Best TWAS P=7.66e-08 · Best GWAS P=1.06e-07 conditioned to 0.356
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | ARHGDIB | 0.10 | 0.06 | enet | 10 | 0.08 | 5.4e-05 | 5.3 | -5.3 | 9.8e-08 | -0.97 | 0.02 | 0.97 | FALSE |
2 | METSIM | Adipose | MGP | 0.04 | 0.04 | bslmm | 359 | 0.04 | 6.2e-07 | 4.7 | -5.1 | 3.0e-07 | -0.82 | 0.17 | 0.82 | FALSE |
3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ERP27 | 0.04 | 0.09 | lasso | 5 | 0.09 | 2.8e-17 | 5.3 | -5.3 | 1.0e-07 | -0.98 | 0.01 | 0.99 | FALSE |
4 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | ERP27 | 0.09 | 0.14 | lasso | 2 | 0.12 | 1.7e-06 | 5.2 | -5.3 | 1.4e-07 | -0.95 | 0.01 | 0.98 | FALSE |
5 | The Cancer Genome Atlas | Glioblastoma Multiforme | ERP27 | 0.18 | 0.07 | blup | 76 | 0.11 | 2.7e-04 | 5.3 | -5.3 | 1.4e-07 | -0.89 | 0.02 | 0.92 | FALSE |
6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ERP27 | 0.10 | 0.18 | lasso | 6 | 0.18 | 1.2e-19 | 5.3 | -5.2 | 1.7e-07 | -0.95 | 0.02 | 0.98 | FALSE |
7 | The Cancer Genome Atlas | Lung Adenocarcinoma | ERP27 | 0.15 | 0.28 | lasso | 6 | 0.28 | 8.3e-33 | 5.2 | -5.3 | 1.2e-07 | -0.97 | 0.01 | 0.99 | FALSE |
8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ERP27 | 0.04 | 0.05 | enet | 12 | 0.04 | 1.0e-03 | 5.1 | -5.3 | 9.3e-08 | -0.96 | 0.02 | 0.94 | FALSE |
9 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ERP27 | 0.14 | 0.12 | lasso | 5 | 0.11 | 2.9e-05 | 5.3 | -5.3 | 1.5e-07 | -0.97 | 0.01 | 0.98 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ERP27 | 0.13 | 0.14 | lasso | 5 | 0.13 | 8.3e-14 | 5.0 | -5.4 | 7.7e-08 | -0.92 | 0.02 | 0.98 | TRUE |
11 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ERP27 | 0.10 | 0.05 | lasso | 1 | 0.08 | 8.9e-04 | 5.3 | -5.3 | 1.2e-07 | -0.98 | 0.02 | 0.96 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | ERP27 | 0.37 | 0.54 | enet | 18 | 0.55 | 2.3e-63 | 5.3 | -5.2 | 2.0e-07 | -0.97 | 0.01 | 0.99 | FALSE |