Best TWAS P=1.61e-12 · Best GWAS P=2.77e-16 conditioned to 4.08e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PPA2 | 0.08 | 0.03 | bslmm | 429 | 0.04 | 2.2e-05 | -4.7 | -5.6 | 2.8e-08 | -0.48 | 0.50 | 0.29 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | PPA2 | 0.15 | 0.02 | enet | 36 | 0.06 | 7.0e-06 | 1.9 | -5.5 | 3.9e-08 | -0.29 | 0.24 | 0.18 | FALSE |
| 3 | GTEx | Artery Aorta | PPA2 | 0.11 | -0.01 | enet | 24 | 0.01 | 1.6e-01 | -6.8 | -5.9 | 3.0e-09 | -0.33 | 0.09 | 0.12 | FALSE |
| 4 | GTEx | Brain Cortex | PPA2 | 0.14 | 0.09 | lasso | 9 | 0.09 | 1.6e-03 | -5.4 | -5.5 | 3.7e-08 | -0.48 | 0.12 | 0.11 | FALSE |
| 5 | GTEx | Esophagus Gastroesophageal Junction | PPA2 | 0.29 | 0.15 | lasso | 5 | 0.14 | 8.8e-06 | -6.8 | -7.1 | 1.6e-12 | -0.48 | 0.56 | 0.06 | TRUE |
| 6 | GTEx | Esophagus Mucosa | PPA2 | 0.18 | 0.06 | enet | 14 | 0.12 | 2.5e-08 | 5.9 | -6.6 | 5.0e-11 | -0.28 | 0.91 | 0.04 | FALSE |
| 7 | GTEx | Heart Atrial Appendage | PPA2 | 0.15 | 0.05 | lasso | 7 | 0.06 | 7.4e-04 | -5.3 | -5.2 | 2.1e-07 | -0.57 | 0.34 | 0.10 | FALSE |
| 8 | GTEx | Lung | PPA2 | 0.09 | 0.02 | enet | 16 | 0.03 | 1.4e-03 | 2.6 | -6.2 | 5.9e-10 | -0.42 | 0.24 | 0.15 | FALSE |