Best TWAS P=2.78e-08 · Best GWAS P=2.74e-10 conditioned to 0.0799
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | METSIM | Adipose | DRAM1 | 0.12 | 0.03 | enet | 24 | 0.08 | 1.1e-12 | 4.5 | 5.5 | 3.9e-08 | 0.13 | 0.99 | 0.00 | TRUE |
| 2 | YFS | Blood | DRAM1 | 0.33 | 0.13 | enet | 101 | 0.19 | 1.6e-58 | 4.1 | 5.2 | 2.5e-07 | 0.12 | 1.00 | 0.00 | FALSE |
| 3 | The Cancer Genome Atlas | Colon Adenocarcinoma | CCDC53 | 0.07 | 0.07 | blup | 55 | 0.06 | 1.3e-04 | 5.3 | -5.6 | 2.8e-08 | -0.75 | 0.02 | 0.98 | FALSE |
| 4 | The Cancer Genome Atlas | Esophageal Carcinoma | CCDC53 | 0.14 | 0.08 | blup | 50 | 0.08 | 1.8e-03 | 4.9 | -5.2 | 1.8e-07 | -0.75 | 0.02 | 0.87 | FALSE |
| 5 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | C12orf48 | 0.09 | 0.08 | lasso | 4 | 0.07 | 3.5e-04 | 5.3 | 5.6 | 2.8e-08 | 0.84 | 0.05 | 0.78 | TRUE |