Best TWAS P=7.42e-27 · Best GWAS P=1.19e-27 conditioned to 0.158
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CENPW | 0.04 | 0.06 | lasso | 10 | 0.06 | 2.4e-07 | -10.7 | 10.7 | 7.4e-27 | -0.92 | 0.03 | 0.97 | TRUE |
| 2 | GTEx | Heart Atrial Appendage | CENPW | 0.17 | 0.01 | enet | 15 | 0.06 | 1.8e-03 | -10.8 | 5.7 | 1.6e-08 | -0.62 | 0.03 | 0.56 | FALSE |
| 3 | GTEx | Vagina | CENPW | 0.24 | -0.01 | lasso | 8 | -0.01 | 7.9e-01 | -3.6 | -5.4 | 7.1e-08 | 0.38 | 0.04 | 0.07 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TRMT11 | 0.03 | 0.03 | lasso | 1 | 0.03 | 3.3e-07 | 5.7 | -5.7 | 1.5e-08 | 0.27 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CENPW | 0.04 | 0.05 | lasso | 5 | 0.05 | 2.6e-06 | -10.8 | 10.1 | 5.0e-24 | -0.90 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CENPW | 0.04 | 0.06 | blup | 35 | 0.05 | 9.2e-07 | -10.8 | 10.4 | 2.1e-25 | -0.93 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TRMT11 | 0.03 | 0.00 | blup | 33 | 0.01 | 1.3e-02 | 5.7 | -6.0 | 1.8e-09 | 0.25 | 0.01 | 0.85 | TRUE |