TWAS
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Models
Genes
Traits
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Traits
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Age when periods started (menarche)
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chr11:27,792,891-28,602,221
Best TWAS P=2.02e-09 · Best GWAS P=4.71e-08 conditioned to 0.695
27.8M
27.9M
28M
28.1M
28.2M
28.3M
28.4M
28.5M
28.6M
0
2
4
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Thyroid Carcinoma
KIF18A
0.04
0.01
blup
69
0.03
0.00129
2.8
-6.0
2.0e-09
-0.88
0.03
0.82
TRUE
2
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
METT5D1
0.02
0.02
enet
6
0.02
0.00241
5.2
5.7
1.1e-08
0.96
0.03
0.75
FALSE
1
The Cancer Genome Atlas
Brain Lower Grade Glioma
METT5D1
0.04
0.03
lasso
2
0.03
0.00017
5.4
5.5
5.1e-08
1.00
0.03
0.95
FALSE