Best TWAS P=3.26e-13 · Best GWAS P=1.8e-18 conditioned to 8.81e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | RP11-876N24.5 | 0.11 | 0.08 | lasso | 2 | 0.10 | 6.0e-06 | -6.8 | -6.4 | 1.2e-10 | 0.68 | 0.06 | 0.91 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | DEXI | 0.12 | 0.07 | enet | 14 | 0.08 | 6.9e-05 | -6.9 | -6.8 | 1.4e-11 | 0.72 | 0.07 | 0.88 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | RP11-876N24.5 | 0.15 | 0.11 | enet | 19 | 0.12 | 1.4e-06 | -6.9 | -6.4 | 1.1e-10 | 0.73 | 0.30 | 0.67 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Male) | DEXI | 0.18 | 0.04 | lasso | 3 | -0.01 | 4.9e-01 | -5.2 | -5.3 | 1.0e-07 | 0.63 | 0.03 | 0.64 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Female) | DEXI | 0.13 | 0.06 | lasso | 2 | 0.04 | 2.0e-02 | -7.3 | -7.3 | 3.3e-13 | 0.79 | 0.06 | 0.50 | TRUE |
| 6 | GTEx | Breast Mammary Tissue (Female) | RP11-876N24.5 | 0.22 | 0.14 | enet | 11 | 0.13 | 1.0e-04 | -4.6 | -6.3 | 2.2e-10 | 0.77 | 0.14 | 0.74 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | DEXI | 0.12 | 0.05 | lasso | 5 | 0.08 | 9.6e-07 | -5.3 | -6.0 | 2.0e-09 | 0.72 | 0.20 | 0.80 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | RP11-876N24.4 | 0.12 | 0.04 | lasso | 5 | 0.08 | 2.1e-06 | -5.3 | -6.1 | 1.4e-09 | 0.73 | 0.20 | 0.80 | FALSE |
| 9 | GTEx | Nerve Tibial | DEXI | 0.11 | 0.05 | enet | 7 | 0.07 | 1.7e-05 | -6.9 | -6.6 | 3.2e-11 | 0.81 | 0.66 | 0.25 | FALSE |
| 10 | GTEx | Testis | CLEC16A | 0.15 | 0.00 | enet | 20 | 0.01 | 1.2e-01 | -6.6 | -6.9 | 4.5e-12 | 0.71 | 0.02 | 0.92 | FALSE |
| 11 | GTEx | Testis | DEXI | 0.21 | 0.11 | lasso | 3 | 0.08 | 2.1e-04 | -5.5 | -5.4 | 8.1e-08 | 0.68 | 0.30 | 0.29 | FALSE |
| 12 | GTEx | Testis | RP11-876N24.4 | 0.21 | 0.06 | lasso | 5 | 0.07 | 6.0e-04 | -5.5 | -5.7 | 1.6e-08 | 0.70 | 0.22 | 0.28 | FALSE |
| 13 | GTEx | Thyroid | RP11-396B14.2 | 0.12 | 0.01 | lasso | 6 | 0.01 | 4.0e-02 | -5.2 | 7.0 | 2.3e-12 | -0.80 | 0.01 | 0.96 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DEXI | 0.04 | 0.02 | blup | 49 | 0.04 | 8.6e-08 | -6.8 | -5.9 | 4.9e-09 | 0.66 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DEXI | 0.05 | 0.02 | lasso | 4 | 0.03 | 1.7e-04 | -5.2 | -5.7 | 1.2e-08 | 0.64 | 0.02 | 0.84 | FALSE |