Best TWAS P=3.64e-12 · Best GWAS P=4.33e-16 conditioned to 0.000373
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | MKLN1-AS2 | 0.12 | 0.10 | lasso | 3 | 0.10 | 3.4e-08 | 5.8 | 5.6 | 1.8e-08 | -0.55 | 0.98 | 0.00 | FALSE |
| 2 | GTEx | Artery Aorta | MKLN1-AS2 | 0.14 | 0.07 | enet | 10 | 0.05 | 1.2e-03 | 5.8 | 5.2 | 1.8e-07 | -0.58 | 0.63 | 0.06 | FALSE |
| 3 | GTEx | Artery Coronary | MKLN1-AS2 | 0.39 | 0.01 | enet | 9 | -0.01 | 6.5e-01 | 6.9 | 5.9 | 3.5e-09 | -0.52 | 0.04 | 0.64 | TRUE |
| 4 | GTEx | Artery Tibial | MKLN1-AS2 | 0.14 | 0.05 | enet | 22 | 0.04 | 2.4e-04 | 3.1 | 5.8 | 5.6e-09 | -0.65 | 0.07 | 0.90 | FALSE |
| 5 | GTEx | Esophagus Gastroesophageal Junction | MKLN1-AS2 | 0.20 | 0.05 | lasso | 6 | 0.02 | 7.8e-02 | 5.6 | 6.7 | 3.0e-11 | -0.68 | 0.06 | 0.76 | FALSE |
| 6 | GTEx | Lung | MKLN1-AS2 | 0.15 | 0.02 | lasso | 5 | 0.03 | 3.0e-03 | 5.6 | 5.6 | 1.8e-08 | -0.55 | 0.26 | 0.04 | FALSE |
| 7 | GTEx | Nerve Tibial | MKLN1-AS2 | 0.20 | 0.16 | lasso | 7 | 0.16 | 1.3e-11 | 5.8 | 7.0 | 3.6e-12 | -0.74 | 0.62 | 0.38 | TRUE |
| 8 | GTEx | Thyroid | MKLN1 | 0.13 | 0.01 | lasso | 4 | 0.02 | 1.7e-02 | 6.8 | 5.6 | 2.1e-08 | -0.44 | 0.15 | 0.06 | FALSE |
| 9 | GTEx | Thyroid | MKLN1-AS2 | 0.28 | 0.22 | lasso | 6 | 0.25 | 8.6e-19 | 5.8 | 6.8 | 1.1e-11 | -0.67 | 1.00 | 0.00 | FALSE |