TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Forced vital capacity (FVC)
:
←
→
chr10:28,113,533-29,610,861
Best TWAS P=7.37e-08 · Best GWAS P=3.13e-10 conditioned to 9.86e-11
28.2M
28.4M
28.6M
28.8M
29M
29.2M
29.4M
29.6M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Brain Hippocampus
WAC-AS1
0.29
0.01
enet
10
-0.01
8.5e-01
5.9
5.4
7.4e-08
-0.03
0.03
0.65
TRUE
3
The Cancer Genome Atlas
Thyroid Carcinoma
WAC
0.06
0.04
lasso
3
0.03
4.2e-04
5.0
5.3
1.1e-07
-0.03
0.02
0.88
FALSE
2
ROSMAP
Brain Pre-frontal Cortex
WAC
0.21
0.29
lasso
5
0.29
5.9e-37
5.0
5.2
1.8e-07
-0.03
0.17
0.83
FALSE