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chr15:89,680,384-91,135,411

Best TWAS P=2.02e-09 · Best GWAS P=1.81e-08 conditioned to 0.804

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adrenal Gland	AP3S2	0.37	0.14	lasso	7	0.11	1.1e-04	5.6	5.5	3.3e-08	0.95	0.01	0.99	FALSE
2	GTEx	Cells Transformed fibroblasts	AP3S2	0.22	0.16	lasso	5	0.18	4.1e-13	5.5	5.5	5.0e-08	0.96	0.01	0.99	FALSE
3	GTEx	Esophagus Mucosa	AP3S2	0.19	0.16	lasso	1	0.15	4.0e-10	5.4	5.4	5.5e-08	0.94	0.01	0.99	FALSE
4	GTEx	Whole Blood	AP3S2	0.19	0.06	lasso	2	0.09	2.8e-08	5.4	5.8	6.0e-09	0.90	0.01	0.99	FALSE
5	NTR	Blood	AP3S2	0.17	0.11	enet	26	0.14	2.7e-43	5.4	5.5	3.4e-08	0.90	0.01	0.99	FALSE
6	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ANPEP	0.07	0.03	enet	4	0.02	9.1e-03	-5.4	5.2	1.6e-07	0.50	0.01	0.85	FALSE
7	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AP3S2	0.19	0.27	lasso	4	0.24	2.0e-20	5.6	5.6	2.0e-08	1.00	0.00	1.00	FALSE
8	The Cancer Genome Atlas	Breast Invasive Carcinoma	AP3S2	0.13	0.19	lasso	5	0.20	5.3e-40	5.5	5.6	2.6e-08	0.97	0.01	0.99	FALSE
9	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	AP3S2	0.23	0.27	lasso	1	0.26	3.8e-13	5.5	5.5	3.0e-08	0.93	0.01	0.99	FALSE
10	The Cancer Genome Atlas	Colon Adenocarcinoma	AP3S2	0.18	0.18	lasso	4	0.17	5.2e-10	5.5	6.0	2.0e-09	0.92	0.01	0.99	TRUE
11	The Cancer Genome Atlas	Esophageal Carcinoma	AP3S2	0.22	0.15	lasso	2	0.13	6.2e-05	5.5	5.5	2.9e-08	0.94	0.01	0.98	FALSE
12	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AP3S2	0.15	0.24	enet	14	0.27	6.3e-30	5.5	5.3	1.3e-07	0.95	0.01	0.99	FALSE
13	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C15orf38	0.02	0.03	lasso	1	0.02	1.9e-03	5.5	-5.5	4.4e-08	-0.95	0.00	0.95	FALSE
14	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AP3S2	0.27	0.38	lasso	4	0.39	3.1e-47	5.4	5.5	3.6e-08	0.97	0.02	0.98	FALSE
15	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ANPEP	0.15	0.05	blup	55	0.07	5.6e-05	-5.5	-5.5	3.9e-08	-0.81	0.01	0.93	FALSE
16	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AP3S2	0.28	0.28	blup	61	0.33	1.5e-19	5.4	5.3	1.5e-07	0.92	0.01	0.99	FALSE
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	AP3S2	0.23	0.27	lasso	6	0.30	3.2e-34	5.5	5.6	1.7e-08	0.96	0.01	0.99	FALSE
18	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	AP3S2	0.27	0.22	lasso	5	0.23	3.0e-11	5.4	5.5	3.6e-08	0.96	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Lung Adenocarcinoma	AP3S2	0.22	0.38	lasso	4	0.39	2.3e-48	5.5	5.6	2.6e-08	0.97	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AP3S2	0.22	0.26	enet	18	0.30	1.6e-34	5.5	5.6	2.1e-08	0.95	0.01	0.99	FALSE
21	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	AP3S2	0.15	0.14	blup	62	0.15	1.8e-10	5.6	5.4	8.5e-08	0.92	0.01	0.99	FALSE
22	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	AP3S2	0.44	0.37	lasso	3	0.39	2.2e-17	5.4	5.5	3.3e-08	0.97	0.01	0.99	FALSE
23	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	AP3S2	0.41	0.45	lasso	6	0.44	4.0e-19	5.5	5.6	2.5e-08	0.97	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Prostate Adenocarcinoma	AP3S2	0.44	0.54	enet	13	0.55	3.3e-68	5.5	5.4	5.8e-08	0.97	0.01	0.99	FALSE
25	The Cancer Genome Atlas	Rectum Adenocarcinoma	AP3S2	0.18	0.19	lasso	5	0.15	2.1e-04	5.5	5.6	2.6e-08	0.97	0.01	0.88	FALSE
26	The Cancer Genome Atlas	Soft Tissue Sarcoma	AP3S2	0.14	0.18	enet	5	0.16	1.2e-09	5.4	5.6	2.5e-08	0.97	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Skin Cutaneous Melanoma	AP3S2	0.19	0.09	lasso	2	0.04	2.7e-02	5.5	5.5	4.7e-08	0.97	0.01	0.85	FALSE
28	The Cancer Genome Atlas	Stomach Adenocarcinoma	AP3S2	0.13	0.16	lasso	2	0.17	2.6e-12	5.4	5.6	2.2e-08	0.98	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Testicular Germ Cell Tumors	AP3S2	0.29	0.32	blup	59	0.32	8.2e-12	5.5	5.7	1.6e-08	0.91	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	AP3S2	0.30	0.45	lasso	7	0.44	7.0e-47	5.4	5.7	1.2e-08	0.97	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	AP3S2	0.26	0.25	lasso	4	0.25	1.4e-07	5.5	5.6	2.0e-08	0.96	0.01	0.99	FALSE