Hub : Genes

CLEC16A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.1520	0.0620	7.0e-03	-0.004	NA	0.010	NA	0.007	5.3e-01	NA	1.2e-01	NA	1.6e-01
2	YFS	Blood	0.0753	0.0181	4.7e-08	0.011	0.027	0.010	0.028	0.012	1.0e-04	2.2e-09	2.0e-04	1.2e-09	7.4e-05
3	TCGA	Thyroid Carcinoma	0.1440	0.0540	8.6e-07	0.064	0.071	0.061	NA	0.088	8.0e-07	1.8e-07	1.5e-06	NA	6.8e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.7	0.9	0.9	0.5	-0.9
Bipolar Disorder or Schizophrenia	0.7	1.6	3.4	0.6	-1.8	-1.0
Depressed Affect (Nagel 2018)	1.1	2.4	6.8	-0.6	2.6	-0.1
Depression (Nagel 2018)	2.5	3.8	7.7	-1.8	2.8	0.8
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.6	0.5	0.8	-1.2
Neuroticism (Nagel 2018)	0.2	0.6	1.1	0.2	1.1	-0.7
Schizophrenia (2018)	1.2	2.4	7.1	0.1	-2.7	-0.4
Schizophrenia vs Biploar Disorder	0.6	0.8	2.2	0.2	0.0	1.5
Worry (Nagel 2018)	0.5	1.1	1.5	1.0	-0.8	-1.2
Alzheimer’s Disease (in mother)	1.1	1.3	3.1	-0.9	-1.7	0.4
Alzheimer’s Disease (in father)	0.5	0.5	0.8	0.9	-0.4	-0.8
Alzheimer’s Disease (including proxy)	1.1	1.7	3.2	-1.8	-0.4	1.2
Crohns Disease (2017)	1.6	3.5	6.5	0.9	-2.6	-1.8
Irritable Bowel Disease (IBD)	1.2	2.9	8.5	-0.2	-2.9	-0.2
Ulcerative Colitis (UC)	0.6	1.2	3.0	-0.7	-1.7	0.3
Major Depression (MDD)	1.2	1.5	3.2	-1.1	1.8	0.1
Reaction Time	0.1	0.2	0.5	0.0	-0.2	0.7
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.9	0.2	-0.1	-2.0
Breast Cancer	0.7	1.6	2.1	-1.4	-1.3	-1.0
Ovarian Cancer	0.4	0.5	1.1	-1.0	-0.6	0.4
Prostate Cancer	1.4	2.0	3.9	-0.3	2.0	1.4
Age at First Birth	1.3	1.9	5.5	-0.3	2.3	0.2
Bipolar Disorder (2011)	1.6	1.5	3.4	1.1	0.0	-1.9
Body Mass Index (BMI) (2010)	0.4	0.5	1.4	0.1	-0.2	-1.2
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.1	0.1	0.2
Crohns Disease (2012)	0.4	0.6	1.5	-0.0	-1.2	-0.6
Mean Putamen Volume	0.6	0.7	1.8	1.4	-0.6	-0.1
Fasting Glucose	0.5	0.6	0.8	0.8	0.3	0.9
HbA1C	1.3	1.5	4.4	-0.2	2.1	0.1
HDL Cholesterol	0.1	0.2	0.4	0.3	0.1	0.6
LDL Cholesterol	0.2	0.4	0.5	0.5	0.6	-0.7
Lupus	3.1	4.7	10.4	-3.2	0.1	1.9
Neuroticism (2016)	0.5	0.7	2.2	-0.1	1.5	0.0
Primary Biliary Cirrhosis	5.9	8.4	10.2	-2.8	-3.2	2.6
Rheumatoid Arthritis	0.4	0.6	0.8	-0.8	0.5	-0.9
Schizophrenia (2014)	1.1	2.5	5.4	0.9	-2.3	-1.2
Triglycerides	0.2	0.4	0.7	-0.3	0.9	-0.6
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.5	-0.7	-0.1	0.5
Ulcerative Colitis	0.6	0.9	2.7	-0.3	-1.6	-0.2
Blood Eosinophil Count	25.6	197.3	441.0	-21.0	-1.4	12.2
Blood Platelet Count	0.3	3.3	6.1	-2.5	0.4	1.9
Blood Red Count	0.6	6.0	9.5	-2.8	0.6	3.1
Blood White Count	1.0	7.3	17.1	-4.1	0.5	2.1
Heel T-Score	0.3	2.3	3.4	1.1	1.8	-1.5
BMI	0.0	0.2	0.5	0.7	0.1	-0.1
Height	0.1	2.5	5.1	0.8	-1.3	-2.3
Waist Hip Ratio (WHR)	3.3	14.6	17.9	3.8	-4.2	-3.4
Systolic Blood Pressure	0.4	1.8	5.1	-0.6	-2.3	-0.1
Smoking Status	2.0	4.8	6.7	-2.3	2.6	1.6
Allergy or Eczema	29.1	76.6	132.2	-11.5	6.6	7.4
Cardiovascular Disease	0.3	1.0	1.5	-1.2	-0.9	0.9
Hypothyroidism (self reported)	0.7	1.7	3.2	-1.8	-0.7	-1.2
Respiratory disease	17.2	38.2	80.0	-8.9	3.5	4.8
Type 2 Diabetes (T2D) (2018)	1.0	1.9	4.4	0.3	-1.1	-2.1
Lung FEV1/FVC ratio	1.6	7.9	12.2	3.5	0.9	-3.3
Lung FVC	1.8	9.0	18.5	4.3	0.6	-2.9
Neuroticism	0.1	0.2	0.5	-0.3	0.7	-0.4
Chronotype (morning person)	1.9	4.4	7.7	2.8	-2.1	-1.0
Hair Pigment	0.0	1.0	2.8	1.7	-0.1	-0.3
Tanning	0.4	4.5	6.2	-2.5	1.1	2.5
Hand grip strength (left)	1.6	4.3	6.7	2.6	0.2	-2.5
Number of treatments/medications taken	5.7	10.2	17.6	-4.2	2.4	2.7
Average weekly spirits intake	0.3	0.4	1.0	0.3	-0.1	-1.0
Sensitivity / hurt feelings	0.5	0.8	1.4	-0.2	-1.0	1.2
Frequency of depressed mood in last 2 weeks	1.8	2.5	4.0	-1.8	2.0	0.6
Hearing difficulty/problems: Yes	2.3	3.5	7.6	-1.7	-0.4	2.8
Relative age of first facial hair	0.3	0.6	1.9	0.2	-1.4	0.1
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	2.6	-1.6	-0.5	0.7
Ever used hormone-replacement therapy (HRT)	1.2	1.6	2.1	-0.8	1.5	1.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.4	-0.6	0.2
Systolic blood pressure, automated reading	0.5	1.6	3.1	-0.1	-1.3	-1.8
Eye problems/disorders: Diabetes related eye disease	2.5	2.8	5.6	0.4	-2.4	-1.6
Angina	0.4	0.5	1.3	0.5	1.1	0.2
Medication for hormone replacement therapy	0.5	0.5	1.5	-0.1	-1.2	0.1
Vitamin and mineral supplements	0.5	0.6	1.5	0.7	-0.1	-1.2
Supplements: Zinc	0.9	1.0	2.0	-0.9	-0.3	1.4
Medication: Co-codamol	0.4	0.5	1.4	-0.0	-1.2	0.2
Medication: Metformin	1.3	1.8	2.8	-0.9	-1.3	-1.7
Diabetes (father)	0.2	0.2	0.3	-0.5	-0.5	-0.5
Diabetes (mother)	1.7	2.2	5.2	-0.3	-2.3	1.1
Severe depression (siblings)	3.1	3.5	6.0	-2.5	-0.3	2.1
Pack years adult smoking proportion	0.4	0.6	1.6	-1.3	-0.0	-0.3
Impedance of leg (right)	0.9	4.6	6.1	2.3	-1.5	-2.5
Leg fat-free mass (left)	0.1	0.3	0.5	-0.5	-0.7	0.3
Trunk fat percentage	0.9	3.5	5.6	2.2	0.3	-2.4
Hand grip strength (right)	1.8	4.9	8.0	2.6	0.2	-2.8
Townsend deprivation index at recruitment	0.4	0.6	1.3	0.6	-1.1	-0.2
Current tobacco smoking	1.4	2.3	3.2	-1.8	1.6	1.0
Average weekly fortified wine intake	1.1	1.3	2.6	1.6	1.1	0.1
Maternal smoking around birth	0.8	1.1	3.1	0.2	0.4	1.8
Fed-up feelings	1.1	2.0	5.6	-0.6	2.4	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	6.9	-1.5	0.8	2.6
Relative age voice broke	0.9	1.4	3.2	1.8	-0.3	-0.9
Taking other prescription medications	2.8	4.4	9.0	-3.0	1.8	0.9
Age when periods started (menarche)	0.9	2.2	6.5	0.2	-2.5	-0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.7	-0.4	-0.0	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.5	0.7	0.5	-0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.5	-0.1	-0.2
Qualifications: CSEs or equivalent	1.6	2.1	5.3	-0.7	-0.6	2.3
Serious illness, injury or assault to yourself	0.7	0.9	1.7	-0.9	0.5	1.3
High blood pressure	0.0	0.1	0.3	-0.6	0.3	-0.1
Hayfever, allergic rhinitis or eczema	26.4	57.4	100.0	-10.0	5.4	6.5
Multivitamins +/- minerals	1.5	1.9	4.4	-1.1	0.1	2.1
Stomach or abdominal pain in last month	0.1	0.1	0.4	0.1	-0.6	-0.0
Supplements: Glucosamine	0.8	1.0	2.3	-1.5	0.5	0.6
Diverticular disease/diverticulitis (self-reported)	2.7	3.3	5.0	-0.7	2.1	2.2
Medication: Atenolol	0.9	1.1	1.8	1.3	-1.0	-0.8
Medication: Levothyroxine sodium	0.1	0.1	0.2	-0.4	-0.3	0.1
Sitting height	1.1	8.1	11.5	3.0	-1.9	-3.4
Chronic bronchitis/emphysema (father)	0.4	0.5	0.8	-0.9	0.1	0.8
High blood pressure (mother)	0.5	0.7	1.6	0.7	1.3	0.0
Body mass index (BMI)	0.0	0.2	0.2	0.2	0.5	-0.5
Impedance of leg (left)	0.8	4.0	6.7	2.1	-0.8	-2.6
Leg predicted mass (left)	0.0	0.2	0.5	-0.5	-0.7	0.2
Trunk fat mass	0.7	2.8	4.7	1.9	0.4	-2.2
Waist circumference	1.1	3.9	6.8	2.1	-0.8	-2.6
Number of incorrect matches in round	0.9	1.6	3.9	-0.9	-0.3	2.0
Past tobacco smoking	0.7	1.3	2.4	1.2	-1.5	0.3
Alcohol usually taken with meals	0.3	0.5	1.1	-0.2	1.0	-0.5
Nervous feelings	0.5	1.0	1.9	0.9	-0.4	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	0.9	-0.7	0.8	1.0
Hearing difficulty/problems with background noise	0.3	0.5	1.4	-0.2	-1.2	0.1
Hair/balding pattern: Pattern 2	0.7	0.9	1.8	-0.1	-1.0	1.3
Had menopause	1.0	1.3	3.0	-1.7	-0.8	-0.5
Had other major operations	1.7	2.1	2.6	-1.5	1.6	1.2
Forced vital capacity (FVC)	1.0	3.9	7.0	2.1	0.2	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.3	1.2	-0.4	-0.8
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.3	-1.1	1.0	0.6
Qualifications: None of the above	0.1	0.3	0.5	-0.3	-0.7	0.5
Financial difficulties in last 2 years	0.2	0.2	0.5	0.2	0.7	-0.4
Mouth/teeth dental problems	0.9	1.4	2.8	0.8	-1.7	0.8
Heart attack	0.8	1.0	2.8	-1.7	0.1	0.5
Allergy	32.7	75.2	132.2	11.5	-5.5	-8.0
Pain all over the body in last month	0.8	0.8	2.3	1.5	0.5	-0.1
Diabetes (self-reported)	1.0	1.6	4.5	-2.1	-0.4	-0.4
Hayfever/allergic rhinitis (self-reported)	9.0	11.9	23.2	-4.8	1.5	3.2
Medication: Ramipril	0.2	0.2	0.4	-0.0	0.4	-0.7
Medication: Simvastatin	2.7	3.9	6.7	-2.6	1.7	1.4
Fluid intelligence score	0.9	1.9	3.1	1.6	-0.1	-1.8
Illnesses of siblings	1.3	1.9	5.2	2.3	0.2	0.6
Neuroticism score	0.2	0.3	0.7	0.6	0.8	0.1
Weight	0.1	0.6	1.6	0.6	-0.2	-1.3
Impedance of arm (right)	0.3	1.5	2.6	1.6	-0.6	-1.3
Arm fat percentage (right)	0.3	1.3	2.1	1.4	0.4	-1.2
Trunk fat-free mass	0.1	0.6	1.5	-1.2	0.0	0.5
Hip circumference	0.2	0.9	1.4	0.2	1.2	-1.2
Time employed in main current job	0.5	0.6	1.3	-0.2	-1.1	0.6
Alcohol intake versus 10 years previously	0.3	0.5	0.6	-0.6	0.8	-0.7
Father’s age at death	2.3	3.1	6.0	2.5	-1.0	-1.5
Worrier / anxious feelings	0.0	0.1	0.1	0.3	-0.3	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	3.0	-0.9	0.2	1.7
Falls in the last year	0.8	1.1	2.0	-1.1	-0.0	1.4
Hair/balding pattern: Pattern 3	0.1	0.2	0.2	-0.5	-0.2	-0.4
Number of live births	0.6	0.8	1.3	-1.1	0.5	1.0
Forced expiratory volume in 1-second (FEV1)	1.3	4.4	6.9	2.6	0.3	-2.5
Pulse rate	2.2	3.6	7.7	2.8	0.5	-1.7
Happiness	0.7	0.8	1.9	1.4	0.7	0.1
Noisy workplace	2.3	2.8	6.5	-2.5	-0.4	1.4
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.6	1.1	1.3	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.1	1.1	0.2	-0.4
Mouth/teeth dental problems: Dentures	1.9	3.1	5.8	-0.1	2.4	-1.9
Asthma	20.8	41.0	82.4	-9.1	3.8	5.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.2	0.8	1.1	0.6
Medication: Cholesterol lowering	0.2	0.3	0.7	-0.8	0.5	-0.0
Depression (self-reported)	0.4	0.5	0.8	-0.2	0.9	0.8
Medication: Lansoprazole	1.4	1.5	4.3	0.5	0.3	-2.1
Prospective memory result	0.8	1.0	1.5	-1.2	-1.2	0.3
Lung cancer (father)	0.5	0.5	1.3	0.5	-0.1	-1.2
Illnesses of mother	0.7	0.9	1.2	1.1	-0.6	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.0	9.0	3.0	-0.3	-2.4
Pulse wave Arterial Stiffness index	1.8	2.1	2.6	1.3	-1.6	-1.4
Impedance of arm (left)	0.6	2.6	3.6	1.9	-0.9	-1.9
Arm fat mass (right)	0.2	0.9	1.9	0.8	0.1	-1.4
Trunk predicted mass	0.1	0.8	1.9	-1.4	0.1	0.7
Standing height	0.1	1.4	2.3	0.2	-1.3	-1.5
Length of working week for main job	1.5	1.6	1.8	1.1	-1.4	-1.4
Exposure to tobacco smoke at home	0.7	0.8	1.6	-0.6	0.7	1.3
Breastfed as a baby	0.3	0.4	0.6	-0.8	0.3	-0.7
Tense / ‘highly strung’	1.2	2.0	5.0	2.2	-0.7	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.2	-0.5	0.9	1.8
Hair/balding pattern: Pattern 4	1.8	4.4	6.6	2.4	0.8	-2.6
Birth weight of first child	0.2	0.3	0.4	0.7	0.7	0.1
Peak expiratory flow (PEF)	1.9	4.5	6.6	2.1	1.6	-2.6
Pulse wave reflection index	2.2	2.7	4.2	-2.0	-2.0	0.3
Ever highly irritable/argumentative for 2 days	0.9	1.0	1.8	-1.0	-0.5	1.3
Loud music exposure frequency	0.7	0.8	1.5	-0.3	-1.2	-0.9
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.7	-0.0	0.6	-0.8
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	2.4	0.6	-0.2	-1.6
Blood clot in the leg (DVT)	0.6	0.8	1.7	-0.8	1.3	0.4
Medication: Paracetamol	1.8	3.0	8.0	-0.4	1.0	2.8
Headache pain in last month	1.1	1.9	3.0	-1.6	0.4	1.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	0.7	-0.6	0.4
Glaucoma (self-reported)	1.1	1.3	2.3	-1.5	1.3	0.2
Gout (self-reported)	1.0	1.3	1.9	0.9	1.4	-1.1
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.1	-1.4	-0.4	-0.6
Medication: Amlodipine	1.1	1.6	3.7	-0.2	-1.0	-1.9
Medication: Ventolin 100micrograms inhaler	7.2	9.3	20.7	-4.5	-0.8	2.5
Birth weight	0.2	0.4	0.7	0.9	-0.3	-0.6
Chronic bronchitis/emphysema (mother)	2.7	3.2	8.0	-1.2	-0.3	2.8
High blood pressure (siblings)	1.3	1.9	5.5	-2.3	0.2	-0.5
Forced vital capacity (FVC), Best measure	0.7	2.5	4.3	1.7	-0.6	-2.1
Body fat percentage	1.1	4.3	6.5	2.5	0.3	-2.5
Leg fat percentage (right)	1.2	4.2	6.9	2.3	0.4	-2.6
Arm fat-free mass (right)	0.0	0.1	0.1	-0.3	-0.2	-0.3
Exposure to tobacco smoke outside home	1.3	1.7	3.8	-1.9	-0.4	1.1
Comparative body size at age 10	1.8	5.0	12.0	-3.5	-0.2	1.7
Number of full brothers	0.4	0.5	1.2	-0.5	-1.1	-0.1
Worry too long after embarrassment	0.6	1.0	2.8	1.7	0.2	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.5	-0.7	0.4	0.3
Wheeze or whistling in the chest in last year	13.7	24.4	47.9	-6.9	1.0	4.9
Number of children fathered	2.6	3.0	5.8	-1.7	-0.5	2.4
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	0.9	-0.1	-0.2
Age at first live birth	1.5	2.7	5.4	2.3	1.5	-0.7
Pulse wave peak to peak time	1.8	2.1	3.0	-1.1	1.7	1.5
Health satisfaction	0.5	0.6	0.8	0.9	0.7	0.8
Shortness of breath walking on level ground	0.1	0.2	0.3	-0.5	0.4	-0.3
Qualifications: College or University degree	0.5	1.5	2.2	1.4	0.5	-1.5
Eye problems/disorders: None of the above	1.3	1.5	2.1	1.5	-0.8	1.3
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.8	-1.4	-0.2	0.5
Emphysema/chronic bronchitis	0.4	0.5	1.3	-1.1	0.1	-0.2
Medication for pain relief, constipation, heartburn	1.3	2.2	2.7	1.6	-1.5	-1.2
Neck or shoulder pain in last month	0.3	0.4	0.6	-0.8	0.4	0.6
Medication: Blood pressure	0.3	0.5	1.1	-0.5	0.4	-1.1
Angina (self-reported)	0.3	0.4	0.9	0.5	0.9	0.3
Migraine (self-reported)	0.6	0.7	1.5	0.2	-1.2	-0.8
Medication: Ibuprofen	0.6	0.7	1.5	-0.0	0.8	1.2
Medication: Allopurinol	0.5	0.7	1.6	0.6	1.3	-0.4
Medication: Omeprazole	0.4	0.5	1.1	-0.6	1.1	0.2
Medication: Seretide 50 evohaler	4.9	5.6	10.8	-3.3	0.1	2.5
Mean time to correctly identify matches	0.0	0.0	0.1	0.3	0.2	0.0
Heart disease (mother)	1.2	1.4	3.2	-0.7	1.8	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.6	-0.5	0.1	-0.8
Whole body fat mass	0.6	2.5	4.3	1.8	0.0	-2.1
Leg fat mass (right)	0.6	2.5	4.7	1.7	-0.0	-2.2
Arm predicted mass (right)	0.0	0.2	0.3	-0.5	-0.4	-0.3
Pulse rate, automated reading	0.5	1.7	3.2	0.9	1.0	-1.8
Alcohol intake frequency.	1.2	2.9	4.4	-2.1	1.1	1.7
Comparative height size at age 10	0.4	2.1	4.3	-2.1	1.1	1.0
Number of full sisters	0.3	0.3	0.4	-0.6	0.6	-0.6
Suffer from ‘nerves’	1.7	2.6	3.0	1.7	-1.5	-1.6
Overall health rating	0.7	1.5	3.2	-1.2	0.2	1.8
Chest pain or discomfort	0.2	0.3	0.7	-0.4	-0.8	0.5
Had major operations	0.4	0.4	0.6	-0.8	-0.1	-0.8
Age at last live birth	2.0	2.9	5.6	2.4	-0.1	-1.7
Family relationship satisfaction	0.9	1.2	2.6	1.6	-0.1	-0.9
Leg pain on walking	0.9	1.1	2.9	-0.1	0.6	1.7
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.3	-0.1	0.5	-0.5
Commuting to job workplace: Car/motor vehicle	3.0	3.4	7.6	-1.2	1.1	2.8
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	1.6	-0.2	-1.3	-0.5
Medication: Aspirin	3.1	4.0	11.3	-3.4	0.9	0.2
Supplements: Vitamin C	0.0	0.1	0.1	0.1	-0.2	-0.3
Knee pain experienced in last month	4.0	6.2	10.1	-3.2	-0.0	2.9
Hypertension (Self-reported)	0.1	0.2	0.2	-0.5	-0.2	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.9	0.5	1.7	-0.6
Illnesses of father: Heart disease	3.1	4.3	10.7	-1.5	-3.3	0.2
Illnesses of siblings: Diabetes	1.5	1.9	5.4	-2.3	-0.0	0.5
Smoking status: Previous	0.2	0.2	0.4	-0.6	0.6	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.6	0.8	-0.6	-0.6
Whole body fat-free mass	0.1	0.4	1.0	-1.0	-0.2	0.4
Leg fat-free mass (right)	0.1	0.4	0.7	-0.8	-0.3	0.5
Arm fat percentage (left)	0.5	2.1	3.3	1.8	0.3	-1.7
Average weekly red wine intake	0.2	0.2	0.2	0.5	0.5	-0.5
Handedness (chirality/laterality): Left-handed	1.9	2.3	5.1	1.2	-2.3	-0.7
Mood swings	0.5	0.9	1.7	0.0	1.3	0.9
Loneliness, isolation	0.2	0.2	0.4	0.5	0.6	0.4
Long-standing illness, disability or infirmity	1.7	2.6	7.7	-2.8	0.2	0.3
Ever had bowel cancer screening	2.6	3.0	7.4	0.8	2.7	-1.1
Diabetes diagnosed by doctor	0.9	1.4	1.9	-1.0	-1.2	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.5	-1.2	-0.3	0.3
Friendships satisfaction	1.0	1.2	2.5	1.0	1.6	-0.3
Qualifications: nursing, teaching	0.2	0.4	0.9	0.1	0.9	-0.4
Commuting to job workplace: Walk	0.2	0.2	0.3	0.5	0.5	-0.0
Eye problems/disorders: Cataract	0.7	0.8	1.5	-1.2	0.9	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	7.8	-2.8	-0.2	0.8
Medication for cholesterol	0.4	0.6	1.1	0.9	1.1	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.6	1.1	-1.0	-0.4	0.8
Back pain experienced in last month	0.5	0.8	1.8	-0.6	-0.4	1.4
Mineral and other dietary supplements	0.5	0.7	0.9	0.7	0.7	-1.0
Breast cancer (self-reported)	3.1	3.7	4.6	-1.9	2.1	1.7
Asthma (self-reported)	19.8	39.5	79.6	-8.9	3.7	5.0
Osteoporosis (self-reported)	0.2	0.3	0.6	0.2	0.3	-0.8
Osteoarthritis (self-reported)	1.7	2.2	4.8	-1.4	-0.3	2.2
Medication: Aspirin	2.2	2.9	8.4	-2.9	0.5	-0.4
Medication: Gliclazide	1.0	1.2	2.0	-1.4	-1.1	0.6
Illnesses of father: None of the above (group 1)	1.9	2.3	3.2	1.8	1.7	-0.8
Smoking status: Current	1.3	2.0	2.8	-1.7	1.6	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.5	5.3	10.4	3.2	-0.7	-2.3
Whole body water mass	0.1	0.4	0.9	-0.9	-0.2	0.4
Leg predicted mass (right)	0.1	0.4	0.8	-0.9	-0.3	0.4
Arm fat mass (left)	0.3	1.3	2.6	1.1	0.2	-1.6
Number of self-reported non-cancer illnesses	5.0	8.6	15.1	-3.9	2.3	2.4
Average weekly champagne plus white wine intake	4.2	5.8	8.9	3.0	-0.5	-2.9
Miserableness	0.9	1.6	3.3	-1.8	1.3	0.2
Guilty feelings	0.1	0.1	0.2	0.4	0.3	-0.3
Wears glasses or contact lenses	0.3	0.3	0.8	0.9	0.1	-0.4
Ever taken oral contraceptive pill	1.2	1.3	2.5	1.2	-1.6	0.0
Hearing aid user	0.0	0.0	0.0	-0.1	0.1	-0.0
Mother’s age at death	1.5	1.9	4.3	0.9	2.1	-0.9
Financial situation satisfaction	0.6	0.7	1.5	1.2	0.7	-0.4
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.0	-1.4	-0.3	0.5
Commuting to job workplace: Public transport	0.4	0.4	1.0	0.4	-0.4	-1.0
Eye problems/disorders: Glaucoma	0.8	1.0	2.4	-1.5	0.7	-0.2
Medication: Blood pressure	0.2	0.4	0.8	-0.9	-0.4	-0.4
Pain type(s) experienced in last month: Hip pain	1.9	2.4	5.5	-0.4	1.2	2.3
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.5	-0.2	-1.2	0.5
High cholesterol (Self-reported)	0.8	1.4	3.6	-1.9	-0.3	0.7
Medication: Bendroflumethiazide	0.2	0.3	0.6	-0.4	-0.8	-0.2
Medication: Paracetamol	1.9	2.9	7.9	-0.8	0.5	2.8
Medication: Lisinopril	0.5	0.7	1.6	-1.3	-0.5	-0.5
Medication: Atorvastatin	0.4	0.5	1.0	0.3	-0.7	-1.0
Illnesses of father: High blood pressure	0.4	0.4	1.3	-0.1	1.1	0.2
Alcohol drinker status: Never	0.3	0.4	0.8	-0.4	0.9	-0.4
Ever smoked	1.1	1.9	4.7	-1.0	2.2	-0.1
Basal metabolic rate	0.0	0.1	0.3	-0.6	-0.3	-0.0
Leg fat percentage (left)	1.1	3.9	6.4	2.2	0.7	-2.5
Arm fat-free mass (left)	0.0	0.2	0.4	-0.7	-0.5	-0.1
Number of operations (self-reported)	6.4	9.5	14.1	-3.8	2.1	3.2
Average weekly beer plus cider intake	0.1	0.2	0.6	-0.1	-0.8	-0.2
Irritability	0.1	0.2	0.6	0.8	-0.3	-0.0
Risk taking	0.1	0.1	0.2	0.4	-0.1	-0.4
Ever had prostate specific antigen (PSA) test	2.5	2.8	3.7	1.9	1.2	-1.9
Fractured/broken bones in last 5 years	2.4	3.1	5.9	-2.4	0.7	1.7
Age started oral contraceptive pill	1.1	1.4	4.1	0.3	-0.1	-2.0
Diastolic blood pressure, automated reading	0.5	1.5	3.8	-0.4	-1.9	-0.7
Ever depressed for a whole week	2.8	3.5	4.1	-2.0	1.8	1.7
Unable to work because of sickness or disability	0.3	0.4	1.1	0.4	-1.1	-0.2
Commuting to job workplace: Cycle	0.8	1.0	1.9	-0.1	1.0	1.4
Myopia	0.3	0.4	1.1	1.1	0.3	-0.1
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.4	0.6	-0.6	-0.4
Cholesterol lowering medication	0.5	0.8	2.1	-1.4	0.2	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.4	-0.2	1.5	0.1
Pain experienced in last month	2.3	3.8	6.1	1.7	1.5	-2.5
Supplements: Calcium	0.1	0.1	0.3	-0.1	-0.5	0.2
Basal cell carcinoma (self-reported)	2.6	3.0	3.3	-1.8	-1.6	-1.8
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.9	-1.7	0.1	0.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	-0.6	1.0	0.2
Heart disease (siblings)	3.5	4.3	6.2	0.8	-2.4	-2.5
Alcohol drinker status: Previous	0.3	0.3	0.7	0.8	-0.1	-0.5
Pack years of smoking	0.4	0.6	1.7	-1.3	0.4	-0.1
Impedance of whole body	0.8	4.2	6.1	2.3	-1.1	-2.5
Leg fat mass (left)	0.6	2.2	4.0	1.6	0.2	-2.0
Arm predicted mass (left)	0.0	0.2	0.4	-0.6	-0.4	0.0