Best TWAS P=2.11e-19 · Best GWAS P=3.69e-34 conditioned to 1.42e-11
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FAM53B | 0.05 | 0.00 | blup | 626 | 0.01 | 1.9e-02 | 6.64 | 7.2 | 6.6e-13 | 0.55 | 0.06 | 0.68 | FALSE |
2 | GTEx | Brain Caudate basal ganglia | METTL10 | 0.33 | 0.16 | lasso | 3 | 0.18 | 7.6e-06 | 8.61 | -7.7 | 1.1e-14 | -0.78 | 0.16 | 0.70 | FALSE |
3 | GTEx | Brain Cerebellum | LHPP | 0.41 | 0.03 | enet | 34 | 0.11 | 4.1e-04 | 7.05 | 6.1 | 1.3e-09 | 0.37 | 0.21 | 0.06 | FALSE |
4 | GTEx | Brain Frontal Cortex BA9 | METTL10 | 0.24 | 0.00 | lasso | 3 | 0.02 | 9.3e-02 | -6.83 | -8.9 | 5.6e-19 | -0.74 | 0.06 | 0.44 | FALSE |
5 | GTEx | Breast Mammary Tissue | METTL10 | 0.13 | 0.08 | enet | 19 | 0.13 | 4.8e-07 | -6.57 | -6.8 | 1.2e-11 | -0.55 | 0.78 | 0.21 | FALSE |
6 | GTEx | Breast Mammary Tissue (Female) | METTL10 | 0.27 | 0.00 | lasso | 5 | 0.04 | 1.8e-02 | -6.57 | -7.3 | 2.6e-13 | -0.47 | 0.08 | 0.62 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | FAM53B | 0.22 | 0.08 | lasso | 8 | 0.07 | 3.7e-06 | -6.61 | 6.3 | 3.4e-10 | 0.41 | 0.90 | 0.02 | FALSE |
8 | GTEx | Colon Transverse | METTL10 | 0.18 | 0.01 | enet | 17 | 0.07 | 2.2e-04 | 12.08 | -9.0 | 2.1e-19 | -0.72 | 0.02 | 0.90 | TRUE |
9 | GTEx | Nerve Tibial | LHPP | 0.18 | 0.05 | lasso | 5 | 0.09 | 4.1e-07 | 4.61 | 5.8 | 5.2e-09 | 0.48 | 0.87 | 0.05 | FALSE |
10 | GTEx | Thyroid | METTL10 | 0.19 | 0.09 | enet | 33 | 0.10 | 3.0e-08 | -3.76 | -6.2 | 7.3e-10 | -0.54 | 0.78 | 0.22 | FALSE |
11 | NTR | Blood | ZRANB1 | 0.04 | 0.01 | bslmm | 567 | 0.02 | 3.8e-06 | -2.73 | 5.6 | 2.0e-08 | 0.33 | 0.96 | 0.01 | FALSE |
12 | ROSMAP | Brain Pre-frontal Cortex | LHPP | 0.22 | 0.07 | bslmm | 582 | 0.16 | 1.8e-19 | 3.87 | 5.5 | 4.6e-08 | 0.48 | 1.00 | 0.00 | FALSE |
13 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | LHPP | 0.08 | 0.00 | blup | 171 | 0.03 | 3.0e-03 | 0.16 | 5.2 | 2.4e-07 | 0.41 | 0.14 | 0.15 | FALSE |
14 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | METTL10 | 0.09 | 0.08 | blup | 43 | 0.11 | 1.2e-09 | -3.63 | -6.4 | 1.5e-10 | -0.60 | 1.00 | 0.00 | FALSE |
15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LHPP | 0.09 | 0.00 | blup | 170 | 0.03 | 9.7e-05 | -1.38 | 5.2 | 1.8e-07 | 0.36 | 0.08 | 0.04 | FALSE |
16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | METTL10 | 0.13 | 0.16 | blup | 43 | 0.18 | 1.8e-20 | -3.63 | -6.8 | 9.7e-12 | -0.61 | 1.00 | 0.00 | FALSE |
17 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | METTL10 | 0.18 | 0.13 | enet | 12 | 0.11 | 2.4e-05 | -3.85 | -5.2 | 1.7e-07 | -0.52 | 0.30 | 0.58 | FALSE |
18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LHPP | 0.09 | 0.00 | blup | 172 | 0.03 | 1.4e-04 | -3.05 | 5.8 | 6.9e-09 | 0.37 | 0.15 | 0.05 | FALSE |
19 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | LHPP | 0.45 | 0.01 | enet | 38 | 0.05 | 5.5e-03 | -3.23 | 5.2 | 1.6e-07 | 0.26 | 0.03 | 0.10 | TRUE |
20 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | METTL10 | 0.13 | 0.08 | blup | 43 | 0.12 | 2.4e-04 | -3.76 | -6.2 | 6.0e-10 | -0.55 | 0.18 | 0.16 | FALSE |