TWAS
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Genes
Traits
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Traits
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Age when periods started (menarche)
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chr17:52,350,677-54,097,059
Best TWAS P=1.62e-10 · Best GWAS P=1.78e-10 conditioned to 0.307
52.4M
52.6M
52.8M
53M
53.2M
53.4M
53.6M
53.8M
54M
54.2M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Thyroid
HLF
0.08
0.05
lasso
4
0.03
1.6e-03
-6.0
6.4
1.6e-10
-0.95
0.02
0.95
TRUE
3
YFS
Blood
STXBP4
0.03
0.03
lasso
4
0.03
1.8e-10
-6.0
5.9
3.8e-09
-0.96
0.03
0.97
FALSE
1
GTEx
Artery Tibial
COX11
0.15
0.08
lasso
4
0.07
2.6e-06
-4.9
-5.5
3.7e-08
0.78
0.21
0.66
FALSE
4
The Cancer Genome Atlas
Kidney Renal Papillary Cell Carcinoma
COX11
0.10
0.00
blup
39
0.01
9.7e-02
-4.7
-5.2
2.4e-07
0.68
0.01
0.44
FALSE