Hub : Traits :

Hair/balding pattern: Pattern 4

956 significantly associated models · 187 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 10391536 12013869 4 2 8.5e-24 5.8e-84 1.5e-47 44 MASP2 RP4-635E18.7
2 1 15829187 16844848 1 1 8.9e-08 1.9e-06 9.5e-03 70 ARHGEF19
3 1 23994201 26380805 6 3 1.2e-21 2.2e-44 1.4e-46 -5 CLIC4 RCAN3 RP3-465N24.5
4 1 40628071 42021616 1 1 6.8e-08 6.2e-18 3.3e-13 29 CITED4
5 1 117708477 120517959 3 2 8.9e-28 2.1e-33 2.5e-25 26 GDAP2 WARS2
6 1 151313774 152712747 1 1 1.5e-12 1.1e-19 1.1e-08 60 S100A11
7 1 152880672 154625632 2 2 1.2e-09 1.1e-09 1.0e+00 100 CRTC2 S100A16
8 1 168932500 171407761 5 7 9.2e-36 2.6e-44 5.8e-01 100 GORAB KIFAP3 PRRX1 SCYL3
9 2 31589414 33088870 2 1 6.2e-11 4.2e-22 1.1e-12 46 SPAST
10 2 42753863 44690514 2 2 3.3e-08 2.8e-11 1.3e-02 86 PLEKHH2 ZFP36L2
11 2 66927859 68326904 1 2 9.4e-11 9.1e-21 1.2e-20 1 ETAA1
12 2 69829251 71228388 1 1 7.8e-08 9.0e-06 2.3e-01 93 FAM136A
13 2 218736292 220632013 3 2 2.7e-08 1.8e-14 1.7e-06 61 RP11-33O4.1 WNT6
14 2 239510492 240078905 1 1 4.3e-15 9.9e-48 1.8e-35 27 TWIST2
15 2 241430049 242849135 2 2 7.2e-08 8.1e-07 1.0e-01 89 ANO7 SEPT2
16 3 40537829 41986787 1 1 2.2e-08 1.4e-08 4.3e-02 87 CTNNB1
17 3 124951821 127452273 2 2 3.8e-11 3.3e-27 1.5e-23 14 ALG1L PLXNA1
18 3 134986214 136558759 1 1 8.4e-09 7.3e-09 1.0e+00 100 PPP2R3A
19 3 138380069 139954262 4 3 6.8e-22 2.4e-86 7.5e-61 30 RBP1 RP11-219D15.3
20 3 140350567 141867638 1 1 3.3e-18 3.1e-19 1.0e+00 100 ZBTB38
21 3 151262987 152878838 1 1 1.5e-14 8.8e-17 1.2e-09 46 MBNL1
22 3 157127290 158951696 1 2 2.8e-08 6.7e-18 1.0e-08 56 RSRC1
23 4 14764460 15315535 1 1 1.8e-07 3.9e-08 5.4e-02 88 CPEB2
24 4 53494816 54762082 3 2 7.0e-10 2.7e-10 1.0e+00 100 LNX1 SCFD2
25 4 80407869 82578407 3 2 7.5e-39 8.0e-40 1.0e+00 100 C4orf22 PRDM8
26 4 107145847 108895012 1 1 5.2e-10 6.2e-13 6.0e-07 52 DKK2
27 4 153688776 155252934 1 1 1.4e-08 1.1e-09 1.9e-02 85 KIAA0922
28 5 121480516 123054717 3 2 1.9e-11 1.5e-20 2.7e-13 38 CTB-36H16.2 SNX2
29 5 171053425 172577403 1 1 3.8e-12 9.8e-14 1.0e+00 100 SH3PXD2B
30 6 240232 940771 1 1 3.0e-07 2.3e-19 3.1e-16 18 EXOC2
31 6 19840492 21930988 1 1 4.9e-08 2.4e-16 7.8e-17 -3 CDKAL1
32 6 37093486 38816574 1 1 1.1e-07 8.7e-08 3.0e-01 96 ZFAND3
33 6 44079216 46043561 1 1 3.6e-14 7.8e-22 4.2e-12 48 SUPT3H
34 6 105033213 107467855 2 2 9.6e-12 2.9e-26 7.2e-19 30 ATG5 PREP
35 6 110883139 112286687 1 1 2.0e-07 9.5e-10 3.8e-14 -53 KIAA1919
36 6 125970401 127355237 2 2 7.4e-27 1.2e-27 1.6e-01 98 CENPW TRMT11
37 6 130901240 131402416 1 1 1.5e-07 2.8e-11 1.5e-06 48 LOC285733
38 6 169458730 170872572 1 1 3.9e-09 8.0e-11 2.2e-04 68 ERMARD
39 7 18364750 19854141 1 2 6.4e-75 1.8e-113 4.0e-48 58 TWIST1
40 7 68365245 70954231 1 1 6.8e-09 1.2e-63 4.1e-60 6 AUTS2
41 7 130101373 131880252 2 2 3.6e-12 4.3e-16 3.7e-04 81 MKLN1-AS2
42 7 139519806 141031540 1 1 2.3e-08 7.0e-09 9.7e-03 80 DENND2A
43 8 77356394 78026317 1 1 7.9e-08 5.2e-11 2.3e-05 58 ZFHX4
44 8 108216908 110190556 4 2 5.3e-19 2.3e-25 2.0e-09 67 EMC2 RSPO2
45 9 12410173 13977570 1 1 7.5e-12 1.5e-12 3.7e-02 91 MPDZ
46 9 128394623 129961152 2 1 1.0e-11 1.5e-14 2.2e-05 70 MVB12B
47 10 31857752 33353843 1 1 2.8e-07 7.0e-11 5.3e-05 62 EPC1
48 10 76664253 80383574 3 3 6.3e-31 1.8e-35 2.6e-08 80 C10orf11 DLG5
49 10 125455780 127372751 4 2 2.1e-19 3.7e-34 1.4e-11 69 LHPP METTL10
50 11 26693196 28189639 1 1 1.9e-09 6.7e-11 1.0e-02 84 LGR4
51 11 43888194 45340720 1 1 2.3e-07 1.7e-30 2.3e-25 18 CD82
52 11 60839578 62290719 4 1 1.8e-08 2.3e-08 1.0e+00 100 TMEM258
53 11 68367007 69880281 1 1 5.0e-10 9.7e-10 1.5e-09 2 MYEOV
54 12 26099201 26643931 1 1 2.6e-20 1.4e-30 6.2e-12 64 SSPN
55 12 28611779 30185513 2 2 4.3e-11 9.1e-22 1.0e-10 55 FAR2 RP11-996F15.2
56 12 49780778 51912062 7 1 4.8e-11 7.9e-10 6.3e-01 99 ATF1
57 13 30336006 31886850 1 1 4.3e-11 4.4e-18 9.2e-17 8 HMGB1
58 15 89921477 91886448 4 1 7.4e-13 8.4e-12 1.0e+00 100 CRTC3
59 16 66666637 68802936 15 2 1.1e-18 4.6e-15 3.7e-01 99 CTCF RLTPR
60 17 1263564 2923933 2 1 1.3e-12 6.4e-12 1.3e-01 95 SRR
61 17 39399566 39838104 1 1 2.6e-08 1.4e-06 1.6e-01 92 KRT34
62 17 42413481 45876022 32 8 5.6e-67 1.0e-58 1.0e+00 100 ARL17B HEXIM1 KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
63 17 54272304 55667722 1 1 3.9e-09 3.8e-32 7.0e-25 24 MIR3614
64 17 78966915 79461486 1 1 1.5e-07 6.3e-07 1.0e-03 56 C17orf89
65 18 52648055 53545463 1 1 7.9e-10 9.8e-12 1.9e-08 32 TCF4
66 19 41165252 42626207 7 1 1.5e-13 2.4e-13 1.0e+00 100 EXOSC5
67 20 21043102 22430527 1 1 7.1e-33 1.7e-125 3.7e-96 24 RPL41P1
68 20 30716979 32128889 1 1 6.7e-08 1.1e-07 2.6e-01 96 MAPRE1
69 20 32254831 34484245 4 1 3.4e-08 2.8e-07 5.0e-01 98 TRPC4AP
70 20 39114404 40683594 4 1 2.7e-15 6.9e-22 4.1e-08 67 ZHX3
71 22 28478985 29894210 2 2 6.5e-13 2.7e-13 2.4e-01 97 CCDC117
72 22 45566702 46074258 1 1 6.9e-08 2.2e-11 6.4e-05 64 RIBC2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 1.07 1 0 0.0 0.00 1.0e+00 TMEM258
Bipolar Disorder or Schizophrenia 1.08 1 0 0.0 0.00 1.0e+00 TRPC4AP
Depressed Affect (Nagel 2018) 2.76 6 6 13.3 -0.99 4.3e-06 ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Depression (Nagel 2018) 1.49 2 0 0.0 0.00 1.0e+00 LRRC37A2 RP4-635E18.7
Intelligence (Savage-Jansen 2018) 1.25 9 1 2.2 0.28 4.3e-01 ARL17B CENPW CRTC2 CTNNB1 LRRC37A LRRC37A2 PPP2R3A SEPT2 TMEM258
Neuroticism (Nagel 2018) 3.06 8 7 15.6 -0.82 6.3e-03 ARL17B CENPW KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P RSRC1
Schizophrenia (2018) 1.29 1 0 0.0 0.00 1.0e+00 PPP2R3A
Worry (Nagel 2018) 1.99 8 5 11.1 -0.75 3.1e-02 ARL17B CENPW KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P RSRC1
Crohns Disease (2017) 1.38 4 2 4.4 -0.59 4.1e-01 TMEM258 ZBTB38 ZFP36L2 ZHX3
Irritable Bowel Disease (IBD) 1.31 2 1 2.2 0.00 1.0e+00 ZFP36L2 ZHX3
Ulcerative Colitis (UC) 1.11 1 0 0.0 0.00 1.0e+00 ZHX3
Verbal and Numeric Reasoning (VNR) 1.37 3 0 0.0 0.00 1.0e+00 ARL17B CENPW TMEM258
Breast Cancer 1.84 9 4 8.9 -0.74 2.4e-02 ARL17B CDKAL1 GDAP2 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P METTL10 ZBTB38
Ovarian Cancer 2.45 6 6 13.3 1.00 3.6e-05 ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Prostate Cancer 2.22 4 1 2.2 0.23 7.7e-01 ANO7 CRTC2 MBNL1 SEPT2
Age at First Birth 1.18 1 1 2.2 0.00 1.0e+00 CRTC2
Crohns Disease (2012) 1.56 2 0 0.0 0.00 1.0e+00 TMEM258 ZFP36L2
Fasting Glucose 1.38 1 1 2.2 0.00 1.0e+00 TMEM258
HDL Cholesterol 1.19 1 1 2.2 0.00 1.0e+00 TMEM258
LDL Cholesterol 1.49 1 1 2.2 0.00 1.0e+00 TMEM258
Neuroticism (2016) 1.70 5 1 2.2 -0.99 1.4e-03 ARL17B LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Primary Biliary Cirrhosis 1.50 2 0 0.0 0.00 1.0e+00 ARL17B LRRC37A
Triglycerides 1.29 1 1 2.2 0.00 1.0e+00 TMEM258
Blood Eosinophil Count 1.50 15 10 22.2 0.78 4.0e-04 ARL17B ATG5 CLIC4 CTCF EXOC2 FAM136A KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P RLTPR SEPT2 TMEM258 ZFP36L2
Blood Platelet Count 1.36 22 18 40.0 -0.36 9.6e-02 ATF1 CDKAL1 CLIC4 CRTC2 CTB-36H16.2 ETAA1 FAM136A FAR2 GDAP2 HEXIM1 KANSL1 LRRC37A LRRC37A17P LRRC37A4P PLEKHH2 PLXNA1 RP3-465N24.5 SRR TMEM258 ZFAND3 ZFP36L2 ZHX3
Blood Red Count 3.53 23 15 33.3 -0.77 7.7e-06 ARL17B ATF1 AUTS2 C4orf22 CCDC117 CENPW CLIC4 CTCF FAM136A HEXIM1 KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P RLTPR SEPT2 SUPT3H TMEM258 TRPC4AP ZBTB38 ZFAND3 ZFP36L2
Blood White Count 1.20 15 8 17.8 -0.18 5.1e-01 ANO7 ATF1 CENPW CITED4 CTB-36H16.2 EPC1 KANSL1 LRRC37A LRRC37A17P LRRC37A4P METTL10 MPDZ SSPN TMEM258 ZHX3
Heel T-Score 3.37 38 31 68.9 0.30 5.5e-02 ARHGEF19 ARL17B ATF1 CCDC117 CPEB2 CRTC3 CTCF CTNNB1 EXOSC5 GORAB HEXIM1 KANSL1 LNX1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P MASP2 MPDZ PLEKHH2 PRRX1 RIBC2 RLTPR RP4-635E18.7 RSPO2 SPAST SRR SSPN SUPT3H TCF4 TMEM258 TRMT11 TRPC4AP TWIST1 WARS2 ZBTB38 ZFP36L2 ZHX3
BMI 0.81 10 5 11.1 0.22 5.4e-01 C4orf22 CTNNB1 HMGB1 MASP2 PPP2R3A RIBC2 RP4-635E18.7 RSRC1 SRR WARS2
Height 3.27 53 40 88.9 -0.10 4.8e-01 ALG1L ANO7 ARL17B ATF1 AUTS2 C10orf11 CENPW CLIC4 CRTC3 CTCF CTNNB1 DENND2A DLG5 EXOSC5 FAM136A GORAB HEXIM1 KANSL1 KIAA1919 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P MAPRE1 MASP2 METTL10 MIR3614 MKLN1-AS2 MPDZ PLEKHH2 PPP2R3A RIBC2 RLTPR RP11-33O4.1 RP11-996F15.2 RP3-465N24.5 RP4-635E18.7 RPL41P1 RSRC1 SCFD2 SEPT2 SPAST SRR SUPT3H TMEM258 TRMT11 TRPC4AP TWIST1 WARS2 WNT6 ZBTB38 ZFHX4 ZFP36L2
Waist Hip Ratio (WHR) 3.24 25 21 46.7 -0.43 2.7e-02 ARL17B CCDC117 CDKAL1 CENPW CTCF EPC1 ETAA1 HMGB1 KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P MPDZ MYEOV PRRX1 RLTPR RP4-635E18.7 SH3PXD2B SSPN TRMT11 TRPC4AP WARS2 ZBTB38 ZFP36L2
Systolic Blood Pressure 2.11 16 10 22.2 0.47 6.3e-02 ARL17B ATF1 C4orf22 CLIC4 CPEB2 HEXIM1 LGR4 LRRC37A LRRC37A4P MKLN1-AS2 MYEOV PRDM8 RSRC1 SRR SSPN ZFHX4
Smoking Status 1.19 5 1 2.2 0.53 3.6e-01 ARL17B CCDC117 HMGB1 LRRC37A2 SRR
Allergy or Eczema 1.43 3 2 4.4 0.00 1.0e+00 CRTC3 HEXIM1 ZBTB38
Cardiovascular Disease 1.58 8 2 4.4 0.53 1.8e-01 ARHGEF19 C4orf22 CLIC4 FAM136A HEXIM1 PRDM8 TCF4 ZFAND3
Hypothyroidism (self reported) 1.02 3 1 2.2 0.00 1.0e+00 CTCF RLTPR TMEM258
Respiratory disease 1.03 2 1 2.2 0.00 1.0e+00 HEXIM1 TMEM258
Type 2 Diabetes (T2D) (2018) 1.62 3 2 4.4 0.00 1.0e+00 CDKAL1 CENPW ZFP36L2
Lung FEV1/FVC ratio 1.27 13 4 8.9 0.54 5.9e-02 ARHGEF19 ARL17B C10orf11 CENPW CTCF CTNNB1 EMC2 LRRC37A LRRC37A2 LRRC37A4P SRR ZBTB38 ZFP36L2
Lung FVC 3.50 20 16 35.6 0.44 4.2e-02 ARL17B ATF1 C10orf11 C17orf89 CENPW CTB-36H16.2 DENND2A FAM136A KANSL1 LOC285733 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P PLXNA1 RCAN3 RSRC1 TRPC4AP TWIST1 ZBTB38
Neuroticism 2.91 8 6 13.3 -0.82 6.2e-03 ARL17B CENPW KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P RSRC1
Hair Pigment 1.68 27 21 46.7 0.01 9.4e-01 C4orf22 CDKAL1 CENPW EMC2 EXOC2 EXOSC5 FAM136A HMGB1 KANSL1 LNX1 LRRC37A LRRC37A17P LRRC37A4P MASP2 MIR3614 MYEOV PLXNA1 RCAN3 RPL41P1 S100A16 SH3PXD2B SUPT3H TMEM258 TWIST1 TWIST2 ZBTB38 ZFP36L2
Tanning 0.86 1 1 2.2 0.00 1.0e+00 EXOC2
Hand grip strength (left) 2.06 10 7 15.6 0.75 1.3e-02 ARL17B DENND2A HEXIM1 KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P TRPC4AP ZBTB38
Number of treatments/medications taken 1.23 1 0 0.0 0.00 1.0e+00 TMEM258
Sensitivity / hurt feelings 3.23 6 6 13.3 -0.99 2.2e-05 ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Frequency of depressed mood in last 2 weeks 1.43 1 0 0.0 0.00 1.0e+00 LRRC37A2
Relative age of first facial hair 5.90 18 10 22.2 -0.90 1.7e-07 ARL17B C4orf22 ETAA1 HEXIM1 KANSL1 LNX1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P MASP2 MIR3614 MKLN1-AS2 MPDZ RIBC2 SPAST TWIST1 ZBTB38
Systolic blood pressure, automated reading 2.08 9 6 13.3 0.78 1.4e-02 ARL17B C4orf22 HEXIM1 LRRC37A LRRC37A17P MKLN1-AS2 RSRC1 SRR TRPC4AP
Diabetes (father) 1.46 2 0 0.0 0.00 1.0e+00 CDKAL1 ZFP36L2
Diabetes (mother) 1.42 2 0 0.0 0.00 1.0e+00 CDKAL1 ZHX3
Impedance of leg (right) 1.52 19 8 17.8 0.25 3.0e-01 ARL17B ATF1 CTCF HEXIM1 KANSL1 LRRC37A MAPRE1 MASP2 MPDZ MVB12B MYEOV PLEKHH2 RIBC2 RLTPR RP4-635E18.7 SUPT3H WARS2 ZFP36L2 ZHX3
Leg fat-free mass (left) 1.76 10 8 17.8 -0.64 4.7e-02 CENPW CTNNB1 EXOSC5 HEXIM1 MAPRE1 MASP2 RP4-635E18.7 SCFD2 TRPC4AP ZBTB38
Trunk fat percentage 1.55 12 6 13.3 0.56 5.7e-02 ARL17B ATF1 C10orf11 CENPW CTNNB1 HMGB1 LRRC37A LRRC37A17P LRRC37A2 TRMT11 ZBTB38 ZHX3
Hand grip strength (right) 1.73 9 6 13.3 0.69 4.0e-02 ARL17B HEXIM1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P MAPRE1 TRPC4AP ZBTB38
Fed-up feelings 1.93 6 5 11.1 -1.00 1.4e-05 ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Relative age voice broke 3.01 7 6 13.3 -1.00 1.7e-06 ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P MKLN1-AS2
Age when periods started (menarche) 1.41 3 2 4.4 0.00 1.0e+00 CENPW CRTC2 ZFHX4
Heel bone mineral density (BMD) T-score, automated (left) 2.10 7 5 11.1 -0.19 6.8e-01 CRTC3 SRR SUPT3H TMEM258 TRPC4AP WARS2 ZHX3
Qualifications: CSEs or equivalent 1.73 1 0 0.0 0.00 1.0e+00 KANSL1
High blood pressure 1.80 6 4 8.9 0.78 6.9e-02 ARL17B C4orf22 HEXIM1 PRDM8 RP3-465N24.5 TCF4
Hayfever, allergic rhinitis or eczema 1.45 3 2 4.4 0.00 1.0e+00 CRTC3 S100A11 ZBTB38
Medication: Atenolol 1.34 1 0 0.0 0.00 1.0e+00 MYEOV
Medication: Levothyroxine sodium 0.97 2 1 2.2 0.00 1.0e+00 CTCF TMEM258
Sitting height 3.27 26 17 37.8 0.03 8.8e-01 ARL17B ATF1 CENPW CTNNB1 DENND2A DLG5 EXOSC5 FAM136A HEXIM1 KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P MASP2 RIBC2 RP4-635E18.7 RSRC1 SCFD2 SPAST SUPT3H TMEM258 TRMT11 TRPC4AP TWIST1 ZBTB38
High blood pressure (mother) 1.26 2 0 0.0 0.00 1.0e+00 AUTS2 C4orf22
Body mass index (BMI) 0.78 3 1 2.2 0.00 1.0e+00 HMGB1 PPP2R3A RP4-635E18.7
Impedance of leg (left) 1.54 18 9 20.0 0.44 6.9e-02 ARL17B ATF1 CTCF HEXIM1 KANSL1 LRRC37A LRRC37A17P MAPRE1 MASP2 MPDZ MVB12B PLEKHH2 RIBC2 RLTPR RP4-635E18.7 SUPT3H WARS2 ZFP36L2
Leg predicted mass (left) 1.76 11 8 17.8 -0.64 3.6e-02 CENPW CTNNB1 EXOSC5 HEXIM1 MAPRE1 MASP2 RP4-635E18.7 SCFD2 SUPT3H TRPC4AP ZBTB38
Trunk fat mass 1.43 10 5 11.1 0.25 4.8e-01 ARL17B ATF1 CTNNB1 HMGB1 LRRC37A LRRC37A2 METTL10 RP4-635E18.7 ZBTB38 ZHX3
Waist circumference 0.99 3 2 4.4 0.00 1.0e+00 CTNNB1 HMGB1 ZBTB38
Past tobacco smoking 1.30 3 0 0.0 0.00 1.0e+00 ARL17B SRR TRPC4AP
Nervous feelings 2.13 6 5 11.1 -0.81 5.3e-02 ARL17B CENPW LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Frequency of tenseness / restlessness in last 2 weeks 2.04 6 5 11.1 -0.99 2.4e-05 ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Hearing difficulty/problems with background noise 1.70 3 0 0.0 0.00 1.0e+00 ARL17B LRRC37A LRRC37A4P
Hair/balding pattern: Pattern 2 5.87 17 9 20.0 -0.78 2.2e-04 ARL17B C10orf11 C4orf22 CENPW CPEB2 EPC1 GORAB KANSL1 LRRC37A LRRC37A17P LRRC37A2 PRDM8 PRRX1 RPL41P1 S100A11 SSPN TWIST1
Forced vital capacity (FVC) 3.40 17 12 26.7 0.33 1.7e-01 ARL17B C10orf11 CENPW CTB-36H16.2 CTNNB1 DENND2A FAM136A KANSL1 LOC285733 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P PLXNA1 RP3-465N24.5 RSRC1 ZBTB38
Heel bone mineral density (BMD) T-score, automated (right) 1.99 8 5 11.1 -0.08 8.5e-01 CRTC3 SRR SUPT3H TMEM258 TRPC4AP WARS2 ZBTB38 ZHX3
Ever unenthusiastic/disinterested for a whole week 1.79 4 0 0.0 -1.00 1.4e-03 ARL17B KANSL1 LRRC37A LRRC37A17P
Qualifications: None of the above 1.29 1 0 0.0 0.00 1.0e+00 EMC2
Allergy 1.32 6 1 2.2 0.06 9.1e-01 CLIC4 CRTC2 CRTC3 HEXIM1 TMEM258 ZBTB38
Medication: Simvastatin 1.22 2 0 0.0 0.00 1.0e+00 MYEOV TMEM258
Fluid intelligence score 1.13 1 0 0.0 0.00 1.0e+00 CRTC2
Neuroticism score 2.65 6 6 13.3 -0.99 2.5e-05 ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Weight 1.46 8 6 13.3 -0.61 1.1e-01 CENPW CTNNB1 EXOSC5 MASP2 RP4-635E18.7 SCFD2 TRPC4AP ZBTB38
Impedance of arm (right) 1.52 15 7 15.6 0.65 4.6e-03 ARL17B ATF1 CCDC117 CENPW HEXIM1 LRRC37A LRRC37A17P LRRC37A2 MASP2 MPDZ PPP2R3A RP4-635E18.7 TCF4 TRMT11 WARS2
Arm fat percentage (right) 0.97 3 1 2.2 0.00 1.0e+00 CENPW HMGB1 SRR
Trunk fat-free mass 2.38 14 9 20.0 -0.74 2.6e-03 CENPW CRTC3 CTNNB1 DLG5 EXOSC5 FAM136A HEXIM1 MASP2 RP4-635E18.7 SCFD2 SEPT2 TRMT11 TRPC4AP ZBTB38
Hip circumference 1.30 9 2 4.4 -0.45 2.2e-01 CTNNB1 MASP2 PRRX1 RP4-635E18.7 SCFD2 TRPC4AP WARS2 ZBTB38 ZHX3
Time employed in main current job 1.75 2 0 0.0 0.00 1.0e+00 LRRC37A17P LRRC37A2
Father's age at death 1.15 1 0 0.0 0.00 1.0e+00 TWIST1
Worrier / anxious feelings 1.66 6 4 8.9 -0.88 2.2e-02 ARL17B LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P SNX2
Hair/balding pattern: Pattern 3 9.59 22 14 31.1 0.83 3.3e-07 ARL17B C4orf22 CENPW HEXIM1 KANSL1 LGR4 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P MIR3614 PRDM8 RBP1 RP11-219D15.3 RP11-33O4.1 RPL41P1 S100A11 SPAST SSPN TWIST1 TWIST2 ZHX3
Number of live births 1.70 4 0 0.0 -0.79 2.1e-01 ARL17B LRRC37A LRRC37A17P TMEM258
Forced expiratory volume in 1-second (FEV1) 3.23 14 11 24.4 0.42 1.1e-01 ARL17B C10orf11 CENPW CTB-36H16.2 CTNNB1 FAM136A KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P RP3-465N24.5 RSRC1 ZBTB38
Pulse rate 1.40 4 2 4.4 0.08 9.2e-01 CTNNB1 MKLN1-AS2 TMEM258 ZBTB38
Noisy workplace 1.34 1 0 0.0 0.00 1.0e+00 CRTC2
Qualifications: A levels/AS levels or equivalent 1.20 2 0 0.0 0.00 1.0e+00 ARL17B LRRC37A
Asthma 1.06 1 1 2.2 0.00 1.0e+00 TMEM258
Medication: Ibuprofen (e.g. Nurofen) 1.70 1 0 0.0 0.00 1.0e+00 LRRC37A
Medication: Cholesterol lowering 1.10 1 0 0.0 0.00 1.0e+00 HMGB1
Forced expiratory volume in 1-second (FEV1), Best measure 3.07 14 11 24.4 0.46 8.7e-02 ARL17B C10orf11 CENPW CTB-36H16.2 CTNNB1 FAM136A KANSL1 LOC285733 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P SNX2 ZBTB38
Impedance of arm (left) 1.63 16 8 17.8 0.72 7.2e-04 ARL17B ATF1 CCDC117 CENPW HEXIM1 KANSL1 LRRC37A LRRC37A17P LRRC37A2 MASP2 MPDZ PPP2R3A RP4-635E18.7 TCF4 TRMT11 WARS2
Arm fat mass (right) 0.92 5 1 2.2 -0.35 5.6e-01 CTNNB1 HMGB1 MASP2 RP4-635E18.7 ZBTB38
Trunk predicted mass 2.37 14 9 20.0 -0.74 2.5e-03 CENPW CRTC3 CTNNB1 DLG5 EXOSC5 FAM136A HEXIM1 MASP2 RP4-635E18.7 SCFD2 SEPT2 TRMT11 TRPC4AP ZBTB38
Standing height 3.10 35 26 57.8 -0.20 2.4e-01 ARL17B ATF1 CENPW CLIC4 CRTC3 CTCF CTNNB1 DENND2A DLG5 EXOSC5 FAM136A HEXIM1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P MASP2 METTL10 PLEKHH2 PPP2R3A RIBC2 RLTPR RP11-33O4.1 RP3-465N24.5 RP4-635E18.7 RSRC1 SCFD2 SEPT2 SPAST TMEM258 TRMT11 TRPC4AP TWIST1 WNT6 ZBTB38
Birth weight of first child 1.46 2 1 2.2 0.00 1.0e+00 ZBTB38 ZFHX4
Peak expiratory flow (PEF) 2.12 8 5 11.1 0.85 7.7e-03 ARL17B C10orf11 KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P ZFP36L2
Medication: Paracetamol 2.61 6 6 13.3 -0.99 3.1e-04 ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Headache pain in last month 2.59 7 6 13.3 -0.91 1.7e-03 ARL17B EXOSC5 KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Medication for cholesterol, blood pressure or diabetes 1.25 1 0 0.0 0.00 1.0e+00 C4orf22
Hypothyroidism/myxoedema (self-reported) 0.99 1 1 2.2 0.00 1.0e+00 TMEM258
Birth weight 1.22 2 0 0.0 0.00 1.0e+00 CENPW SRR
High blood pressure (siblings) 1.50 1 0 0.0 0.00 1.0e+00 HEXIM1
Forced vital capacity (FVC), Best measure 3.38 15 11 24.4 0.29 2.6e-01 ARL17B C10orf11 CENPW CTB-36H16.2 CTNNB1 FAM136A KANSL1 LOC285733 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P RSRC1 TWIST1 ZBTB38
Body fat percentage 1.31 10 3 6.7 0.50 1.4e-01 ARL17B ATF1 C10orf11 CENPW CTNNB1 HMGB1 LRRC37A2 TRMT11 ZBTB38 ZHX3
Leg fat percentage (right) 1.14 6 2 4.4 0.35 4.9e-01 CENPW HMGB1 PRRX1 RSRC1 SPAST ZHX3
Arm fat-free mass (right) 1.99 12 7 15.6 -0.71 9.2e-03 CENPW CTNNB1 DLG5 EXOSC5 HEXIM1 MASP2 RP4-635E18.7 SCFD2 SUPT3H TRMT11 TRPC4AP ZBTB38
Comparative body size at age 10 1.15 3 2 4.4 0.00 1.0e+00 ETAA1 KANSL1 SRR
Number of full brothers 1.24 2 0 0.0 0.00 1.0e+00 ARL17B LRRC37A2
Worry too long after embarrassment 1.41 3 0 0.0 0.00 1.0e+00 LRRC37A LRRC37A17P LRRC37A2
Wheeze or whistling in the chest in last year 1.30 1 0 0.0 0.00 1.0e+00 TMEM258
Qualifications: College or University degree 1.34 7 5 11.1 0.98 6.2e-05 ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P TRPC4AP
Medication for pain relief, constipation, heartburn 2.01 7 3 6.7 0.97 3.1e-04 ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P PRDM8
Medication: Blood pressure 1.41 2 2 4.4 0.00 1.0e+00 C4orf22 PRDM8
Mean time to correctly identify matches 0.94 1 0 0.0 0.00 1.0e+00 KANSL1
Whole body fat mass 1.20 6 4 8.9 -0.43 4.0e-01 CTNNB1 HMGB1 MASP2 RP4-635E18.7 ZBTB38 ZHX3
Leg fat mass (right) 1.01 6 3 6.7 -0.44 3.8e-01 CTNNB1 HMGB1 MASP2 RP4-635E18.7 ZBTB38 ZHX3
Arm predicted mass (right) 1.96 12 7 15.6 -0.72 8.9e-03 CENPW CTNNB1 DLG5 EXOSC5 HEXIM1 MASP2 RP4-635E18.7 SCFD2 SUPT3H TCF4 TRPC4AP ZBTB38
Pulse rate, automated reading 1.71 7 4 8.9 -0.41 3.2e-01 C4orf22 CTNNB1 KIAA0922 MKLN1-AS2 TMEM258 ZBTB38 ZHX3
Alcohol intake frequency. 1.51 7 4 8.9 -0.99 2.2e-05 ARL17B AUTS2 KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Comparative height size at age 10 3.39 27 19 42.2 -0.14 4.7e-01 ARL17B CENPW CRTC3 CTCF CTNNB1 DLG5 EXOSC5 FAM136A LRRC37A LRRC37A17P LRRC37A2 MAPRE1 MASP2 METTL10 PLEKHH2 PPP2R3A RLTPR RP11-33O4.1 RP4-635E18.7 SEPT2 TRMT11 TRPC4AP TWIST1 WARS2 ZBTB38 ZFHX4 ZFP36L2
Suffer from 'nerves' 1.21 1 0 0.0 0.00 1.0e+00 LRRC37A2
Overall health rating 1.22 3 0 0.0 0.00 1.0e+00 AUTS2 HEXIM1 SPAST
Supplements: Vitamin C 1.57 1 0 0.0 0.00 1.0e+00 LRRC37A17P
Hypertension (Self-reported) 1.82 6 4 8.9 0.77 7.2e-02 ARL17B C4orf22 CLIC4 HEXIM1 PRDM8 RP3-465N24.5
Forced expiratory volume in 1-second (FEV1), predicted 1.92 3 2 4.4 0.00 1.0e+00 CENPW HEXIM1 ZBTB38
Whole body fat-free mass 2.13 13 9 20.0 -0.72 5.2e-03 CENPW CTNNB1 DLG5 EXOSC5 HEXIM1 MASP2 RP4-635E18.7 SCFD2 SEPT2 SUPT3H TRMT11 TRPC4AP ZBTB38
Leg fat-free mass (right) 1.79 12 8 17.8 -0.65 2.2e-02 CENPW CTNNB1 DLG5 EXOSC5 HEXIM1 MAPRE1 MASP2 RP4-635E18.7 SCFD2 SUPT3H TRPC4AP ZBTB38
Arm fat percentage (left) 1.02 3 1 2.2 0.00 1.0e+00 CENPW HMGB1 SRR
Handedness (chirality/laterality): Left-handed 2.19 4 3 6.7 0.98 2.9e-03 ARL17B LRRC37A LRRC37A17P LRRC37A2
Mood swings 2.38 6 6 13.3 -0.99 1.8e-05 ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Loneliness, isolation 1.56 3 0 0.0 0.00 1.0e+00 ARL17B LRRC37A LRRC37A2
Diabetes diagnosed by doctor 1.32 2 0 0.0 0.00 1.0e+00 CENPW ZFP36L2
Mouth/teeth dental problems: Mouth ulcers 2.09 6 4 8.9 -0.99 2.6e-05 ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Medication for cholesterol 1.56 2 0 0.0 0.00 1.0e+00 C4orf22 MYEOV
Asthma (self-reported) 1.03 1 1 2.2 0.00 1.0e+00 TMEM258
Medication: Gliclazide 1.25 1 0 0.0 0.00 1.0e+00 SSPN
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.57 8 6 13.3 0.85 4.1e-03 ARL17B C10orf11 EPC1 KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Whole body water mass 2.11 13 9 20.0 -0.72 5.3e-03 CENPW CTNNB1 DLG5 EXOSC5 HEXIM1 MASP2 RP4-635E18.7 SCFD2 SEPT2 SUPT3H TRMT11 TRPC4AP ZBTB38
Leg predicted mass (right) 1.79 12 8 17.8 -0.65 2.1e-02 CENPW CTNNB1 DLG5 EXOSC5 HEXIM1 MAPRE1 MASP2 RP4-635E18.7 SCFD2 SUPT3H TRPC4AP ZBTB38
Arm fat mass (left) 0.91 5 2 4.4 -0.33 5.8e-01 CTNNB1 HMGB1 MASP2 RP4-635E18.7 ZBTB38
Average weekly champagne plus white wine intake 1.83 6 1 2.2 0.82 4.8e-02 ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A4P TMEM258
Miserableness 1.80 6 4 8.9 -1.00 2.4e-05 ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Guilty feelings 1.72 3 0 0.0 0.00 1.0e+00 KANSL1 LRRC37A LRRC37A17P
Medication: Blood pressure 1.99 6 1 2.2 0.95 4.2e-03 ARL17B C4orf22 HEXIM1 KANSL1 LRRC37A MYEOV
Supplements: Fish oil (including cod liver oil) 1.05 2 0 0.0 0.00 1.0e+00 HEXIM1 TMEM258
High cholesterol (Self-reported) 1.16 2 0 0.0 0.00 1.0e+00 FAM136A TMEM258
Medication: Paracetamol 2.55 6 5 11.1 -0.99 2.6e-04 ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Illnesses of father: High blood pressure 1.30 1 0 0.0 0.00 1.0e+00 C4orf22
Ever smoked 1.13 2 0 0.0 0.00 1.0e+00 CTNNB1 SRR
Basal metabolic rate 1.94 10 9 20.0 -0.70 2.4e-02 CENPW CTNNB1 DLG5 EXOSC5 HEXIM1 MASP2 RP4-635E18.7 SCFD2 TRPC4AP ZBTB38
Leg fat percentage (left) 1.10 5 2 4.4 0.50 3.9e-01 CENPW HMGB1 RSRC1 SPAST ZHX3
Arm fat-free mass (left) 1.96 10 7 15.6 -0.70 2.5e-02 CENPW CTNNB1 DLG5 EXOSC5 HEXIM1 MASP2 RP4-635E18.7 SCFD2 TRPC4AP ZBTB38
Irritability 2.00 8 4 8.9 -0.90 2.3e-03 ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P TMEM258 ZFHX4
Ever had prostate specific antigen (PSA) test 1.39 1 0 0.0 0.00 1.0e+00 ZBTB38
Fractured/broken bones in last 5 years 1.82 2 0 0.0 0.00 1.0e+00 ARL17B SCFD2
Diastolic blood pressure, automated reading 1.50 8 4 8.9 0.80 1.7e-02 ATF1 C4orf22 CLIC4 CTNNB1 HEXIM1 RSRC1 SRR ZHX3
Myopia 1.32 1 0 0.0 0.00 1.0e+00 ARL17B
Vascular/heart problems diagnosed by doctor 1.70 6 2 4.4 -0.76 8.0e-02 ARL17B C4orf22 CRTC2 HEXIM1 PRDM8 RP3-465N24.5
Cholesterol lowering medication 1.15 1 0 0.0 0.00 1.0e+00 ARHGEF19
Pain experienced in last month 1.32 1 0 0.0 0.00 1.0e+00 CENPW
Impedance of whole body 1.68 17 12 26.7 0.62 5.6e-03 ARL17B ATF1 CCDC117 CENPW HEXIM1 KANSL1 LRRC37A LRRC37A17P LRRC37A2 MASP2 MPDZ MYEOV RIBC2 RLTPR RP4-635E18.7 TRMT11 WARS2
Leg fat mass (left) 0.98 6 3 6.7 -0.44 3.9e-01 CTNNB1 HMGB1 MASP2 RP4-635E18.7 ZBTB38 ZHX3
Arm predicted mass (left) 1.92 9 7 15.6 -0.69 4.0e-02 CENPW CTNNB1 EXOSC5 HEXIM1 MASP2 RP4-635E18.7 SCFD2 TRPC4AP ZBTB38

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 20 0.57 2.3
GTEx Adipose Visceral Omentum 11 0.54 2.6
GTEx Adrenal Gland 13 0.89 2.7
GTEx Artery Aorta 23 0.77 2.6
GTEx Artery Coronary 16 1.35 3.9
GTEx Artery Tibial 19 0.51 2.2
GTEx Brain Caudate basal ganglia 10 1.09 3.4
GTEx Brain Cerebellar Hemisphere 13 0.87 3.0
GTEx Brain Cerebellum 15 0.76 2.7
GTEx Brain Cortex 10 0.97 3.5
GTEx Brain Frontal Cortex BA9 12 1.30 3.5
GTEx Brain Hippocampus 6 1.15 4.0
GTEx Brain Hypothalamus 7 1.19 4.0
GTEx Brain Nucleus accumbens basal ganglia 10 1.16 3.6
GTEx Brain Putamen basal ganglia 7 1.12 3.7
GTEx Breast Mammary Tissue 14 0.71 2.8
GTEx Breast Mammary Tissue (Male) 11 0.92 3.5
GTEx Breast Mammary Tissue (Female) 15 0.91 3.0
GTEx Cells EBV-transformed lymphocytes 14 0.98 3.4
GTEx Cells Transformed fibroblasts 27 0.64 2.4
GTEx Colon Sigmoid 10 0.68 3.0
GTEx Colon Transverse 15 0.73 2.8
GTEx Esophagus Gastroesophageal Junction 16 1.11 3.2
GTEx Esophagus Mucosa 19 0.57 2.5
GTEx Esophagus Muscularis 22 0.68 2.5
GTEx Heart Atrial Appendage 11 0.70 2.8
GTEx Heart Left Ventricle 11 0.72 2.8
GTEx Liver 7 0.98 3.2
GTEx Lung 23 0.80 2.7
GTEx Muscle Skeletal 17 0.59 2.5
GTEx Nerve Tibial 27 0.62 2.4
GTEx Ovary 9 0.99 3.5
GTEx Pancreas 14 0.86 3.1
GTEx Pituitary 11 0.99 3.0
GTEx Prostate 6 0.72 3.1
GTEx Skin Not Sun Exposed Suprapubic 17 0.69 2.6
GTEx Skin Sun Exposed Lower leg 19 0.52 2.5
GTEx Small Intestine Terminal Ileum 4 0.87 3.7
GTEx Spleen 11 0.78 2.8
GTEx Stomach 17 1.17 3.2
GTEx Testis 22 0.70 2.6
GTEx Thyroid 29 0.73 2.5
GTEx Uterus 7 1.23 4.4
GTEx Vagina 8 1.26 3.9
GTEx Whole Blood 12 0.60 2.6
METSIM Adipose 16 0.35 1.8
NTR Blood 9 0.37 2.1
ROSMAP Brain Pre-frontal Cortex 6 0.14 1.7
YFS Blood 16 0.35 1.7
CommonMind Brain Pre-frontal Cortex 29 0.54 2.0
The Cancer Genome Atlas Bladder Urothelial Carcinoma 10 0.60 2.3
The Cancer Genome Atlas Breast Invasive Carcinoma 17 0.39 2.0
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 7 0.64 2.4
The Cancer Genome Atlas Colon Adenocarcinoma 9 0.44 2.0
The Cancer Genome Atlas Esophageal Carcinoma 4 0.58 2.9
The Cancer Genome Atlas Glioblastoma Multiforme 5 0.49 2.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 13 0.48 1.9
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 21 0.51 2.0
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 4 0.20 1.9
The Cancer Genome Atlas Brain Lower Grade Glioma 20 0.46 2.1
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 5 0.45 2.3
The Cancer Genome Atlas Lung Adenocarcinoma 13 0.44 2.1
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 11 0.44 2.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 9 0.57 2.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 8 0.48 2.1
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 7 0.53 2.5
The Cancer Genome Atlas Prostate Adenocarcinoma 24 0.52 2.1
The Cancer Genome Atlas Rectum Adenocarcinoma 5 0.72 2.8
The Cancer Genome Atlas Soft Tissue Sarcoma 7 0.66 2.6
The Cancer Genome Atlas Skin Cutaneous Melanoma 1 0.19 2.3
The Cancer Genome Atlas Stomach Adenocarcinoma 8 0.48 2.4
The Cancer Genome Atlas Testicular Germ Cell Tumors 8 0.63 2.2
The Cancer Genome Atlas Thyroid Carcinoma 24 0.47 1.9
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 3 0.59 2.6