Hub : Traits :

Hair/balding pattern: Pattern 4

956 significantly associated models · 187 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	10391536	12013869	4	2	8.5e-24	5.8e-84	1.5e-47	44	MASP2 RP4-635E18.7
2	1	15829187	16844848	1	1	8.9e-08	1.9e-06	9.5e-03	70	ARHGEF19
3	1	23994201	26380805	6	3	1.2e-21	2.2e-44	1.4e-46	-5	CLIC4 RCAN3 RP3-465N24.5
4	1	40628071	42021616	1	1	6.8e-08	6.2e-18	3.3e-13	29	CITED4
5	1	117708477	120517959	3	2	8.9e-28	2.1e-33	2.5e-25	26	GDAP2 WARS2
6	1	151313774	152712747	1	1	1.5e-12	1.1e-19	1.1e-08	60	S100A11
7	1	152880672	154625632	2	2	1.2e-09	1.1e-09	1.0e+00	100	CRTC2 S100A16
8	1	168932500	171407761	5	7	9.2e-36	2.6e-44	5.8e-01	100	GORAB KIFAP3 PRRX1 SCYL3
9	2	31589414	33088870	2	1	6.2e-11	4.2e-22	1.1e-12	46	SPAST
10	2	42753863	44690514	2	2	3.3e-08	2.8e-11	1.3e-02	86	PLEKHH2 ZFP36L2
11	2	66927859	68326904	1	2	9.4e-11	9.1e-21	1.2e-20	1	ETAA1
12	2	69829251	71228388	1	1	7.8e-08	9.0e-06	2.3e-01	93	FAM136A
13	2	218736292	220632013	3	2	2.7e-08	1.8e-14	1.7e-06	61	RP11-33O4.1 WNT6
14	2	239510492	240078905	1	1	4.3e-15	9.9e-48	1.8e-35	27	TWIST2
15	2	241430049	242849135	2	2	7.2e-08	8.1e-07	1.0e-01	89	ANO7 SEPT2
16	3	40537829	41986787	1	1	2.2e-08	1.4e-08	4.3e-02	87	CTNNB1
17	3	124951821	127452273	2	2	3.8e-11	3.3e-27	1.5e-23	14	ALG1L PLXNA1
18	3	134986214	136558759	1	1	8.4e-09	7.3e-09	1.0e+00	100	PPP2R3A
19	3	138380069	139954262	4	3	6.8e-22	2.4e-86	7.5e-61	30	RBP1 RP11-219D15.3
20	3	140350567	141867638	1	1	3.3e-18	3.1e-19	1.0e+00	100	ZBTB38
21	3	151262987	152878838	1	1	1.5e-14	8.8e-17	1.2e-09	46	MBNL1
22	3	157127290	158951696	1	2	2.8e-08	6.7e-18	1.0e-08	56	RSRC1
23	4	14764460	15315535	1	1	1.8e-07	3.9e-08	5.4e-02	88	CPEB2
24	4	53494816	54762082	3	2	7.0e-10	2.7e-10	1.0e+00	100	LNX1 SCFD2
25	4	80407869	82578407	3	2	7.5e-39	8.0e-40	1.0e+00	100	C4orf22 PRDM8
26	4	107145847	108895012	1	1	5.2e-10	6.2e-13	6.0e-07	52	DKK2
27	4	153688776	155252934	1	1	1.4e-08	1.1e-09	1.9e-02	85	KIAA0922
28	5	121480516	123054717	3	2	1.9e-11	1.5e-20	2.7e-13	38	CTB-36H16.2 SNX2
29	5	171053425	172577403	1	1	3.8e-12	9.8e-14	1.0e+00	100	SH3PXD2B
30	6	240232	940771	1	1	3.0e-07	2.3e-19	3.1e-16	18	EXOC2
31	6	19840492	21930988	1	1	4.9e-08	2.4e-16	7.8e-17	-3	CDKAL1
32	6	37093486	38816574	1	1	1.1e-07	8.7e-08	3.0e-01	96	ZFAND3
33	6	44079216	46043561	1	1	3.6e-14	7.8e-22	4.2e-12	48	SUPT3H
34	6	105033213	107467855	2	2	9.6e-12	2.9e-26	7.2e-19	30	ATG5 PREP
35	6	110883139	112286687	1	1	2.0e-07	9.5e-10	3.8e-14	-53	KIAA1919
36	6	125970401	127355237	2	2	7.4e-27	1.2e-27	1.6e-01	98	CENPW TRMT11
37	6	130901240	131402416	1	1	1.5e-07	2.8e-11	1.5e-06	48	LOC285733
38	6	169458730	170872572	1	1	3.9e-09	8.0e-11	2.2e-04	68	ERMARD
39	7	18364750	19854141	1	2	6.4e-75	1.8e-113	4.0e-48	58	TWIST1
40	7	68365245	70954231	1	1	6.8e-09	1.2e-63	4.1e-60	6	AUTS2
41	7	130101373	131880252	2	2	3.6e-12	4.3e-16	3.7e-04	81	MKLN1-AS2
42	7	139519806	141031540	1	1	2.3e-08	7.0e-09	9.7e-03	80	DENND2A
43	8	77356394	78026317	1	1	7.9e-08	5.2e-11	2.3e-05	58	ZFHX4
44	8	108216908	110190556	4	2	5.3e-19	2.3e-25	2.0e-09	67	EMC2 RSPO2
45	9	12410173	13977570	1	1	7.5e-12	1.5e-12	3.7e-02	91	MPDZ
46	9	128394623	129961152	2	1	1.0e-11	1.5e-14	2.2e-05	70	MVB12B
47	10	31857752	33353843	1	1	2.8e-07	7.0e-11	5.3e-05	62	EPC1
48	10	76664253	80383574	3	3	6.3e-31	1.8e-35	2.6e-08	80	C10orf11 DLG5
49	10	125455780	127372751	4	2	2.1e-19	3.7e-34	1.4e-11	69	LHPP METTL10
50	11	26693196	28189639	1	1	1.9e-09	6.7e-11	1.0e-02	84	LGR4
51	11	43888194	45340720	1	1	2.3e-07	1.7e-30	2.3e-25	18	CD82
52	11	60839578	62290719	4	1	1.8e-08	2.3e-08	1.0e+00	100	TMEM258
53	11	68367007	69880281	1	1	5.0e-10	9.7e-10	1.5e-09	2	MYEOV
54	12	26099201	26643931	1	1	2.6e-20	1.4e-30	6.2e-12	64	SSPN
55	12	28611779	30185513	2	2	4.3e-11	9.1e-22	1.0e-10	55	FAR2 RP11-996F15.2
56	12	49780778	51912062	7	1	4.8e-11	7.9e-10	6.3e-01	99	ATF1
57	13	30336006	31886850	1	1	4.3e-11	4.4e-18	9.2e-17	8	HMGB1
58	15	89921477	91886448	4	1	7.4e-13	8.4e-12	1.0e+00	100	CRTC3
59	16	66666637	68802936	15	2	1.1e-18	4.6e-15	3.7e-01	99	CTCF RLTPR
60	17	1263564	2923933	2	1	1.3e-12	6.4e-12	1.3e-01	95	SRR
61	17	39399566	39838104	1	1	2.6e-08	1.4e-06	1.6e-01	92	KRT34
62	17	42413481	45876022	32	8	5.6e-67	1.0e-58	1.0e+00	100	ARL17B HEXIM1 KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
63	17	54272304	55667722	1	1	3.9e-09	3.8e-32	7.0e-25	24	MIR3614
64	17	78966915	79461486	1	1	1.5e-07	6.3e-07	1.0e-03	56	C17orf89
65	18	52648055	53545463	1	1	7.9e-10	9.8e-12	1.9e-08	32	TCF4
66	19	41165252	42626207	7	1	1.5e-13	2.4e-13	1.0e+00	100	EXOSC5
67	20	21043102	22430527	1	1	7.1e-33	1.7e-125	3.7e-96	24	RPL41P1
68	20	30716979	32128889	1	1	6.7e-08	1.1e-07	2.6e-01	96	MAPRE1
69	20	32254831	34484245	4	1	3.4e-08	2.8e-07	5.0e-01	98	TRPC4AP
70	20	39114404	40683594	4	1	2.7e-15	6.9e-22	4.1e-08	67	ZHX3
71	22	28478985	29894210	2	2	6.5e-13	2.7e-13	2.4e-01	97	CCDC117
72	22	45566702	46074258	1	1	6.9e-08	2.2e-11	6.4e-05	64	RIBC2

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Hair/balding pattern: Pattern 3	9.59	22	14	31.1	0.83	3.3e-07	ARL17B C4orf22 CENPW HEXIM1 KANSL1 LGR4 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P MIR3614 PRDM8 RBP1 RP11-219D15.3 RP11-33O4.1 RPL41P1 S100A11 SPAST SSPN TWIST1 TWIST2 ZHX3
Relative age of first facial hair	5.90	18	10	22.2	-0.90	1.7e-07	ARL17B C4orf22 ETAA1 HEXIM1 KANSL1 LNX1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P MASP2 MIR3614 MKLN1-AS2 MPDZ RIBC2 SPAST TWIST1 ZBTB38
Hair/balding pattern: Pattern 2	5.87	17	9	20.0	-0.78	2.2e-04	ARL17B C10orf11 C4orf22 CENPW CPEB2 EPC1 GORAB KANSL1 LRRC37A LRRC37A17P LRRC37A2 PRDM8 PRRX1 RPL41P1 S100A11 SSPN TWIST1
Blood Red Count	3.53	23	15	33.3	-0.77	7.7e-06	ARL17B ATF1 AUTS2 C4orf22 CCDC117 CENPW CLIC4 CTCF FAM136A HEXIM1 KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P RLTPR SEPT2 SUPT3H TMEM258 TRPC4AP ZBTB38 ZFAND3 ZFP36L2
Lung FVC	3.50	20	16	35.6	0.44	4.2e-02	ARL17B ATF1 C10orf11 C17orf89 CENPW CTB-36H16.2 DENND2A FAM136A KANSL1 LOC285733 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P PLXNA1 RCAN3 RSRC1 TRPC4AP TWIST1 ZBTB38
Forced vital capacity (FVC)	3.40	17	12	26.7	0.33	1.7e-01	ARL17B C10orf11 CENPW CTB-36H16.2 CTNNB1 DENND2A FAM136A KANSL1 LOC285733 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P PLXNA1 RP3-465N24.5 RSRC1 ZBTB38
Comparative height size at age 10	3.39	27	19	42.2	-0.14	4.7e-01	ARL17B CENPW CRTC3 CTCF CTNNB1 DLG5 EXOSC5 FAM136A LRRC37A LRRC37A17P LRRC37A2 MAPRE1 MASP2 METTL10 PLEKHH2 PPP2R3A RLTPR RP11-33O4.1 RP4-635E18.7 SEPT2 TRMT11 TRPC4AP TWIST1 WARS2 ZBTB38 ZFHX4 ZFP36L2
Forced vital capacity (FVC), Best measure	3.38	15	11	24.4	0.29	2.6e-01	ARL17B C10orf11 CENPW CTB-36H16.2 CTNNB1 FAM136A KANSL1 LOC285733 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P RSRC1 TWIST1 ZBTB38
Heel T-Score	3.37	38	31	68.9	0.30	5.5e-02	ARHGEF19 ARL17B ATF1 CCDC117 CPEB2 CRTC3 CTCF CTNNB1 EXOSC5 GORAB HEXIM1 KANSL1 LNX1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P MASP2 MPDZ PLEKHH2 PRRX1 RIBC2 RLTPR RP4-635E18.7 RSPO2 SPAST SRR SSPN SUPT3H TCF4 TMEM258 TRMT11 TRPC4AP TWIST1 WARS2 ZBTB38 ZFP36L2 ZHX3
Height	3.27	53	40	88.9	-0.10	4.8e-01	ALG1L ANO7 ARL17B ATF1 AUTS2 C10orf11 CENPW CLIC4 CRTC3 CTCF CTNNB1 DENND2A DLG5 EXOSC5 FAM136A GORAB HEXIM1 KANSL1 KIAA1919 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P MAPRE1 MASP2 METTL10 MIR3614 MKLN1-AS2 MPDZ PLEKHH2 PPP2R3A RIBC2 RLTPR RP11-33O4.1 RP11-996F15.2 RP3-465N24.5 RP4-635E18.7 RPL41P1 RSRC1 SCFD2 SEPT2 SPAST SRR SUPT3H TMEM258 TRMT11 TRPC4AP TWIST1 WARS2 WNT6 ZBTB38 ZFHX4 ZFP36L2
Sitting height	3.27	26	17	37.8	0.03	8.8e-01	ARL17B ATF1 CENPW CTNNB1 DENND2A DLG5 EXOSC5 FAM136A HEXIM1 KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P MASP2 RIBC2 RP4-635E18.7 RSRC1 SCFD2 SPAST SUPT3H TMEM258 TRMT11 TRPC4AP TWIST1 ZBTB38
Waist Hip Ratio (WHR)	3.24	25	21	46.7	-0.43	2.7e-02	ARL17B CCDC117 CDKAL1 CENPW CTCF EPC1 ETAA1 HMGB1 KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P MPDZ MYEOV PRRX1 RLTPR RP4-635E18.7 SH3PXD2B SSPN TRMT11 TRPC4AP WARS2 ZBTB38 ZFP36L2
Sensitivity / hurt feelings	3.23	6	6	13.3	-0.99	2.2e-05	ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Forced expiratory volume in 1-second (FEV1)	3.23	14	11	24.4	0.42	1.1e-01	ARL17B C10orf11 CENPW CTB-36H16.2 CTNNB1 FAM136A KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P RP3-465N24.5 RSRC1 ZBTB38
Standing height	3.10	35	26	57.8	-0.20	2.4e-01	ARL17B ATF1 CENPW CLIC4 CRTC3 CTCF CTNNB1 DENND2A DLG5 EXOSC5 FAM136A HEXIM1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P MASP2 METTL10 PLEKHH2 PPP2R3A RIBC2 RLTPR RP11-33O4.1 RP3-465N24.5 RP4-635E18.7 RSRC1 SCFD2 SEPT2 SPAST TMEM258 TRMT11 TRPC4AP TWIST1 WNT6 ZBTB38
Forced expiratory volume in 1-second (FEV1), Best measure	3.07	14	11	24.4	0.46	8.7e-02	ARL17B C10orf11 CENPW CTB-36H16.2 CTNNB1 FAM136A KANSL1 LOC285733 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P SNX2 ZBTB38
Neuroticism (Nagel 2018)	3.06	8	7	15.6	-0.82	6.3e-03	ARL17B CENPW KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P RSRC1
Relative age voice broke	3.01	7	6	13.3	-1.00	1.7e-06	ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P MKLN1-AS2
Neuroticism	2.91	8	6	13.3	-0.82	6.2e-03	ARL17B CENPW KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P RSRC1
Depressed Affect (Nagel 2018)	2.76	6	6	13.3	-0.99	4.3e-06	ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Neuroticism score	2.65	6	6	13.3	-0.99	2.5e-05	ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Medication: Paracetamol	2.61	6	6	13.3	-0.99	3.1e-04	ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Headache pain in last month	2.59	7	6	13.3	-0.91	1.7e-03	ARL17B EXOSC5 KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.57	8	6	13.3	0.85	4.1e-03	ARL17B C10orf11 EPC1 KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Medication: Paracetamol	2.55	6	5	11.1	-0.99	2.6e-04	ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Ovarian Cancer	2.45	6	6	13.3	1.00	3.6e-05	ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Trunk fat-free mass	2.38	14	9	20.0	-0.74	2.6e-03	CENPW CRTC3 CTNNB1 DLG5 EXOSC5 FAM136A HEXIM1 MASP2 RP4-635E18.7 SCFD2 SEPT2 TRMT11 TRPC4AP ZBTB38
Mood swings	2.38	6	6	13.3	-0.99	1.8e-05	ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Trunk predicted mass	2.37	14	9	20.0	-0.74	2.5e-03	CENPW CRTC3 CTNNB1 DLG5 EXOSC5 FAM136A HEXIM1 MASP2 RP4-635E18.7 SCFD2 SEPT2 TRMT11 TRPC4AP ZBTB38
Prostate Cancer	2.22	4	1	2.2	0.23	7.7e-01	ANO7 CRTC2 MBNL1 SEPT2
Handedness (chirality/laterality): Left-handed	2.19	4	3	6.7	0.98	2.9e-03	ARL17B LRRC37A LRRC37A17P LRRC37A2
Nervous feelings	2.13	6	5	11.1	-0.81	5.3e-02	ARL17B CENPW LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Whole body fat-free mass	2.13	13	9	20.0	-0.72	5.2e-03	CENPW CTNNB1 DLG5 EXOSC5 HEXIM1 MASP2 RP4-635E18.7 SCFD2 SEPT2 SUPT3H TRMT11 TRPC4AP ZBTB38
Peak expiratory flow (PEF)	2.12	8	5	11.1	0.85	7.7e-03	ARL17B C10orf11 KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P ZFP36L2
Systolic Blood Pressure	2.11	16	10	22.2	0.47	6.3e-02	ARL17B ATF1 C4orf22 CLIC4 CPEB2 HEXIM1 LGR4 LRRC37A LRRC37A4P MKLN1-AS2 MYEOV PRDM8 RSRC1 SRR SSPN ZFHX4
Whole body water mass	2.11	13	9	20.0	-0.72	5.3e-03	CENPW CTNNB1 DLG5 EXOSC5 HEXIM1 MASP2 RP4-635E18.7 SCFD2 SEPT2 SUPT3H TRMT11 TRPC4AP ZBTB38
Heel bone mineral density (BMD) T-score, automated (left)	2.10	7	5	11.1	-0.19	6.8e-01	CRTC3 SRR SUPT3H TMEM258 TRPC4AP WARS2 ZHX3
Mouth/teeth dental problems: Mouth ulcers	2.09	6	4	8.9	-0.99	2.6e-05	ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Systolic blood pressure, automated reading	2.08	9	6	13.3	0.78	1.4e-02	ARL17B C4orf22 HEXIM1 LRRC37A LRRC37A17P MKLN1-AS2 RSRC1 SRR TRPC4AP
Hand grip strength (left)	2.06	10	7	15.6	0.75	1.3e-02	ARL17B DENND2A HEXIM1 KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P TRPC4AP ZBTB38
Frequency of tenseness / restlessness in last 2 weeks	2.04	6	5	11.1	-0.99	2.4e-05	ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Medication for pain relief, constipation, heartburn	2.01	7	3	6.7	0.97	3.1e-04	ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P PRDM8
Irritability	2.00	8	4	8.9	-0.90	2.3e-03	ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P TMEM258 ZFHX4
Worry (Nagel 2018)	1.99	8	5	11.1	-0.75	3.1e-02	ARL17B CENPW KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P RSRC1
Heel bone mineral density (BMD) T-score, automated (right)	1.99	8	5	11.1	-0.08	8.5e-01	CRTC3 SRR SUPT3H TMEM258 TRPC4AP WARS2 ZBTB38 ZHX3
Arm fat-free mass (right)	1.99	12	7	15.6	-0.71	9.2e-03	CENPW CTNNB1 DLG5 EXOSC5 HEXIM1 MASP2 RP4-635E18.7 SCFD2 SUPT3H TRMT11 TRPC4AP ZBTB38
Medication: Blood pressure	1.99	6	1	2.2	0.95	4.2e-03	ARL17B C4orf22 HEXIM1 KANSL1 LRRC37A MYEOV
Arm predicted mass (right)	1.96	12	7	15.6	-0.72	8.9e-03	CENPW CTNNB1 DLG5 EXOSC5 HEXIM1 MASP2 RP4-635E18.7 SCFD2 SUPT3H TCF4 TRPC4AP ZBTB38
Arm fat-free mass (left)	1.96	10	7	15.6	-0.70	2.5e-02	CENPW CTNNB1 DLG5 EXOSC5 HEXIM1 MASP2 RP4-635E18.7 SCFD2 TRPC4AP ZBTB38
Basal metabolic rate	1.94	10	9	20.0	-0.70	2.4e-02	CENPW CTNNB1 DLG5 EXOSC5 HEXIM1 MASP2 RP4-635E18.7 SCFD2 TRPC4AP ZBTB38
Fed-up feelings	1.93	6	5	11.1	-1.00	1.4e-05	ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Forced expiratory volume in 1-second (FEV1), predicted	1.92	3	2	4.4	0.00	1.0e+00	CENPW HEXIM1 ZBTB38
Arm predicted mass (left)	1.92	9	7	15.6	-0.69	4.0e-02	CENPW CTNNB1 EXOSC5 HEXIM1 MASP2 RP4-635E18.7 SCFD2 TRPC4AP ZBTB38
Breast Cancer	1.84	9	4	8.9	-0.74	2.4e-02	ARL17B CDKAL1 GDAP2 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P METTL10 ZBTB38
Average weekly champagne plus white wine intake	1.83	6	1	2.2	0.82	4.8e-02	ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A4P TMEM258
Hypertension (Self-reported)	1.82	6	4	8.9	0.77	7.2e-02	ARL17B C4orf22 CLIC4 HEXIM1 PRDM8 RP3-465N24.5
Fractured/broken bones in last 5 years	1.82	2	0	0.0	0.00	1.0e+00	ARL17B SCFD2
High blood pressure	1.80	6	4	8.9	0.78	6.9e-02	ARL17B C4orf22 HEXIM1 PRDM8 RP3-465N24.5 TCF4
Miserableness	1.80	6	4	8.9	-1.00	2.4e-05	ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Ever unenthusiastic/disinterested for a whole week	1.79	4	0	0.0	-1.00	1.4e-03	ARL17B KANSL1 LRRC37A LRRC37A17P
Leg fat-free mass (right)	1.79	12	8	17.8	-0.65	2.2e-02	CENPW CTNNB1 DLG5 EXOSC5 HEXIM1 MAPRE1 MASP2 RP4-635E18.7 SCFD2 SUPT3H TRPC4AP ZBTB38
Leg predicted mass (right)	1.79	12	8	17.8	-0.65	2.1e-02	CENPW CTNNB1 DLG5 EXOSC5 HEXIM1 MAPRE1 MASP2 RP4-635E18.7 SCFD2 SUPT3H TRPC4AP ZBTB38
Leg fat-free mass (left)	1.76	10	8	17.8	-0.64	4.7e-02	CENPW CTNNB1 EXOSC5 HEXIM1 MAPRE1 MASP2 RP4-635E18.7 SCFD2 TRPC4AP ZBTB38
Leg predicted mass (left)	1.76	11	8	17.8	-0.64	3.6e-02	CENPW CTNNB1 EXOSC5 HEXIM1 MAPRE1 MASP2 RP4-635E18.7 SCFD2 SUPT3H TRPC4AP ZBTB38
Time employed in main current job	1.75	2	0	0.0	0.00	1.0e+00	LRRC37A17P LRRC37A2
Hand grip strength (right)	1.73	9	6	13.3	0.69	4.0e-02	ARL17B HEXIM1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P MAPRE1 TRPC4AP ZBTB38
Qualifications: CSEs or equivalent	1.73	1	0	0.0	0.00	1.0e+00	KANSL1
Guilty feelings	1.72	3	0	0.0	0.00	1.0e+00	KANSL1 LRRC37A LRRC37A17P
Pulse rate, automated reading	1.71	7	4	8.9	-0.41	3.2e-01	C4orf22 CTNNB1 KIAA0922 MKLN1-AS2 TMEM258 ZBTB38 ZHX3
Neuroticism (2016)	1.70	5	1	2.2	-0.99	1.4e-03	ARL17B LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Hearing difficulty/problems with background noise	1.70	3	0	0.0	0.00	1.0e+00	ARL17B LRRC37A LRRC37A4P
Number of live births	1.70	4	0	0.0	-0.79	2.1e-01	ARL17B LRRC37A LRRC37A17P TMEM258
Medication: Ibuprofen (e.g. Nurofen)	1.70	1	0	0.0	0.00	1.0e+00	LRRC37A
Vascular/heart problems diagnosed by doctor	1.70	6	2	4.4	-0.76	8.0e-02	ARL17B C4orf22 CRTC2 HEXIM1 PRDM8 RP3-465N24.5
Hair Pigment	1.68	27	21	46.7	0.01	9.4e-01	C4orf22 CDKAL1 CENPW EMC2 EXOC2 EXOSC5 FAM136A HMGB1 KANSL1 LNX1 LRRC37A LRRC37A17P LRRC37A4P MASP2 MIR3614 MYEOV PLXNA1 RCAN3 RPL41P1 S100A16 SH3PXD2B SUPT3H TMEM258 TWIST1 TWIST2 ZBTB38 ZFP36L2
Impedance of whole body	1.68	17	12	26.7	0.62	5.6e-03	ARL17B ATF1 CCDC117 CENPW HEXIM1 KANSL1 LRRC37A LRRC37A17P LRRC37A2 MASP2 MPDZ MYEOV RIBC2 RLTPR RP4-635E18.7 TRMT11 WARS2
Worrier / anxious feelings	1.66	6	4	8.9	-0.88	2.2e-02	ARL17B LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P SNX2
Impedance of arm (left)	1.63	16	8	17.8	0.72	7.2e-04	ARL17B ATF1 CCDC117 CENPW HEXIM1 KANSL1 LRRC37A LRRC37A17P LRRC37A2 MASP2 MPDZ PPP2R3A RP4-635E18.7 TCF4 TRMT11 WARS2
Type 2 Diabetes (T2D) (2018)	1.62	3	2	4.4	0.00	1.0e+00	CDKAL1 CENPW ZFP36L2
Cardiovascular Disease	1.58	8	2	4.4	0.53	1.8e-01	ARHGEF19 C4orf22 CLIC4 FAM136A HEXIM1 PRDM8 TCF4 ZFAND3
Supplements: Vitamin C	1.57	1	0	0.0	0.00	1.0e+00	LRRC37A17P
Crohns Disease (2012)	1.56	2	0	0.0	0.00	1.0e+00	TMEM258 ZFP36L2
Loneliness, isolation	1.56	3	0	0.0	0.00	1.0e+00	ARL17B LRRC37A LRRC37A2
Medication for cholesterol	1.56	2	0	0.0	0.00	1.0e+00	C4orf22 MYEOV
Trunk fat percentage	1.55	12	6	13.3	0.56	5.7e-02	ARL17B ATF1 C10orf11 CENPW CTNNB1 HMGB1 LRRC37A LRRC37A17P LRRC37A2 TRMT11 ZBTB38 ZHX3
Impedance of leg (left)	1.54	18	9	20.0	0.44	6.9e-02	ARL17B ATF1 CTCF HEXIM1 KANSL1 LRRC37A LRRC37A17P MAPRE1 MASP2 MPDZ MVB12B PLEKHH2 RIBC2 RLTPR RP4-635E18.7 SUPT3H WARS2 ZFP36L2
Impedance of leg (right)	1.52	19	8	17.8	0.25	3.0e-01	ARL17B ATF1 CTCF HEXIM1 KANSL1 LRRC37A MAPRE1 MASP2 MPDZ MVB12B MYEOV PLEKHH2 RIBC2 RLTPR RP4-635E18.7 SUPT3H WARS2 ZFP36L2 ZHX3
Impedance of arm (right)	1.52	15	7	15.6	0.65	4.6e-03	ARL17B ATF1 CCDC117 CENPW HEXIM1 LRRC37A LRRC37A17P LRRC37A2 MASP2 MPDZ PPP2R3A RP4-635E18.7 TCF4 TRMT11 WARS2
Alcohol intake frequency.	1.51	7	4	8.9	-0.99	2.2e-05	ARL17B AUTS2 KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P
Primary Biliary Cirrhosis	1.50	2	0	0.0	0.00	1.0e+00	ARL17B LRRC37A
Blood Eosinophil Count	1.50	15	10	22.2	0.78	4.0e-04	ARL17B ATG5 CLIC4 CTCF EXOC2 FAM136A KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P RLTPR SEPT2 TMEM258 ZFP36L2
High blood pressure (siblings)	1.50	1	0	0.0	0.00	1.0e+00	HEXIM1
Diastolic blood pressure, automated reading	1.50	8	4	8.9	0.80	1.7e-02	ATF1 C4orf22 CLIC4 CTNNB1 HEXIM1 RSRC1 SRR ZHX3
Depression (Nagel 2018)	1.49	2	0	0.0	0.00	1.0e+00	LRRC37A2 RP4-635E18.7
LDL Cholesterol	1.49	1	1	2.2	0.00	1.0e+00	TMEM258
Diabetes (father)	1.46	2	0	0.0	0.00	1.0e+00	CDKAL1 ZFP36L2
Weight	1.46	8	6	13.3	-0.61	1.1e-01	CENPW CTNNB1 EXOSC5 MASP2 RP4-635E18.7 SCFD2 TRPC4AP ZBTB38
Birth weight of first child	1.46	2	1	2.2	0.00	1.0e+00	ZBTB38 ZFHX4
Hayfever, allergic rhinitis or eczema	1.45	3	2	4.4	0.00	1.0e+00	CRTC3 S100A11 ZBTB38
Allergy or Eczema	1.43	3	2	4.4	0.00	1.0e+00	CRTC3 HEXIM1 ZBTB38
Frequency of depressed mood in last 2 weeks	1.43	1	0	0.0	0.00	1.0e+00	LRRC37A2
Trunk fat mass	1.43	10	5	11.1	0.25	4.8e-01	ARL17B ATF1 CTNNB1 HMGB1 LRRC37A LRRC37A2 METTL10 RP4-635E18.7 ZBTB38 ZHX3
Diabetes (mother)	1.42	2	0	0.0	0.00	1.0e+00	CDKAL1 ZHX3
Age when periods started (menarche)	1.41	3	2	4.4	0.00	1.0e+00	CENPW CRTC2 ZFHX4
Worry too long after embarrassment	1.41	3	0	0.0	0.00	1.0e+00	LRRC37A LRRC37A17P LRRC37A2
Medication: Blood pressure	1.41	2	2	4.4	0.00	1.0e+00	C4orf22 PRDM8
Pulse rate	1.40	4	2	4.4	0.08	9.2e-01	CTNNB1 MKLN1-AS2 TMEM258 ZBTB38
Ever had prostate specific antigen (PSA) test	1.39	1	0	0.0	0.00	1.0e+00	ZBTB38
Crohns Disease (2017)	1.38	4	2	4.4	-0.59	4.1e-01	TMEM258 ZBTB38 ZFP36L2 ZHX3
Fasting Glucose	1.38	1	1	2.2	0.00	1.0e+00	TMEM258
Verbal and Numeric Reasoning (VNR)	1.37	3	0	0.0	0.00	1.0e+00	ARL17B CENPW TMEM258
Blood Platelet Count	1.36	22	18	40.0	-0.36	9.6e-02	ATF1 CDKAL1 CLIC4 CRTC2 CTB-36H16.2 ETAA1 FAM136A FAR2 GDAP2 HEXIM1 KANSL1 LRRC37A LRRC37A17P LRRC37A4P PLEKHH2 PLXNA1 RP3-465N24.5 SRR TMEM258 ZFAND3 ZFP36L2 ZHX3
Medication: Atenolol	1.34	1	0	0.0	0.00	1.0e+00	MYEOV
Noisy workplace	1.34	1	0	0.0	0.00	1.0e+00	CRTC2
Qualifications: College or University degree	1.34	7	5	11.1	0.98	6.2e-05	ARL17B KANSL1 LRRC37A LRRC37A17P LRRC37A2 LRRC37A4P TRPC4AP
Allergy	1.32	6	1	2.2	0.06	9.1e-01	CLIC4 CRTC2 CRTC3 HEXIM1 TMEM258 ZBTB38
Diabetes diagnosed by doctor	1.32	2	0	0.0	0.00	1.0e+00	CENPW ZFP36L2
Myopia	1.32	1	0	0.0	0.00	1.0e+00	ARL17B
Pain experienced in last month	1.32	1	0	0.0	0.00	1.0e+00	CENPW
Irritable Bowel Disease (IBD)	1.31	2	1	2.2	0.00	1.0e+00	ZFP36L2 ZHX3
Body fat percentage	1.31	10	3	6.7	0.50	1.4e-01	ARL17B ATF1 C10orf11 CENPW CTNNB1 HMGB1 LRRC37A2 TRMT11 ZBTB38 ZHX3
Past tobacco smoking	1.30	3	0	0.0	0.00	1.0e+00	ARL17B SRR TRPC4AP
Hip circumference	1.30	9	2	4.4	-0.45	2.2e-01	CTNNB1 MASP2 PRRX1 RP4-635E18.7 SCFD2 TRPC4AP WARS2 ZBTB38 ZHX3
Wheeze or whistling in the chest in last year	1.30	1	0	0.0	0.00	1.0e+00	TMEM258
Illnesses of father: High blood pressure	1.30	1	0	0.0	0.00	1.0e+00	C4orf22
Schizophrenia (2018)	1.29	1	0	0.0	0.00	1.0e+00	PPP2R3A
Triglycerides	1.29	1	1	2.2	0.00	1.0e+00	TMEM258
Qualifications: None of the above	1.29	1	0	0.0	0.00	1.0e+00	EMC2
Lung FEV1/FVC ratio	1.27	13	4	8.9	0.54	5.9e-02	ARHGEF19 ARL17B C10orf11 CENPW CTCF CTNNB1 EMC2 LRRC37A LRRC37A2 LRRC37A4P SRR ZBTB38 ZFP36L2
High blood pressure (mother)	1.26	2	0	0.0	0.00	1.0e+00	AUTS2 C4orf22
Intelligence (Savage-Jansen 2018)	1.25	9	1	2.2	0.28	4.3e-01	ARL17B CENPW CRTC2 CTNNB1 LRRC37A LRRC37A2 PPP2R3A SEPT2 TMEM258
Medication for cholesterol, blood pressure or diabetes	1.25	1	0	0.0	0.00	1.0e+00	C4orf22
Medication: Gliclazide	1.25	1	0	0.0	0.00	1.0e+00	SSPN
Number of full brothers	1.24	2	0	0.0	0.00	1.0e+00	ARL17B LRRC37A2
Number of treatments/medications taken	1.23	1	0	0.0	0.00	1.0e+00	TMEM258
Medication: Simvastatin	1.22	2	0	0.0	0.00	1.0e+00	MYEOV TMEM258
Birth weight	1.22	2	0	0.0	0.00	1.0e+00	CENPW SRR
Overall health rating	1.22	3	0	0.0	0.00	1.0e+00	AUTS2 HEXIM1 SPAST
Suffer from 'nerves'	1.21	1	0	0.0	0.00	1.0e+00	LRRC37A2
Blood White Count	1.20	15	8	17.8	-0.18	5.1e-01	ANO7 ATF1 CENPW CITED4 CTB-36H16.2 EPC1 KANSL1 LRRC37A LRRC37A17P LRRC37A4P METTL10 MPDZ SSPN TMEM258 ZHX3
Qualifications: A levels/AS levels or equivalent	1.20	2	0	0.0	0.00	1.0e+00	ARL17B LRRC37A
Whole body fat mass	1.20	6	4	8.9	-0.43	4.0e-01	CTNNB1 HMGB1 MASP2 RP4-635E18.7 ZBTB38 ZHX3
HDL Cholesterol	1.19	1	1	2.2	0.00	1.0e+00	TMEM258
Smoking Status	1.19	5	1	2.2	0.53	3.6e-01	ARL17B CCDC117 HMGB1 LRRC37A2 SRR
Age at First Birth	1.18	1	1	2.2	0.00	1.0e+00	CRTC2
High cholesterol (Self-reported)	1.16	2	0	0.0	0.00	1.0e+00	FAM136A TMEM258
Father's age at death	1.15	1	0	0.0	0.00	1.0e+00	TWIST1
Comparative body size at age 10	1.15	3	2	4.4	0.00	1.0e+00	ETAA1 KANSL1 SRR
Cholesterol lowering medication	1.15	1	0	0.0	0.00	1.0e+00	ARHGEF19
Leg fat percentage (right)	1.14	6	2	4.4	0.35	4.9e-01	CENPW HMGB1 PRRX1 RSRC1 SPAST ZHX3
Fluid intelligence score	1.13	1	0	0.0	0.00	1.0e+00	CRTC2
Ever smoked	1.13	2	0	0.0	0.00	1.0e+00	CTNNB1 SRR
Ulcerative Colitis (UC)	1.11	1	0	0.0	0.00	1.0e+00	ZHX3
Medication: Cholesterol lowering	1.10	1	0	0.0	0.00	1.0e+00	HMGB1
Leg fat percentage (left)	1.10	5	2	4.4	0.50	3.9e-01	CENPW HMGB1 RSRC1 SPAST ZHX3
Bipolar Disorder or Schizophrenia	1.08	1	0	0.0	0.00	1.0e+00	TRPC4AP
Bipolar Disorder (2018)	1.07	1	0	0.0	0.00	1.0e+00	TMEM258
Asthma	1.06	1	1	2.2	0.00	1.0e+00	TMEM258
Supplements: Fish oil (including cod liver oil)	1.05	2	0	0.0	0.00	1.0e+00	HEXIM1 TMEM258
Respiratory disease	1.03	2	1	2.2	0.00	1.0e+00	HEXIM1 TMEM258
Asthma (self-reported)	1.03	1	1	2.2	0.00	1.0e+00	TMEM258
Hypothyroidism (self reported)	1.02	3	1	2.2	0.00	1.0e+00	CTCF RLTPR TMEM258
Arm fat percentage (left)	1.02	3	1	2.2	0.00	1.0e+00	CENPW HMGB1 SRR
Leg fat mass (right)	1.01	6	3	6.7	-0.44	3.8e-01	CTNNB1 HMGB1 MASP2 RP4-635E18.7 ZBTB38 ZHX3
Waist circumference	0.99	3	2	4.4	0.00	1.0e+00	CTNNB1 HMGB1 ZBTB38
Hypothyroidism/myxoedema (self-reported)	0.99	1	1	2.2	0.00	1.0e+00	TMEM258
Leg fat mass (left)	0.98	6	3	6.7	-0.44	3.9e-01	CTNNB1 HMGB1 MASP2 RP4-635E18.7 ZBTB38 ZHX3
Medication: Levothyroxine sodium	0.97	2	1	2.2	0.00	1.0e+00	CTCF TMEM258
Arm fat percentage (right)	0.97	3	1	2.2	0.00	1.0e+00	CENPW HMGB1 SRR
Mean time to correctly identify matches	0.94	1	0	0.0	0.00	1.0e+00	KANSL1
Arm fat mass (right)	0.92	5	1	2.2	-0.35	5.6e-01	CTNNB1 HMGB1 MASP2 RP4-635E18.7 ZBTB38
Arm fat mass (left)	0.91	5	2	4.4	-0.33	5.8e-01	CTNNB1 HMGB1 MASP2 RP4-635E18.7 ZBTB38
Tanning	0.86	1	1	2.2	0.00	1.0e+00	EXOC2
BMI	0.81	10	5	11.1	0.22	5.4e-01	C4orf22 CTNNB1 HMGB1 MASP2 PPP2R3A RIBC2 RP4-635E18.7 RSRC1 SRR WARS2
Body mass index (BMI)	0.78	3	1	2.2	0.00	1.0e+00	HMGB1 PPP2R3A RP4-635E18.7

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Uterus	7	1.23	4.4
GTEx	Brain Hippocampus	6	1.15	4.0
GTEx	Brain Hypothalamus	7	1.19	4.0
GTEx	Artery Coronary	16	1.35	3.9
GTEx	Vagina	8	1.26	3.9
GTEx	Brain Putamen basal ganglia	7	1.12	3.7
GTEx	Small Intestine Terminal Ileum	4	0.87	3.7
GTEx	Brain Nucleus accumbens basal ganglia	10	1.16	3.6
GTEx	Brain Cortex	10	0.97	3.5
GTEx	Brain Frontal Cortex BA9	12	1.30	3.5
GTEx	Breast Mammary Tissue (Male)	11	0.92	3.5
GTEx	Ovary	9	0.99	3.5
GTEx	Brain Caudate basal ganglia	10	1.09	3.4
GTEx	Cells EBV-transformed lymphocytes	14	0.98	3.4
GTEx	Esophagus Gastroesophageal Junction	16	1.11	3.2
GTEx	Liver	7	0.98	3.2
GTEx	Stomach	17	1.17	3.2
GTEx	Pancreas	14	0.86	3.1
GTEx	Prostate	6	0.72	3.1
GTEx	Brain Cerebellar Hemisphere	13	0.87	3.0
GTEx	Breast Mammary Tissue (Female)	15	0.91	3.0
GTEx	Colon Sigmoid	10	0.68	3.0
GTEx	Pituitary	11	0.99	3.0
The Cancer Genome Atlas	Esophageal Carcinoma	4	0.58	2.9
GTEx	Breast Mammary Tissue	14	0.71	2.8
GTEx	Colon Transverse	15	0.73	2.8
GTEx	Heart Atrial Appendage	11	0.70	2.8
GTEx	Heart Left Ventricle	11	0.72	2.8
GTEx	Spleen	11	0.78	2.8
The Cancer Genome Atlas	Rectum Adenocarcinoma	5	0.72	2.8
GTEx	Adrenal Gland	13	0.89	2.7
GTEx	Brain Cerebellum	15	0.76	2.7
GTEx	Lung	23	0.80	2.7
GTEx	Adipose Visceral Omentum	11	0.54	2.6
GTEx	Artery Aorta	23	0.77	2.6
GTEx	Skin Not Sun Exposed Suprapubic	17	0.69	2.6
GTEx	Testis	22	0.70	2.6
GTEx	Whole Blood	12	0.60	2.6
The Cancer Genome Atlas	Soft Tissue Sarcoma	7	0.66	2.6
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	3	0.59	2.6
GTEx	Esophagus Mucosa	19	0.57	2.5
GTEx	Esophagus Muscularis	22	0.68	2.5
GTEx	Muscle Skeletal	17	0.59	2.5
GTEx	Skin Sun Exposed Lower leg	19	0.52	2.5
GTEx	Thyroid	29	0.73	2.5
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	7	0.53	2.5
GTEx	Cells Transformed fibroblasts	27	0.64	2.4
GTEx	Nerve Tibial	27	0.62	2.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	7	0.64	2.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	9	0.57	2.4
The Cancer Genome Atlas	Stomach Adenocarcinoma	8	0.48	2.4
GTEx	Adipose Subcutaneous	20	0.57	2.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	10	0.60	2.3
The Cancer Genome Atlas	Glioblastoma Multiforme	5	0.49	2.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	5	0.45	2.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	1	0.19	2.3
GTEx	Artery Tibial	19	0.51	2.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	11	0.44	2.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	8	0.63	2.2
NTR	Blood	9	0.37	2.1
The Cancer Genome Atlas	Brain Lower Grade Glioma	20	0.46	2.1
The Cancer Genome Atlas	Lung Adenocarcinoma	13	0.44	2.1
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	8	0.48	2.1
The Cancer Genome Atlas	Prostate Adenocarcinoma	24	0.52	2.1
CommonMind	Brain Pre-frontal Cortex	29	0.54	2.0
The Cancer Genome Atlas	Breast Invasive Carcinoma	17	0.39	2.0
The Cancer Genome Atlas	Colon Adenocarcinoma	9	0.44	2.0
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	21	0.51	2.0
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	13	0.48	1.9
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	4	0.20	1.9
The Cancer Genome Atlas	Thyroid Carcinoma	24	0.47	1.9
METSIM	Adipose	16	0.35	1.8
ROSMAP	Brain Pre-frontal Cortex	6	0.14	1.7
YFS	Blood	16	0.35	1.7