TWAS hub - KCNJ11

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0360	0.0160	6.3e-03	0.031	0.011	0.027	0.012	0.027	1.0e-04	0.0150	2.7e-04	1.1e-02	2.6e-04
2	GTEx	Artery Aorta	0.1220	0.0450	4.1e-03	0.036	NA	0.084	NA	0.069	4.3e-03	NA	2.2e-05	NA	1.2e-04
3	GTEx	Artery Tibial	0.1814	0.0408	6.2e-09	0.191	NA	0.150	NA	0.186	6.6e-15	NA	7.8e-12	NA	1.6e-14
4	GTEx	Brain Cortex	0.1740	0.0680	2.9e-03	0.011	NA	0.064	NA	0.032	1.6e-01	NA	7.7e-03	NA	4.6e-02
5	GTEx	Brain Frontal Cortex BA9	0.4392	0.1192	4.1e-03	0.144	NA	0.075	NA	0.120	1.2e-04	NA	5.0e-03	NA	4.6e-04
6	GTEx	Esophagus Gastroesophageal Junction	0.1950	0.0740	2.9e-03	0.147	NA	0.170	NA	0.181	5.4e-06	NA	9.6e-07	NA	4.0e-07
7	GTEx	Esophagus Mucosa	0.2680	0.0530	2.0e-12	0.155	NA	0.207	NA	0.216	1.5e-10	NA	7.2e-14	NA	1.6e-14
8	GTEx	Esophagus Muscularis	0.1980	0.0500	1.4e-05	0.161	NA	0.114	NA	0.136	4.8e-10	NA	2.1e-07	NA	1.3e-08
9	GTEx	Skin Not Sun Exposed Suprapubic	0.1770	0.0490	8.4e-06	0.072	NA	0.110	NA	0.115	9.0e-05	NA	1.3e-06	NA	7.0e-07
10	GTEx	Skin Sun Exposed Lower leg	0.2320	0.0480	7.3e-11	0.094	NA	0.115	NA	0.125	3.2e-08	NA	9.9e-10	NA	1.7e-10
11	ROSMAP	Brain Pre-frontal Cortex	0.0524	0.0229	5.2e-03	0.055	0.015	0.052	0.029	0.051	1.1e-07	0.0039	3.0e-07	9.5e-05	3.1e-07
12	TCGA	Breast Invasive Carcinoma	0.0207	0.0104	4.9e-03	0.006	0.010	0.013	NA	0.009	1.7e-02	0.0036	1.0e-03	NA	4.3e-03
13	TCGA	Thyroid Carcinoma	0.0400	0.0220	8.8e-03	0.010	0.010	0.019	NA	0.004	3.2e-02	0.0300	4.9e-03	NA	1.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Diabetes (self-reported)	11.2	17.3	37.5	6.1	-2.6	-4.2	3.8	-0.1	-3.2	-5.6	0.3	-5.9	-5.9	4.6	0.6	4.0
Diabetes diagnosed by doctor	10.9	17.9	36.9	6.1	-3.0	-4.6	3.6	0.1	-3.0	-5.6	-0.0	-6.0	-5.7	5.0	0.1	4.3
Type 2 Diabetes (T2D) (2018)	10.7	20.1	44.9	6.7	-2.7	-4.5	3.8	-1.5	-3.0	-5.9	0.4	-6.5	-6.4	5.5	0.4	3.9
Systolic Blood Pressure	10.0	49.9	104.0	10.2	-4.7	-7.6	7.4	-0.5	-6.3	-9.1	-1.2	-9.8	-10.1	7.3	-0.8	5.7
Medication: Gliclazide	8.9	10.0	19.8	4.0	-2.4	-3.6	3.5	0.8	-3.0	-4.5	-0.8	-4.1	-4.4	2.9	0.4	3.0
Medication: Metformin	7.2	10.2	22.8	4.8	-1.7	-3.2	3.0	0.1	-2.0	-4.5	0.4	-4.5	-4.5	3.6	-0.1	2.9
High blood pressure (mother)	6.7	9.3	17.9	3.4	-3.4	-4.1	2.5	1.0	-3.0	-3.3	-2.2	-3.7	-4.2	3.0	-0.4	3.0
Financial situation satisfaction	6.7	8.3	18.9	-3.2	2.2	3.1	-4.3	0.8	2.5	3.7	1.0	3.8	3.3	-3.1	0.9	-2.3
Mouth/teeth dental problems: Dentures	6.6	11.1	22.1	-3.4	2.6	3.5	-4.6	-0.3	2.6	4.7	0.9	4.4	4.0	-3.2	1.9	-3.7
Type 2 Diabetes (T2D) (2012)	5.9	6.8	17.8	4.2	-1.4	-2.6	1.8	0.3	-1.2	-3.2	1.3	-3.7	-3.7	2.7	1.3	2.9
Fluid intelligence score	5.6	11.7	25.4	4.6	-3.0	-3.7	3.7	0.8	-2.7	-4.5	-0.9	-4.5	-5.0	4.2	-1.2	1.5
Medication: Bendroflumethiazide	5.6	8.5	14.8	3.0	-3.4	-3.8	2.5	-0.5	-3.3	-3.1	-2.5	-3.6	-3.6	1.6	-0.1	3.5
Irritable Bowel Disease (IBD)	5.2	12.3	22.4	-2.5	4.7	4.5	-3.8	-0.7	4.7	4.2	3.8	3.7	3.3	-1.3	2.3	-3.3
Ever smoked	5.2	9.2	16.9	-3.4	2.5	3.6	-4.1	2.3	2.6	3.4	1.3	3.7	3.4	-2.4	0.4	-3.9
High blood pressure	5.0	13.9	27.2	4.9	-3.1	-4.4	3.7	-0.5	-3.6	-4.3	-1.6	-5.1	-5.2	3.5	0.7	3.6
Hypertension (Self-reported)	4.6	12.7	23.4	4.5	-3.2	-4.4	3.6	-0.5	-3.6	-4.1	-1.8	-4.8	-4.8	3.1	1.0	3.4
Schizophrenia (2014)	4.5	9.8	23.6	-3.7	2.4	3.5	-4.9	-1.7	2.5	3.9	1.3	3.9	3.9	-3.0	2.0	-1.7
Comparative height size at age 10	4.5	25.0	52.3	6.7	-1.8	-4.6	7.2	-3.1	-3.8	-6.1	0.3	-6.5	-6.5	5.3	1.7	5.1
Impedance of leg (right)	4.3	21.0	46.1	6.0	-3.7	-4.8	4.5	-0.1	-3.4	-5.9	-1.4	-6.6	-6.8	5.1	-2.3	3.3
Past tobacco smoking	4.3	7.9	14.0	3.1	-2.4	-3.6	3.2	-2.3	-2.6	-3.3	-1.4	-3.7	-3.4	2.2	0.0	3.0
Impedance of leg (left)	4.2	20.2	45.1	6.1	-3.5	-4.7	4.0	-0.2	-3.2	-5.7	-1.2	-6.4	-6.7	5.4	-2.5	3.1
Impedance of arm (right)	4.2	19.8	42.8	6.4	-2.7	-4.2	4.7	0.5	-3.3	-6.0	-0.6	-6.2	-6.5	5.3	-2.9	2.1
Impedance of arm (left)	4.2	19.4	37.7	5.9	-3.3	-4.6	4.4	0.9	-3.4	-5.8	-1.5	-6.0	-6.1	5.1	-3.5	2.1
Ulcerative Colitis	4.1	5.9	13.1	-0.9	3.0	2.7	-3.6	0.0	3.4	3.2	2.7	1.9	1.5	0.1	2.6	-2.1
Smoking Status	4.1	9.8	32.0	-4.5	0.7	2.2	-5.7	1.5	1.1	3.6	-1.2	3.5	3.4	-4.1	0.7	-3.3
Diabetes (mother)	4.1	5.3	11.5	3.4	-1.3	-3.0	1.3	1.7	-1.1	-2.4	0.1	-3.0	-2.8	3.4	1.8	1.8
Impedance of whole body	4.1	20.9	44.0	6.3	-3.3	-4.5	4.6	0.1	-3.3	-6.0	-1.0	-6.4	-6.6	5.4	-3.0	2.7
Cardiovascular Disease	4.0	13.1	23.4	4.8	-2.8	-4.1	4.5	-0.3	-2.8	-4.5	-0.7	-4.8	-4.6	4.0	0.4	3.7
Ulcerative Colitis (UC)	3.9	7.3	15.1	-0.9	3.8	3.1	-3.6	-0.5	3.9	2.8	3.6	1.9	1.7	0.1	2.7	-2.6
Systolic blood pressure, automated reading	3.9	11.2	23.0	4.8	-1.2	-3.2	4.2	-0.5	-3.3	-4.4	-0.1	-4.5	-4.5	3.0	0.1	3.6
Current tobacco smoking	3.9	6.4	25.7	-3.3	1.0	2.0	-5.1	-0.2	1.1	2.6	-0.5	2.5	2.4	-3.5	1.6	-2.5
Eye problems/disorders: Diabetes related eye disease	3.8	4.2	8.5	2.6	-1.8	-2.3	1.6	0.9	-1.9	-2.9	-0.1	-2.7	-2.7	2.1	-0.0	2.3
Smoking status: Current	3.8	6.0	26.8	-3.2	0.9	1.8	-5.2	0.2	1.1	2.4	-0.4	2.3	2.2	-2.9	1.8	-2.7
Crohns Disease (2017)	3.5	7.6	14.5	-2.7	3.6	3.8	-1.8	-0.9	3.2	3.4	2.3	3.7	3.1	-2.2	0.7	-2.1
Mouth/teeth dental problems	3.3	5.1	12.0	2.9	-1.0	-2.5	2.2	0.9	-0.9	-3.2	0.4	-3.5	-2.9	3.1	-0.1	2.0
Medication: Blood pressure	3.1	5.9	14.0	3.7	-1.6	-2.3	3.4	-0.8	-1.6	-2.5	-0.4	-3.2	-3.1	3.0	-1.2	1.8
Illnesses of mother	3.0	3.7	7.2	-2.2	1.6	2.4	-1.6	0.4	1.6	2.0	0.9	2.4	2.4	-2.1	-1.1	-2.7
Qualifications: O levels/GCSEs or equivalent	3.0	4.8	10.2	1.9	-2.2	-2.6	3.2	-0.1	-1.8	-2.6	-1.2	-2.7	-2.4	2.3	-2.3	1.6
Back pain experienced in last month	3.0	4.4	10.4	-2.2	1.1	1.3	-3.2	1.3	2.6	3.0	0.6	2.2	3.0	-0.1	0.8	-2.7
Pain type(s) experienced in last month: Hip pain	3.0	3.7	7.3	-2.5	1.9	2.4	-2.0	-0.0	1.8	2.2	0.7	2.6	2.7	-2.0	0.3	-1.1
Commuting to job workplace: Cycle	3.0	3.6	7.5	2.2	-1.5	-2.3	1.3	-1.0	-1.3	-2.5	-0.1	-2.7	-2.6	2.7	0.9	1.4
Noisy workplace	2.9	3.6	8.0	-2.7	0.8	2.1	-1.6	-1.4	1.0	2.8	-0.3	2.7	2.4	-2.4	-0.4	-1.2
Number of children fathered	2.9	3.3	6.4	-2.0	2.0	2.2	-1.8	1.4	2.1	1.9	1.1	2.4	2.5	-0.8	-0.1	-1.7
Average weekly red wine intake	2.9	4.2	10.0	2.0	-1.7	-2.3	1.9	-0.9	-2.3	-3.2	-0.7	-2.7	-2.1	1.7	-0.9	2.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.9	3.4	10.8	-2.2	-0.5	1.2	-2.4	2.5	-0.5	1.4	-1.4	2.2	1.8	-3.3	-0.8	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	2.8	5.7	15.0	3.8	-0.2	-1.3	2.0	-3.1	-0.9	-2.8	1.3	-3.2	-3.9	2.6	1.1	1.1
Vascular/heart problems diagnosed by doctor	2.8	7.7	14.9	-3.8	2.1	3.4	-2.6	0.0	2.3	3.0	0.8	3.9	3.9	-2.9	-1.5	-2.8
Body Mass Index (BMI) (2010)	2.7	3.7	11.4	-3.4	0.8	1.7	-1.9	0.0	1.3	2.0	-0.1	2.9	3.0	-2.1	0.7	-0.8
Qualifications: None of the above	2.7	5.8	11.6	-1.9	2.9	2.9	-2.4	-1.3	2.7	3.4	1.7	2.8	2.9	-2.5	1.2	-0.9
Bipolar Disorder or Schizophrenia	2.6	6.2	11.6	-2.8	2.1	2.5	-3.4	-2.2	2.2	3.4	1.3	3.0	2.9	-1.8	2.7	-0.6
Vitamin and mineral supplements	2.6	3.6	7.2	2.2	-1.0	-1.9	2.5	-1.1	-1.6	-2.4	-0.4	-2.2	-2.7	1.6	-1.0	2.4
Medication: Co-codamol	2.6	3.0	7.7	-2.3	0.5	1.5	-2.8	0.1	1.5	2.2	-0.5	1.9	2.4	-1.9	-1.1	-1.4
Health satisfaction	2.6	3.3	6.9	-2.0	1.6	2.0	-1.9	-1.1	1.9	2.4	1.2	2.2	2.6	-2.1	1.1	-0.0
Waist Hip Ratio (WHR)	2.5	11.2	28.4	5.3	-2.2	-3.0	2.7	0.2	-2.2	-4.0	0.6	-4.8	-4.9	4.9	0.4	1.9
Cholesterol lowering medication	2.5	3.6	6.5	2.5	-1.8	-2.2	2.5	1.0	-1.3	-2.2	-0.2	-2.5	-1.7	2.4	-0.1	2.0
Intelligence (Savage-Jansen 2018)	2.4	7.3	13.8	3.0	-2.1	-2.4	2.9	2.8	-1.4	-3.7	-0.5	-3.4	-3.5	3.7	-2.4	0.1
Height	2.4	46.5	100.0	9.3	-2.3	-5.5	10.0	-4.3	-5.6	-9.2	0.2	-9.0	-9.0	5.8	1.1	7.3
Prospective memory result	2.4	3.0	5.7	-2.0	1.9	2.1	-1.4	-1.2	2.1	2.4	1.1	1.8	2.1	-1.6	1.1	-1.0
Exposure to tobacco smoke at home	2.4	2.7	6.0	-1.9	1.0	1.5	-2.2	1.0	1.0	2.4	-0.4	2.5	0.9	-2.0	0.2	-2.1
Smoking status: Previous	2.4	3.6	7.7	-2.0	1.6	2.5	-1.2	1.6	1.9	2.5	0.9	2.8	2.5	-1.4	-0.9	-1.6
Ever used hormone-replacement therapy (HRT)	2.3	2.9	8.3	-2.0	0.7	1.3	-0.7	1.9	1.3	2.5	-0.2	2.3	2.9	-2.0	-0.8	-1.4
Diabetes (father)	2.3	2.8	10.6	3.2	0.6	-1.0	1.0	0.3	-0.1	-1.5	1.5	-1.6	-2.2	3.3	0.5	1.1
Multivitamins +/- minerals	2.3	2.9	8.1	-1.6	0.9	1.5	-2.5	0.9	1.6	1.8	1.0	1.6	2.3	-0.8	1.5	-2.8
Standing height	2.3	22.8	47.1	6.8	-0.7	-3.6	6.9	-4.0	-3.0	-6.1	1.3	-5.9	-6.3	5.1	1.8	4.7
Birth weight	2.3	5.0	11.7	-3.0	2.0	2.1	-2.2	-1.4	2.4	3.0	0.8	2.9	3.4	-1.6	1.1	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	2.3	2.7	7.0	0.1	-2.3	-2.3	1.0	0.2	-2.6	-2.1	-2.5	-1.5	-0.8	0.2	-0.2	1.7
Shortness of breath walking on level ground	2.3	2.8	6.3	-2.5	0.8	1.8	-1.9	-0.7	0.8	2.0	-0.2	2.2	2.1	-2.5	0.2	-1.4
Heart disease (siblings)	2.2	2.7	6.6	-1.5	1.3	1.4	-2.4	0.7	2.2	2.2	0.9	1.7	2.6	-1.0	0.3	-1.2
Coronary Artery Disease (CAD)	2.1	2.5	7.8	2.8	-1.2	-1.8	0.2	-1.4	-1.3	-1.4	-0.6	-2.2	-2.5	1.3	1.3	0.6
Father’s age at death	2.1	2.8	8.6	0.2	-2.2	-2.1	0.5	-0.8	-2.9	-1.9	-2.6	-1.3	-1.4	-0.0	-1.3	1.2
Wheeze or whistling in the chest in last year	2.1	3.7	7.5	-1.7	1.3	1.7	-2.3	0.7	1.5	2.7	0.8	2.2	2.2	-2.3	2.4	-1.8
Chest pain or discomfort	2.1	3.1	7.0	-1.4	1.5	2.0	-1.1	-0.3	2.1	2.6	1.3	1.9	2.2	-1.2	2.2	-1.6
Verbal and Numeric Reasoning (VNR)	2.0	4.8	11.2	2.9	-1.7	-1.5	2.4	2.0	-1.5	-3.0	0.0	-2.6	-3.3	3.0	-1.2	-0.5
Crohns Disease (2012)	2.0	3.2	8.3	-1.0	2.3	2.4	0.5	0.4	2.9	2.6	1.8	2.2	2.3	-0.3	-0.9	-1.0
Townsend deprivation index at recruitment	2.0	2.8	4.4	-1.4	1.8	2.1	-1.7	2.1	1.7	1.8	1.1	2.0	1.6	-1.9	0.5	-1.2
Maternal smoking around birth	2.0	2.9	9.6	-1.9	0.5	2.0	0.3	-1.0	0.7	3.1	-0.3	2.4	1.9	-2.7	0.9	-1.0
Illnesses of father: High blood pressure	2.0	2.5	6.5	1.3	-1.7	-1.9	2.5	0.4	-1.5	-1.8	-1.1	-1.6	-1.6	1.1	-1.0	2.0
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	11.1	0.9	-1.5	-1.5	3.3	0.3	-0.6	-1.8	-0.5	-1.3	0.0	1.1	-1.5	2.5
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	4.5	1.3	-1.9	-2.1	2.1	-0.1	-2.0	-1.6	-1.9	-1.7	-1.4	0.7	-1.8	0.8
Schizophrenia (2018)	1.9	4.0	7.3	-2.5	1.1	2.1	-2.3	-2.6	1.3	2.7	0.3	2.5	2.3	-2.2	1.5	-0.3
Body mass index (BMI)	1.9	8.2	17.9	-4.2	1.2	2.5	-2.3	1.4	1.6	4.0	-0.7	4.2	4.1	-4.2	0.5	-1.6
Medication: Ramipril	1.9	2.4	7.5	2.0	-0.1	-1.0	2.5	-0.6	0.0	-1.6	1.0	-1.9	-1.5	2.7	1.1	1.2
Blood clot in the leg (DVT)	1.9	2.4	4.3	1.4	-1.7	-2.0	1.9	-0.3	-2.1	-1.6	-1.8	-1.7	-1.6	0.7	-1.6	0.7
Glaucoma (self-reported)	1.9	2.2	4.6	2.1	-1.0	-1.8	2.0	-0.7	-1.1	-1.9	-0.3	-1.9	-1.7	1.4	0.3	1.5
Medication: Omeprazole	1.9	2.2	9.2	1.2	-1.1	-1.2	3.0	-0.0	-0.4	-1.9	0.1	-1.6	-0.4	1.6	-1.2	2.4
Illnesses of siblings: Diabetes	1.9	2.4	5.2	1.8	-0.4	-1.7	-0.5	2.0	0.1	-1.5	1.0	-2.1	-1.5	2.3	2.2	0.5
Mother’s age at death	1.9	2.4	7.1	-0.1	-2.3	-2.7	-0.7	0.0	-1.8	-1.5	-2.5	-1.5	-0.8	0.9	-0.6	1.5
Bipolar Disorder (2018)	1.8	2.8	6.5	-1.3	1.9	1.4	-2.5	-0.3	2.0	2.1	1.7	1.7	1.7	-0.2	2.3	-0.6
Depressed Affect (Nagel 2018)	1.8	3.8	8.8	-2.6	1.1	1.9	-1.0	-1.3	1.3	2.7	0.0	3.0	2.6	-2.7	1.6	-0.9
Reaction Time	1.8	3.4	9.7	-1.1	1.6	0.9	-3.1	0.5	2.4	2.0	1.6	1.1	2.2	0.3	2.6	-1.9
Lupus	1.8	2.7	4.4	-1.9	1.4	2.0	-1.4	2.1	1.5	1.1	1.6	2.1	2.0	-1.5	0.7	-1.1
Hair/balding pattern: Pattern 4	1.8	4.3	9.4	-2.0	1.8	2.9	-2.0	-0.9	2.1	3.1	1.0	2.7	2.6	-1.8	0.5	-1.6
Medication: Amlodipine	1.8	2.5	6.7	1.9	-1.7	-2.6	-0.0	-0.4	-1.1	-1.6	-0.7	-2.1	-2.1	1.9	-0.2	1.2
Medication: Blood pressure	1.8	3.1	7.0	2.7	-1.0	-1.9	1.8	-0.2	-1.4	-2.1	-0.3	-2.6	-2.4	1.3	1.0	1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	3.7	-0.7	1.6	1.9	-1.2	1.2	1.9	1.5	1.7	1.6	1.8	-0.0	0.4	-0.7
BMI	1.7	9.9	26.9	-5.2	0.9	2.5	-2.5	1.9	1.7	4.0	-1.1	4.6	4.8	-4.3	-0.2	-1.8
Medication for pain relief, constipation, heartburn	1.7	2.9	7.3	2.2	-1.2	-2.3	0.5	-0.6	-1.4	-2.1	-0.3	-2.4	-2.7	2.0	1.0	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	9.6	0.8	-1.5	-1.0	3.1	0.6	-1.1	-1.7	-0.7	-1.3	-1.1	1.1	-1.2	1.6
Loneliness, isolation	1.7	2.4	6.0	-1.6	0.4	1.2	-1.1	0.4	1.2	2.5	0.1	2.3	2.0	-1.8	2.0	-0.9
Medication: Paracetamol	1.7	2.6	6.2	-2.4	0.0	1.6	-2.0	1.3	0.5	1.9	-0.4	2.5	2.1	-2.1	-0.9	-0.6
Ovarian Cancer	1.6	2.1	6.0	1.7	-1.0	-1.2	1.7	-1.2	-1.5	-2.4	-0.3	-1.7	-2.0	0.7	-0.1	1.5
Number of incorrect matches in round	1.6	2.7	8.4	-1.0	2.2	1.8	-0.8	-1.1	1.5	2.9	0.9	1.5	1.9	-1.6	2.0	-0.9
Hearing difficulty/problems with background noise	1.6	2.5	7.1	-0.2	2.5	2.2	-0.4	-0.1	2.2	0.8	2.7	0.9	1.2	0.3	1.1	-2.3
Pulse wave reflection index	1.6	1.9	4.8	-1.5	0.9	1.8	-0.9	-0.4	1.3	2.2	0.2	1.9	1.4	-1.3	0.0	-2.0
Angina (self-reported)	1.6	2.1	3.8	-1.4	1.0	1.2	-1.8	1.5	1.6	1.4	1.2	1.4	1.8	-0.9	1.9	-1.0
Age at last live birth	1.6	2.3	5.3	1.6	-1.4	-1.2	1.8	0.6	-1.7	-1.8	-1.0	-1.8	-2.3	1.2	-1.6	0.0
Breast Cancer	1.5	3.6	9.1	1.4	-2.2	-3.0	-0.5	2.2	-2.2	-2.4	-1.6	-2.1	-1.5	1.5	-0.9	1.7
Primary Biliary Cirrhosis	1.5	2.1	5.4	-1.6	1.8	1.6	-1.0	-1.4	2.3	1.1	1.9	1.1	1.5	-0.5	1.4	0.5
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	5.4	-0.6	-2.1	-1.4	0.7	-1.5	-1.7	-0.1	-2.3	-0.2	-1.0	-1.7	0.6	0.9
Heart attack	1.5	1.9	5.8	-0.6	1.7	0.9	-0.4	0.6	2.4	1.0	2.3	1.0	1.9	0.7	1.4	-1.0
Medication: Simvastatin	1.5	2.2	5.4	2.3	-0.9	-1.6	1.6	0.8	-0.3	-1.4	0.0	-2.3	-1.6	1.9	0.9	1.6
Mood swings	1.5	2.8	5.9	-1.8	1.5	2.1	-0.6	-1.4	1.9	2.4	0.6	2.4	1.7	-2.0	0.6	-1.0
Heart attack/myocardial infarction (self-reported)	1.5	2.0	5.9	-0.7	1.7	0.9	-0.6	0.6	2.4	0.9	2.3	1.1	1.9	0.7	1.6	-1.0
Angina	1.4	1.9	3.8	-1.3	0.9	1.1	-1.7	1.5	1.6	1.2	1.2	1.3	1.7	-0.9	2.0	-0.8
Pack years adult smoking proportion	1.4	2.1	7.8	-0.9	2.0	1.5	-1.5	-0.3	1.4	1.1	1.4	1.1	1.0	-0.9	2.8	-1.3
Medication: Paracetamol	1.4	2.4	5.1	-2.0	0.7	1.9	-1.9	0.9	0.8	1.8	0.1	2.3	2.2	-1.6	-1.4	-0.3
Medication: Ibuprofen	1.4	1.7	4.5	-1.2	1.1	1.8	-0.2	0.5	0.9	2.0	0.4	2.1	1.2	-1.5	0.0	-1.6
Mean time to correctly identify matches	1.4	2.6	8.9	-0.6	1.4	0.7	-3.0	0.7	2.4	1.7	1.4	0.6	2.0	0.6	1.5	-1.9
Number of self-reported non-cancer illnesses	1.4	2.4	5.6	2.4	-1.2	-1.5	1.9	1.6	-1.5	-1.6	-0.5	-2.0	-1.6	1.5	0.0	1.4
Pack years of smoking	1.4	2.1	6.7	-0.7	2.3	1.6	-1.1	-0.0	1.8	1.0	1.8	1.0	1.1	-0.5	2.6	-1.2
Major Depression (MDD)	1.3	1.5	3.9	-1.9	0.6	1.0	-1.1	0.8	0.7	0.9	-0.0	1.9	2.0	-1.5	-0.9	-1.1
Fasting Glucose	1.3	1.6	5.8	-2.0	0.3	0.7	-1.0	1.5	1.5	1.3	-0.0	1.6	2.4	-0.4	-0.6	-0.6
Blood Platelet Count	1.3	14.7	36.7	-6.1	1.3	2.5	-5.6	2.5	2.6	5.1	-0.9	5.2	4.3	-3.3	-1.6	-4.1
Financial difficulties in last 2 years	1.3	1.7	6.8	-1.5	0.2	1.0	-2.4	-0.0	-0.7	0.6	-0.6	1.1	0.4	-1.8	2.6	-0.7
Happiness	1.3	1.6	6.2	-1.5	0.4	0.3	-2.5	-0.6	1.1	1.7	0.3	1.5	1.5	-0.4	1.4	-0.9
Age at first live birth	1.3	2.4	5.7	2.0	-0.8	-1.3	1.9	-1.5	-1.0	-1.7	-0.4	-2.2	-2.4	1.8	-0.8	-0.0
Eye problems/disorders: None of the above	1.3	1.5	4.7	-1.3	1.2	1.5	-1.3	-0.5	0.8	1.5	0.2	1.3	0.9	-1.2	-0.2	-2.2
Overall health rating	1.3	2.9	7.6	-2.2	0.5	1.2	-1.7	0.4	1.2	2.5	-0.3	2.2	2.3	-2.8	1.4	-0.8
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.6	-1.1	1.1	1.3	0.4	-1.8	1.0	1.6	0.3	1.6	1.4	-1.9	-0.1	-0.0
Hair/balding pattern: Pattern 2	1.2	1.5	5.6	2.2	0.5	-0.7	2.4	0.4	-0.3	-1.0	0.8	-1.1	-0.9	1.5	-0.6	1.2
Falls in the last year	1.2	1.7	3.0	-1.7	1.0	1.1	-1.5	0.2	1.4	1.3	0.9	1.5	1.7	-1.6	0.7	-1.3
Qualifications: A levels/AS levels or equivalent	1.2	2.7	6.5	1.3	-1.3	-2.0	2.1	-0.9	-1.4	-2.5	-0.7	-2.4	-1.5	1.9	-0.8	0.7
Tense / ‘highly strung’	1.2	1.9	3.4	-1.3	1.3	1.7	-1.3	-1.6	1.3	1.9	0.4	1.6	1.4	-1.1	0.9	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	9.3	-1.2	-1.0	-0.3	-3.0	2.0	-0.8	0.6	-1.3	0.9	-0.1	-0.7	0.9	-1.6
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	3.8	-1.8	1.3	1.7	-1.4	-1.3	1.3	1.6	0.6	2.0	1.5	-1.2	-0.9	-1.1
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.9	1.7	-1.2	-1.4	1.1	-1.2	-1.5	-1.1	-0.9	-1.4	-1.6	0.3	-0.7	0.9
Illnesses of father: None of the above (group 1)	1.2	1.5	7.3	-1.2	0.9	1.5	-1.4	1.5	1.0	0.9	0.4	1.2	0.5	-0.7	-0.0	-2.7
Unable to work because of sickness or disability	1.2	1.6	5.2	-1.9	0.2	0.4	-2.3	1.1	0.7	1.2	-0.5	1.4	1.4	-1.7	1.2	-0.2
Alzheimer’s Disease (in mother)	1.1	1.3	3.5	-0.7	-1.5	-0.6	-0.2	-1.0	-1.9	-0.7	-1.6	-0.4	-0.7	-1.5	0.6	1.7
Blood Eosinophil Count	1.1	8.7	18.2	1.5	-4.1	-3.8	4.3	0.1	-3.5	-3.4	-3.4	-2.9	-2.6	0.9	-0.6	3.2
Hearing difficulty/problems: Yes	1.1	1.6	4.1	1.8	1.3	0.1	1.5	-0.4	0.4	-1.1	2.0	-0.9	-0.6	1.6	2.0	0.3
Supplements: Zinc	1.1	1.2	6.5	0.7	0.6	-0.2	-1.4	0.6	1.5	0.1	1.9	-0.2	0.3	2.6	0.3	-0.6
Time employed in main current job	1.1	1.3	2.9	0.9	0.1	-1.4	0.6	-1.3	-0.6	-1.6	-0.2	-1.5	-0.7	1.1	-1.5	1.7
Alcohol intake versus 10 years previously	1.1	1.6	6.1	-0.1	1.8	1.4	0.1	-0.1	1.4	0.8	2.0	0.8	1.0	-0.1	2.5	1.2
Lung cancer (father)	1.1	1.2	4.8	1.2	0.6	-0.7	-1.0	1.2	2.2	0.3	1.2	-0.8	0.3	1.9	0.2	-0.5
Length of working week for main job	1.1	1.2	4.9	-1.2	-0.0	1.0	0.7	-2.2	0.3	1.5	-0.1	1.5	1.0	-1.1	1.0	-0.2
Loud music exposure frequency	1.1	1.2	2.3	0.5	-1.4	-1.3	1.0	-1.0	-1.2	-1.5	-1.0	-1.4	-1.1	0.4	-1.1	0.6
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.7	-1.8	0.1	1.0	-0.5	0.1	0.5	1.9	-0.5	1.8	1.6	-1.5	0.4	-0.1
Osteoarthritis (self-reported)	1.1	1.4	3.4	-0.9	1.2	1.8	-0.2	1.4	0.8	1.4	0.8	1.8	1.6	-1.4	0.3	0.1
Miserableness	1.1	1.9	6.2	-1.9	0.2	1.1	-1.2	-0.8	0.1	1.8	-1.0	1.9	1.2	-2.5	0.4	-1.5
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.5	1.2	-1.2	-0.5	1.8	-1.8	-0.2	0.2	-0.8	-0.6	-0.7	0.7	-1.9	1.2
Mean Putamen Volume	1.0	1.1	3.3	1.8	0.2	-0.5	0.8	0.3	-0.2	-1.3	0.7	-1.7	-1.6	1.6	-0.5	0.0
Respiratory disease	1.0	2.3	6.0	-1.7	1.0	1.8	-0.4	2.5	1.1	1.5	0.3	1.7	1.8	-1.7	-1.2	-1.5
Age when periods started (menarche)	1.0	2.3	6.2	-1.5	1.4	1.8	-2.5	-1.0	1.0	1.9	0.5	2.0	0.8	-1.8	1.0	-1.4
Breastfed as a baby	1.0	1.2	3.1	0.7	-0.8	-1.6	0.8	1.4	0.1	-1.0	-0.1	-1.1	-0.3	1.8	-1.4	1.6
Migraine (self-reported)	1.0	1.2	4.7	-0.5	-2.0	-0.9	-0.3	-0.5	-1.6	-0.1	-2.2	-0.4	-0.6	-1.1	-0.0	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.8	0.2	1.2	1.2	1.6	1.2	1.7	1.2	1.2	0.8	1.1	-0.1	-0.2	-0.6
Medication for cholesterol	1.0	1.5	4.4	-1.7	1.1	1.5	-2.1	0.4	0.5	1.0	0.2	1.6	0.9	-1.7	0.9	-0.7
Hearing aid user	1.0	1.2	3.6	-0.1	1.3	1.0	-0.2	1.9	0.6	1.3	0.6	1.1	0.9	-1.4	1.3	-0.8
High cholesterol (Self-reported)	1.0	1.7	3.9	1.8	-1.2	-1.5	1.6	0.5	-0.5	-1.1	-0.7	-2.0	-1.3	1.8	-0.8	1.2
Alzheimer’s Disease (including proxy)	0.9	1.2	3.0	0.4	-1.4	-1.2	0.9	-1.5	-1.3	-0.5	-0.8	-1.1	-1.1	0.2	1.1	1.7
Rheumatoid Arthritis	0.9	1.3	4.6	-0.3	-1.0	-0.9	0.3	-1.3	-1.4	-0.9	-1.9	-0.5	-0.1	-0.8	-2.1	1.2
Average weekly spirits intake	0.9	1.1	3.4	-0.4	0.9	1.8	0.1	0.1	0.7	1.5	0.7	1.7	1.4	-1.5	-0.2	-0.5
Average weekly fortified wine intake	0.9	1.1	3.5	-0.9	0.6	1.0	-1.1	1.6	0.0	0.9	-0.4	0.8	0.3	-0.6	-1.7	-1.9
Stomach or abdominal pain in last month	0.9	1.1	3.4	-1.8	-0.0	0.4	-1.8	-0.2	0.5	0.7	0.1	1.2	1.6	-1.6	0.9	0.1
Sitting height	0.9	6.5	16.2	3.1	-0.2	-1.7	4.0	-2.6	-1.5	-3.2	0.7	-3.0	-3.1	2.7	1.7	2.6
Chronic bronchitis/emphysema (father)	0.9	1.0	3.6	-1.4	0.8	0.5	-0.2	0.5	1.8	1.4	0.2	1.0	1.9	-1.0	-0.0	-0.2
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	3.5	-0.9	-1.1	-0.4	-1.2	1.4	-0.5	1.4	-1.9	0.9	0.5	-1.4	-0.9	-0.9
Number of live births	0.9	1.3	5.1	0.7	-0.6	-1.1	0.4	0.4	-0.9	-1.7	0.2	-1.1	-0.6	0.7	1.8	2.2
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	5.5	1.1	-1.6	-2.0	2.0	-1.3	-1.6	-2.4	-1.1	-2.2	-2.3	1.6	-0.7	1.7
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	2.6	-1.0	1.3	1.5	0.0	0.4	1.2	1.5	0.7	1.6	1.1	-0.6	-0.3	-1.4
Medication: Cholesterol lowering	0.9	1.3	2.9	1.6	-0.8	-1.2	0.9	1.4	-0.3	-1.1	-0.0	-1.7	-1.1	1.4	0.9	1.2
Depression (self-reported)	0.9	1.1	2.2	-1.1	0.9	1.5	-0.9	-0.5	0.6	1.1	0.5	1.3	1.4	-1.5	0.7	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	4.8	-1.5	-0.9	-0.3	-1.1	2.2	-0.3	0.4	-1.3	0.9	0.9	-0.9	-0.8	-1.1
Qualifications: College or University degree	0.9	2.8	6.9	0.9	-1.9	-2.6	1.1	0.3	-1.9	-2.6	-1.2	-2.3	-2.0	1.6	0.5	-0.4
Family relationship satisfaction	0.9	1.1	3.6	-1.0	0.7	0.7	-1.9	-0.2	1.2	1.4	0.7	1.3	1.0	-0.9	1.0	0.3
Bipolar Disorder (2011)	0.8	0.8	2.8	0.8	-0.4	-0.4	-0.1	-1.7	-0.4	-0.5	0.3	-0.7	-1.2	1.0	1.2	1.4
Chronotype (morning person)	0.8	1.9	5.8	1.9	1.7	1.4	1.6	-1.4	1.4	-0.1	2.4	-0.3	-0.8	1.8	-0.4	-0.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	7.6	-1.4	-0.6	-0.2	-0.2	2.8	0.3	0.5	-0.4	0.6	1.6	-0.4	-0.0	0.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.0	-1.4	-0.3	0.4	-1.0	0.0	0.3	0.7	-1.1	1.1	1.1	-1.2	-1.4	-0.8
Nervous feelings	0.8	1.4	4.4	0.2	2.1	1.1	-1.1	0.6	1.7	0.7	1.8	0.6	0.1	0.5	1.2	-1.6
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.2	-1.5	0.0	1.1	-0.3	-0.5	0.2	1.3	-0.6	1.4	0.9	-1.5	-0.5	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	4.0	-1.0	0.9	1.3	0.3	-2.0	0.9	0.9	0.3	1.4	1.1	-2.0	0.3	0.6
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.7	-1.3	0.8	1.6	-0.4	-0.3	0.8	1.1	0.9	1.5	0.9	-1.1	0.8	-0.4
Exposure to tobacco smoke outside home	0.8	1.0	3.0	-0.4	1.2	1.3	-0.2	0.3	1.2	0.9	1.6	1.1	0.4	-0.1	1.7	-0.9
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.4	-0.9	1.2	0.9	-1.1	0.8	0.9	0.8	1.0	0.9	1.1	0.4	0.4	-1.6
Medication: Seretide 50 evohaler	0.8	1.0	3.1	-0.9	0.7	1.3	-1.0	1.3	-0.1	0.9	-0.1	1.1	1.1	-1.8	0.7	-0.3
Heart disease (mother)	0.8	0.9	3.9	0.9	-0.2	-0.7	1.4	-1.6	-0.3	-0.4	0.0	-0.6	-0.3	0.6	1.1	2.0
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	7.3	-1.3	-1.2	0.1	0.7	0.3	-0.7	0.1	-1.2	0.9	0.8	-1.3	-2.7	0.2
Ever had prostate specific antigen (PSA) test	0.8	0.9	3.4	-1.4	-0.4	0.1	-1.4	0.6	-0.4	0.4	-1.1	0.6	1.2	-0.9	0.3	-1.8
Pain experienced in last month	0.8	1.3	3.5	1.1	-0.1	-1.1	1.3	0.2	-0.1	-1.6	0.8	-1.8	-1.5	1.9	0.2	0.4
Alcohol drinker status: Previous	0.8	0.9	3.7	-1.0	-1.0	-0.1	-0.0	-0.5	-0.6	0.4	-1.6	0.7	0.6	-1.4	-1.9	-0.1
Hypothyroidism (self reported)	0.7	1.5	11.1	1.1	-0.7	-0.6	3.3	-1.3	-0.1	-1.0	0.3	-1.1	-0.2	1.0	-0.3	1.3
Hair/balding pattern: Pattern 3	0.7	1.0	3.4	-1.6	-1.9	-0.8	-0.7	-0.6	-1.1	-0.1	-1.8	0.3	0.5	-0.8	0.1	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	3.7	1.1	0.2	-0.4	0.4	0.7	0.6	-1.1	1.1	-1.0	-0.9	1.9	-0.6	-0.2
High blood pressure (siblings)	0.7	1.0	3.6	1.5	0.6	-0.6	1.7	0.8	0.1	-0.4	0.4	-0.7	-0.7	1.1	-0.1	1.9
Pulse rate, automated reading	0.7	2.4	9.1	-1.2	-2.1	-1.1	-0.3	0.5	-2.5	-0.6	-3.0	0.4	-0.2	-1.9	-1.9	0.8
Illnesses of father: Heart disease	0.7	1.0	7.0	0.3	-0.3	-0.8	0.1	0.1	-0.9	-1.0	0.3	-0.5	0.3	0.4	1.6	2.6
Ever had bowel cancer screening	0.7	0.9	2.9	-1.1	-0.3	0.1	-0.8	0.6	0.7	0.8	-1.2	0.7	0.9	-0.8	-1.7	-1.2
Guilty feelings	0.7	1.0	3.3	-0.7	0.7	1.3	-0.1	1.1	0.7	1.0	0.3	1.2	0.7	-0.3	-1.6	-1.8
Wears glasses or contact lenses	0.7	0.8	3.3	-0.3	-1.1	-1.2	1.1	-0.2	-0.4	-0.7	-1.2	-0.6	0.1	0.7	-1.8	0.8
Ever depressed for a whole week	0.7	0.9	2.0	-1.2	0.3	0.8	-0.6	1.4	1.0	1.0	0.2	1.1	0.9	-0.4	-0.7	-1.4
Supplements: Calcium	0.7	0.7	3.5	-1.4	-0.8	-0.4	-1.9	0.7	0.5	0.8	-0.4	0.5	0.6	-0.4	0.7	-0.8
Forced vital capacity (FVC)	0.6	2.3	5.2	1.0	-1.0	-1.8	1.3	-1.7	-1.5	-2.1	-0.9	-1.9	-2.3	1.5	-0.4	1.2
Neuroticism score	0.6	1.2	4.0	-1.1	0.7	1.2	-0.6	-0.3	1.2	1.6	-0.1	1.6	0.8	-0.9	-0.4	-2.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	4.0	1.3	-0.6	-1.2	1.8	-1.3	-1.2	-2.0	-0.2	-1.7	-2.0	1.4	-0.6	0.8
Number of full brothers	0.6	0.8	3.2	-1.0	0.0	-0.6	-1.8	0.4	1.7	0.4	0.5	0.2	1.1	0.9	-0.4	0.4
Alcohol intake frequency.	0.6	1.4	3.7	-0.3	1.8	1.2	0.9	0.3	1.9	1.1	1.7	1.4	1.6	-0.2	0.3	0.6
Number of full sisters	0.6	0.7	2.3	-0.5	0.9	0.8	-0.1	0.1	1.5	1.5	0.4	0.8	1.0	-0.1	0.2	-1.0
Had major operations	0.6	0.8	3.8	-0.3	-0.3	-0.5	1.9	-0.4	-0.6	-0.8	-0.2	0.1	0.3	0.4	-1.7	1.1
Leg pain on walking	0.6	0.8	2.4	-1.1	0.4	0.4	-1.6	1.1	0.9	0.8	0.2	0.9	1.4	-0.6	-0.5	-0.6
Supplements: Vitamin C	0.6	0.7	2.6	0.1	0.9	0.9	-0.7	0.9	1.6	1.3	0.8	0.6	0.8	0.1	-0.2	-0.8
Knee pain experienced in last month	0.6	0.9	2.5	-0.6	0.0	1.2	-0.7	-0.1	0.4	1.6	-0.4	1.4	1.1	-1.1	-1.1	-1.1
Number of operations (self-reported)	0.6	0.8	4.8	-0.4	-0.1	0.7	0.1	1.7	-0.3	0.4	-0.4	1.2	0.7	-0.5	-2.2	-0.4
Irritability	0.6	1.0	3.1	0.7	-0.7	-1.1	-0.8	-1.5	-0.8	-0.6	-0.4	-1.3	-1.1	0.1	1.8	0.5
Schizophrenia vs Biploar Disorder	0.5	0.7	1.7	-1.0	0.1	1.2	-0.4	0.4	0.2	1.1	-0.2	1.3	0.8	-1.2	-0.1	-1.0
Alzheimer’s Disease (in father)	0.5	0.5	1.4	-0.1	0.9	0.8	0.2	-1.2	1.0	0.9	1.0	0.5	0.9	0.0	0.0	-0.2
Blood Red Count	0.5	4.6	11.8	-2.6	-2.5	-0.8	1.7	2.7	-1.3	0.8	-3.4	1.4	1.9	-2.4	-3.1	0.7
Allergy or Eczema	0.5	1.4	4.5	-0.7	0.3	0.8	-0.5	1.8	1.1	1.3	-0.1	1.2	1.3	-0.7	-1.4	-2.1
Neuroticism	0.5	1.2	3.5	-1.3	0.5	1.2	-0.3	-0.5	0.7	1.6	-0.1	1.9	1.2	-1.7	0.5	-1.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.7	1.4	0.6	-0.1	1.6	0.5	0.4	-0.4	0.7	-0.6	-0.8	1.0	0.0	-0.2
Medication: Atenolol	0.5	0.6	2.8	-0.3	0.5	0.9	-0.4	-0.9	0.6	1.0	0.4	0.5	0.5	-0.4	1.7	-1.0
Illnesses of siblings	0.5	0.7	5.5	-0.2	-0.5	-0.2	0.3	-2.4	-0.9	-0.5	-0.4	-0.4	-0.7	-0.2	-0.0	-1.0
Hip circumference	0.5	2.3	6.8	-2.0	1.1	1.3	-0.1	0.1	0.8	2.2	-0.5	2.4	2.1	-2.6	0.1	-0.4
Worrier / anxious feelings	0.5	1.0	4.4	0.3	-1.1	-0.5	0.1	1.6	-0.8	-0.4	-1.6	0.0	-0.8	0.2	-2.1	-1.0
Headache pain in last month	0.5	0.8	3.9	0.5	-1.0	-0.6	1.1	0.7	-0.8	-0.6	-0.9	0.0	-0.6	0.4	-2.0	0.8
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	5.3	0.6	-1.2	-0.7	2.3	-0.1	-0.3	-0.9	-0.3	-0.8	-0.0	0.7	-0.9	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.0	-0.3	-0.4	0.6	-0.5	1.0	-0.7	0.3	-1.0	0.8	0.1	-1.2	-1.4	-0.2
Friendships satisfaction	0.5	0.6	1.5	-1.2	-0.3	-0.2	-1.1	1.0	0.6	0.7	-0.3	0.9	0.6	-0.9	0.6	0.4
Commuting to job workplace: Public transport	0.5	0.6	4.2	-0.7	-0.4	-0.0	-0.6	2.1	-0.2	0.5	-0.9	0.2	0.4	-0.7	-0.7	-0.8
Eye problems/disorders: Glaucoma	0.5	0.6	1.7	1.0	-0.3	-0.8	1.0	-0.0	-0.5	-1.3	-0.1	-1.0	-0.9	0.7	0.5	1.0
Average weekly beer plus cider intake	0.5	0.7	1.9	-0.7	1.0	1.3	-1.0	0.3	0.7	0.7	0.9	0.9	0.5	-0.0	0.2	-1.4
Myopia	0.5	0.7	1.6	1.0	0.4	-0.0	-0.5	1.3	0.4	-0.6	0.8	-0.7	-1.1	1.2	0.2	-1.3
Arm predicted mass (left)	0.5	2.4	8.5	-1.3	1.6	1.4	0.8	-2.1	0.7	1.4	0.9	1.6	1.4	-1.9	2.9	1.0
Depression (Nagel 2018)	0.4	0.6	4.5	-0.3	0.2	-0.3	-0.5	-1.2	0.4	0.2	0.6	0.2	0.6	-0.0	2.1	0.4
Neuroticism (Nagel 2018)	0.4	0.9	1.9	-0.4	1.0	1.2	-0.3	-0.7	0.8	1.1	0.7	1.2	0.6	-0.9	1.2	-1.4
HDL Cholesterol	0.4	0.7	3.4	1.1	-0.5	-0.7	0.5	-1.8	-0.6	-0.5	-0.3	-0.8	-0.8	-0.0	-0.7	1.0
Number of treatments/medications taken	0.4	0.8	1.9	1.1	-1.4	-0.6	1.3	1.0	-1.0	-0.4	-1.0	-0.8	-0.7	0.2	-0.5	0.3
Severe depression (siblings)	0.4	0.5	2.0	-0.5	0.8	0.7	0.3	0.5	1.4	0.8	0.9	0.6	0.8	0.3	-0.0	-0.2
Leg fat-free mass (left)	0.4	2.3	4.8	-1.6	1.8	1.6	0.3	-1.0	0.8	1.5	0.7	2.2	1.9	-2.2	2.0	-0.2
Relative age voice broke	0.4	0.6	1.8	0.4	-1.3	-1.2	-1.1	-0.6	-0.7	-0.7	-0.6	-0.8	-0.6	0.3	-0.4	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	3.1	-0.4	1.1	1.4	0.6	-0.8	1.1	1.8	0.4	0.8	0.3	-0.8	-0.6	-0.7
Serious illness, injury or assault to yourself	0.4	0.5	1.7	-0.1	-0.3	0.0	1.1	1.3	0.5	-0.5	0.4	-0.1	0.7	0.3	-0.9	1.2
Hayfever, allergic rhinitis or eczema	0.4	1.0	3.4	-0.6	-0.4	0.4	0.3	1.8	0.4	0.6	-0.4	0.8	0.8	-0.5	-1.8	-1.8
Leg predicted mass (left)	0.4	2.4	4.9	-1.7	1.7	1.6	0.2	-1.0	0.8	1.5	0.7	2.2	2.0	-2.2	2.0	-0.3
Had other major operations	0.4	0.4	1.4	-1.2	-0.7	0.2	0.7	-0.1	-0.6	0.2	-0.6	0.6	0.8	-1.0	-0.3	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.8	-0.6	0.6	1.3	0.9	-0.7	0.2	1.6	-0.2	1.1	0.5	-1.7	-1.3	-0.8
Pain all over the body in last month	0.4	0.5	2.8	0.4	-0.4	-0.8	-0.2	1.7	-1.0	-0.7	-0.5	-0.5	-0.2	-0.1	0.5	0.1
Pulse rate	0.4	0.7	1.7	-0.9	-0.8	-0.6	-0.9	1.3	-1.2	-0.9	-1.3	0.0	-0.3	-0.9	-0.2	0.3
Arm fat mass (right)	0.4	1.5	6.0	-1.6	0.6	1.2	0.1	0.8	0.3	1.6	-0.6	2.0	1.6	-2.4	0.1	-0.1
Birth weight of first child	0.4	0.7	2.3	-1.0	-0.6	-0.1	0.4	-1.5	-0.7	0.5	-1.4	0.4	0.5	-1.0	-0.6	0.0
Medication: Ventolin 100micrograms inhaler	0.4	0.6	2.2	-0.4	-0.7	0.0	0.2	1.0	-0.9	0.5	-1.1	0.6	-0.2	-1.5	-0.3	0.8
Forced vital capacity (FVC), Best measure	0.4	1.6	4.4	1.4	0.2	-0.9	1.4	-1.5	-0.8	-1.8	0.3	-1.5	-2.1	1.6	0.1	0.2
Arm fat-free mass (right)	0.4	2.1	6.8	-1.3	1.4	1.3	0.3	-2.0	0.7	1.3	0.7	1.7	1.5	-1.9	2.6	0.8
Arm predicted mass (right)	0.4	2.0	5.7	-1.3	1.4	1.2	0.6	-1.7	0.7	1.2	0.8	1.7	1.6	-1.7	2.4	0.9
Leg fat-free mass (right)	0.4	2.2	4.9	-1.6	1.8	1.6	0.0	-1.0	0.8	1.5	0.7	2.2	1.9	-1.9	1.9	-0.3
Arm fat percentage (left)	0.4	1.7	5.2	-1.5	-0.2	0.6	-0.3	1.9	-0.2	1.4	-1.4	1.7	1.3	-2.3	-1.1	-0.5
Handedness (chirality/laterality): Left-handed	0.4	0.5	2.1	-0.7	-0.8	-0.5	-0.7	0.5	-0.5	0.0	-1.2	0.4	0.1	-0.3	-1.5	0.2
Long-standing illness, disability or infirmity	0.4	0.7	2.0	0.0	1.0	0.9	-0.5	0.3	1.4	1.0	1.0	0.8	1.1	-0.3	0.3	-0.4
Eye problems/disorders: Cataract	0.4	0.5	2.3	0.2	-0.7	-1.1	0.3	-1.0	-0.0	-0.6	0.1	-0.7	-0.2	0.3	0.6	1.5
Breast cancer (self-reported)	0.4	0.5	2.9	0.2	0.5	0.7	1.7	0.2	0.0	-0.1	0.2	0.1	0.3	-0.9	-0.2	1.2
Whole body water mass	0.4	2.1	8.6	-1.0	1.8	1.3	0.6	-1.8	0.7	1.1	1.1	1.6	1.3	-1.5	2.9	0.6
Leg predicted mass (right)	0.4	2.2	4.8	-1.6	1.8	1.6	0.0	-1.0	0.8	1.5	0.7	2.2	1.9	-1.9	1.9	-0.3
Supplements: Fish oil (including cod liver oil)	0.4	0.5	3.7	0.1	-0.7	-0.5	-0.8	-0.0	-0.2	0.1	-1.0	-0.3	0.2	-0.0	-1.9	-0.5
Medication: Lisinopril	0.4	0.6	2.8	1.2	-0.5	-0.3	1.7	-0.2	-0.4	-0.5	-0.2	-0.6	-0.9	0.2	-0.8	0.3
Medication: Atorvastatin	0.4	0.5	1.3	0.1	-1.0	-1.1	-0.2	0.8	-0.9	-0.9	-0.6	-0.8	-0.3	0.5	0.1	1.0
Alcohol drinker status: Never	0.4	0.5	1.8	0.5	-0.3	-0.7	1.3	0.5	-0.1	-0.9	0.3	-0.6	-0.1	0.8	-0.5	1.3
Arm fat-free mass (left)	0.4	2.1	7.6	-1.1	1.4	1.3	0.9	-1.8	0.5	1.2	0.8	1.6	1.2	-1.8	2.8	1.1
Leg fat mass (left)	0.4	1.6	5.3	-1.7	0.5	1.1	-0.4	0.8	0.5	1.7	-0.6	1.9	1.7	-2.3	0.2	-0.2
Prostate Cancer	0.3	0.4	1.4	0.8	0.1	-0.3	0.3	0.5	0.3	-0.3	0.9	-0.6	-0.6	1.2	0.9	0.5
Neuroticism (2016)	0.3	0.4	2.1	-0.7	-0.9	-0.2	0.4	1.4	-0.3	-0.3	-0.9	0.3	0.5	-0.3	-0.5	0.1
Triglycerides	0.3	0.5	2.5	0.2	0.5	0.6	-0.6	1.5	-0.3	-0.0	0.6	0.0	0.2	-0.2	1.6	-0.1
Blood White Count	0.3	1.9	9.4	1.1	-1.0	-1.0	3.1	1.4	-0.8	-1.6	-0.5	-0.8	-1.1	1.1	-1.4	1.2
Lung FEV1/FVC ratio	0.3	1.3	3.6	-1.3	-1.9	-0.8	0.5	-0.7	-0.9	-0.2	-1.7	0.1	1.2	-1.1	-0.8	1.7
Lung FVC	0.3	1.5	4.6	-1.7	-0.8	-0.9	-1.0	-2.0	-0.7	0.3	-2.1	0.3	0.5	-1.3	-1.7	0.5
Sensitivity / hurt feelings	0.3	0.4	1.1	-0.6	0.6	0.7	0.4	0.7	0.8	0.5	0.5	1.0	0.6	-0.1	0.5	-0.9
Relative age of first facial hair	0.3	0.7	5.3	-0.6	0.0	0.0	-2.3	0.2	1.0	0.4	0.3	0.5	1.1	-0.1	-0.2	-0.7
Medication for hormone replacement therapy	0.3	0.3	1.4	-1.2	-0.6	-0.5	-0.6	0.1	0.0	0.3	-0.8	0.3	0.7	-0.2	-0.7	-0.5
Fed-up feelings	0.3	0.5	1.3	-0.6	-0.0	0.8	0.4	-0.4	0.5	0.9	-0.5	1.1	0.3	-1.1	-1.0	-0.4
Qualifications: CSEs or equivalent	0.3	0.4	1.5	0.5	0.7	0.8	-0.3	-0.2	0.2	0.9	0.8	0.6	-0.4	-1.0	1.2	0.1
Alcohol usually taken with meals	0.3	0.5	1.9	0.6	-0.3	-0.7	0.8	-0.4	0.5	-0.5	0.4	-0.8	0.1	1.4	-1.3	0.2
Had menopause	0.3	0.4	1.8	-0.0	-0.7	-0.8	0.9	0.9	-0.2	-0.2	-0.5	-0.4	0.7	0.0	-0.3	1.3
Allergy	0.3	0.7	3.0	0.3	0.8	-0.2	-1.3	-0.8	0.3	-0.6	1.0	-0.5	-0.5	1.0	1.7	0.6
Arm fat percentage (right)	0.3	1.4	5.1	-1.4	0.1	0.8	-0.1	1.6	-0.2	1.3	-1.1	1.7	1.1	-2.2	-0.7	-0.4
Trunk fat-free mass	0.3	1.6	10.3	-0.1	1.4	0.6	1.1	-2.1	0.0	0.2	1.0	0.5	0.2	-0.6	3.2	1.2
Asthma	0.3	0.6	1.6	0.6	-0.9	-0.2	1.0	1.3	-1.1	-0.1	-0.8	-0.4	-0.8	-0.6	-1.0	0.7
Medication: Lansoprazole	0.3	0.4	1.2	0.1	0.0	0.6	0.6	-0.7	-0.0	1.1	-0.5	0.7	0.3	-0.9	-0.7	-0.2
Pulse wave Arterial Stiffness index	0.3	0.3	0.9	1.0	0.6	0.3	0.5	-0.9	0.4	0.1	0.4	-0.3	-0.7	0.7	-0.6	-0.5
Trunk predicted mass	0.3	1.6	9.7	-0.0	1.3	0.5	1.1	-2.0	-0.0	0.1	1.0	0.5	0.1	-0.6	3.1	1.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.2	0.6	-0.3	0.2	1.1	-0.8	-0.7	-0.1	-0.3	-0.1	-0.4	-0.4	-0.8	0.8
Gout (self-reported)	0.3	0.4	0.9	-0.9	0.0	0.9	0.8	0.0	-0.1	0.2	-0.4	0.4	0.9	-0.9	-0.6	0.0
Leg fat percentage (right)	0.3	0.9	3.2	-1.2	-0.5	0.2	0.0	1.4	-0.2	1.1	-1.4	1.0	0.8	-1.8	-0.5	0.1
Comparative body size at age 10	0.3	1.0	3.2	-0.8	-1.8	-1.4	-0.6	0.5	-1.0	-0.8	-1.8	-0.3	0.3	-0.2	-0.9	0.4
Worry too long after embarrassment	0.3	0.5	2.8	0.6	0.1	0.3	0.4	1.1	0.1	-0.2	-0.1	-0.1	-0.6	0.5	-1.7	-1.2
Emphysema/chronic bronchitis	0.3	0.4	1.2	-1.0	0.1	0.2	0.4	0.9	0.1	-0.1	0.1	0.4	0.9	-1.1	0.1	0.7
Medication: Allopurinol	0.3	0.3	0.9	-0.9	-0.0	0.8	0.7	0.3	-0.2	0.2	-0.5	0.6	0.7	-1.0	-0.5	0.3
Leg fat mass (right)	0.3	1.3	5.2	-1.6	0.4	0.9	0.1	0.8	0.3	1.4	-0.8	1.7	1.4	-2.3	0.0	0.1
Suffer from ‘nerves’	0.3	0.4	2.0	0.9	0.8	0.3	-0.4	-0.2	0.4	0.3	0.5	-0.3	-1.4	0.5	0.5	-0.7
Whole body fat-free mass	0.3	2.0	8.4	-0.9	1.8	1.3	0.6	-1.8	0.6	1.0	1.1	1.5	1.2	-1.5	2.9	0.5
Qualifications: nursing, teaching	0.3	0.4	2.5	-0.2	0.7	-0.6	-0.2	1.6	-0.1	-0.7	0.1	-0.5	-0.1	0.7	0.8	-0.2
Commuting to job workplace: Walk	0.3	0.4	3.9	0.0	0.2	0.1	-0.2	2.0	-0.3	-0.5	0.2	0.2	0.0	-0.2	0.2	-0.0
Asthma (self-reported)	0.3	0.6	2.2	0.4	-0.8	-0.1	0.9	1.5	-1.0	-0.1	-0.8	-0.2	-0.7	-0.7	-1.1	0.4
Arm fat mass (left)	0.3	1.4	5.3	-1.6	0.3	0.8	0.0	1.0	0.0	1.4	-0.9	1.8	1.4	-2.3	-0.1	-0.1
Average weekly champagne plus white wine intake	0.3	0.4	2.2	0.0	0.1	0.7	-1.0	0.3	0.0	1.0	-0.1	0.6	0.1	-0.7	0.4	-1.5
Basal metabolic rate	0.3	1.6	5.8	-1.0	1.5	1.1	0.7	-1.4	0.5	1.0	0.7	1.5	1.1	-1.6	2.4	0.6
Leg fat percentage (left)	0.3	1.1	3.1	-1.4	-0.2	0.5	-0.7	1.4	0.2	1.5	-1.1	1.4	1.2	-1.8	-0.4	-0.4
Age started oral contraceptive pill	0.3	0.3	1.4	-1.2	-0.5	-0.6	-0.2	0.7	-0.2	0.1	-0.5	0.3	0.9	-0.5	0.5	0.1
Worry (Nagel 2018)	0.2	0.5	2.8	0.3	0.8	0.7	-0.6	0.0	0.7	0.3	0.7	0.3	-0.3	0.3	0.4	-1.7
HbA1C	0.2	0.3	1.6	0.3	-0.0	-0.3	-0.4	1.3	0.4	-0.4	0.5	-0.5	0.6	0.5	0.1	0.2
LDL Cholesterol	0.2	0.3	1.1	0.4	-0.1	-0.3	1.1	0.5	-0.5	-0.9	0.1	-0.3	-0.6	0.3	0.1	0.4
Heel T-Score	0.2	1.6	5.5	1.9	-0.1	-0.8	1.8	0.2	-1.5	-1.3	-0.5	-1.4	-2.3	0.9	0.8	-0.1
Hair Pigment	0.2	4.7	13.5	-0.9	2.3	3.4	0.5	-0.4	2.6	3.7	1.5	3.2	2.4	-1.8	-0.9	-1.0
Tanning	0.2	2.6	6.4	-2.5	0.0	0.7	-2.5	-0.6	-0.5	1.1	-1.0	1.6	0.9	-2.3	2.5	-1.9
Hand grip strength (left)	0.2	0.5	1.9	0.6	-0.7	-0.5	0.6	-0.3	-0.5	-0.7	-0.6	-0.6	-1.1	0.8	-1.4	0.3
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.2	-0.4	0.3	-0.1	-0.3	-0.4	0.9	0.2	0.8	0.2	0.5	-0.0	1.1	0.2
Ever had hysterectomy (womb removed)	0.2	0.2	0.7	0.2	-0.4	-0.6	-0.8	0.6	-0.4	-0.6	-0.2	-0.2	-0.0	0.3	0.1	0.6
Trunk fat percentage	0.2	0.7	2.7	-0.0	-0.6	-0.3	1.0	1.1	-0.7	0.1	-1.5	0.3	0.1	-1.1	-1.6	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.3	-0.5	-0.1	-0.1	-1.1	-0.9	0.7	0.5	0.1	0.2	0.5	-0.2	0.4	0.0
Taking other prescription medications	0.2	0.3	1.6	0.4	-0.4	0.2	1.3	0.4	0.1	-0.4	0.1	-0.1	0.2	-0.2	-0.2	1.2
Supplements: Glucosamine	0.2	0.2	1.1	0.3	-0.7	-0.2	0.0	0.5	-0.3	-0.8	-0.0	-0.4	-0.0	1.0	-0.6	0.0
Medication: Levothyroxine sodium	0.2	0.3	2.3	0.1	0.2	0.3	1.5	0.2	0.2	-0.4	0.4	-0.3	0.2	0.1	-0.1	0.8
Weight	0.2	1.0	3.2	-1.1	0.8	0.8	0.9	-0.5	0.1	1.0	-0.2	1.4	1.0	-1.8	1.2	0.6
Peak expiratory flow (PEF)	0.2	0.5	2.1	0.2	-0.5	-0.4	1.4	0.8	-0.2	-1.3	0.4	-0.6	-0.5	0.5	-0.4	0.8
Body fat percentage	0.2	0.9	2.5	-0.6	-0.5	0.1	0.4	1.6	-0.4	0.7	-1.4	0.8	0.6	-1.6	-1.2	-0.0
Pulse wave peak to peak time	0.2	0.3	0.7	-0.4	-0.6	-0.6	0.1	0.6	-0.6	-0.6	-0.2	-0.2	0.2	-0.1	0.7	0.9
Whole body fat mass	0.2	0.6	2.8	-0.8	-0.1	0.3	0.6	0.7	-0.3	0.7	-1.1	1.1	0.8	-1.7	-0.3	0.2
Mineral and other dietary supplements	0.2	0.3	1.4	0.4	0.3	0.1	0.7	0.2	-0.3	-0.1	0.3	-0.0	-0.8	-0.5	1.2	0.5
Osteoporosis (self-reported)	0.2	0.2	1.3	-0.4	-0.3	0.2	0.4	0.4	-0.4	0.3	-0.5	0.6	-0.0	-1.1	-0.3	0.0
Ever taken oral contraceptive pill	0.2	0.3	0.8	-0.6	-0.8	-0.2	0.0	0.9	-0.3	-0.5	-0.5	0.5	-0.4	-0.1	-0.5	-0.7
Fractured/broken bones in last 5 years	0.2	0.3	1.8	-0.2	-0.9	-0.3	-0.3	-1.3	-0.2	-0.3	-0.5	-0.0	0.1	-0.6	0.6	0.0
Diastolic blood pressure, automated reading	0.2	0.5	2.5	0.4	0.1	-0.7	1.2	0.1	-1.0	-0.8	-0.2	-0.2	-0.5	-0.2	0.5	1.6
Basal cell carcinoma (self-reported)	0.2	0.2	0.8	-0.5	-0.3	0.6	-0.2	-0.1	0.3	0.5	0.0	0.9	0.8	-0.5	-0.2	0.0
Age at First Birth	0.1	0.2	0.6	0.2	0.6	0.5	-0.7	-0.2	0.4	0.8	-0.1	0.2	-0.1	-0.1	-0.2	-0.5
Hand grip strength (right)	0.1	0.3	0.9	0.2	-0.8	-0.3	0.7	-0.6	-0.6	-0.7	-0.6	-0.1	-0.5	0.4	-0.9	0.4
Trunk fat mass	0.1	0.5	1.6	-0.2	-0.3	-0.2	1.1	0.5	-0.7	0.1	-1.2	0.4	0.1	-1.3	-0.7	0.6
Waist circumference	0.1	0.5	1.8	-0.8	-0.1	0.4	0.0	0.9	-0.3	1.1	-0.8	1.1	0.6	-1.3	0.2	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	0.6	-0.7	-0.5	-0.7	-0.3	-0.1	-0.3	-0.1	-0.4	-0.4	0.1	0.4	-0.1
Neck or shoulder pain in last month	0.1	0.1	0.5	0.0	-0.4	0.2	0.5	-0.7	0.3	0.6	-0.1	0.4	0.3	-0.2	0.1	-0.1
Medication: Aspirin	0.1	0.2	0.5	-0.2	0.4	0.3	0.6	-0.3	0.6	0.7	0.2	0.2	0.5	-0.3	-0.0	0.2
Medication: Aspirin	0.1	0.2	0.8	0.1	0.5	0.5	0.9	-0.3	0.5	0.5	0.4	0.1	0.2	-0.4	-0.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.9	-0.5	-0.8	-0.6	0.6	-0.9	-0.3	0.1	-1.0	-0.3	0.1	-0.0	-0.5	0.4
Risk taking	0.1	0.1	0.6	-0.3	-0.1	0.3	-0.3	0.2	0.1	0.6	-0.1	0.1	0.3	-0.4	0.8	-0.5

Hub : Genes

KCNJ11

Models

Trait associations