[Hub]/) : Traits : Trunk predicted mass :

chr4:105,373,669-107,092,169

Best TWAS P=6.57e-27 · Best GWAS P=1.73e-31 conditioned to 3.44e-07

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PPA2 0.08 0.03 bslmm 429 0.04 2.2e-05 -7.1 -7.8 9.5e-15 0.61 0.09 0.88 FALSE
2 GTEx Adipose Subcutaneous PPA2 0.15 0.02 enet 36 0.06 7.0e-06 4.7 -5.6 1.8e-08 0.38 0.27 0.09 FALSE
3 GTEx Artery Aorta PPA2 0.11 -0.01 enet 24 0.01 1.6e-01 -11.2 -8.4 4.9e-17 0.58 0.07 0.33 FALSE
4 GTEx Brain Cerebellum PPA2 0.22 0.01 lasso 4 0.03 3.7e-02 -7.7 -6.3 3.7e-10 0.55 0.09 0.14 FALSE
5 GTEx Brain Cortex PPA2 0.14 0.09 lasso 9 0.09 1.6e-03 -9.0 -9.2 5.0e-20 0.79 0.06 0.55 FALSE
6 GTEx Cells Transformed fibroblasts PPA2 0.11 0.03 lasso 3 0.01 6.5e-02 -7.0 -7.6 2.1e-14 0.59 0.42 0.10 FALSE
7 GTEx Esophagus Gastroesophageal Junction PPA2 0.29 0.15 lasso 5 0.14 8.8e-06 -11.2 -10.7 6.6e-27 0.81 0.06 0.90 TRUE
8 GTEx Esophagus Mucosa PPA2 0.18 0.06 enet 14 0.12 2.5e-08 8.9 -9.8 1.6e-22 0.68 0.14 0.85 FALSE
9 GTEx Heart Atrial Appendage PPA2 0.15 0.05 lasso 7 0.06 7.4e-04 -9.3 -7.4 1.7e-13 0.70 0.24 0.37 FALSE
10 GTEx Muscle Skeletal PPA2 0.19 0.06 enet 28 0.11 8.7e-11 -9.1 -6.5 6.6e-11 0.67 0.80 0.20 FALSE
11 GTEx Nerve Tibial PPA2 0.13 0.07 enet 23 0.07 2.1e-05 -7.7 -7.5 8.4e-14 0.63 0.50 0.24 FALSE
12 GTEx Ovary PPA2 0.18 0.10 lasso 3 0.14 2.2e-04 -7.7 -9.0 3.1e-19 0.72 0.07 0.64 FALSE
13 GTEx Skin Sun Exposed Lower leg TET2 0.09 0.01 enet 18 0.02 3.6e-03 -11.5 -7.3 2.3e-13 0.58 0.02 0.87 FALSE
14 GTEx Thyroid PPA2 0.22 0.01 enet 18 0.12 2.9e-09 6.0 -5.8 5.3e-09 0.50 0.76 0.05 FALSE
15 ROSMAP Brain Pre-frontal Cortex PPA2 0.32 0.38 lasso 2 0.38 1.1e-51 4.5 -5.2 1.9e-07 0.42 1.00 0.00 FALSE
16 YFS Blood PPA2 0.22 0.05 lasso 19 0.12 9.7e-38 -3.4 5.4 6.3e-08 -0.40 1.00 0.00 FALSE
17 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PPA2 0.29 0.01 blup 84 0.10 4.3e-06 -5.8 -5.2 2.7e-07 0.42 0.13 0.12 FALSE
18 The Cancer Genome Atlas Thyroid Carcinoma PPA2 0.04 0.02 blup 84 0.04 6.1e-05 -9.1 -8.3 9.8e-17 0.74 0.14 0.65 FALSE