Best TWAS P=5.11e-09 · Best GWAS P=1.99e-10 conditioned to 0.000668
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | RP11-613D13.5 | 0.17 | 0.18 | lasso | 6 | 0.18 | 2.4e-14 | -4.5 | 5.1 | 2.9e-07 | -0.69 | 0.86 | 0.13 | FALSE |
| 2 | GTEx | Brain Caudate basal ganglia | RP11-613D13.5 | 0.32 | 0.14 | enet | 24 | 0.13 | 1.6e-04 | -4.2 | 5.8 | 5.1e-09 | -0.64 | 0.24 | 0.51 | TRUE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | HSD17B12 | 0.51 | 0.35 | lasso | 7 | 0.37 | 3.1e-14 | -4.5 | 5.2 | 1.8e-07 | -0.73 | 0.54 | 0.46 | FALSE |
| 4 | GTEx | Esophagus Muscularis | RP11-613D13.5 | 0.21 | 0.20 | lasso | 2 | 0.19 | 9.6e-12 | -4.5 | 5.2 | 2.0e-07 | -0.64 | 0.97 | 0.03 | FALSE |
| 5 | GTEx | Testis | HSD17B12 | 0.67 | 0.58 | lasso | 10 | 0.60 | 8.5e-33 | -4.5 | 5.2 | 2.2e-07 | -0.72 | 0.97 | 0.03 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | HSD17B12 | 0.45 | 0.37 | enet | 72 | 0.47 | 1.1e-68 | -4.5 | 5.3 | 1.5e-07 | -0.60 | 0.95 | 0.04 | FALSE |