Best TWAS P=6.12e-22 · Best GWAS P=8.01e-20 conditioned to 0.304
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | QSOX2 | 0.18 | 0.11 | lasso | 4 | 0.10 | 1.0e-12 | 7.2 | 8.9 | 6.8e-19 | -0.70 | 0.78 | 0.22 | FALSE |
2 | GTEx | Cells Transformed fibroblasts | QSOX2 | 0.40 | 0.25 | enet | 11 | 0.30 | 5.2e-23 | -9.0 | 9.5 | 2.6e-21 | -0.88 | 0.00 | 1.00 | FALSE |
3 | GTEx | Esophagus Muscularis | QSOX2 | 0.16 | 0.07 | lasso | 4 | 0.06 | 1.4e-04 | 7.1 | 6.3 | 2.7e-10 | -0.35 | 0.54 | 0.02 | FALSE |
4 | GTEx | Nerve Tibial | QSOX2 | 0.22 | 0.12 | enet | 12 | 0.17 | 4.6e-12 | 6.3 | 5.9 | 3.0e-09 | -0.44 | 1.00 | 0.00 | FALSE |
5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | QSOX2 | 0.05 | 0.03 | blup | 32 | 0.03 | 2.8e-07 | -9.0 | 9.0 | 1.5e-19 | -0.76 | 0.00 | 1.00 | FALSE |
6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | QSOX2 | 0.10 | 0.03 | enet | 6 | 0.06 | 3.4e-07 | 6.1 | 8.2 | 1.6e-16 | -0.72 | 0.01 | 0.99 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | QSOX2 | 0.04 | 0.01 | enet | 4 | 0.03 | 3.6e-04 | -9.0 | 9.3 | 1.0e-20 | -0.85 | 0.00 | 0.98 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | QSOX2 | 0.10 | 0.11 | lasso | 2 | 0.10 | 1.6e-06 | -9.0 | 9.2 | 4.9e-20 | -0.96 | 0.00 | 1.00 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | QSOX2 | 0.06 | 0.05 | lasso | 2 | 0.05 | 2.5e-06 | 7.2 | 9.0 | 2.7e-19 | -0.71 | 0.02 | 0.96 | FALSE |
10 | The Cancer Genome Atlas | Lung Adenocarcinoma | QSOX2 | 0.05 | 0.05 | enet | 4 | 0.05 | 2.7e-06 | -9.0 | 9.6 | 1.2e-21 | -0.90 | 0.00 | 1.00 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | QSOX2 | 0.08 | 0.07 | lasso | 4 | 0.08 | 1.2e-08 | -9.0 | 9.6 | 6.1e-22 | -0.90 | 0.00 | 1.00 | TRUE |
12 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | QSOX2 | 0.28 | 0.01 | enet | 4 | 0.05 | 1.6e-02 | -9.0 | 9.0 | 1.9e-19 | -0.85 | 0.00 | 0.65 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | QSOX2 | 0.06 | 0.01 | blup | 32 | 0.05 | 1.6e-05 | 6.1 | 7.5 | 5.6e-14 | -0.61 | 0.01 | 0.84 | FALSE |