Best TWAS P=1.24e-09 · Best GWAS P=1.48e-10 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | KCNJ11 | 0.04 | 0.03 | lasso | 3 | 0.03 | 2.6e-04 | 6.4 | 6.1 | 1.2e-09 | 0.97 | 0.01 | 0.99 | TRUE |
2 | GTEx | Adipose Subcutaneous | RP1-239B22.5 | 0.11 | 0.06 | enet | 21 | 0.07 | 1.5e-06 | 5.9 | -5.5 | 3.3e-08 | -0.80 | 0.01 | 0.99 | FALSE |
3 | GTEx | Esophagus Mucosa | KCNJ11 | 0.27 | 0.16 | lasso | 8 | 0.22 | 1.6e-14 | -3.9 | -5.6 | 2.1e-08 | -0.74 | 0.73 | 0.27 | FALSE |
4 | GTEx | Skin Not Sun Exposed Suprapubic | KCNJ11 | 0.18 | 0.07 | lasso | 6 | 0.12 | 7.0e-07 | 6.4 | -6.0 | 1.5e-09 | -0.88 | 0.01 | 0.99 | FALSE |
5 | GTEx | Skin Sun Exposed Lower leg | KCNJ11 | 0.23 | 0.09 | lasso | 10 | 0.12 | 1.7e-10 | 6.0 | -5.7 | 1.0e-08 | -0.84 | 0.02 | 0.98 | FALSE |
6 | GTEx | Skin Sun Exposed Lower leg | RP1-239B22.5 | 0.06 | 0.06 | lasso | 2 | 0.07 | 8.6e-07 | -4.0 | -5.4 | 8.4e-08 | -0.75 | 0.05 | 0.94 | FALSE |
7 | GTEx | Thyroid | RP1-239B22.5 | 0.08 | 0.07 | enet | 16 | 0.08 | 1.8e-06 | 5.8 | -5.3 | 1.1e-07 | -0.81 | 0.02 | 0.97 | FALSE |
8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | DKFZp686O24166 | 0.04 | 0.00 | blup | 71 | 0.02 | 7.1e-03 | -4.2 | -5.6 | 2.1e-08 | -0.79 | 0.01 | 0.78 | FALSE |
9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DKFZp686O24166 | 0.05 | 0.03 | blup | 71 | 0.04 | 1.2e-05 | -4.3 | -5.8 | 6.5e-09 | -0.80 | 0.05 | 0.93 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DKFZp686O24166 | 0.03 | 0.01 | blup | 72 | 0.03 | 2.4e-04 | 5.9 | -5.6 | 2.3e-08 | -0.81 | 0.01 | 0.95 | FALSE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | DKFZp686O24166 | 0.04 | 0.01 | blup | 71 | 0.02 | 1.5e-03 | 5.9 | -5.5 | 4.8e-08 | -0.84 | 0.01 | 0.92 | FALSE |