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chr12:30,084,002-31,526,510

Best TWAS P=4.17e-10 · Best GWAS P=2.43e-08 conditioned to 0.734

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	IPO8	0.22	0.28	lasso	8	0.29	1.0e-35	5.5	-5.5	3.2e-08	-0.99	0.02	0.98	FALSE
2	GTEx	Adipose Subcutaneous	IPO8	0.13	0.09	lasso	6	0.12	2.7e-10	5.3	-6.1	1.3e-09	-0.91	0.02	0.98	FALSE
3	GTEx	Adipose Visceral Omentum	IPO8	0.17	0.08	lasso	2	0.05	9.9e-04	5.5	-5.5	4.8e-08	-0.99	0.02	0.97	FALSE
4	GTEx	Artery Tibial	IPO8	0.17	0.14	lasso	4	0.14	4.5e-11	5.5	-5.8	7.9e-09	-0.93	0.02	0.98	FALSE
5	GTEx	Breast Mammary Tissue	IPO8	0.11	0.11	lasso	10	0.08	4.3e-05	5.3	-5.6	2.8e-08	-0.97	0.02	0.98	FALSE
6	GTEx	Breast Mammary Tissue (Female)	IPO8	0.12	0.10	lasso	3	0.04	2.0e-02	5.3	-5.5	3.6e-08	-0.93	0.03	0.84	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	IPO8	0.22	0.14	lasso	4	0.14	2.5e-05	-5.3	-6.2	6.7e-10	-0.82	0.03	0.97	FALSE
8	GTEx	Cells Transformed fibroblasts	IPO8	0.25	0.22	enet	19	0.26	9.4e-20	5.5	-5.9	3.0e-09	-0.90	0.02	0.98	FALSE
9	GTEx	Colon Transverse	IPO8	0.11	0.11	lasso	2	0.10	2.4e-05	5.3	-5.5	4.8e-08	-0.98	0.02	0.98	FALSE
10	GTEx	Esophagus Mucosa	IPO8	0.30	0.14	lasso	6	0.19	1.1e-12	5.3	-5.5	4.9e-08	-0.81	0.02	0.98	FALSE
11	GTEx	Esophagus Muscularis	IPO8	0.24	0.19	lasso	6	0.18	5.7e-11	5.5	-5.6	1.8e-08	-0.96	0.02	0.98	FALSE
12	GTEx	Lung	IPO8	0.07	0.06	lasso	5	0.07	7.5e-06	5.3	-5.6	2.4e-08	-0.89	0.03	0.97	FALSE
13	GTEx	Nerve Tibial	IPO8	0.21	0.16	lasso	6	0.15	1.3e-10	-5.4	-5.5	4.9e-08	-0.53	0.04	0.96	FALSE
14	GTEx	Skin Sun Exposed Lower leg	IPO8	0.23	0.08	lasso	10	0.13	1.1e-10	-5.3	-6.2	4.7e-10	-0.85	0.03	0.97	FALSE
15	GTEx	Stomach	IPO8	0.14	0.11	lasso	4	0.09	6.6e-05	3.8	-5.2	2.0e-07	-0.84	0.03	0.95	FALSE
16	GTEx	Whole Blood	IPO8	0.09	0.00	lasso	4	0.00	2.9e-01	5.5	-5.4	8.0e-08	-0.96	0.03	0.84	FALSE
17	METSIM	Adipose	IPO8	0.06	0.04	lasso	6	0.03	9.2e-06	5.5	-5.6	2.0e-08	-0.99	0.02	0.98	FALSE
18	NTR	Blood	IPO8	0.03	0.00	blup	615	0.01	1.5e-05	5.3	-5.7	9.9e-09	-0.63	0.03	0.97	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	IPO8	0.21	0.23	lasso	12	0.22	8.0e-28	5.3	-5.5	3.1e-08	-0.95	0.02	0.98	FALSE
20	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IPO8	0.06	0.04	lasso	8	0.03	1.5e-03	5.5	-5.6	2.8e-08	-0.98	0.02	0.93	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	IPO8	0.05	0.03	lasso	3	0.03	1.3e-06	5.5	-5.8	6.4e-09	-0.96	0.02	0.98	FALSE
22	The Cancer Genome Atlas	Colon Adenocarcinoma	IPO8	0.06	0.06	blup	64	0.05	6.2e-04	5.5	-5.3	1.0e-07	-0.97	0.02	0.95	FALSE
23	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IPO8	0.06	0.02	blup	58	0.02	3.0e-03	2.8	-5.2	2.2e-07	-0.83	0.02	0.83	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	IPO8	0.12	0.07	lasso	4	0.07	3.2e-08	5.5	-5.6	2.3e-08	-0.99	0.01	0.99	FALSE
25	The Cancer Genome Atlas	Lung Adenocarcinoma	IPO8	0.06	0.04	blup	58	0.04	1.5e-05	5.5	-6.2	4.2e-10	-0.91	0.02	0.98	TRUE
26	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IPO8	0.04	0.03	blup	58	0.03	9.7e-05	5.3	-6.0	1.5e-09	-0.95	0.02	0.97	FALSE
27	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IPO8	0.09	0.05	blup	64	0.03	2.9e-02	5.5	-5.6	1.8e-08	-0.98	0.02	0.87	FALSE
28	The Cancer Genome Atlas	Stomach Adenocarcinoma	IPO8	0.04	0.04	enet	7	0.02	8.1e-03	5.5	-5.3	1.0e-07	-0.98	0.02	0.92	FALSE