Best TWAS P=1.98e-08 · Best GWAS P=3.89e-08 conditioned to 0.233
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | SPPL3 | 0.08 | 0.05 | enet | 16 | 0.05 | 1.2e-04 | 5.4 | 5.6 | 2.0e-08 | 0.88 | 0.01 | 0.98 | TRUE |
| 2 | GTEx | Brain Cerebellum | SPPL3 | 0.29 | 0.22 | enet | 9 | 0.24 | 8.6e-08 | 5.4 | 5.2 | 1.5e-07 | 0.94 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | SPPL3 | 0.24 | 0.14 | enet | 7 | 0.03 | 5.1e-02 | 5.3 | 5.1 | 2.8e-07 | 0.91 | 0.03 | 0.90 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | SPPL3 | 0.25 | 0.19 | lasso | 3 | 0.23 | 5.6e-09 | 5.4 | 5.1 | 2.7e-07 | 0.92 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Pancreas | SPPL3 | 0.14 | 0.10 | lasso | 3 | 0.09 | 9.3e-05 | 5.3 | 5.2 | 2.4e-07 | 0.91 | 0.02 | 0.93 | FALSE |
| 6 | GTEx | Testis | SPPL3 | 0.31 | 0.30 | lasso | 3 | 0.27 | 2.0e-12 | 5.5 | 5.5 | 4.0e-08 | 1.00 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SPPL3 | 0.11 | 0.01 | lasso | 1 | 0.01 | 1.0e-01 | 5.3 | 5.3 | 1.1e-07 | 0.93 | 0.01 | 0.75 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SPPL3 | 0.07 | 0.09 | lasso | 3 | 0.09 | 9.9e-11 | 5.4 | 5.1 | 2.9e-07 | 0.96 | 0.01 | 0.99 | FALSE |