Best TWAS P=6.26e-31 · Best GWAS P=1.8e-35 conditioned to 2.61e-08
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | C10orf11 | 0.28 | 0.05 | bslmm | 829 | 0.17 | 3.3e-20 | -4.2 | 7.7 | 1.3e-14 | -0.32 | 0.99 | 0.01 | TRUE |
2 | GTEx | Adipose Subcutaneous | DLG5 | 0.39 | 0.40 | lasso | 12 | 0.43 | 1.9e-38 | 5.1 | 5.4 | 8.5e-08 | 0.01 | 0.01 | 0.99 | FALSE |
3 | GTEx | Adipose Subcutaneous | RP13-39P12.3 | 0.31 | 0.27 | lasso | 12 | 0.34 | 1.1e-28 | 5.1 | 5.3 | 1.3e-07 | 0.00 | 0.01 | 0.99 | FALSE |
4 | GTEx | Adipose Visceral Omentum | DLG5 | 0.26 | 0.23 | lasso | 8 | 0.21 | 5.7e-11 | 5.1 | 5.3 | 9.5e-08 | 0.00 | 0.01 | 0.99 | FALSE |
5 | GTEx | Adipose Visceral Omentum | RP13-39P12.3 | 0.18 | 0.07 | lasso | 7 | 0.06 | 3.3e-04 | 5.1 | 5.3 | 1.1e-07 | -0.02 | 0.01 | 0.98 | FALSE |
6 | GTEx | Adrenal Gland | DLG5 | 0.22 | 0.14 | lasso | 6 | 0.11 | 8.5e-05 | 5.1 | 5.2 | 2.2e-07 | 0.05 | 0.01 | 0.98 | FALSE |
7 | GTEx | Artery Aorta | DLG5 | 0.26 | 0.19 | enet | 10 | 0.22 | 2.6e-12 | 4.9 | 5.2 | 2.2e-07 | 0.02 | 0.01 | 0.98 | FALSE |
8 | GTEx | Artery Aorta | RP13-39P12.3 | 0.14 | 0.13 | enet | 9 | 0.12 | 2.2e-07 | 4.9 | 5.3 | 1.4e-07 | 0.02 | 0.01 | 0.98 | FALSE |
9 | GTEx | Artery Coronary | DLG5 | 0.33 | 0.25 | lasso | 4 | 0.27 | 1.4e-09 | 5.0 | 5.3 | 1.1e-07 | 0.02 | 0.01 | 0.99 | FALSE |
10 | GTEx | Artery Coronary | RP13-39P12.3 | 0.21 | 0.03 | lasso | 4 | 0.09 | 7.2e-04 | 5.0 | 5.1 | 2.8e-07 | 0.01 | 0.03 | 0.92 | FALSE |
11 | GTEx | Artery Tibial | DLG5 | 0.24 | 0.18 | lasso | 5 | 0.18 | 9.7e-14 | 5.2 | 5.2 | 1.9e-07 | 0.01 | 0.01 | 0.99 | FALSE |
12 | GTEx | Artery Tibial | RP13-39P12.3 | 0.14 | 0.04 | lasso | 7 | 0.05 | 7.3e-05 | 5.2 | 5.4 | 6.3e-08 | -0.01 | 0.02 | 0.98 | FALSE |
13 | GTEx | Brain Caudate basal ganglia | C10orf11 | 0.35 | 0.27 | lasso | 4 | 0.25 | 9.8e-08 | -11.0 | 11.0 | 4.6e-28 | -0.79 | 0.23 | 0.75 | FALSE |
14 | GTEx | Brain Cerebellum | DLG5 | 0.36 | 0.28 | lasso | 7 | 0.36 | 1.6e-11 | 5.1 | 5.2 | 1.8e-07 | 0.01 | 0.01 | 0.98 | FALSE |
15 | GTEx | Brain Cortex | C10orf11 | 0.32 | 0.15 | lasso | 8 | 0.21 | 1.4e-06 | -10.9 | 11.6 | 6.3e-31 | -0.78 | 0.17 | 0.81 | TRUE |
16 | GTEx | Brain Frontal Cortex BA9 | C10orf11 | 0.33 | 0.18 | enet | 11 | 0.19 | 9.3e-06 | -11.0 | 11.3 | 9.7e-30 | -0.79 | 0.27 | 0.64 | FALSE |
17 | GTEx | Breast Mammary Tissue | DLG5 | 0.15 | 0.09 | lasso | 7 | 0.08 | 6.7e-05 | 4.9 | 5.2 | 2.6e-07 | 0.02 | 0.02 | 0.96 | FALSE |
18 | GTEx | Cells Transformed fibroblasts | DLG5 | 0.25 | 0.18 | lasso | 11 | 0.16 | 2.0e-12 | 5.1 | 5.4 | 7.3e-08 | 0.01 | 0.01 | 0.99 | FALSE |
19 | GTEx | Cells Transformed fibroblasts | RP13-39P12.3 | 0.19 | 0.13 | lasso | 7 | 0.15 | 4.5e-11 | 5.1 | 5.7 | 1.6e-08 | 0.01 | 0.01 | 0.99 | FALSE |
20 | GTEx | Colon Sigmoid | DLG5 | 0.23 | 0.11 | lasso | 5 | 0.15 | 4.6e-06 | -3.9 | 5.2 | 1.7e-07 | -0.01 | 0.03 | 0.92 | FALSE |
21 | GTEx | Colon Transverse | DLG5 | 0.23 | 0.17 | lasso | 8 | 0.19 | 1.4e-09 | 5.0 | 5.3 | 1.5e-07 | 0.02 | 0.01 | 0.99 | FALSE |
22 | GTEx | Esophagus Gastroesophageal Junction | DLG5 | 0.27 | 0.03 | enet | 13 | 0.06 | 3.9e-03 | 4.5 | 5.7 | 1.2e-08 | 0.04 | 0.02 | 0.94 | FALSE |
23 | GTEx | Esophagus Mucosa | DLG5 | 0.21 | 0.16 | lasso | 5 | 0.18 | 5.2e-12 | 5.1 | 5.3 | 1.1e-07 | 0.01 | 0.01 | 0.99 | FALSE |
24 | GTEx | Esophagus Muscularis | DLG5 | 0.14 | 0.04 | enet | 27 | 0.06 | 1.9e-04 | -3.5 | 5.8 | 6.1e-09 | 0.03 | 0.06 | 0.90 | TRUE |
25 | GTEx | Heart Atrial Appendage | DLG5 | 0.32 | 0.23 | lasso | 4 | 0.24 | 3.9e-11 | 4.9 | 5.1 | 2.9e-07 | 0.01 | 0.01 | 0.99 | FALSE |
26 | GTEx | Lung | DLG5 | 0.41 | 0.38 | lasso | 8 | 0.37 | 7.9e-30 | 5.1 | 5.2 | 1.9e-07 | 0.01 | 0.01 | 0.99 | FALSE |
27 | GTEx | Muscle Skeletal | C10orf11 | 0.11 | 0.13 | lasso | 3 | 0.12 | 5.1e-12 | -10.9 | 11.3 | 8.3e-30 | -0.82 | 0.60 | 0.40 | FALSE |
28 | GTEx | Nerve Tibial | DLG5 | 0.51 | 0.44 | lasso | 6 | 0.50 | 1.4e-39 | 5.2 | 5.3 | 1.4e-07 | 0.02 | 0.01 | 0.99 | FALSE |
29 | GTEx | Nerve Tibial | RP13-39P12.3 | 0.31 | 0.25 | lasso | 7 | 0.36 | 1.3e-26 | 5.1 | 5.2 | 2.1e-07 | 0.00 | 0.01 | 0.99 | FALSE |
30 | GTEx | Ovary | DLG5 | 0.62 | 0.38 | lasso | 6 | 0.40 | 5.3e-11 | 5.1 | 5.2 | 2.5e-07 | 0.02 | 0.01 | 0.99 | FALSE |
31 | GTEx | Pancreas | RP13-39P12.3 | 0.20 | 0.24 | lasso | 3 | 0.23 | 3.8e-10 | 5.1 | 5.1 | 2.8e-07 | 0.01 | 0.01 | 0.99 | FALSE |
32 | GTEx | Pituitary | DLG5 | 0.45 | 0.36 | lasso | 11 | 0.31 | 1.9e-08 | 5.1 | 5.3 | 1.3e-07 | 0.01 | 0.01 | 0.99 | FALSE |
33 | GTEx | Pituitary | RP13-39P12.3 | 0.38 | 0.22 | lasso | 11 | 0.17 | 3.8e-05 | 5.1 | 5.3 | 9.1e-08 | 0.01 | 0.02 | 0.96 | FALSE |
34 | GTEx | Skin Sun Exposed Lower leg | DLG5 | 0.12 | 0.06 | lasso | 4 | 0.06 | 4.9e-06 | 5.1 | 5.3 | 1.1e-07 | 0.00 | 0.01 | 0.99 | FALSE |
35 | GTEx | Spleen | DLG5 | 0.51 | 0.46 | lasso | 4 | 0.44 | 1.1e-12 | 5.2 | 5.2 | 1.6e-07 | 0.02 | 0.01 | 0.99 | FALSE |
36 | GTEx | Spleen | RP13-39P12.3 | 0.38 | 0.34 | lasso | 2 | 0.35 | 8.8e-10 | 5.2 | 5.4 | 5.8e-08 | 0.00 | 0.01 | 0.99 | FALSE |
37 | GTEx | Stomach | DLG5 | 0.20 | 0.12 | lasso | 7 | 0.08 | 1.3e-04 | 5.2 | 5.2 | 2.3e-07 | 0.02 | 0.01 | 0.99 | FALSE |
38 | GTEx | Stomach | RP13-39P12.3 | 0.17 | 0.02 | lasso | 5 | 0.02 | 2.5e-02 | -3.9 | 5.1 | 3.0e-07 | -0.03 | 0.02 | 0.84 | FALSE |
39 | GTEx | Thyroid | RP13-39P12.3 | 0.28 | 0.30 | lasso | 8 | 0.29 | 3.3e-22 | 5.1 | 5.2 | 2.1e-07 | 0.01 | 0.01 | 0.99 | FALSE |
40 | METSIM | Adipose | DLG5 | 0.18 | 0.19 | lasso | 11 | 0.22 | 2.2e-32 | 5.1 | 5.4 | 7.7e-08 | -0.01 | 0.01 | 0.99 | FALSE |
41 | ROSMAP | Brain Pre-frontal Cortex | C10orf11 | 0.20 | 0.23 | lasso | 4 | 0.23 | 1.1e-29 | -10.9 | 11.1 | 1.8e-28 | -0.78 | 1.00 | 0.00 | FALSE |
42 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | DLG5 | 0.12 | 0.01 | blup | 116 | 0.03 | 1.2e-02 | 5.0 | 5.1 | 2.7e-07 | -0.02 | 0.02 | 0.62 | FALSE |