Best TWAS P=1.62e-10 · Best GWAS P=1.78e-10 conditioned to 0.307
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | COX11 | 0.15 | 0.08 | lasso | 4 | 0.07 | 2.6e-06 | -4.9 | -5.5 | 3.7e-08 | 0.78 | 0.21 | 0.66 | FALSE |
| 2 | GTEx | Thyroid | HLF | 0.08 | 0.05 | lasso | 4 | 0.03 | 1.6e-03 | -6.0 | 6.4 | 1.6e-10 | -0.95 | 0.02 | 0.95 | TRUE |
| 3 | YFS | Blood | STXBP4 | 0.03 | 0.03 | lasso | 4 | 0.03 | 1.8e-10 | -6.0 | 5.9 | 3.8e-09 | -0.96 | 0.03 | 0.97 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | COX11 | 0.10 | 0.00 | blup | 39 | 0.01 | 9.7e-02 | -4.7 | -5.2 | 2.4e-07 | 0.68 | 0.01 | 0.44 | FALSE |