Best TWAS P=8.53e-24 · Best GWAS P=5.76e-84 conditioned to 1.52e-47
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | MASP2 | 0.10 | 0.06 | lasso | 2 | 0.03 | 8.8e-04 | -6.2 | -6.2 | 4.3e-10 | 0.31 | 0.70 | 0.01 | FALSE |
| 2 | GTEx | Brain Cerebellum | RP4-635E18.7 | 0.17 | 0.17 | lasso | 5 | 0.09 | 1.3e-03 | -4.9 | -5.5 | 5.1e-08 | 0.26 | 0.33 | 0.16 | TRUE |
| 3 | GTEx | Brain Putamen basal ganglia | MTOR | 0.35 | -0.01 | enet | 34 | 0.06 | 1.5e-02 | 1.2 | -5.8 | 8.1e-09 | 0.25 | 0.05 | 0.12 | FALSE |
| 4 | GTEx | Nerve Tibial | MASP2 | 0.14 | 0.07 | lasso | 5 | 0.09 | 1.2e-06 | -6.2 | -6.2 | 5.2e-10 | 0.32 | 0.78 | 0.01 | FALSE |
| 5 | METSIM | Adipose | EXOSC10 | 0.05 | 0.06 | lasso | 1 | 0.05 | 3.5e-08 | -5.9 | -5.9 | 4.1e-09 | 0.27 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | MASP2 | 0.05 | 0.03 | blup | 30 | 0.04 | 6.0e-03 | -4.2 | 10.1 | 8.5e-24 | -0.50 | 0.03 | 0.29 | TRUE |