Best TWAS P=8.13e-18 · Best GWAS P=1.74e-18 conditioned to 0.00216
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Muscularis | EIF2S2P3 | 0.09 | 0.04 | lasso | 6 | 0.04 | 1.1e-03 | -8.5 | -8.6 | 8.1e-18 | 0.81 | 0.05 | 0.84 | TRUE |
| 2 | GTEx | Prostate | EIF2S2P3 | 0.21 | 0.05 | lasso | 4 | 0.11 | 1.1e-03 | -8.5 | -7.5 | 7.9e-14 | 0.78 | 0.04 | 0.56 | FALSE |
| 3 | GTEx | Spleen | EIF2S2P3 | 0.32 | 0.04 | enet | 15 | 0.11 | 1.2e-03 | -5.8 | -7.5 | 9.4e-14 | 0.82 | 0.02 | 0.77 | FALSE |
| 4 | GTEx | Testis | HHEX | 0.11 | 0.02 | enet | 8 | 0.00 | 4.2e-01 | -6.7 | -6.1 | 8.9e-10 | 0.70 | 0.09 | 0.21 | FALSE |
| 5 | GTEx | Thyroid | EIF2S2P3 | 0.15 | 0.14 | lasso | 2 | 0.14 | 6.2e-11 | -8.5 | -8.4 | 6.3e-17 | 0.88 | 0.04 | 0.96 | FALSE |
| 6 | GTEx | Whole Blood | EIF2S2P3 | 0.10 | 0.02 | lasso | 6 | 0.05 | 2.2e-05 | -8.8 | -7.5 | 9.1e-14 | 0.76 | 0.00 | 1.00 | FALSE |
| 7 | NTR | Blood | KIF11 | 0.11 | 0.10 | lasso | 8 | 0.10 | 3.0e-29 | 6.0 | -6.1 | 9.8e-10 | 0.68 | 1.00 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | HHEX | 0.03 | 0.00 | blup | 28 | 0.02 | 1.4e-03 | -4.2 | -5.2 | 1.9e-07 | 0.65 | 0.01 | 0.29 | FALSE |