[Hub]/) : Traits : Age when periods started (menarche) :

chr6:151,030,107-152,470,136

Best TWAS P=2.05e-09 · Best GWAS P=1.32e-08 conditioned to 0.07

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Lung RMND1 0.26 0.14 lasso 7 0.15 1.7e-11 -5.0 5.5 4.7e-08 -0.56 0.05 0.94 FALSE
2 YFS Blood RMND1 0.06 0.06 lasso 12 0.05 6.5e-16 -5.5 5.5 5.2e-08 -0.74 0.01 0.99 FALSE
3 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma RMND1 0.16 0.10 lasso 7 0.12 1.6e-06 -5.5 6.0 2.1e-09 -0.75 0.02 0.98 TRUE
4 The Cancer Genome Atlas Colon Adenocarcinoma RMND1 0.11 0.09 lasso 4 0.10 2.9e-06 -5.6 5.6 1.8e-08 -0.78 0.01 0.99 FALSE
5 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma RMND1 0.07 0.06 blup 58 0.09 1.4e-10 -5.5 5.4 6.6e-08 -0.76 0.01 0.99 FALSE
6 The Cancer Genome Atlas Brain Lower Grade Glioma C6orf211 0.05 0.03 lasso 3 0.04 6.3e-05 -4.6 5.3 1.4e-07 -0.57 0.32 0.65 FALSE
7 The Cancer Genome Atlas Lung Adenocarcinoma RMND1 0.05 0.06 lasso 2 0.07 4.3e-08 -4.8 5.2 2.2e-07 -0.54 0.06 0.93 FALSE
8 The Cancer Genome Atlas Lung Squamous Cell Carcinoma RMND1 0.09 0.02 lasso 6 0.03 2.3e-04 -5.0 5.5 4.0e-08 -0.65 0.02 0.98 FALSE
9 The Cancer Genome Atlas Skin Cutaneous Melanoma RMND1 0.16 0.15 enet 7 0.09 2.7e-03 -4.8 5.2 2.7e-07 -0.54 0.02 0.86 FALSE
10 The Cancer Genome Atlas Stomach Adenocarcinoma RMND1 0.06 0.04 blup 57 0.06 4.9e-05 -5.0 5.4 6.9e-08 -0.54 0.03 0.88 FALSE
11 The Cancer Genome Atlas Thyroid Carcinoma RMND1 0.13 0.13 enet 6 0.14 6.6e-14 -5.6 5.3 9.5e-08 -0.70 0.01 0.99 FALSE