1.3 0.8 -0.2 -0.2 -0.2 0.6
Lupus 0.4 0.6 3.3 -0.1 -1.8 0.1 -0.1 0.5 0.6 -0.7 0.4
Neuroticism (2016) 0.9 1.2 7.0 -0.4 2.6 -0.9 0.3 -1.1 -0.9 0.2 -0.2
Primary Biliary Cirrhosis 0.5 0.8 1.6 -0.9 0.4 0.2 0.6 1.1 1.3 1.1 1.0
Rheumatoid Arthritis 3.8 5.3 11.6 2.0 -0.6 -2.3 -2.8 -1.5 -1.9 -3.4 -2.7
Schizophrenia (2014) 4.7 10.3 17.7 -3.9 0.1 2.4 4.1 3.0 3.5 2.4 4.2
Triglycerides 0.9 1.6 3.1 1.8 -0.3 -0.6 -1.5 -1.6 -1.3 -0.2 -1.6
Type 2 Diabetes (T2D) (2012) 0.9 1.1 5.9 0.3 2.4 -1.4 -0.4 -0.3 -0.1 -0.6 -0.6
Ulcerative Colitis 0.3 0.4 1.1 1.1 0.3 -0.5 -0.7 -0.3 -0.3 -0.5 -0.8
Blood Eosinophil Count 0.8 6.0 14.1 1.7 3.8 -2.9 -2.7 -1.3 -1.4 -2.6 -2.0
Blood Platelet Count 0.3 3.7 9.2 -0.9 3.0 0.4 1.9 1.3 2.0 2.6 1.9
Blood Red Count 0.1 0.6 2.4 0.0 0.1 -0.1 0.3 1.3 1.5 0.8 0.6
Blood White Count 0.5 4.0 12.1 2.4 -0.2 -3.5 -1.8 -0.8 -1.3 -2.3 -1.8
Heel T-Score 0.4 3.0 5.9 2.1 1.1 -2.0 -2.4 -0.2 -0.8 -2.3 -1.5
BMI 3.1 18.0 45.7 4.9 -2.3 -6.8 -5.1 -0.5 -1.2 -5.2 -3.8
Height 0.3 5.8 11.6 3.2 -1.6 -3.1 -3.4 1.9 1.5 -2.2 -1.2
Waist Hip Ratio (WHR) 1.9 8.7 13.7 3.5 -0.7 -3.0 -3.3 -2.6 -2.5 -3.2 -3.7
Systolic Blood Pressure 0.6 2.8 10.5 3.2 -0.3 -0.8 -2.6 0.9 1.1 1.1 -1.1
Smoking Status 0.8 2.0 5.6 -1.6 2.4 1.5 1.5 0.9 0.5 -0.6 1.5
Allergy or Eczema 0.3 0.8 2.4 0.8 1.1 0.5 -0.6 1.1 0.7 1.5 -0.1
Cardiovascular Disease 0.6 2.1 8.5 2.2 -0.8 -2.9 -1.4 0.2 0.3 0.1 -0.8
Hypothyroidism (self reported) 0.5 1.2 5.0 0.8 2.2 -0.9 -1.0 1.1 0.7 -0.3 -0.1
Respiratory disease 0.2 0.4 1.3 0.5 0.7 0.6 -0.5 -0.1 0.4 1.2 -0.1
Type 2 Diabetes (T2D) (2018) 0.7 1.3 6.0 1.0 2.4 -1.1 -0.8 0.0 0.5 -0.8 -0.6
Lung FEV1/FVC ratio 0.1 0.5 1.5 0.6 -0.8 -0.2 -0.3 0.6 1.0 1.2 0.2
Lung FVC 0.4 2.1 7.7 0.6 -0.7 -0.7 -0.0 -2.4 -2.8 -1.2 -1.1
Neuroticism 0.3 0.7 3.4 -0.8 1.8 0.3 0.8 0.0 0.3 0.5 0.7
Chronotype (morning person) 0.8 1.8 3.8 -1.5 1.9 1.9 1.3 0.5 0.5 0.7 1.5
Hair Pigment 0.0 0.3 0.7 -0.9 0.7 -0.5 0.7 0.2 -0.0 0.6 0.5
Tanning 0.3 4.2 6.7 -1.6 -1.8 2.6 2.1 2.1 1.4 2.4 2.1
Hand grip strength (left) 3.2 8.3 16.4 4.0 0.6 -3.4 -3.4 -1.1 -1.1 -4.0 -2.9
Number of treatments/medications taken 0.8 1.4 3.6 -0.2 1.8 0.4 0.5 0.9 1.6 1.9 0.8
Average weekly spirits intake 3.0 3.7 10.0 1.6 1.3 -3.2 -2.1 -0.1 -0.6 -2.8 -1.7
Sensitivity / hurt feelings 2.9 5.0 7.1 2.2 2.4 -2.0 -2.3 -1.9 -1.8 -2.5 -2.7
Frequency of depressed mood in last 2 weeks 0.9 1.2 5.0 -0.9 2.2 0.4 1.0 0.7 0.8 0.9 0.8
Hearing difficulty/problems: Yes 3.0 4.5 24.4 1.7 4.9 -1.2 -2.2 -0.5 -0.3 0.3 -1.5
Relative age of first facial hair 0.2 0.5 2.1 -0.4 -1.0 1.5 0.3 -0.5 -0.5 -0.3 -0.0
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 2.3 -0.7 0.0 -0.2 0.7 0.8 0.4 1.5 0.6
Ever used hormone-replacement therapy (HRT) 0.3 0.4 2.2 -0.1 -0.4 0.3 0.1 0.6 0.3 1.5 0.0
Ever had hysterectomy (womb removed) 1.4 1.6 3.8 1.8 -0.7 -1.9 -1.8 0.4 -0.0 -0.7 -1.1
Systolic blood pressure, automated reading 1.4 3.9 8.9 3.0 -2.3 -2.5 -2.8 0.6 0.1 -0.3 -1.6
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 3.0 1.1 0.9 -1.4 -1.7 0.4 -0.3 -0.9 -0.9
Angina 1.6 2.1 5.2 -0.7 1.7 0.3 1.0 2.3 2.0 -0.5 1.7
Medication for hormone replacement therapy 1.3 1.4 3.0 0.8 1.7 -0.9 -1.2 -1.7 -1.0 0.4 -1.2
Vitamin and mineral supplements 0.6 0.8 3.5 -0.8 1.9 -0.5 1.0 0.6 0.3 0.2 0.9
Supplements: Zinc 0.2 0.2 0.7 -0.4 -0.7 0.9 0.5 0.1 -0.3 -0.3 0.3
Medication: Co-codamol 0.8 1.0 4.8 -0.6 2.2 1.0 0.6 0.2 0.5 0.8 0.6
Medication: Metformin 0.4 0.6 3.3 0.2 1.8 0.2 -0.4 0.2 0.8 0.4 0.2
Diabetes (father) 0.4 0.5 1.2 -0.3 0.4 0.6 0.6 0.9 1.1 0.1 0.9
Diabetes (mother) 0.3 0.4 1.2 0.8 0.0 0.2 -0.6 1.1 0.6 -0.8 -0.2
Severe depression (siblings) 2.6 3.0 9.4 -0.4 0.6 -0.2 -0.5 3.0 3.1 1.4 1.6
Pack years adult smoking proportion 1.3 2.1 5.2 -1.5 2.3 0.6 1.3 1.7 1.5 0.3 1.3
Impedance of leg (right) 2.1 10.4 19.5 -3.7 2.2 3.9 4.4 0.5 1.5 4.1 3.3
Leg fat-free mass (left) 2.6 13.6 28.6 4.2 -2.2 -5.3 -4.8 0.1 -0.7 -4.9 -3.2
Trunk fat percentage 0.8 3.2 10.4 1.4 -2.3 -3.2 -1.5 1.4 1.0 -1.7 -0.5
Hand grip strength (right) 2.7 7.3 13.7 3.7 -0.4 -3.6 -3.2 -1.1 -0.8 -3.7 -2.4
Townsend deprivation index at recruitment 2.1 3.0 5.6 -2.1 2.4 0.6 2.1 1.8 1.4 0.1 1.9
Current tobacco smoking 4.7 7.7 17.1 -4.1 2.7 2.5 4.1 1.2 0.8 1.4 3.3
Average weekly fortified wine intake 2.7 3.1 9.6 2.1 0.6 -3.1 -2.0 -1.2 -0.6 -1.4 -1.7
Maternal smoking around birth 0.5 0.8 2.8 -0.1 1.7 -1.0 0.4 0.9 0.6 -0.9 0.3
Fed-up feelings 0.5 0.9 4.8 -0.5 2.2 0.3 0.1 0.3 0.8 1.1 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.8 -0.6 0.9 -0.1 0.3 0.2 0.2 0.8 0.7
Relative age voice broke 0.7 1.0 3.6 0.2 -1.9 1.0 -0.6 -0.8 -0.9 -1.3 -0.6
Taking other prescription medications 0.5 0.8 2.9 -1.1 1.7 0.0 0.8 -0.1 0.3 1.3 0.4
Age when periods started (menarche) 0.4 1.0 2.3 0.5 1.5 0.5 -0.2 0.9 1.4 1.4 0.8
Bilateral oophorectomy (both ovaries removed) 1.2 1.3 3.4 1.8 -0.6 -1.2 -1.8 0.1 -0.2 -0.4 -1.4
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 3.7 1.1 -0.1 -0.9 -1.3 1.9 1.1 -1.0 -0.1
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 1.0 -1.0 -0.3 0.3 0.8 0.1 0.1 0.1 0.1
Qualifications: CSEs or equivalent 0.8 1.0 3.2 -0.1 -1.6 -0.3 0.1 0.7 1.8 1.2 0.6
Serious illness, injury or assault to yourself 4.1 5.0 7.6 -1.9 2.8 1.5 2.1 1.9 2.3 2.5 2.6
High blood pressure 0.6 1.5 4.0 1.7 -1.5 -2.0 -1.5 -0.3 -0.2 0.5 -0.7
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.1 0.9 0.5 0.6 -0.7 0.6 0.1 1.4 -0.5
Multivitamins +/- minerals 0.6 0.8 1.9 1.1 -1.0 -0.3 -1.4 -0.1 0.1 -1.2 -0.9
Stomach or abdominal pain in last month 1.0 1.2 2.0 -1.4 0.9 1.4 1.4 -0.4 -0.5 1.3 0.8
Supplements: Glucosamine 1.2 1.6 7.1 -0.4 -1.0 1.0 0.4 0.8 1.2 2.7 1.0
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.1 -0.9 0.4 1.0 0.8 0.7 0.4 0.6 0.8
Medication: Atenolol 1.9 2.4 8.7 2.5 -0.3 -3.0 -1.8 -0.1 0.2 -0.3 -0.8
Medication: Levothyroxine sodium 0.4 0.6 2.7 0.3 1.6 0.3 -0.1 1.1 0.9 -0.2 0.3
Sitting height 0.1 0.4 1.4 0.3 -0.5 -0.4 -0.8 0.9 0.4 -1.2 -0.2
Chronic bronchitis/emphysema (father) 0.4 0.5 1.4 -0.4 1.0 -0.7 0.3 1.2 0.6 -0.3 0.3
High blood pressure (mother) 0.6 0.9 2.2 1.3 -0.5 -1.5 -1.4 0.4 0.3 -0.5 -0.6
Body mass index (BMI) 2.0 8.4 25.5 2.9 -2.2 -5.0 -3.2 0.8 0.1 -3.8 -1.9
Impedance of leg (left) 1.9 9.0 16.3 -3.4 1.6 3.6 4.0 0.7 1.7 4.0 3.1
Leg predicted mass (left) 2.6 13.8 29.1 4.2 -2.3 -5.4 -4.9 0.1 -0.7 -4.9 -3.2
Trunk fat mass 1.5 6.6 20.8 2.5 -2.3 -4.6 -2.8 1.1 0.6 -2.9 -1.4
Waist circumference 3.7 13.6 38.9 3.7 -2.6 -6.2 -4.2 -0.5 -1.4 -4.3 -3.3
Number of incorrect matches in round 0.4 0.6 1.3 -0.7 0.5 -0.9 0.6 1.0 1.1 0.2 1.0
Past tobacco smoking 0.5 0.9 3.6 0.7 -0.8 -1.9 -0.4 -1.0 -0.8 0.1 -0.5
Alcohol usually taken with meals 2.5 4.0 11.0 3.3 -1.3 -1.9 -3.3 -0.4 -0.5 0.7 -2.1
Nervous feelings 1.1 2.1 3.6 -1.9 0.8 1.2 1.9 0.9 1.3 1.1 1.9
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 2.6 -0.2 1.6 -0.2 0.2 1.2 0.9 -0.7 0.7
Hearing difficulty/problems with background noise 2.1 3.4 19.1 1.2 4.4 0.4 -0.9 -1.2 -0.6 1.8 -0.7
Hair/balding pattern: Pattern 2 1.1 1.4 3.1 -1.0 -1.0 1.6 1.8 0.9 0.9 0.7 1.2
Had menopause 0.4 0.5 2.6 -0.5 -1.6 0.3 0.1 0.3 -0.1 1.0 0.2
Had other major operations 0.8 1.0 5.6 0.1 -2.4 -0.2 0.0 -0.7 -0.8 1.0 -0.5
Forced vital capacity (FVC) 0.5 1.8 3.0 1.7 -0.9 -1.3 -1.0 -1.6 -1.6 -1.2 -1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 2.0 0.8 0.4 -1.3 -1.0 0.8 0.1 -1.4 -0.3
Ever unenthusiastic/disinterested for a whole week 1.8 2.2 4.4 -2.1 1.4 1.0 1.2 1.5 1.7 1.0 1.7
Qualifications: None of the above 0.3 0.7 1.3 -0.8 -0.2 1.1 1.1 1.0 0.7 -0.5 0.9
Financial difficulties in last 2 years 3.7 4.9 7.8 -2.8 2.5 1.2 2.6 2.3 2.0 1.3 2.6
Mouth/teeth dental problems 1.4 2.2 3.6 1.2 -0.5 -1.0 -1.5 -1.9 -1.8 -1.6 -1.7
Heart attack 0.8 1.0 2.9 0.4 1.2 -1.7 -0.5 1.0 0.5 -1.3 0.0
Allergy 0.2 0.5 1.2 -0.8 -1.1 -0.5 0.8 -0.4 0.1 -0.8 0.5
Pain all over the body in last month 0.9 0.9 3.9 0.9 0.7 -2.0 -1.0 0.5 0.3 -0.8 -0.4
Diabetes (self-reported) 0.4 0.7 3.7 0.6 1.9 -0.5 -0.8 0.0 0.4 -0.1 -0.5
Hayfever/allergic rhinitis (self-reported) 4.7 6.2 11.1 3.3 1.4 -2.3 -3.2 -1.9 -2.1 -1.6 -3.3
Medication: Ramipril 0.1 0.1 0.2 -0.2 0.1 0.1 0.3 -0.0 0.2 0.5 0.4
Medication: Simvastatin 0.9 1.4 3.8 -0.4 1.3 0.2 0.5 2.0 1.9 0.2 1.1
Fluid intelligence score 0.7 1.4 4.8 0.3 0.8 0.7 -0.6 -2.2 -2.0 0.0 -1.0
Illnesses of siblings 0.9 1.3 4.6 -1.6 -0.6 2.1 1.5 0.0 -0.2 -0.2 0.8
Neuroticism score 0.6 1.3 3.0 -1.5 1.7 0.6 1.4 0.5 0.8 0.5 1.3
Weight 2.7 13.4 36.5 4.0 -2.7 -6.0 -4.4 0.4 -0.3 -4.4 -2.8
Impedance of arm (right) 2.3 10.9 18.4 -3.6 0.4 4.3 4.0 2.0 2.4 4.2 3.4
Arm fat percentage (right) 1.0 4.0 13.6 1.3 -2.1 -3.7 -1.6 1.9 1.3 -2.0 -0.4
Trunk fat-free mass 2.9 16.7 37.7 4.6 -1.4 -6.1 -5.2 -1.3 -1.8 -4.9 -4.0
Hip circumference 1.5 6.7 23.7 2.4 -2.0 -4.9 -2.8 1.1 0.4 -2.9 -1.3
Time employed in main current job 0.3 0.3 0.7 -0.5 0.1 0.5 0.9 -0.4 -0.9 -0.7 0.1
Alcohol intake versus 10 years previously 0.5 0.8 1.7 1.3 -1.3 0.3 -1.1 0.8 0.8 0.1 -0.3
Father’s age at death 0.3 0.3 1.2 -1.1 -0.3 0.3 0.6 -0.4 -0.5 0.7 0.0
Worrier / anxious feelings 1.1 2.0 7.9 -1.3 2.8 0.2 1.3 1.1 1.4 0.2 1.3
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.2 15.1 0.2 3.9 -0.4 -0.3 -0.2 0.7 1.3 0.1
Falls in the last year 1.6 2.1 7.1 1.3 1.5 -2.7 -1.7 -0.5 -1.1 -0.8 -1.1
Hair/balding pattern: Pattern 3 0.2 0.3 0.9 0.4 -1.0 0.1 -0.2 0.0 0.2 0.9 0.2
Number of live births 0.2 0.2 0.6 -0.4 -0.7 0.1 0.4 0.7 0.1 -0.6 0.3
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 2.8 1.7 -1.0 -1.3 -0.9 -1.2 -1.0 -0.8 -1.2
Pulse rate 0.3 0.5 1.1 -1.0 0.1 0.8 0.8 -0.6 -0.4 1.0 0.1
Happiness 0.2 0.2 0.5 -0.5 -0.6 -0.7 0.0 -0.5 -0.1 -0.3 -0.1
Noisy workplace 0.9 1.1 3.3 -0.0 1.8 0.5 0.4 1.4 1.3 1.0 0.8
Qualifications: A levels/AS levels or equivalent 0.1 0.2 1.4 0.1 1.2 -0.4 -0.3 -0.2 -0.2 0.1 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 3.0 0.6 -1.7 0.1 -1.2 0.5 0.7 -0.9 -0.2
Mouth/teeth dental problems: Dentures 0.5 0.8 2.0 -0.4 1.4 0.8 0.5 1.0 1.1 0.2 1.0
Asthma 0.1 0.2 0.5 0.4 0.7 -0.4 -0.4 0.7 0.5 0.1 -0.0
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.6 1.3 -0.4 -1.0 -0.8 0.6 0.7 -0.6 -0.6
Medication: Cholesterol lowering 2.4 3.8 7.1 -1.6 2.7 0.4 1.6 2.5 2.6 0.2 2.1
Depression (self-reported) 2.9 3.5 5.8 -2.4 1.7 1.3 2.2 1.9 1.8 0.5 2.4
Medication: Lansoprazole 1.0 1.2 3.0 -1.7 0.4 -0.3 1.4 0.8 0.8 0.7 1.5
Prospective memory result 2.2 2.7 3.9 -1.8 0.0 1.9 1.8 2.0 1.7 1.1 1.8
Lung cancer (father) 0.6 0.7 1.5 1.1 -1.0 -1.2 -0.6 0.7 0.5 -1.0 -0.1
Illnesses of mother 1.9 2.4 4.2 -2.0 2.0 1.8 2.0 -0.3 0.5 0.8 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.3 1.5 -1.0 -1.3 -0.9 -0.3 -0.2 -0.9 -0.8
Pulse wave Arterial Stiffness index 0.1 0.1 0.6 0.4 0.8 -0.1 0.1 0.0 -0.4 -0.2 -0.4
Impedance of arm (left) 2.0 9.4 17.8 -3.4 0.4 4.1 3.6 1.5 2.0 4.2 3.1
Arm fat mass (right) 2.0 8.2 25.6 2.8 -2.8 -5.1 -3.0 1.2 0.5 -3.4 -1.7
Trunk predicted mass 3.0 17.0 38.6 4.7 -1.4 -6.2 -5.2 -1.4 -1.9 -5.0 -4.0
Standing height 0.5 4.9 10.0 2.9 -1.7 -2.8 -3.2 -0.7 -0.8 -2.2 -2.1
Length of working week for main job 0.9 1.0 2.7 1.6 -0.2 -0.6 -1.2 1.0 0.9 -1.0 -0.6
Exposure to tobacco smoke at home 0.6 0.7 1.9 1.1 -0.5 -0.1 -1.4 -0.1 -0.6 0.0 -1.1
Breastfed as a baby 1.5 1.8 3.9 1.4 -0.3 -0.2 -2.0 -1.3 -1.9 -0.8 -1.7
Tense / ‘highly strung’ 0.3 0.5 1.9 -1.4 -0.1 0.3 1.0 -0.2 0.2 0.5 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 2.0 3.1 5.1 -2.3 0.6 1.1 2.0 2.0 2.1 0.6 2.2
Hair/balding pattern: Pattern 4 0.7 1.8 10.6 -1.2 3.3 0.5 0.5 0.4 0.8 0.3 0.9
Birth weight of first child 2.7 4.9 10.2 1.7 -1.5 -0.9 -2.0 -2.9 -3.2 -1.2 -3.1
Peak expiratory flow (PEF) 0.4 0.9 3.0 1.5 0.5 -1.7 -1.1 -0.2 0.3 -0.0 -0.6
Pulse wave reflection index 0.0 0.0 0.1 0.1 -0.2 0.2 -0.0 -0.2 -0.2 0.0 -0.3
Ever highly irritable/argumentative for 2 days 2.7 3.2 5.1 -1.8 1.9 -0.2 1.9 1.9 2.2 1.4 2.2
Loud music exposure frequency 0.6 0.7 1.9 1.4 0.6 -0.4 -1.1 -0.6 -0.2 0.7 -0.9
Qualifications: O levels/GCSEs or equivalent 1.0 1.7 3.1 1.3 -1.3 -1.3 -1.4 -1.0 -1.2 -0.9 -1.8
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 2.8 -1.2 0.8 0.2 1.5 1.4 1.5 1.7 1.3
Blood clot in the leg (DVT) 0.4 0.5 2.5 -0.6 -1.6 0.2 0.6 -0.1 -0.6 -0.1 0.2
Medication: Paracetamol 1.0 1.6 6.2 1.2 2.5 -1.6 -1.2 -0.3 -0.1 -0.2 -1.0
Headache pain in last month 1.9 3.3 13.8 -0.3 3.7 1.3 0.3 1.7 2.1 1.4 1.2
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 4.4 0.4 -2.1 0.2 -0.6 -0.9 -1.1 -0.4 -0.5
Glaucoma (self-reported) 0.6 0.7 2.3 -0.4 -0.6 1.0 0.3 -0.2 1.1 1.5 0.7
Gout (self-reported) 0.3 0.5 1.1 0.3 -0.8 -0.3 0.1 -1.1 -1.0 -0.3 -0.7
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.7 0.7 1.3 -0.3 -0.8 1.1 0.6 -0.7 -0.2
Medication: Amlodipine 1.0 1.5 3.5 1.1 0.6 -1.9 -1.3 -1.0 -1.0 -1.0 -1.3
Medication: Ventolin 100micrograms inhaler 1.2 1.6 6.0 -0.2 2.5 1.3 0.4 1.3 1.3 0.6 0.8
Birth weight 0.8 1.8 6.0 2.0 -0.1 -1.4 -2.4 0.1 0.1 -0.1 -1.6
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.5 0.6 0.4 -1.2 -0.6 0.1 -0.1 -0.4 -0.5
High blood pressure (siblings) 0.7 1.0 2.6 1.2 1.5 -1.6 -0.9 0.3 0.7 0.7 -0.2
Forced vital capacity (FVC), Best measure 0.2 0.6 1.5 1.1 -0.6 -1.2 -0.5 -0.2 -0.2 -1.0 -0.5
Body fat percentage 1.0 3.9 13.5 1.5 -2.3 -3.7 -1.6 1.6 1.1 -2.0 -0.5
Leg fat percentage (right) 0.9 3.3 13.5 1.3 -1.2 -3.7 -1.3 1.5 1.0 -2.2 -0.4
Arm fat-free mass (right) 3.3 16.8 38.2 4.8 -1.9 -6.2 -5.2 -0.9 -1.4 -5.1 -3.7
Exposure to tobacco smoke outside home 1.4 1.9 4.8 -0.6 0.9 0.1 0.3 1.9 2.2 2.0 1.3
Comparative body size at age 10 3.2 8.9 27.8 2.5 0.8 -5.3 -3.3 -0.6 -1.2 -4.1 -2.5
Number of full brothers 0.8 1.0 3.2 0.1 -0.2 0.7 0.0 1.8 1.5 1.0 1.0
Worry too long after embarrassment 0.5 0.9 2.6 0.6 0.6 0.8 -0.2 -1.1 -1.2 -1.6 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 3.0 3.8 6.7 -2.4 1.5 1.8 2.1 1.3 2.1 1.4 2.6
Wheeze or whistling in the chest in last year 0.4 0.8 3.6 0.5 1.9 -0.7 -0.0 0.6 0.6 1.1 0.3
Number of children fathered 0.5 0.6 1.8 0.0 1.3 -0.1 -0.3 -0.9 -1.2 -0.1 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.2 -0.8 0.9 1.1 0.7 -0.8 -0.1 0.6 0.2
Age at first live birth 0.4 0.8 2.0 -0.3 -1.3 0.1 0.4 -1.0 -1.4 -1.2 0.0
Pulse wave peak to peak time 0.1 0.2 1.0 -0.0 -1.0 -0.2 -0.5 -0.1 0.3 -0.0 0.1
Health satisfaction 1.2 1.5 5.1 0.7 2.3 -1.7 -1.2 -0.4 -0.5 -0.8 -1.2
Shortness of breath walking on level ground 0.7 0.8 1.4 -0.2 1.1 -1.1 0.8 1.0 1.2 -0.5 0.7
Qualifications: College or University degree 0.2 0.7 1.7 1.2 1.3 -0.2 -1.1 0.2 0.6 0.6 -0.3
Eye problems/disorders: None of the above 0.4 0.5 1.7 0.0 0.9 1.3 0.2 -0.2 -0.5 -0.9 -0.2
Mouth/teeth dental problems: Loose teeth 0.7 0.8 1.5 -0.7 0.5 0.0 1.1 1.2 1.1 0.4 1.1
Emphysema/chronic bronchitis 1.6 1.8 3.3 -0.9 1.3 -0.4 0.9 1.7 1.8 1.3 1.6
Medication for pain relief, constipation, heartburn 1.2 2.0 8.7 -1.1 -3.0 2.1 0.5 -0.7 -0.6 0.5 0.2
Neck or shoulder pain in last month 1.9 2.7 11.1 0.1 3.3 -0.3 0.6 2.2 1.8 0.9 1.0
Medication: Blood pressure 0.1 0.3 1.0 0.1 1.0 -0.8 0.2 -0.1 0.5 0.3 -0.0
Angina (self-reported) 1.5 2.0 5.1 -0.5 1.8 0.1 0.9 2.3 1.9 -0.7 1.6
Migraine (self-reported) 0.6 0.8 1.5 -1.2 -0.3 1.0 0.9 0.9 0.9 0.3 1.0
Medication: Ibuprofen 0.3 0.4 0.8 0.7 -0.2 -0.9 -0.5 0.9 0.9 0.0 -0.2
Medication: Allopurinol 0.4 0.5 1.7 0.2 -1.3 -0.2 0.2 -1.0 -1.0 -0.1 -0.6
Medication: Omeprazole 0.6 0.7 1.9 -1.2 -0.7 0.2 1.4 -0.4 -0.1 0.9 1.0
Medication: Seretide 50 evohaler 1.0 1.2 3.6 -0.3 0.5 0.0 0.8 1.9 1.8 0.2 1.2
Mean time to correctly identify matches 0.4 0.8 3.5 -0.0 1.9 -0.8 -0.7 -0.3 0.4 1.2 -0.1
Heart disease (mother) 2.4 2.9 9.6 2.1 -3.1 -1.1 -1.8 -0.5 -0.9 -1.3 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.9 2.5 0.7 0.7 -0.5 -0.6 -1.1 -1.0 -1.6 -0.9
Whole body fat mass 1.9 7.9 25.5 2.8 -2.3 -5.0 -3.0 1.2 0.5 -3.3 -1.6
Leg fat mass (right) 1.8 7.1 22.8 2.5 -2.1 -4.8 -2.8 1.1 0.5 -3.4 -1.5
Arm predicted mass (right) 3.5 17.8 39.7 4.8 -2.0 -6.3 -5.4 -1.0 -1.6 -5.3 -3.9
Pulse rate, automated reading 0.2 0.6 1.4 -1.2 0.0 -0.0 0.6 -1.0 -1.1 -0.9 -0.4
Alcohol intake frequency. 0.8 1.8 4.9 -0.1 2.2 -0.5 -0.0 1.9 2.1 0.4 1.0
Comparative height size at age 10 0.4 2.3 8.5 1.4 -1.7 -2.9 -1.6 0.0 -0.5 -1.0 -0.9
Number of full sisters 0.7 0.8 1.7 -0.7 1.1 0.2 0.7 1.2 1.3 -0.9 0.9
Suffer from ‘nerves’ 0.5 0.7 1.9 -0.9 1.4 1.0 0.8 0.6 0.5 0.3 1.0
Overall health rating 1.0 2.1 11.1 0.2 3.3 -1.9 -0.2 0.5 0.8 1.0 0.1
Chest pain or discomfort 1.7 2.5 12.1 -0.5 3.5 0.3 1.1 -0.4 0.6 2.1 1.0
Had major operations 0.3 0.4 1.1 0.2 -0.8 1.1 0.2 -0.4 0.0 1.0 0.3
Age at last live birth 0.8 1.2 2.6 -1.0 -1.6 1.6 1.3 0.2 -0.2 -0.5 1.0
Family relationship satisfaction 1.4 1.7 4.8 -2.2 -0.6 1.0 1.4 1.3 1.0 0.8 1.5
Leg pain on walking 2.3 2.8 5.2 -2.0 2.3 1.1 2.0 0.5 1.1 2.1 1.5
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 0.5 0.7 -0.7 -0.5 -0.5 -0.6 -0.4 0.2 -0.6
Commuting to job workplace: Car/motor vehicle 1.1 1.3 3.2 1.3 0.0 -1.2 -1.2 1.4 0.7 -1.8 -0.4
Illness, injury, bereavement, stress in last 2 years 4.0 4.9 10.3 2.1 0.3 -2.0 -1.9 -2.6 -3.2 -1.5 -2.7
Medication: Aspirin 1.6 2.1 9.3 0.6 3.0 -1.0 0.0 1.5 1.6 0.6 1.0
Supplements: Vitamin C 0.9 1.0 3.2 -0.8 -1.8 0.8 0.9 -0.7 0.1 1.5 0.3
Knee pain experienced in last month 0.8 1.2 3.9 -0.4 2.0 -0.2 0.2 1.4 1.4 1.2 0.7
Hypertension (Self-reported) 0.6 1.7 4.4 1.9 -1.3 -2.1 -1.5 -0.4 -0.4 0.3 -0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 3.1 -1.5 1.5 0.7 1.8 0.1 0.6 1.0 1.3
Illnesses of father: Heart disease 0.3 0.4 1.2 -0.1 0.2 0.1 0.3 0.6 1.1 1.0 0.7
Illnesses of siblings: Diabetes 1.1 1.4 4.8 -0.6 0.1 0.0 0.1 2.2 2.1 0.7 1.1
Smoking status: Previous 0.5 0.7 1.8 1.0 -0.4 0.9 -1.3 0.0 0.3 -1.0 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.9 3.2 1.8 -1.5 -1.4 -1.7 0.1 0.2 -1.7 -1.4
Whole body fat-free mass 2.9 16.7 37.3 4.7 -1.9 -6.1 -5.3 -0.7 -1.4 -5.1 -3.8
Leg fat-free mass (right) 2.6 13.7 27.0 4.3 -2.5 -5.2 -4.9 0.2 -0.6 -4.8 -3.2
Arm fat percentage (left) 1.1 4.4 14.8 1.7 -2.1 -3.9 -2.0 1.6 1.1 -2.2 -0.8
Average weekly red wine intake 0.1 0.2 0.7 0.1 0.3 0.0 -0.8 -0.5 -0.4 0.1 -0.4
Handedness (chirality/laterality): Left-handed 0.6 0.7 2.0 1.0 -0.5 -0.3 -0.7 1.4 1.4 0.5 0.1
Mood swings 0.5 0.9 2.5 -1.0 1.6 -0.4 0.7 1.0 1.1 0.6 0.8
Loneliness, isolation 4.6 6.3 10.8 -2.7 0.8 1.6 3.3 1.9 2.2 3.2 3.2
Long-standing illness, disability or infirmity 0.5 0.7 3.1 -0.6 1.8 -0.7 0.3 0.1 0.0 1.3 0.1
Ever had bowel cancer screening 1.1 1.3 3.2 1.4 1.8 -0.5 -1.0 -1.1 -1.2 -0.4 -1.1
Diabetes diagnosed by doctor 0.4 0.7 4.1 0.4 2.0 -0.2 -0.8 0.2 0.7 -0.3 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 2.0 -0.8 -1.4 0.8 0.8 0.1 -0.0 0.6 0.6
Friendships satisfaction 0.5 0.6 2.2 0.6 -0.4 -1.5 -1.0 0.2 -0.1 -0.8 -0.7
Qualifications: nursing, teaching 0.5 0.8 3.2 0.3 0.0 -1.8 -0.5 -1.0 -0.9 -0.3 -0.8
Commuting to job workplace: Walk 0.1 0.1 0.4 -0.3 0.3 -0.5 -0.1 -0.2 0.1 0.6 0.2
Eye problems/disorders: Cataract 1.8 2.1 4.2 1.3 -1.3 -2.1 -1.1 -0.9 -1.5 -1.5 -1.5
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.0 -0.5 0.1 0.6 0.3 0.7 0.4 1.0 0.5
Medication for cholesterol 0.9 1.3 3.4 -1.8 0.9 1.3 1.6 0.6 0.8 0.2 1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.1 -0.7 -0.8 -0.7 0.7 0.9 1.1 0.5 0.7
Back pain experienced in last month 1.5 2.2 6.4 -0.6 2.5 -0.7 0.9 1.7 1.7 1.2 1.4
Mineral and other dietary supplements 0.7 0.9 2.1 0.2 1.5 -1.4 -0.0 -0.9 -1.1 -1.1 -0.3
Breast cancer (self-reported) 0.1 0.2 0.4 -0.3 0.3 -0.5 0.0 0.5 0.6 -0.1 0.3
Asthma (self-reported) 0.1 0.2 0.9 0.0 0.4 -0.2 -0.1 0.9 0.6 0.1 0.3
Osteoporosis (self-reported) 1.0 1.3 3.7 1.1 0.7 -1.0 -1.6 -0.1 -0.4 -1.9 -0.9
Osteoarthritis (self-reported) 0.3 0.3 1.0 -0.6 0.9 -0.5 0.5 0.1 0.4 1.0 0.2
Medication: Aspirin 1.5 2.0 7.8 0.8 2.8 -1.2 -0.3 1.4 1.7 0.6 0.8
Medication: Gliclazide 0.4 0.5 1.3 0.2 -1.1 0.2 -0.9 -0.1 -0.3 -1.1 -0.6
Illnesses of father: None of the above (group 1) 0.6 0.8 2.8 -0.2 -0.4 -0.1 0.2 -1.6 -1.7 0.2 -0.6
Smoking status: Current 5.8 9.2 19.9 -4.4 2.7 3.0 4.5 1.4 1.0 1.7 3.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 3.0 1.4 -0.8 -1.7 -0.5 -0.6 -0.5 -1.1 -0.7
Whole body water mass 2.9 16.4 36.7 4.6 -2.0 -6.1 -5.2 -0.6 -1.3 -5.1 -3.7
Leg predicted mass (right) 2.6 13.9 27.5 4.3 -2.4 -5.2 -5.0 0.2 -0.7 -4.9 -3.2
Arm fat mass (left) 2.3 9.4 29.6 3.1 -2.6 -5.4 -3.3 0.9 0.3 -3.6 -2.0
Number of self-reported non-cancer illnesses 1.1 1.9 4.3 1.7 1.3 -2.1 -1.9 -0.8 -0.5 0.1 -1.5
Average weekly champagne plus white wine intake 0.4 0.5 2.2 -0.3 -0.4 -1.1 -0.4 -0.4 -0.2 1.5 -0.2
Miserableness 1.1 2.0 8.2 -1.1 2.9 -0.6 0.8 0.4 1.0 1.6 1.3
Guilty feelings 1.4 2.1 6.3 1.2 -0.6 -2.5 -1.5 -0.2 -0.0 -2.3 -0.8
Wears glasses or contact lenses 0.1 0.1 0.6 0.3 -0.8 0.2 0.1 0.2 -0.1 0.3 0.1
Ever taken oral contraceptive pill 0.8 0.8 2.4 -1.5 0.3 0.8 1.0 0.9 0.9 0.4 0.9
Hearing aid user 1.1 1.3 3.6 1.4 0.4 -1.9 -1.3 -0.6 -0.6 -0.7 -1.2
Mother’s age at death 0.6 0.7 2.3 0.3 -1.5 -1.5 -0.4 0.0 -0.5 0.7 -0.6
Financial situation satisfaction 0.2 0.3 0.7 -0.5 -0.4 -0.8 0.2 0.5 0.7 -0.6 0.3
Tinnitus: Yes, now most or all of the time 3.0 3.6 7.0 -2.0 -0.8 1.0 1.8 2.6 2.5 0.8 2.4
Commuting to job workplace: Public transport 0.5 0.5 2.1 -0.4 1.1 -0.2 0.5 -0.3 0.4 1.4 0.5
Eye problems/disorders: Glaucoma 1.3 1.6 5.0 -1.2 0.6 1.4 1.1 -0.3 1.1 2.2 1.2
Medication: Blood pressure 1.1 2.1 4.6 2.2 -1.3 -1.8 -2.1 -0.6 -1.0 -0.2 -1.3
Pain type(s) experienced in last month: Hip pain 1.1 1.4 7.0 -1.0 2.6 0.3 0.6 -0.1 0.3 1.5 0.3
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.9 0.8 -1.7 0.4 -1.1 0.6 0.4 -0.6 -0.7
High cholesterol (Self-reported) 0.5 0.9 2.0 -1.1 -0.1 -0.3 1.4 0.8 1.1 0.9 1.2
Medication: Bendroflumethiazide 0.5 0.7 2.1 1.4 0.2 -0.9 -1.4 0.6 0.6 -0.1 -0.5
Medication: Paracetamol 1.0 1.6 6.2 1.1 2.5 -1.7 -1.3 0.2 0.1 0.0 -0.8
Medication: Lisinopril 0.4 0.5 1.4 0.7 -1.1 -0.3 -1.2 0.1 0.3 0.3 -0.6
Medication: Atorvastatin 1.1 1.4 3.4 1.1 0.1 -0.8 -0.7 -1.3 -1.6 -1.8 -1.2
Illnesses of father: High blood pressure 1.2 1.4 3.5 0.3 1.4 1.2 -0.1 1.1 1.9 1.3 1.1
Alcohol drinker status: Never 1.3 1.6 2.5 -1.6 0.7 -0.2 1.6 0.8 1.4 1.5 1.5
Ever smoked 1.5 2.7 6.4 -1.3 2.1 2.5 1.2 1.3 1.5 1.4 1.4
Basal metabolic rate 2.9 16.1 38.1 4.6 -2.2 -6.2 -5.1 -0.4 -1.1 -5.0 -3.5
Leg fat percentage (left) 1.3 4.6 16.9 1.8 -1.7 -4.1 -1.9 1.5 1.0 -2.5 -0.7
Arm fat-free mass (left) 3.6 18.2 42.5 4.8 -2.2 -6.5 -5.2 -0.8 -1.5 -5.4 -3.9
Number of operations (self-reported) 0.9 1.4 3.3 1.8 -1.5 0.6 -1.4 -0.8 -0.9 0.1 -1.4
Average weekly beer plus cider intake 1.9 2.7 7.1 -2.4 1.0 2.1 2.7 0.4 0.2 0.5 1.8
Irritability 1.3 2.1 3.8 -1.7 0.6 1.1 1.2 1.2 1.9 1.8 1.6
Risk taking 0.6 0.8 3.9 -0.9 -0.1 1.0 0.8 -0.2 -0.1 2.0 0.5
Ever had prostate specific antigen (PSA) test 0.4 0.4 1.5 0.2 1.2 -1.0 -0.3 -0.5 -0.6 0.3 -0.2
Fractured/broken bones in last 5 years 0.4 0.5 1.2 0.0 0.2 1.1 0.2 0.5 0.9 1.1 0.6
Age started oral contraceptive pill 0.7 0.9 2.1 0.7 -1.2 -0.4 -1.0 -0.5 -1.4 -0.9 -0.8
Diastolic blood pressure, automated reading 1.5 4.6 11.5 3.0 -0.7 -3.4 -3.2 0.3 -0.2 -1.3 -1.9
Ever depressed for a whole week 2.2 2.7 4.0 -1.8 2.0 1.3 1.4 1.6 1.9 1.2 1.8
Unable to work because of sickness or disability 2.9 3.7 8.0 -1.4 1.7 0.3 1.8 2.5 2.8 1.8 2.1
Commuting to job workplace: Cycle 0.3 0.3 0.8 -0.5 -0.7 0.4 0.5 -0.3 -0.9 -0.6 0.3
Myopia 1.0 1.4 2.8 1.5 0.0 -0.6 -1.1 -0.9 -1.5 -1.7 -1.3
Vascular/heart problems diagnosed by doctor 0.3 0.9 2.9 -1.4 0.7 1.7 1.2 -0.4 -0.2 -0.3 0.4
Cholesterol lowering medication 0.7 1.0 1.6 1.1 -1.3 -1.0 -0.8 -0.6 -1.1 -1.2 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.0 -0.6 -0.4 -1.0 0.8 -0.7 -0.2 0.3 0.5
Pain experienced in last month 2.9 4.9 16.4 0.5 -4.0 -0.3 -1.0 -3.2 -2.6 -1.0 -1.9
Supplements: Calcium 0.5 0.6 1.3 -1.1 0.8 0.0 1.2 0.2 0.2 0.8 0.9
Basal cell carcinoma (self-reported) 0.1 0.1 0.3 0.5 0.4 -0.5 0.0 0.6 0.2 0.0 0.0
Heart attack/myocardial infarction (self-reported) 0.8 1.0 3.0 0.6 1.0 -1.7 -0.6 0.9 0.3 -1.5 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 1.4 -0.4 -1.2 -0.2 0.4 -0.3 -0.8 -0.4 0.0
Heart disease (siblings) 0.8 0.9 3.2 0.9 -0.5 -1.8 -1.4 0.6 0.9 0.0 -0.4
Alcohol drinker status: Previous 2.4 2.8 4.2 -1.5 2.0 1.4 1.3 1.5 2.1 1.4 2.0
Pack years of smoking 1.0 1.4 4.3 -1.1 2.1 0.3 1.0 1.6 1.2 -0.1 1.0
Impedance of whole body 2.5 12.7 23.6 -3.9 0.9 4.6 4.5 1.4 2.2 4.9 3.7
Leg fat mass (left) 2.2 8.6 25.9 3.0 -2.2 -5.1 -3.2 1.1 0.5 -3.7 -1.8
Arm predicted mass (left) 3.3 16.7 39.1 4.8 -2.1 -6.2 -5.2 -0.7 -1.4 -5.0 -3.7