Best TWAS P=7.54e-12 · Best GWAS P=4.15e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | ASCC3 | 0.06 | 0.03 | lasso | 3 | 0.02 | 4.3e-02 | -5.5 | -5.6 | 2.1e-08 | 0.80 | 0.12 | 0.43 | FALSE |
| 2 | GTEx | Artery Tibial | ASCC3 | 0.10 | 0.08 | lasso | 3 | 0.06 | 3.8e-05 | -5.5 | -5.7 | 9.4e-09 | 0.79 | 0.49 | 0.40 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | RP3-467N11.1 | 0.02 | 0.00 | blup | 287 | 0.01 | 2.3e-02 | 6.1 | -6.5 | 1.1e-10 | 0.83 | 0.06 | 0.47 | FALSE |
| 4 | The Cancer Genome Atlas | Esophageal Carcinoma | ASCC3 | 0.11 | 0.07 | blup | 131 | 0.07 | 2.4e-03 | 5.2 | 6.5 | 6.0e-11 | -0.92 | 0.07 | 0.74 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | ASCC3 | 0.06 | 0.05 | lasso | 1 | 0.04 | 2.0e-04 | -6.8 | 6.8 | 7.5e-12 | -1.00 | 0.02 | 0.98 | TRUE |