Hub : Traits :

Fractured/broken bones in last 5 years

25 significantly associated models · 9 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 4 305291 1717024 1 2 2.1e-07 7.1e-07 0.00089 55 FGFRL1
2 6 127196109 127764305 1 1 6.3e-13 2.6e-13 0.07360 94 RSPO3
3 6 151569243 152184020 1 1 2.5e-07 2.4e-06 0.32800 96 C6orf97
4 12 14337924 15812575 3 1 7.7e-08 1.1e-07 0.35600 97 ERP27

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 3.22 1 0 0.0 0.00 1.0000 RSPO3
Breast Cancer 9.86 2 1 2.2 0.00 1.0000 C6orf97 RSPO3
Crohns Disease (2012) 2.61 1 0 0.0 0.00 1.0000 RSPO3
HDL Cholesterol 2.41 1 0 0.0 0.00 1.0000 RSPO3
Triglycerides 3.04 1 0 0.0 0.00 1.0000 RSPO3
Blood Platelet Count 0.38 1 0 0.0 0.00 1.0000 RSPO3
Blood Red Count 2.79 1 1 2.2 0.00 1.0000 RSPO3
Heel T-Score 125.02 4 4 8.9 -0.95 0.0133 C6orf97 ERP27 FGFRL1 RSPO3
Height 0.54 2 0 0.0 0.00 1.0000 ERP27 FGFRL1
Waist Hip Ratio (WHR) 22.87 2 2 4.4 0.00 1.0000 FGFRL1 RSPO3
Systolic Blood Pressure 1.07 1 0 0.0 0.00 1.0000 C6orf97
Smoking Status 1.42 1 0 0.0 0.00 1.0000 FGFRL1
Cardiovascular Disease 1.50 1 0 0.0 0.00 1.0000 C6orf97
Hair Pigment 0.12 1 0 0.0 0.00 1.0000 FGFRL1
Hand grip strength (left) 8.52 2 1 2.2 0.00 1.0000 ERP27 RSPO3
Systolic blood pressure, automated reading 0.93 1 0 0.0 0.00 1.0000 C6orf97
Impedance of leg (right) 0.86 1 0 0.0 0.00 1.0000 RSPO3
Leg fat-free mass (left) 1.19 2 0 0.0 0.00 1.0000 ERP27 FGFRL1
Hand grip strength (right) 7.30 1 1 2.2 0.00 1.0000 ERP27
Heel bone mineral density (BMD) T-score, automated (left) 82.49 4 3 6.7 -0.96 0.0106 C6orf97 ERP27 FGFRL1 RSPO3
High blood pressure 2.51 1 0 0.0 0.00 1.0000 C6orf97
Supplements: Glucosamine 4.23 1 0 0.0 0.00 1.0000 ERP27
Sitting height 1.53 4 0 0.0 -0.99 0.0115 C6orf97 ERP27 FGFRL1 RSPO3
Impedance of leg (left) 0.96 1 0 0.0 0.00 1.0000 RSPO3
Leg predicted mass (left) 1.18 2 0 0.0 0.00 1.0000 ERP27 FGFRL1
Waist circumference 1.23 1 0 0.0 0.00 1.0000 RSPO3
Forced vital capacity (FVC) 2.09 2 0 0.0 0.00 1.0000 FGFRL1 RSPO3
Heel bone mineral density (BMD) T-score, automated (right) 77.43 3 3 6.7 -0.99 0.0053 C6orf97 FGFRL1 RSPO3
Heart attack 3.84 1 0 0.0 0.00 1.0000 FGFRL1
Weight 0.81 1 0 0.0 0.00 1.0000 FGFRL1
Impedance of arm (right) 1.22 1 0 0.0 0.00 1.0000 ERP27
Trunk fat-free mass 1.77 2 1 2.2 0.00 1.0000 ERP27 FGFRL1
Hip circumference 3.08 2 1 2.2 0.00 1.0000 FGFRL1 RSPO3
Number of live births 2.23 1 0 0.0 0.00 1.0000 C6orf97
Forced expiratory volume in 1-second (FEV1) 2.01 2 0 0.0 0.00 1.0000 FGFRL1 RSPO3
Impedance of arm (left) 1.35 1 0 0.0 0.00 1.0000 ERP27
Trunk predicted mass 1.75 2 1 2.2 0.00 1.0000 ERP27 FGFRL1
Standing height 0.71 1 0 0.0 0.00 1.0000 FGFRL1
Hair/balding pattern: Pattern 4 1.75 1 0 0.0 0.00 1.0000 RSPO3
Pulse wave reflection index 3.38 1 0 0.0 0.00 1.0000 FGFRL1
Birth weight 1.85 1 0 0.0 0.00 1.0000 RSPO3
Arm fat-free mass (right) 1.76 2 0 0.0 0.00 1.0000 ERP27 FGFRL1
Neck or shoulder pain in last month 2.50 1 0 0.0 0.00 1.0000 FGFRL1
Arm predicted mass (right) 1.74 2 0 0.0 0.00 1.0000 ERP27 FGFRL1
Pulse rate, automated reading 1.88 2 0 0.0 0.00 1.0000 FGFRL1 RSPO3
Comparative height size at age 10 1.03 1 0 0.0 0.00 1.0000 FGFRL1
Leg pain on walking 2.73 1 0 0.0 0.00 1.0000 FGFRL1
Commuting to job workplace: Car/motor vehicle 2.57 1 0 0.0 0.00 1.0000 C6orf97
Hypertension (Self-reported) 2.59 2 0 0.0 0.00 1.0000 C6orf97 RSPO3
Illnesses of siblings: Diabetes 2.47 1 0 0.0 0.00 1.0000 FGFRL1
Whole body fat-free mass 1.55 2 0 0.0 0.00 1.0000 ERP27 FGFRL1
Leg fat-free mass (right) 1.22 2 0 0.0 0.00 1.0000 ERP27 FGFRL1
Osteoporosis (self-reported) 7.38 2 0 0.0 0.00 1.0000 FGFRL1 RSPO3
Whole body water mass 1.60 2 0 0.0 0.00 1.0000 ERP27 FGFRL1
Leg predicted mass (right) 1.19 2 0 0.0 0.00 1.0000 ERP27 FGFRL1
Basal metabolic rate 1.45 2 0 0.0 0.00 1.0000 ERP27 FGFRL1
Arm fat-free mass (left) 1.83 2 1 2.2 0.00 1.0000 ERP27 FGFRL1
Vascular/heart problems diagnosed by doctor 2.04 1 0 0.0 0.00 1.0000 C6orf97
Supplements: Calcium 4.12 1 0 0.0 0.00 1.0000 ERP27
Heart attack/myocardial infarction (self-reported) 3.51 1 0 0.0 0.00 1.0000 FGFRL1
Impedance of whole body 1.17 1 0 0.0 0.00 1.0000 ERP27
Arm predicted mass (left) 1.61 2 0 0.0 0.00 1.0000 ERP27 FGFRL1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.029 1.3
GTEx Adipose Visceral Omentum 0 0.000 1.3
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 1 0.034 1.4
GTEx Artery Coronary 0 0.000 1.4
GTEx Artery Tibial 2 0.053 1.4
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.3
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 0 0.000 1.4
GTEx Brain Hippocampus 0 0.000 1.4
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.3
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.3
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 1 0.024 1.3
GTEx Colon Sigmoid 0 0.000 1.3
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.4
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.3
GTEx Lung 0 0.000 1.3
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.4
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 1 0.027 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.4
GTEx Spleen 0 0.000 1.3
GTEx Stomach 0 0.000 1.3
GTEx Testis 0 0.000 1.3
GTEx Thyroid 1 0.025 1.3
GTEx Uterus 0 0.000 1.5
GTEx Vagina 0 0.000 1.4
GTEx Whole Blood 0 0.000 1.3
METSIM Adipose 2 0.043 1.3
NTR Blood 0 0.000 1.3
ROSMAP Brain Pre-frontal Cortex 1 0.023 1.2
YFS Blood 0 0.000 1.3
CommonMind Brain Pre-frontal Cortex 0 0.000 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 1 0.060 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 2 0.045 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 1 0.091 1.4
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.098 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.040 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 2 0.126 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 1 0.075 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 2 0.043 1.3
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.3
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 1 0.078 1.2
The Cancer Genome Atlas Thyroid Carcinoma 1 0.019 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2