Best TWAS P=2.05e-09 · Best GWAS P=1.32e-08 conditioned to 0.07
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Lung | RMND1 | 0.26 | 0.14 | lasso | 7 | 0.15 | 1.7e-11 | -5.0 | 5.5 | 4.7e-08 | -0.56 | 0.05 | 0.94 | FALSE |
2 | YFS | Blood | RMND1 | 0.06 | 0.06 | lasso | 12 | 0.05 | 6.5e-16 | -5.5 | 5.5 | 5.2e-08 | -0.74 | 0.01 | 0.99 | FALSE |
3 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RMND1 | 0.16 | 0.10 | lasso | 7 | 0.12 | 1.6e-06 | -5.5 | 6.0 | 2.1e-09 | -0.75 | 0.02 | 0.98 | TRUE |
4 | The Cancer Genome Atlas | Colon Adenocarcinoma | RMND1 | 0.11 | 0.09 | lasso | 4 | 0.10 | 2.9e-06 | -5.6 | 5.6 | 1.8e-08 | -0.78 | 0.01 | 0.99 | FALSE |
5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RMND1 | 0.07 | 0.06 | blup | 58 | 0.09 | 1.4e-10 | -5.5 | 5.4 | 6.6e-08 | -0.76 | 0.01 | 0.99 | FALSE |
6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C6orf211 | 0.05 | 0.03 | lasso | 3 | 0.04 | 6.3e-05 | -4.6 | 5.3 | 1.4e-07 | -0.57 | 0.32 | 0.65 | FALSE |
7 | The Cancer Genome Atlas | Lung Adenocarcinoma | RMND1 | 0.05 | 0.06 | lasso | 2 | 0.07 | 4.3e-08 | -4.8 | 5.2 | 2.2e-07 | -0.54 | 0.06 | 0.93 | FALSE |
8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RMND1 | 0.09 | 0.02 | lasso | 6 | 0.03 | 2.3e-04 | -5.0 | 5.5 | 4.0e-08 | -0.65 | 0.02 | 0.98 | FALSE |
9 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | RMND1 | 0.16 | 0.15 | enet | 7 | 0.09 | 2.7e-03 | -4.8 | 5.2 | 2.7e-07 | -0.54 | 0.02 | 0.86 | FALSE |
10 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RMND1 | 0.06 | 0.04 | blup | 57 | 0.06 | 4.9e-05 | -5.0 | 5.4 | 6.9e-08 | -0.54 | 0.03 | 0.88 | FALSE |
11 | The Cancer Genome Atlas | Thyroid Carcinoma | RMND1 | 0.13 | 0.13 | enet | 6 | 0.14 | 6.6e-14 | -5.6 | 5.3 | 9.5e-08 | -0.70 | 0.01 | 0.99 | FALSE |