Hub : Traits :

Fractured/broken bones in last 5 years

25 significantly associated models · 9 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	4	305291	1717024	1	2	2.1e-07	7.1e-07	0.00089	55	FGFRL1
2	6	127196109	127764305	1	1	6.3e-13	2.6e-13	0.07360	94	RSPO3
3	6	151569243	152184020	1	1	2.5e-07	2.4e-06	0.32800	96	C6orf97
4	12	14337924	15812575	3	1	7.7e-08	1.1e-07	0.35600	97	ERP27

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Heel T-Score	125.02	4	4	8.9	-0.95	0.0133	C6orf97 ERP27 FGFRL1 RSPO3
Heel bone mineral density (BMD) T-score, automated (left)	82.49	4	3	6.7	-0.96	0.0106	C6orf97 ERP27 FGFRL1 RSPO3
Heel bone mineral density (BMD) T-score, automated (right)	77.43	3	3	6.7	-0.99	0.0053	C6orf97 FGFRL1 RSPO3
Waist Hip Ratio (WHR)	22.87	2	2	4.4	0.00	1.0000	FGFRL1 RSPO3
Breast Cancer	9.86	2	1	2.2	0.00	1.0000	C6orf97 RSPO3
Hand grip strength (left)	8.52	2	1	2.2	0.00	1.0000	ERP27 RSPO3
Osteoporosis (self-reported)	7.38	2	0	0.0	0.00	1.0000	FGFRL1 RSPO3
Hand grip strength (right)	7.30	1	1	2.2	0.00	1.0000	ERP27
Supplements: Glucosamine	4.23	1	0	0.0	0.00	1.0000	ERP27
Supplements: Calcium	4.12	1	0	0.0	0.00	1.0000	ERP27
Heart attack	3.84	1	0	0.0	0.00	1.0000	FGFRL1
Heart attack/myocardial infarction (self-reported)	3.51	1	0	0.0	0.00	1.0000	FGFRL1
Pulse wave reflection index	3.38	1	0	0.0	0.00	1.0000	FGFRL1
Crohns Disease (2017)	3.22	1	0	0.0	0.00	1.0000	RSPO3
Hip circumference	3.08	2	1	2.2	0.00	1.0000	FGFRL1 RSPO3
Triglycerides	3.04	1	0	0.0	0.00	1.0000	RSPO3
Blood Red Count	2.79	1	1	2.2	0.00	1.0000	RSPO3
Leg pain on walking	2.73	1	0	0.0	0.00	1.0000	FGFRL1
Crohns Disease (2012)	2.61	1	0	0.0	0.00	1.0000	RSPO3
Hypertension (Self-reported)	2.59	2	0	0.0	0.00	1.0000	C6orf97 RSPO3
Commuting to job workplace: Car/motor vehicle	2.57	1	0	0.0	0.00	1.0000	C6orf97
High blood pressure	2.51	1	0	0.0	0.00	1.0000	C6orf97
Neck or shoulder pain in last month	2.50	1	0	0.0	0.00	1.0000	FGFRL1
Illnesses of siblings: Diabetes	2.47	1	0	0.0	0.00	1.0000	FGFRL1
HDL Cholesterol	2.41	1	0	0.0	0.00	1.0000	RSPO3
Number of live births	2.23	1	0	0.0	0.00	1.0000	C6orf97
Forced vital capacity (FVC)	2.09	2	0	0.0	0.00	1.0000	FGFRL1 RSPO3
Vascular/heart problems diagnosed by doctor	2.04	1	0	0.0	0.00	1.0000	C6orf97
Forced expiratory volume in 1-second (FEV1)	2.01	2	0	0.0	0.00	1.0000	FGFRL1 RSPO3
Pulse rate, automated reading	1.88	2	0	0.0	0.00	1.0000	FGFRL1 RSPO3
Birth weight	1.85	1	0	0.0	0.00	1.0000	RSPO3
Arm fat-free mass (left)	1.83	2	1	2.2	0.00	1.0000	ERP27 FGFRL1
Trunk fat-free mass	1.77	2	1	2.2	0.00	1.0000	ERP27 FGFRL1
Arm fat-free mass (right)	1.76	2	0	0.0	0.00	1.0000	ERP27 FGFRL1
Trunk predicted mass	1.75	2	1	2.2	0.00	1.0000	ERP27 FGFRL1
Hair/balding pattern: Pattern 4	1.75	1	0	0.0	0.00	1.0000	RSPO3
Arm predicted mass (right)	1.74	2	0	0.0	0.00	1.0000	ERP27 FGFRL1
Arm predicted mass (left)	1.61	2	0	0.0	0.00	1.0000	ERP27 FGFRL1
Whole body water mass	1.60	2	0	0.0	0.00	1.0000	ERP27 FGFRL1
Whole body fat-free mass	1.55	2	0	0.0	0.00	1.0000	ERP27 FGFRL1
Sitting height	1.53	4	0	0.0	-0.99	0.0115	C6orf97 ERP27 FGFRL1 RSPO3
Cardiovascular Disease	1.50	1	0	0.0	0.00	1.0000	C6orf97
Basal metabolic rate	1.45	2	0	0.0	0.00	1.0000	ERP27 FGFRL1
Smoking Status	1.42	1	0	0.0	0.00	1.0000	FGFRL1
Impedance of arm (left)	1.35	1	0	0.0	0.00	1.0000	ERP27
Waist circumference	1.23	1	0	0.0	0.00	1.0000	RSPO3
Impedance of arm (right)	1.22	1	0	0.0	0.00	1.0000	ERP27
Leg fat-free mass (right)	1.22	2	0	0.0	0.00	1.0000	ERP27 FGFRL1
Leg fat-free mass (left)	1.19	2	0	0.0	0.00	1.0000	ERP27 FGFRL1
Leg predicted mass (right)	1.19	2	0	0.0	0.00	1.0000	ERP27 FGFRL1
Leg predicted mass (left)	1.18	2	0	0.0	0.00	1.0000	ERP27 FGFRL1
Impedance of whole body	1.17	1	0	0.0	0.00	1.0000	ERP27
Systolic Blood Pressure	1.07	1	0	0.0	0.00	1.0000	C6orf97
Comparative height size at age 10	1.03	1	0	0.0	0.00	1.0000	FGFRL1
Impedance of leg (left)	0.96	1	0	0.0	0.00	1.0000	RSPO3
Systolic blood pressure, automated reading	0.93	1	0	0.0	0.00	1.0000	C6orf97
Impedance of leg (right)	0.86	1	0	0.0	0.00	1.0000	RSPO3
Weight	0.81	1	0	0.0	0.00	1.0000	FGFRL1
Standing height	0.71	1	0	0.0	0.00	1.0000	FGFRL1
Height	0.54	2	0	0.0	0.00	1.0000	ERP27 FGFRL1
Blood Platelet Count	0.38	1	0	0.0	0.00	1.0000	RSPO3
Hair Pigment	0.12	1	0	0.0	0.00	1.0000	FGFRL1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Uterus	0	0.000	1.5
GTEx	Artery Aorta	1	0.034	1.4
GTEx	Artery Coronary	0	0.000	1.4
GTEx	Artery Tibial	2	0.053	1.4
GTEx	Brain Cortex	0	0.000	1.4
GTEx	Brain Frontal Cortex BA9	0	0.000	1.4
GTEx	Brain Hippocampus	0	0.000	1.4
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.4
GTEx	Ovary	0	0.000	1.4
GTEx	Small Intestine Terminal Ileum	0	0.000	1.4
GTEx	Vagina	0	0.000	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.4
GTEx	Adipose Subcutaneous	1	0.029	1.3
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Cerebellum	0	0.000	1.3
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue	0	0.000	1.3
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	1	0.024	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Liver	0	0.000	1.3
GTEx	Lung	0	0.000	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Skin Sun Exposed Lower leg	1	0.027	1.3
GTEx	Spleen	0	0.000	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
GTEx	Thyroid	1	0.025	1.3
GTEx	Whole Blood	0	0.000	1.3
METSIM	Adipose	2	0.043	1.3
NTR	Blood	0	0.000	1.3
YFS	Blood	0	0.000	1.3
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	1	0.060	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	2	0.045	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.098	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	2	0.126	1.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	2	0.043	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.3
ROSMAP	Brain Pre-frontal Cortex	1	0.023	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	1	0.040	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2